The interplay between cytokines and the Kynurenine pathway in inflammation and atherosclerosis.


:The kynurenine pathway (KP) is the major metabolic route of tryptophan (Trp) metabolism. Indoleamine 2,3-dioxygenase (IDO1), the enzyme responsible for the first and rate-limiting step in the pathway, as well as other enzymes in the pathway, have been shown to be highly regulated by cytokines. Hence, the KP has been implicated in several pathologic conditions, including infectious diseases, psychiatric disorders, malignancies, and autoimmune and chronic inflammatory diseases. Additionally, recent studies have linked the KP with atherosclerosis, suggesting that Trp metabolism could play an essential role in the maintenance of immune homeostasis in the vascular wall. This review summarizes experimental and clinical evidence of the interplay between cytokines and the KP and the potential role of the KP in cardiovascular diseases.






Baumgartner R,Forteza MJ,Ketelhuth DFJ




Has Abstract


2019-10-01 00:00:00














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    abstract::Previously, two binding sites for interleukin 5 (IL-5) were identified on the IL-5 receptor alpha chain (IL-5Ralpha). They are located within the CD loop of the first fibronectin type III (FnIII)-like domain and the EF loop of the second FnIII-like domain. The first binding site was identified by exploiting the differ...


    pub_type: 杂志文章


    authors: Czabotar PE,Holland J,Sanderson CJ

    更新日期:2000-07-01 00:00:00

  • The interferon-induced gene ISG12 is regulated by various cytokines as the gene 6-16 in human cell lines.

    abstract::The gene for ISG12 (originally designated p27) was isolated as an oestrogen-induced gene. The authors undertook a comprehensive study using quantitative RT-PCR, in which we delineate the regulation of ISG12 by seven different cytokines including interferons and poly(I). poly(C) in seven human cell lines of different o...


    pub_type: 杂志文章


    authors: Gjermandsen IM,Justesen J,Martensen PM

    更新日期:2000-03-01 00:00:00

  • Lack of tumor necrosis factor receptor type 1 inhibits liver fibrosis induced by carbon tetrachloride in mice.

    abstract::Chronic liver injury causes liver regeneration, resulting in fibrosis. The proinflammatory cytokine tumor necrosis factor (TNF) is involved in the pathogenesis of many acute and chronic liver diseases. TNF has pleiotropic functions, but its role in liver fibrosis has not been clarified. Chronic repeated injection of C...


    pub_type: 杂志文章


    authors: Sudo K,Yamada Y,Moriwaki H,Saito K,Seishima M

    更新日期:2005-03-07 00:00:00

  • Effects of aspirin and nimesulide on tissue damage in diabetic rats.

    abstract::This study was designed to compare the effect of Aspirin (AS) and Nimesulide (NM) on renal failure and vascular disorder in streptozotocin (STZ)-induced diabetic rats. Rats were divided into four groups; control, diabetic rats, diabetic rats plus AS and diabetic rats plus NM, which are COX inhibitors. The renal and ao...


    pub_type: 杂志文章


    authors: Yesilot S,Ozer MK,Bayram D,Oncu M,Karabacak HI,Cicek E

    更新日期:2010-12-01 00:00:00

  • Macrophage inflammatory protein-1alpha: a link between innate immunity and familial Mediterranean fever?

    abstract::The aim of this study is to investigate the relationship between chemokines and the inflammation in Familial Mediterranean Fever (FMF). Forty-nine patients with FMF (41 in remission and 8 in acute attack period) and 20 healthy controls were included in the study. Serum levels of macrophage inflammatory protein-1alpha ...


    pub_type: 杂志文章


    authors: Dizdar O,Kalyoncu U,Karadag O,Akdogan A,Kiraz S,Ertenli I,Barista I,Calguneri M

    更新日期:2007-01-01 00:00:00

  • The role of BAFF in the progression of rheumatoid arthritis.

    abstract::Rheumatoid arthritis (RA) is a common autoimmune disease that is marked by a systemic inflammatory reaction and joint erosions. Elevated levels of B cell activating factor (BAFF) have been detected in the serum and synovial fluid of RA patients. Moreover, the levels of BAFF increase in cases of autoimmune disease and ...


    pub_type: 杂志文章,评审


    authors: Wei F,Chang Y,Wei W

    更新日期:2015-12-01 00:00:00

  • Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations.

