当前位置： SCI文献检索 > CYTOKINE期刊下所有文献 > Regulation of the interleukin 2 receptor complex tyrosine kinase activity in vitro.

Regulation of the interleukin 2 receptor complex tyrosine kinase activity in vitro.

Abstract：

:Interleukin 2 (IL-2) has been shown to stimulate tyrosine phosphorylation of a number of proteins requiring only the p75 beta chain of the IL-2 receptor. Unlike the receptors for epidermal growth factor, insulin, and other growth factors, the p55-alpha and p75-beta chains of the IL-2 receptor have no tyrosine protein kinase domain suggesting that the IL-2 receptor complex activates protein kinases by a unique mechanism. The activation of tyrosine kinases by IL-2 in situ was studied and using a novel methodology has shown tyrosine kinase activity associated with the purified IL-2R complex in vitro. IL-2 stimulated the in situ tyrosine phosphorylation of 97 kDa and 58 kDa proteins which bound to poly(Glu,Tyr)4:1, a substrate for tyrosine protein kinases, suggesting these proteins had characteristics found in almost all tyrosine kinases. IL-2 was found to stimulate tyrosine protein kinase activity in receptor extracts partially purified from human T lymphocytes and the YT cell line. Biotinylated IL-2 was used to precipitate the high-affinity-receptor complex and phosphoproteins associated with it. The data indicated that the 97-kDa and 58-kDa phosphotyrosyl proteins were tightly associated with the IL-2 receptor complex. These proteins were phosphorylated on tyrosine residues by IL-2 stimulation of intact cells and ligand treatment of in vitro receptor extracts. Furthermore, the 97-kDa and 58-kDa proteins were found in streptavidin-agarose/biotinylated IL-2 purified receptor preparations and showed high affinity for tyrosine kinase substrate support matrixes. The experiments suggest that these two proteins are potential candidates for tyrosine kinases involved in the IL-2R complex signal transduction process.

journal_name

Cytokine

journal_title

Cytokine

authors

Michiel DF,Garcia GG,Evans GA,Farrar WL

doi

10.1016/1043-4666(91)90047-h

subject

Has Abstract

pub_date

1991-09-01 00:00:00

pages

428-38

issue

5

eissn

1043-4666

issn

1096-0023

pii

1043-4666(91)90047-H

journal_volume

3

pub_type

杂志文章

相关文献

CYTOKINE文献大全
  • A functional variant rs1464938 in the promoter of fibroblast growth factor 12 is associated with an increased risk of bladder transitional cell carcinoma.

    abstract：:Increasing evidence shows that inflammation plays critical roles in the tumorigenesis of bladder cancer. Fibroblast growth factor 12 (FGF12), a kind of inflammatory cytokine, is located in the region of 3q28 that has been demonstrated to be a bladder cancer risk locus by genome wide association study (GWAS). In this s...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2020.155294

    authors： Wu J,Huang H,Huang Q,Qiu R,Huang M,Meng D

    更新日期：2020-12-01 00:00:00

  • The chemokine C10: immunological and functional analysis of the sequence encoded by the novel second exon.

    abstract：:The gene for C10, a member of the beta-chemokine family of cytokines, contains a novel second exon encoding a 16 amino acid sequence which is inserted into the amino-terminal region of the protein. We propose a model of C10 structure in which the sequence encoded by the second exon is located on the surface of the pro...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1996.0060

    authors： Berger MS,Taub DD,Orlofsky A,Kleyman TR,Coupaye-Gerard B,Eisner D,Cohen SA

    更新日期：1996-06-01 00:00:00

  • Association between VEGF gene promoter polymorphisms and bladder cancer: An updated meta-analysis.

    abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is the key regulator of angiogenesis in the development of various cancers. Previous studies have examined the relationship between VEGF gene promoter polymorphisms such as -2578C/A and -460C/T and bladder cancer risk; however, these results are inconclusive. Therefo...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2020.155112

    authors： Chen CH,Ho CH,Kuan-Hua Huang S,Shen CH,Wu CC,Wang YH

    更新日期：2020-07-01 00:00:00

  • PAS-1, a protein from Ascaris suum, modulates allergic inflammation via IL-10 and IFN-gamma, but not IL-12.

