Abstract:
PURPOSE:Tumor necrosis factor (TNFα) is a proinflammatory cytokine and has been a target for intervention in human sepsis. However, inhibition of TNF-α with a high dose of a TNF-receptor fusion protein in patients with septic shock worsened patient survival. This study was designed to investigate whether blocking TNF-α enhances mortality in infected burn mice through the induction of IL-1β. METHODS:WT or Tnfrsf1a(-/-) mice received Pseudomonas aeruginosa injection in the back at 8h after burn injury. The animals were sacrificed at 24h after burn and lung tissues were harvested and examined for determining myeloperoxidase (MPO) activity, pulmonary microvascular dysfunction, NF-κB DNA binding activity, and IL-1β expression. Also, the lung and blood were harvested for bacterial count assay. RESULT:Thermal injury alone induced NF-κB DNA binding activity and neutrophil infiltration in the lung in WT but not in Tnfrsf1a(-/-) mice. A 50% total body surface area (TBSA) burn induced a significant increase of mortality in WT compared with Tnfrsf1a(-/-) mice. In contrast, P. aeruginosa injection with a 30% TBSA burn pretreatment enhanced IL-1β expression, bacterial counts in lung and blood, pulmonary microvascular dysfunction, and mortality in Tnfrsf1a(-/-) mice compared with WT mice. Injection of the IL-1 receptor antagonist, Anakinra, reduced P. aeruginosa infection with burn pretreatment-induced blood bacterial counts, IL-1β levels as well as permeability of lung, and mortality in Tnfrsf1a(-/-) mice. CONCLUSIONS:Our findings suggest that thermal injury induces lung NF-κB activation and neutrophil sequestration through TNFα signaling. However, blocking TNF-α enhances P. aeruginosa infection-induced lung damage in burn mice via induction of IL-1β. Using an IL-1 receptor antagonist combined with the neutralization of TNF-α could be a useful strategy for decreasing P. aeruginosa infection-induced mortality in burn patients.
journal_name
Cytokinejournal_title
Cytokineauthors
Tsay TB,Yang MC,Chen PH,Lai KH,Huang HT,Hsu CM,Chen LWdoi
10.1016/j.cyto.2013.04.002subject
Has Abstractpub_date
2013-07-01 00:00:00pages
58-66issue
1eissn
1043-4666issn
1096-0023pii
S1043-4666(13)00150-6journal_volume
63pub_type
杂志文章相关文献
CYTOKINE文献大全abstract::Estrogens have been associated with risk for epithelial ovarian cancer (OVCA). Both IL-6 and IL-8 are also likely involved in the progression of OVCA. In order to discover the underline molecular mechanism, we investigated the modulation of estrogen and two cytokines in the growth and progression of epithelial OVCA. I...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.03.013
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Published studies on association between IL12B (G/A) rs10045431, (T/C)rs6887695 polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian population have yielded conflicting results. The aim of this study was to potentially provide more reliable conclusions by conducting a meta-analysis. METHODS:...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155296
更新日期:2020-12-01 00:00:00
abstract::Published data on the association between CYP1A1 gene polymorphism and ovarian cancer risk are conflicting and heterogeneous. To derive a more precise estimation of the relationship, a meta-analysis was performed. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were performed for heterozygous, homozyg...
journal_title:Cytokine
pub_type: 杂志文章,meta分析
doi:10.1016/j.cyto.2011.12.025
更新日期:2012-04-01 00:00:00
abstract::The regulation of macrophage lipoprotein lipase (LPL) by cytokines is potentially of crucial importance in the pathogenesis of atherosclerosis and in septic shock. The effect of combinations of lipopolysaccharide (LPS) and cytokines on the expression of LPL in macrophages was studied using the murine J774.2 cell line....
