The interplay between cytokines and the Kynurenine pathway in inflammation and atherosclerosis.

Abstract:

:The kynurenine pathway (KP) is the major metabolic route of tryptophan (Trp) metabolism. Indoleamine 2,3-dioxygenase (IDO1), the enzyme responsible for the first and rate-limiting step in the pathway, as well as other enzymes in the pathway, have been shown to be highly regulated by cytokines. Hence, the KP has been implicated in several pathologic conditions, including infectious diseases, psychiatric disorders, malignancies, and autoimmune and chronic inflammatory diseases. Additionally, recent studies have linked the KP with atherosclerosis, suggesting that Trp metabolism could play an essential role in the maintenance of immune homeostasis in the vascular wall. This review summarizes experimental and clinical evidence of the interplay between cytokines and the KP and the potential role of the KP in cardiovascular diseases.

journal_name

Cytokine

journal_title

Cytokine

authors

Baumgartner R,Forteza MJ,Ketelhuth DFJ

doi

10.1016/j.cyto.2017.09.004

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

154148

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(17)30259-4

journal_volume

122

pub_type

杂志文章,评审

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