    abstract：:Helminths and their products have a profound immunomodulatory effect upon the inductive and effector phases of inflammatory responses, including allergy. We have demonstrated that PAS-1, a protein isolated from Ascaris suum worms, has an inhibitory effect on lung allergic inflammation due to its ability to down-regula...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2008.09.005

    authors： Araújo CA,Perini A,Martins MA,Macedo MS,Macedo-Soares MF

    更新日期：2008-12-01 00:00:00

  • Expression of canine interleukin-4 in canine chondrocytes inhibits inflammatory cascade through STAT6.

    abstract：:Interleukin-4 (IL-4) is a pleiotropic cytokine with broad spectrum of biological effects on target cells. This study deals with the mammalian expression of canine IL-4 (cIL-4) in canine articular chondrocytes (CAC) and its ability to down-regulate pro-inflammatory cytokines, enzyme mediators and their catabolites. We ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2008.07.470

    authors： Rachakonda PS,Rai MF,Manning K,Schmidt MF

    更新日期：2008-10-01 00:00:00

  • FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4.

    abstract：:We have identified a novel fibroblast growth factor, FGF-19, the most distant member of the FGF family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4 and is the first member of the FGF family to show exclusive binding to FGFR4. Human FGF-19 maps to chromosome 11 q13.1, a region associ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1999.0485

    authors： Xie MH,Holcomb I,Deuel B,Dowd P,Huang A,Vagts A,Foster J,Liang J,Brush J,Gu Q,Hillan K,Goddard A,Gurney AL

    更新日期：1999-10-01 00:00:00

  • Use of a solid-phase random peptide library to identify inhibitors of TNF-alpha mediated cytotoxicity in vitro.

    abstract：:Tumour necrosis factor (TNF) is a pleiotropic cytokine which plays a central role in infection, inflammation and autoimmune diseases. Its functions are mediated through binding to high affinity cell surface receptors. An approach to modulate excessive levels of TNF-alpha in the serum is the use of soluble receptors. I...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1996.0158

    authors： Chirinos-Rojas CL,Steward MW,Partidos CD

    更新日期：1997-04-01 00:00:00

  • Serological signatures of clinical cure following successful treatment with sodium stibogluconate in Ethiopian visceral leishmaniasis.

    abstract：BACKGROUND:In Ethiopia, visceral leishmaniasis (VL) is a growing public health threat. Among the key challenges in VL control in Ethiopia is lack of an effective test of cure. The recommended test of cure is parasite detection. As sterile cure is not expected with the current widely used drugs, the value of parasite de...

    journal_title：Cytokine

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.cyto.2016.11.016

    authors： Gadisa E,Tasew G,Abera A,Gelaye W,Chanyalew M,Abebe M,Laskay T,Aseffa A

    更新日期：2017-03-01 00:00:00

  • Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations.

    abstract：:Emerging evidence indicates that chemokine receptor expression patterns are critical in determining the spectrum of action of the chemokines. We have analysed the expression patterns of 17 chemokine receptors and two orphan chemokine receptor-like genes in various freshly prepared human peripheral blood leucocyte popu...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2000.0851

    authors： Patel L,Charlton SJ,Chambers JK,Macphee CH

    更新日期：2001-04-07 00:00:00

  • Gut immune stimulation by non pathogenic Gram(+) and Gram(-) bacteria. Comparison with a probiotic strain.

    abstract：:We analyzed the gut immune stimulation induced by Gram-positive bacteria: non probiotic Lactobacillus acidophilus CRL 1462 and Lactobacillus acidophilus A9; two potentially probiotic strains: L. acidophilus CRL 924 and Lactobacillusdelbrueckii subsp. bulgaricus CRL 423; comparatively with a probiotic strain: Lactobaci...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2007.11.014

    authors： Dogi CA,Galdeano CM,Perdigón G

    更新日期：2008-03-01 00:00:00

  • Upregulation of bone morphogenetic protein GDF-3/Vgr-2 expression in adipose tissue of FABP4/aP2 null mice.