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1998.0447
更新日期:1999-06-01 00:00:00
abstract:INTRODUCTION:Transfersomes (TF) are new, ultradeformable carriers with characteristics that enable them to penetrate the skin spontaneously. TFs are able to transport noninvasively both low- and high-molecular-weight molecules into the body. MATERIALS AND METHODS:TFs contain phosphatidylcholine and sodium cholate. Rec...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2003.10.010
更新日期:2004-02-21 00:00:00
abstract::Vascular smooth muscle cells (VSMC) may be programmed by nutrient deprivation. We found that after 2 and 12 h exposure to 75% reduced amino acids, the release of basic fibroblast growth factor (bFGF) and transforming growth factor beta1 (TGF beta 1) from VSMC was significantly greater than that from cells maintained i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0710
更新日期:2000-09-01 00:00:00
abstract::The purpose of the study was to reassess the utility of transforming growth factor-beta-1 (TGF-beta1) together with dosimetric and tumor parameters as a predictor for radiation pneumonitis (RP). Of the 121 patients studied, 32 (26.4%) developed grade > or =1 RP, and 27 (22.3%) developed grade > or =2 RP. For the endpo...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.07.021
更新日期:2006-08-01 00:00:00
abstract::Interleukin 12 (IL-12) is a heterodimer comprising p35 and p40 subunits which are encoded and regulated separately. The authors previously demonstrated deficient IL-12 production in SLE which correlates negatively with disease activity. The present study was designed to determine whether deficiency of IL-12 and excess...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1999.0512
更新日期:1999-10-01 00:00:00
abstract::Interleukin-6 (IL-6) is a multifunctional cytokine having primarily anti-apoptotic and anti-inflammatory effects. Recent reports have documented that IL-6 plays a key role in liver regeneration. Intracellular deficiency of S-adenosylmethionine (SAMe) is a hallmark of toxin-induced liver injury. Although the administra...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2004.08.004
更新日期:2004-12-21 00:00:00
abstract::Interleukin 1 (IL-1) activates p42/p44 and p38 mitogen-activated protein kinases (MAP kinases) in target cells. Here we have used two specific inhibitors, PD98059 which inhibits MAP kinase kinase (MEK), and SB203580 which inhibits p38 MAP kinase to explore the involvement of these kinases in the induction of IL-2 by I...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1998.0478
更新日期:1999-09-01 00:00:00
abstract::Interleukin 6 (IL-6) stimulates fibrinogen (Fg) gene expression both in vivo and in vitro; while interleukin 1 (IL-1) paradoxically stimulates in vivo, yet inhibits in vitro, Fg synthesis. The naturally occurring interleukin 1 receptor antagonist (IL-1ra) and passive immunization with anti-IL-6 antiserum were used to ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(93)90035-4
更新日期:1993-09-01 00:00:00
abstract::Literature studies suggest important protective effects of low-frequency, low-energy pulsed electromagnetic fields (PEMFs) on inflammatory pathways affecting joint and cerebral diseases. However, it is not clear on which bases they affect neuroprotection and the mechanism responsible is yet unknown. Therefore the aim ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2019.154777
更新日期:2020-01-01 00:00:00
abstract::Intestinal immunity differs from systemic immunity in several aspects and is frequently studied separately. In this work we have analysed the frequency of mononuclear cells spontaneously secreting the cytokines IL-2, IL-4, IL-5, IL-6, IL-10, interferon gamma (IFN-gamma) and tumour necrosis factor (TNF-alpha), in Peyer...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0706
更新日期:2000-08-01 00:00:00
abstract::Enteroviruses are associated with chronic inflammatory and autoimmune diseases in humans. In these conditions, the cytokine network is supposed to have an important role in inflammation and modulation of the (auto)immune response. In the present study, we demonstrate that coxsackie virus B4 and poliovirus type 1 induc...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0786
更新日期:2000-12-01 00:00:00
abstract:AIMS:There is interest in using blood C-reactive protein (CRP) to predict adverse prognosis outcomes patients with type 2 diabetes. This meta-analysis aimed to investigate the association between elevated baseline CRP level and unfavorable outcomes in type 2 diabetes patients. MATERIALS/METHODS:PubMed and Embase datab...
