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Cytokine dependent and independent iNKT cell activation.

Abstract：

:Invariant NKT (iNKT) cells have been extensively studied throughout the last decade due to their ability to polarize and amplify the downstream immune response. Only recently however, have the various mechanisms underlying NKT cell activation begun to unfold. iNKT cells have the ability to respond as innate immune cells with minimal TCR involvement as well as through direct TCR recognition of glycolipid antigens. Additionally, the existence of several subsets of iNKT cells creates the potential for other unique pathways, which are not yet clearly defined. Here, we provide an overview of the known mechanisms of invariant NKT cell activation, focusing on cytokine driven pathways and the resulting cytokine responses.

journal_name

Cytokine

journal_title

Cytokine

authors

Reilly EC,Wands JR,Brossay L

doi

10.1016/j.cyto.2010.04.016

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

227-31

issue

3

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(10)00126-2

journal_volume

51

pub_type

杂志文章,评审

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