    abstract：:High-fat-fed C57Bl/6J FABP4/aP2 null mice develop obesity but not the related hyperglycemia or hyperinsulinemia characteristic of type II diabetes. FABP4/aP2 protein's function to bind fatty acids in the adipocytes may promote total body energy homeostasis by linking energy depots to the ability to express signaling m...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2001.0864

    authors： Witthuhn BA,Bernlohr DA

    更新日期：2001-05-07 00:00:00

  • Length dependent activation of OAS proteins by dsRNA.

    abstract：:The oligoadenylate synthetase (OAS) family of enzymes are interferon-inducible antiviral proteins, which synthesize the secondary messenger 2'-5'-linked oligoadenosine (2-5A) in response to viral infection. The production of 2-5As induces RNA decay within the infected cells, thereby effectively preventing further vira...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2019.154867

    authors： Wang Y,Holleufer A,Gad HH,Hartmann R

    更新日期：2020-02-01 00:00:00

  • Homeopathic medicines cause Th1 predominance and induce spleen and megakaryocytes changes in BALB/c mice infected with Leishmania infantum.

    abstract：:The prevalence of Th1/Th2 response, spleen changes and megakaryocytes were investigated in BALB/c mice (n=138) infected with Leishmania infantum, and treated with Leishmania infantum 30× (10-30) biotherapy - BioLi30×. We performed controlled experiments using 8-to-12-week-old mice, infected with 5×107L. infantum proma...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2017.02.010

    authors： Cajueiro APB,Goma EP,Dos Santos HAM,Almeida Rodrigues I,Toma HK,Araújo SM,Bonamin LV,Gomes NBN,Castelo-Branco MTL,de Souza Dias EP,Dos Santos Pyrrho A,Holandino C

    更新日期：2017-07-01 00:00:00

  • Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxin.

    abstract：:Although tumor necrosis factor (TNF) and interleukin 6 (IL 6) are purported to be important mediators of inflammatory responses following trauma, it is not known if the serum levels of these cytokines are altered by simple hemorrhage. The objective of this study therefore was to determine whether or not: 1) there is a...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(90)90012-i

    authors： Ayala A,Perrin MM,Meldrum DR,Ertel W,Chaudry IH

    更新日期：1990-05-01 00:00:00

  • Cytokine profile of macrophage activation syndrome associated with Kawasaki disease.

    abstract：:The present study aimed to assess the kinetics of cytokine release and compare the accuracy of serum biomarkers for the diagnosis of macrophage activation syndrome (MAS) associated with Kawasaki disease (KD). Serum neopterin, interleukin (IL)-18, IL-6 and soluble tumour necrosis factor receptor type I (sTNFR-I) and sT...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2019.03.001

    authors： Jinkawa A,Shimizu M,Nishida K,Kaneko S,Usami M,Sakumura N,Irabu H,Takakuwa M,Inoue N,Mizuta M,Ikawa Y,Fujita S,Yachie A

    更新日期：2019-07-01 00:00:00

  • Shark cartilage extract induces cytokines expression and release in endothelial cells and induces E-selectin, plasminogen and t-PA genes expression through an antioxidant-sensitive mechanism.

    abstract：:Neovastat® is a standardized extract of marine cartilage, an avascular tissue, which contains many biologically active molecules and has multiple antiangiogenic properties. In addition to VEGFR2 and MMPs inhibition, shark cartilage extract (SCE) has recently been shown to induce tissue plasminogen activator gene (PLAT...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.08.035

    authors： Simard B,Ratel D,Dupré I,Pautre V,Berger F

    更新日期：2013-01-01 00:00:00

  • Cytokine dependent and independent iNKT cell activation.

