Abstract:
:Invariant Natural Killer T (iNKT) cells represent a population of innate T lymphocytes which act as 'first-responders' to infection. While they have long been considered a versatile cell, capable of secretion of multiple cytokines upon activation, recent evidence now indicates that distinct lineages of iNKT cells with unique transcriptional and cytokine profiles exist in different peripheral tissue and as such represent 'fine-tuning' of these cells, which act as mediators between the innate and adaptive immune systems. Here we discuss the molecules regulating the differentiation of iNKT cell lineages, the transcription factors associated with their development, and the role of E protein transcription factors and their negative regulators the Id proteins, as these cells develop from immature progenitor cells to terminally differentiated cells in peripheral tissue.
journal_name
Cytokinejournal_title
Cytokineauthors
Buechel HM,Stradner MH,D'Cruz LMdoi
10.1016/j.cyto.2014.12.005subject
Has Abstractpub_date
2015-04-01 00:00:00pages
204-9issue
2eissn
1043-4666issn
1096-0023pii
S1043-4666(14)00619-Xjournal_volume
72pub_type
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