    abstract::Emerging evidence indicates that chemokine receptor expression patterns are critical in determining the spectrum of action of the chemokines. We have analysed the expression patterns of 17 chemokine receptors and two orphan chemokine receptor-like genes in various freshly prepared human peripheral blood leucocyte popu...


    pub_type: 杂志文章


    authors: Patel L,Charlton SJ,Chambers JK,Macphee CH

    更新日期:2001-04-07 00:00:00

  • Association of plasma CD40L with acute chest syndrome in sickle cell anemia.

    abstract::Platelet activation and platelet-derived cytokines contribute to the vascular inflammation and increased thrombotic activity known to occur in patients with sickle cell anemia (SCA). CD40 ligand (CD40L), a platelet-associated pro-inflammatory molecule that promotes endothelial cell activation, is elevated in the circu...


    pub_type: 杂志文章


    authors: Garrido VT,Sonzogni L,Mtatiro SN,Costa FF,Conran N,Thein SL

    更新日期:2017-09-01 00:00:00

  • Local levels of interleukin-1beta, -4, -6 and tumor necrosis factor alpha in an experimental model of murine osteomyelitis due to staphylococcus aureus.

    abstract::The purpose of this study is to evaluate local levels of interleukin-1 beta (IL-1 beta), -4 (IL-4), -6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha), in a model of murine osteomyelitis due to Staphylococcus aureus. Cytokine levels in supernatants derived from bone homogenates were determined by enzyme-linked im...


    pub_type: 杂志文章


    authors: Yoshii T,Magara S,Miyai D,Nishimura H,Kuroki E,Furudoi S,Komori T,Ohbayashi C

    更新日期:2002-07-21 00:00:00

  • Association of interleukin (IL)-4 variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms with susceptibility to pediatric autoimmune hepatitis type 1.

    abstract:OBJECTIVE:Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease mediated by an autoimmune reaction to hepatocytes, the present study aimed to assess the possible associations between interleukin-4 (IL-4) variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms and susceptibility to aut...


    pub_type: 杂志文章


    authors: Mansour AI,Behairy OG,Abd Almonaem ER,Abd-Rabuh RM,Ahmed IAE

    更新日期:2018-10-01 00:00:00

  • Chemotaxis and chemotactic selection induced with cytokines (IL-8, RANTES and TNF-alpha) in the unicellular Tetrahymena pyriformis.

    abstract::Three representative cytokines interleukin (IL-8), RANTES and tumour necrosis factor alpha (TNF-alpha) have a concentration-dependent chemotactic effect on the unicellular Tetrahymena. Maximal effective concentrations of IL-8 (1 ng/ml) and RANTES (75 ng/ml) are in the same range as in mammals, which indicates an evolu...


    pub_type: 杂志文章


    authors: Köhidai L,Csaba G

    更新日期:1998-07-01 00:00:00

  • The G to A polymorphism at -597 of the interleukin-6 gene is extremely rare in southern Han Chinese.

    abstract::Interleukin-6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes including essential hypertension (EH). Associations of the IL-6 promoter region polymorphisms with circulating level of IL-6 have been reported in various studies. We detected the IL-6-597G/A polymorphism in 246 EH pati...


    pub_type: 杂志文章


    authors: Gao SP,Pan M,Chen C,Ge LJ,Jiang MH,Luan H,Zheng JG,Deng XT,Pan HY,Zhu JH

    更新日期:2011-07-01 00:00:00

  • Extensive serum biomarker analysis in patients with non-small-cell lung carcinoma.

    abstract::Lung cancer is a common malignant disease, nearly 2.09 million new patients occurred last year. Approximately 85% of the patients are classified as non-small-cell lung cancer (NSCLC). It is therefore important to identify new diagnostic and prognostic biomarkers for the early detection of this disease. The presented s...


    pub_type: 杂志文章


    authors: Cai D,Xu Y,Ding R,Qiu K,Zhang R,Wang H,Huang L,Xie X,Yan H,Deng Y,Lin X,Shao J,Luo X,Duan C

    更新日期:2020-02-01 00:00:00

  • Comparison of the functional properties of murine dendritic cells generated in vivo with Flt3 ligand, GM-CSF and Flt3 ligand plus GM-SCF.