    abstract：:Invariant NKT (iNKT) cells have been extensively studied throughout the last decade due to their ability to polarize and amplify the downstream immune response. Only recently however, have the various mechanisms underlying NKT cell activation begun to unfold. iNKT cells have the ability to respond as innate immune cel...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2010.04.016

    authors： Reilly EC,Wands JR,Brossay L

    更新日期：2010-09-01 00:00:00

  • Association of TNF-α-(308(GG)), IL-10(-819(TT)), IL-10(-1082(GG)) and IL-1R1(+1970(CC)) genotypes with the susceptibility and progression of leprosy in North Indian population.

    abstract：:Leprosy is an infectious disease caused by M. leprae. We analyzed 48 cytokine polymorphisms in 13 (pro as well as anti-inflammatory) cytokine genes using PCR-SSP assay in 102 leprosy patients and 120 healthy controls with intent to find out a link between cytokine polymorphisms and disease susceptibility. TNF-α (-308)...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.01.014

    authors： Tarique M,Naqvi RA,Santosh KV,Kamal VK,Khanna N,Rao DN

    更新日期：2015-05-01 00:00:00

  • Potential genetic markers for prediction of treatment response in Egyptian children infected with HCV genotype 4.

    abstract：BACKGROUND:Egypt has a high prevalence of hepatitis C virus (HCV) infection. Limitations of the current HCV treatment in children are low rate of sustained virological response, significant side effects and high expenses, making prediction of treatment response crucial. AIM:This study aimed to investigate association ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.04.005

    authors： Rady NH,Darwish RK,Mogahed EA,Mandour IA,Abo Youssef H,Sharaf SA,El-Karaksy HM

    更新日期：2015-10-01 00:00:00

  • Effect of tear supplements on signs, symptoms and inflammatory markers in dry eye.

    abstract：PURPOSE:Three tear supplements were compared for their effects on the signs, symptoms and inflammatory status of subjects with dry eye disease. Assessments were made before and after both 2 and 4 weeks of treatment. METHODS:In this masked, randomized, 3-way crossover trial, eighteen dry eye subjects were recruited. At...

    journal_title：Cytokine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.cyto.2018.02.009

    authors： Martin E,Oliver KM,Pearce EI,Tomlinson A,Simmons P,Hagan S

    更新日期：2018-05-01 00:00:00

  • Stages versus subsets: Invariant Natural Killer T cell lineage differentiation.

    abstract：:Invariant Natural Killer T (iNKT) cells represent a population of innate T lymphocytes which act as 'first-responders' to infection. While they have long been considered a versatile cell, capable of secretion of multiple cytokines upon activation, recent evidence now indicates that distinct lineages of iNKT cells with...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2014.12.005

    authors： Buechel HM,Stradner MH,D'Cruz LM

    更新日期：2015-04-01 00:00:00

  • Interferon alpha induces generation of semi-mature dendritic cells with high pro-inflammatory and cytotoxic potential.

    abstract：:Dendritic cell-based vaccines are considered as a new and promising immunotherapeutic approach for cancer treatment. However, the choice of optimal protocol of dendritic cell generation in vitro represents the major challenge. Here, we compared phenotype and functional characteristics of human monocyte-derived dendrit...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2014.07.258

    authors： Leplina OY,Tyrinova TV,Tikhonova MA,Ostanin AA,Chernykh ER

    更新日期：2015-01-01 00:00:00

  • Farnesol promotes epithelial cell defense against Candida albicans through Toll-like receptor 2 expression, interleukin-6 and human beta-defensin 2 production.

    abstract：:Farnesol, a quorum-sensing molecule, regulates virulence and morphogenesis in Candida albicans and is involved in various human pathologies including oral candidiasis. Oral epithelial cells are involved in innate immunity against Candida infections via Toll-like receptors (TLRs) and inflammatory mediators. We investig...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2008.11.011

    authors： Décanis N,Savignac K,Rouabhia M

    更新日期：2009-02-01 00:00:00

  • Methylation of RNA N6-methyladenosine in modulation of cytokine responses and tumorigenesis.

