Abstract:
:Neovastat® is a standardized extract of marine cartilage, an avascular tissue, which contains many biologically active molecules and has multiple antiangiogenic properties. In addition to VEGFR2 and MMPs inhibition, shark cartilage extract (SCE) has recently been shown to induce tissue plasminogen activator gene (PLAT) expression in bovine endothelial cells in a TNF like manner, by inducing the typical mediators NF-κB and JNK. There is now compelling evidences that the NF-κB and JNK pathways are activated by cytokines induced generation of reactive oxygen species (ROS). We used macroarray genes expression analysis on human umbilical vein endothelial cells, to investigate if that mechanism could mediate the effect of SCE. Transcriptomic results showed that SCE induced expression of several cytokines. Their impact must be important, given that treatment of endothelial cells with the cytokine TNF-α was able to reproduce most of the effects of cartilage extract on genes expression. In addition, most of the genes, known to be inducible by NF-κB or JNK following cytokines stimulation, were less induced by SCE when endothelial cells were pretreated with the antioxidant N-Acetylcysteine (NAC), suggesting a role of ROS in endothelial cell activation by SCE. Finally, the possible effects of PLAT, PLG, SELE, IL8 and PRDX2 (those validated by q-PCR) on angiogenesis, will also be discussed.
journal_name
Cytokinejournal_title
Cytokineauthors
Simard B,Ratel D,Dupré I,Pautre V,Berger Fdoi
10.1016/j.cyto.2012.08.035subject
Has Abstractpub_date
2013-01-01 00:00:00pages
104-11issue
1eissn
1043-4666issn
1096-0023pii
S1043-4666(12)00676-Xjournal_volume
61pub_type
杂志文章相关文献
CYTOKINE文献大全abstract::Thymic vulnerability, a leading cause of defective immunity, was discovered decades ago. To date, several strategies have been investigated to unveil any immunorestorative capacities they might confer. Studies exploiting castration, transplantation, adoptive cell therapies, hormones/growth factors, and cytokines have ...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2019.05.009
更新日期:2019-08-01 00:00:00
abstract::Although numerous studies have shown that visfatin is linked to several cancers, its prognostic value is still unclear. This first comprehensive meta-analysis was performed to evaluate the prognostic effect of visfatin in cancer patients. A systematic search was conducted for relevant studies in health-related electro...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2019.154964
更新日期:2020-03-01 00:00:00
abstract::Tumour necrosis factor (TNF) is a key regulator of inflammation and immunity. The cellular effects exerted by TNF depend, apart from NF-kappaB-directed gene transcription, largely on its ability to activate phospholipase A2(PLA2), yielding the release of arachidonic acid (AA) and its metabolites. AA metabolites, espec...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1998.0404
更新日期:1999-02-01 00:00:00
abstract::In atherosclerotic plaques, macrophages (MAC) and smooth muscle cells (SMC) frequently reside in close proximity and resistin (Rs) and fractalkine (Fk) are present at increased levels, resistin being associated with CD68 macrophages and fractalkine predominantly associated with intimal SMC; however, their role in this...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2016.04.019
更新日期:2016-07-01 00:00:00
abstract::Expression of GPCR fatty acid sensor/receptor genes in adipocytes is modulated by inflammatory mediators, particularly IL-1β. In this study we examined whether the IL-1 gene superfamily member, IL-33, also regulates expression of the fatty acid receptor genes in adipocytes. Human fat cells, differentiated from preadip...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.05.008
更新日期:2018-10-01 00:00:00
abstract::Autoantibodies against a variety of growth factors and cytokines are present in preparations of pooled normal human IgG, such as IVIg. The present study demonstrated that healthy Danish blood donors produced high concentrations of anti-IL-10 IgG antibodies that bound IL-10 with extremely high avidity. The antibodies w...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.06.009
更新日期:2010-09-01 00:00:00
abstract::Burn injury is associated with profound inflammation and activation of the innate immune system involving gammadelta T-cells. Similarly, Toll-like receptors (TLR) are associated with activation of the innate immune response; however, it is unclear whether TLR expression is altered in gammadelta T-cells after major bur...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.09.001
更新日期:2008-12-01 00:00:00
abstract::Monocytes/macrophages (Mphi) play a pivotal role in the persistence of chronic inflammation and local tissue destruction in diseases such as rheumatoid arthritis and atherosclerosis. The production by Mphi of cytokines, chemokines, metalloproteinases and their inhibitors is an essential component in this process, whic...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2002.1945
更新日期:2002-06-21 00:00:00
abstract::Intestinal immunity differs from systemic immunity in several aspects and is frequently studied separately. In this work we have analysed the frequency of mononuclear cells spontaneously secreting the cytokines IL-2, IL-4, IL-5, IL-6, IL-10, interferon gamma (IFN-gamma) and tumour necrosis factor (TNF-alpha), in Peyer...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0706
更新日期:2000-08-01 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is the key regulator of angiogenesis in the development of various cancers. Previous studies have examined the relationship between VEGF gene promoter polymorphisms such as -2578C/A and -460C/T and bladder cancer risk; however, these results are inconclusive. Therefo...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155112
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:Current orthopedic therapies, aimed solely at symptomatic control, are unable to restore the cytokine imbalance that produces the hallmark clinical profile of osteoarthritis. While a myriad of chemical factors in the cytokine network stimulate local joint inflammation and pain, Interleukin 1 (IL-1) is widely ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2016.03.008
更新日期:2016-05-01 00:00:00
abstract::Although tumor necrosis factor (TNF) and interleukin 6 (IL 6) are purported to be important mediators of inflammatory responses following trauma, it is not known if the serum levels of these cytokines are altered by simple hemorrhage. The objective of this study therefore was to determine whether or not: 1) there is a...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(90)90012-i