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    pub_type: 杂志文章


    authors: Daro E,Butz E,Smith J,Teepe M,Maliszewski CR,McKenna HJ

    更新日期:2002-02-07 00:00:00

  • Decreased nerve growth factor levels in hyperthyroid Graves' ophthalmopathy highlighting the role of neuroprotective factor in autoimmune thyroid diseases.

    abstract::Nerve growth factor (NGF), which is a neurotrophic factor, is involved in autoimmune and inflammatory processes. Serum NGF levels were investigated in 131 patients with autoimmune (95 with Graves' disease, of whom 57 had ophthalmopathy, 19 with Hashimoto's thyroiditis) and nonimmune thyroid diseases (17 with toxic nod...


    pub_type: 杂志文章,评审


    authors: Molnár I,Bokk A

    更新日期:2006-08-01 00:00:00

  • Interleukin-6 in irritable bowel syndrome: A systematic review and meta-analysis of IL-6 (-G174C) and circulating IL-6 levels.

    abstract:BACKGROUND:Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder which presents with abdominal pain and alterations of the bowel habits. The pathophysiology of IBS is not well-recognized. Low grade inflammation has been suggested as one of the underlying mechanisms of IBS. Variations in the ci...


    pub_type: 杂志文章,meta分析,评审


    authors: Bashashati M,Moradi M,Sarosiek I

    更新日期:2017-11-01 00:00:00

  • IL-10 -592A/C polymorphism is associated with severity of Hashimoto's disease.

    abstract::The genetic producibilities of T helper type 1 (Th1) and T helper type 2 (Th2) cytokines are associated with the prognosis of autoimmune thyroid diseases (AITDs). Interleukin (IL)-10 is considered to be a Th2 cytokine that can exhibit an anti-inflammatory role. Furthermore, IL-10 may be associated with the development...


    pub_type: 杂志文章


    authors: Inoue N,Watanabe M,Wada M,Morita M,Hidaka Y,Iwatani Y

    更新日期:2013-10-01 00:00:00

  • Role of the citrulline-nitric oxide cycle in the functional response of adult human and rodent pancreatic islets to cytokines.

    abstract::The present study aims to characterize the role of the citrulline-nitric oxide cycle in the response of adult human and rat pancreatic islets to cytokines. Citrulline (0.1-1.0 mM) or arginine (0.1-1.0 mM) led to a similar dose dependent nitric oxide (NO) production by rat islets exposed to interleukin 1 beta (IL-1 bet...


    pub_type: 杂志文章


    authors: Flodström M,Morris SM Jr,Eizirik DL

    更新日期:1996-08-01 00:00:00

  • Altered serum profile of the interleukin-22 system in inflammatory bowel disease.

    abstract:BACKGROUND AND AIM:Interleukin-22 (IL-22), plays a vital role in the mucosal repair of inflammatory bowel disease (IBD). Serum levels of IL-22 and IL-22 binding protein (IL-22BP), a soluble inhibitory IL-22 receptor, were measured in patients with IBD to investigate the profile of IL-22 in the systemic circulation. ME...


    pub_type: 杂志文章


    authors: Sakemi R,Mitsuyama K,Morita M,Yoshioka S,Kuwaki K,Tokuyasu H,Fukunaga S,Mori A,Araki T,Yoshimura T,Yamasaki H,Tsuruta K,Morita T,Yamasaki S,Mizoguchi A,Sou S,Torimura T

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  • Effect of tear supplements on signs, symptoms and inflammatory markers in dry eye.

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    pub_type: 杂志文章,随机对照试验


    authors: Martin E,Oliver KM,Pearce EI,Tomlinson A,Simmons P,Hagan S

    更新日期:2018-05-01 00:00:00

  • Synergism between lipopolysaccharide and interferon gamma in the regulation of lipoprotein lipase in macrophages.

    abstract::The regulation of macrophage lipoprotein lipase (LPL) by cytokines is potentially of crucial importance in the pathogenesis of atherosclerosis and in septic shock. The effect of combinations of lipopolysaccharide (LPS) and cytokines on the expression of LPL in macrophages was studied using the murine J774.2 cell line....


    pub_type: 杂志文章


    authors: Tengku-Muhammad TS,Hughes TR,Cryer A,Ramji DP

    更新日期:1999-06-01 00:00:00

  • Restoring thymic function: Then and now.

    abstract::Thymic vulnerability, a leading cause of defective immunity, was discovered decades ago. To date, several strategies have been investigated to unveil any immunorestorative capacities they might confer. Studies exploiting castration, transplantation, adoptive cell therapies, hormones/growth factors, and cytokines have ...


    pub_type: 杂志文章,评审


    authors: El-Kadiry AE,Rafei M

    更新日期:2019-08-01 00:00:00

  • Regulation and role of interleukin 6 in wounded human epithelial keratinocytes.