    abstract：:Among myriads of distinct chemical modification in RNAs, the dynamic, reversible and fine-tuned methylation of N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic mRNAs. This RNA mark is generated by proteins that act as m6A writers and can be reversed by proteins that act as m6A erasers. The RNA...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2018.06.018

    authors： Chang G,Leu JS,Ma L,Xie K,Huang S

    更新日期：2019-06-01 00:00:00

  • Chronic inflammation and hemodialysis reduce immune competence of peripheral blood leukocytes in end-stage renal failure patients.

    abstract：:Immunoincompetence is a profound problem in end-stage renal failure patients undergoing hemodialysis, and chronic inflammation with altered serum levels of inflammation markers has been reported. Gene expression patterns have had little relevance for leukocyte research so far because of limitations in transcript level...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2004.12.011

    authors： Knerr K,Füth R,Hemsen P,Mohné W,Heinig A,Kleophas W,Scherbaum WA,Martin S

    更新日期：2005-05-07 00:00:00

  • An innovative three-dimensional model of normal human skin to study the proinflammatory psoriatic effects of tumor necrosis factor-alpha and interleukin-17.

    abstract：BACKGROUND:Among all cytokines involved in the pathogenesis and in the progression of psoriasis, Tumor Necrosis Factor (TNF)-alpha and interleukin (IL)-17 play a pivotal role. OBJECTIVE:The aim of the present study was to mimic a psoriatic microenvironment and to investigate the early effects of TNF-alpha and IL-17 in...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2014.03.003

    authors： Donetti E,Cornaghi L,Gualerzi A,Baruffaldi Preis FW,Prignano F

    更新日期：2014-07-01 00:00:00

  • Genetic and environmental influences on IL-6 and TNF-alpha plasma levels in apparently healthy general population.

    abstract：:Dysregulation of cytokines synthesis is thought to play a role in the development of a number of age-related conditions, such as rheumatoid arthritis, osteoporosis, atherosclerosis, and others, but observational studies have led to contradictory results. We investigated potential familial influences on the plasma leve...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2002.1959

    authors： Pantsulaia I,Trofimov S,Kobyliansky E,Livshits G

    更新日期：2002-08-07 00:00:00

  • Modulation of PGE(2) and TNFalpha by nitric oxide and LPS-activated RAW 264.7 cells.

    abstract：:Prostaglandins (PGs), the arachidonic acid (AA) metabolites of the cyclooxygenase (COX) pathway, and the cytokine TNFalpha play major roles in inflammation and they are synthesised mainly by macrophages. Their syntheses have been shown to be regulated by several factors, including nitric oxide, a further important mac...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2002.1955

    authors： Guastadisegni C,Nicolini A,Balduzzi M,Ajmone-Cat MA,Minghetti L

    更新日期：2002-08-21 00:00:00

  • The tertiary structure of γc cytokines dictates receptor sharing.

    abstract：:The γc family of cytokines comprising interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15 and IL-2 is an important group of 4-helix bundle cytokines that signals through receptors incorporating the common gamma chain (γc). These cytokines are involved in lymphocyte biology and their specific functions are contingent on bind...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2019.01.007

    authors： Reche PA

    更新日期：2019-04-01 00:00:00

  • Interleukin 35 (IL-35) and IL-37: Intestinal and peripheral expression by T and B regulatory cells in patients with Inflammatory Bowel Disease.

    abstract：:The aim of the study was to characterize and to quantify peripheral and tissue. IL-35- and IL-37-producing cells in Inflammatory Bowel Disease (IBD) patients. We studied a total of 38 active UC, 31 inactive UC, 17 active CD, and 13 inactive CD and 50 non-inflamed tissues as control group. Gene expression was measured ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.04.009

    authors： Fonseca-Camarillo G,Furuzawa-Carballeda J,Yamamoto-Furusho JK

    更新日期：2015-10-01 00:00:00