journal_title:Cytokine
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.cyto.2019.02.005
更新日期:2019-05-01 00:00:00
abstract::In hypertension studies, anti-inflammatory cytokine interleukin-10 (IL-10) has been shown to prevent angiotensin II (Ang II)-induced vasoconstriction and regulate vascular function by down-regulating pro-inflammatory cytokine and superoxide production in vascular cells. However, little is known about the mechanism beh...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2015.09.002
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:Vascular endothelial cell growth factor (VEGF) plays an important role in the biology of gynecological cancer, usually linked with aggressive tumour behaviour and a poor postoperative outcome. Yet, its role in benign breast/gynecological conditions is less clear. METHODS:Serum VEGF was analysed in a series ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.12.007
更新日期:2011-03-01 00:00:00
abstract::The prevalence of Th1/Th2 response, spleen changes and megakaryocytes were investigated in BALB/c mice (n=138) infected with Leishmania infantum, and treated with Leishmania infantum 30× (10-30) biotherapy - BioLi30×. We performed controlled experiments using 8-to-12-week-old mice, infected with 5×107L. infantum proma...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.02.010
更新日期:2017-07-01 00:00:00
abstract::Allogeneic bone marrow transplantation was performed in a 24-year-old woman with acute myelogenous leukemia in the first remission (FAB classification: M4). Graft-versus-host disease occurred from around day 150 after bone marrow transplantation. The levels of tumour necrosis factor-alpha, interleukin 12, and intercel...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0698
更新日期:2000-08-01 00:00:00
abstract::Three representative cytokines interleukin (IL-8), RANTES and tumour necrosis factor alpha (TNF-alpha) have a concentration-dependent chemotactic effect on the unicellular Tetrahymena. Maximal effective concentrations of IL-8 (1 ng/ml) and RANTES (75 ng/ml) are in the same range as in mammals, which indicates an evolu...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0328
更新日期:1998-07-01 00:00:00
abstract::Human milk is a complex biological fluid. It contains many nutrients, anti-infectious and biologically active substance. Human milk also contains many angiogenic polypeptides. We have determined four of these: Vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF), insulin-like growth factor...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.02.008
更新日期:2010-05-01 00:00:00
abstract::There are indications that bone regulatory and immune systems are closely related. Of special interest in this context is the acute otitis media (AOM), which mainly affects immunologically immature patients and, when complicated, involves bone tissue. To explore host responses in bone tissue during Haemophilus influen...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2003.11.009
更新日期:2004-03-21 00:00:00
abstract::Granulocyte colony-stimulating factor (G-CSF) is the major cytokine involved in the control of neutrophil development. G-CSF activates the special receptor, the G-CSF receptor (GCSF-R), which subsequently triggers multiple signaling events. To obtain more interactive molecules with GCSF-R and to further understand the...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.01.008
更新日期:2006-02-21 00:00:00
abstract::The clinical phenotype in sepsis that is observed as LPS tolerance is determined by silencing of pro-inflammatory genes like IL-1 beta (IL-1β). This study shows that facultative heterochromatin (fHC) silences IL-1β expression during sepsis, where we find dephosphorylated histone H3 serine 10 and increased binding of h...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.10.007
更新日期:2011-02-01 00:00:00
abstract::Fetal liver is the main site of haematopoiesis during mid-gestation. The adult liver still provides a favourable environment for extramedullary haematopoiesis. Nevertheless, regulation of liver haematopoiesis by cell-cell contacts or by cytokines remains poorly understood. Recently, we have shown that rat liver epithe...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1999.0639
更新日期:2000-07-01 00:00:00
abstract::Effector CD4+ T cells can be classified by the cytokines they secrete, with T helper 1 (Th1) cells generating interferon (IFN)γ and Th17 cells secreting interleukin (IL)-17. Both Th1 and Th17 cells are strongly implicated in the initiation and chronicity of autoimmune diseases such as multiple sclerosis. The endoplasm...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2019.154944
更新日期:2020-05-01 00:00:00
abstract::Flt3 ligand (FL) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are important growth factors for dendritic cells (DC). Substantial numbers of DC can be generated in vivo following the administration of either factor. We sought to extend our knowledge of the functional properties of these cells including...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2001.0995
更新日期:2002-02-07 00:00:00
abstract::Cardiotrophin-1 (CT-1) can induce expression of the protective heat shock proteins (hsps) in cardiac cells. We show here that, unlike the stress induced accumulation of hsps, the effect of CT-1 is not accompanied by increased hsp mRNA levels and is insensitive to the RNA synthesis inhibitor actinomycin D, suggesting t...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0778
更新日期:2000-11-01 00:00:00
abstract::The expression of oncostatin M and leukemia inhibitory factor (LIF), JAK-STAT activators and members of the interleukin-6 family of cytokines, were examined in a series of primary ovarian carcinomas using immunohistochemistry. The malignant epithelial cells of all 29 ovarian carcinomas examined expressed oncostatin M;...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2002.1022
更新日期:2002-03-21 00:00:00
abstract::Platelet activation and platelet-derived cytokines contribute to the vascular inflammation and increased thrombotic activity known to occur in patients with sickle cell anemia (SCA). CD40 ligand (CD40L), a platelet-associated pro-inflammatory molecule that promotes endothelial cell activation, is elevated in the circu...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.05.017
更新日期:2017-09-01 00:00:00