    abstract::Dermal wounding is accompanied by inflammation and the resulting proinflammatory cytokines, including interleukin (IL)-6, are thought to play an important role in the repair process. IL-6 is produced by normal human keratinocytes to various dermatological diseases and we have recently shown it is also required for nor...


    pub_type: 杂志文章


    authors: Sugawara T,Gallucci RM,Simeonova PP,Luster MI

    更新日期:2001-09-21 00:00:00

  • The TGFβ1 pathway is required for NFκB dependent gene expression in mouse keratinocytes.

    abstract::The transforming growth factor-beta 1 (TGFβ1) and NFκB pathways are important regulators of epidermal homeostasis, inflammatory responses and carcinogenesis. Previous studies have shown extensive crosstalk between these pathways that is cell type and context dependent, but this has not been well-characterized in epide...


    pub_type: 杂志文章


    authors: Hogan KA,Ravindran A,Podolsky MA,Glick AB

    更新日期:2013-12-01 00:00:00

  • Cytokine gene expression in splenic macrophages and Kupffer cells following haemorrhage.

    abstract::TNF-alpha, IL-1, IL-6 and TGF-beta are important macrophage-derived mediators which play the pleiotropic role in inflammatory, metabolic, hematopoietic and immunologic processes. Studies have shown that haemorrhagic shock without significant tissue trauma induces profound immunosuppression which is associated with ele...


    pub_type: 杂志文章


    authors: Zhu XL,Zellweger R,Zhu XH,Ayala A,Chaudry IH

    更新日期:1995-01-01 00:00:00

  • Periapical fluid RANKL and IL-8 are differentially regulated in pulpitis and apical periodontitis.

    abstract::The dental pulp space can become infected due to a breach in the surrounding hard tissues. This leads to inflammation of the pulp (pulpitis), soft tissue breakdown, and finally to bone loss around the root apex (apical periodontitis). The succession of the molecular events leading to apical periodontitis is currently ...


    pub_type: 杂志文章


    authors: Rechenberg DK,Bostanci N,Zehnder M,Belibasakis GN

    更新日期:2014-09-01 00:00:00

  • Physical training prior to myocardial infarction potentializes stem cell therapy, SDF-1/CXCR4 axis activation and inhibits the vasoconstrictor response in hypertensive rats.

    abstract::Stem cell therapy is a promising strategy for recovering of injured cardiac tissue after acute myocardial infarction. The effects promoted by preventive physical training, beneficial for regeneration, are not yet understood on stem cell homing. In the present study, we evaluated the effect of preventive physical train...


    pub_type: 杂志文章


    authors: Schaun MI,Kristochek M,Dias LD,Peres TR,Lehnen AM,Irigoyen MC,Markoski MM

    更新日期:2020-02-01 00:00:00

  • Endogenous IL-18 in experimentally induced asthma affects cytokine serum levels but is irrelevant for clinical symptoms.

    abstract::T cells and T cell derived cytokines are involved in the complex pathogenesis of asthma. The role of the cytokine IL-18 however, is not clearly defined so far. On the one hand side IL-18 induces Th1-type cytokines and thereby might counter-regulate Th2-mediated allergic asthma. On the other hand IL-18 also bears pro-i...


    pub_type: 杂志文章


    authors: Hartwig C,Tschernig T,Mazzega M,Braun A,Neumann D

    更新日期:2008-06-01 00:00:00

  • Association of CTLA-4 and TNF-α polymorphism with recurrent miscarriage among North Indian women.

    abstract:CONTEXT:CTLA-4 is engaged on effector cells that may alter signal transduction and subsequently cytokine production. The transmission of longer repeats of (AT)(n) alleles of CTLA-4 is also associated with women undergoing recurrent miscarriage. The TNF-α known as an embryo-toxic cytokine is reported to be greater in pl...


    pub_type: 杂志文章


    authors: Gupta R,Prakash S,Parveen F,Agrawal S

    更新日期:2012-11-01 00:00:00

  • Stages versus subsets: Invariant Natural Killer T cell lineage differentiation.

    abstract::Invariant Natural Killer T (iNKT) cells represent a population of innate T lymphocytes which act as 'first-responders' to infection. While they have long been considered a versatile cell, capable of secretion of multiple cytokines upon activation, recent evidence now indicates that distinct lineages of iNKT cells with...


    pub_type: 杂志文章,评审


    authors: Buechel HM,Stradner MH,D'Cruz LM

    更新日期:2015-04-01 00:00:00