更新日期:1990-05-01 00:00:00
abstract::Ocular trauma affects 20% of Americans in their lifetime and can cause permanent visual system damage. We have used a mouse model of ocular trauma (exposure to an air blast from a paintball gun) to examine pathways that trigger the resulting retinal damage and to develop treatment strategies that might ameliorate the ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.07.004
更新日期:2014-12-01 00:00:00
abstract::Interleukin (IL)-7 stimulation improves virus- and tumor-specific CD8+ T cell responses. However, the role of IL-7 in modulation of dysfunctional CD8+ T cells in hepatocellular carcinoma (HCC) was not completely understood. In this study, a total of 37 HLA-A2 restricted patients with HCC and 16 healthy individuals wer...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.04.003
更新日期:2019-06-01 00:00:00
abstract::Platelet activation and platelet-derived cytokines contribute to the vascular inflammation and increased thrombotic activity known to occur in patients with sickle cell anemia (SCA). CD40 ligand (CD40L), a platelet-associated pro-inflammatory molecule that promotes endothelial cell activation, is elevated in the circu...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.05.017
更新日期:2017-09-01 00:00:00
abstract:INTRODUCTION:A growing body of evidence indicates that brain cytokines are involved in the control of the cardiovascular system. Tumour necrosis factor (TNF) is an archetypal cytokine, which exerts its proinflammatory actions via type 1 receptor (TNFR1). Interleukin 10 (IL-10) plays a critical anti-inflammatory role by...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.07.003
更新日期:2019-01-01 00:00:00
abstract::Recently, a novel technique for "real time" quantitative Reverse Transcriptase-PCR which measures PCR-product accumulation during the exponential phase of the PCR reaction using a dual-labelled fluorogenic probe, has been developed. This method allows direct detection of PCR-product formation by measuring the increase...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1998.0426
更新日期:1999-04-01 00:00:00
abstract::High mobility group box 1 protein (HMGB1) was recently discovered to be a critical late-acting cytokine and innate immune-modulating factor in sepsis, but the potential role and mechanism of HMGB1 in adaptive immunity remains elusive. The present study demonstrated that HMGB1 had a dual influence on immune function of...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.03.026
更新日期:2012-07-01 00:00:00
abstract::CCR2, and its principle ligand MCP-1/CCL2, have been well documented for their ability to induce monocyte infiltration and promote the pathogenesis of rheumatoid arthritis and atherosclerosis. In order to assess additional roles for CCR2, we inserted allogeneic implants into CCR2-/- and MCP-1-/- mice and characterized...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2002.1031
更新日期:2002-05-21 00:00:00
abstract::The self-renewal capacity of germline derived stem cells (GSCs) makes them an ideal source for research and use in clinics. Despite the presence of active gene network similarities between embryonic stem cells (ESCs) and GSCs, there are unanswered questions regarding the roles of evolutionary conserved genes in GSCs. ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.02.021
更新日期:2018-06-01 00:00:00
abstract::A number of chemokines induce angiogenesis and endothelial cells express several chemokine receptors. To date, only a limited number of CC chemokines for CCR1 have been reported to induce angiogenic responses. We investigated the ability of CCL23 (also known as MPIF-1, MIP-3, or CKbeta8) to promote angiogenesis, which...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2005.01.018
更新日期:2005-06-07 00:00:00
abstract:OBJECTIVE:To describe the relationship between the two mechanisms involved in sIL6R generation in rheumatoid arthritis (RA). METHOD:RA patients were selected from a group of subjects genotyped for the rs8192284 SNP, located at the proteolytic cleavage site of IL-6R. sIL6R and protease levels (ADAM17) were measured and...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.12.025
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:In pregnancy, the placental contribution of cytokines to maternal immunosuppression has been established, however their role in normal maternal blood pressure regulation has not been identified. We investigate the contribution of interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha) to the vasod...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2004.10.011
更新日期:2005-02-21 00:00:00
abstract::Angiopoietin-like proteins (ANGPTL) are responsible for inhibiting lipoprotein lipase activity, and ANGPTL3 and ANGPTL4 deficiencies have been shown to lower lipoprotein levels in animal models and in humans carrying loss-of-function mutations. Sickle cell anemia (SCA) is a hereditary hemolytic anemia characterized by...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2019.04.014
更新日期:2019-08-01 00:00:00
abstract::Obesity, a chronic low-grade inflammation metabolic abnormality, is related to high proinflammatory cytokines concentrations. Epstein-Barr virus-induced gene 3 (EBI3) encodes for the EBI3 beta subunit that constitutes interleukin (IL) 27 and 35. Our objective was to assess the association of three EBI3 single nucleoti...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155225
更新日期:2020-11-01 00:00:00
abstract::IL-12p70 is a proinflammatory cytokine secreted by dendritic cells, monocytes and macrophages. It plays a crucial role in cell-mediated immunity by inducing proliferation of T cell and natural killer cells, and enhancing their cytotoxic activity. In adaptive immune response, it acts on naive T cells to differentiate i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.03.021
更新日期:2013-06-01 00:00:00
abstract::Ras expression has been suggested to be a marker for tumor aggressiveness of breast cancer. We previously showed that H-Ras, but not N-Ras, induced invasive/migratory phenotypes in MCF10A human breast epithelial cells. The present study aimed to determine the role of granulocyte colony-stimulating factor in H-Ras-indu...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.03.002
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Soy products contain several compounds with anti-inflammatory properties like genistein and daidzein which reported to act through different pathways. Present study conducted considering the inconsistent results and lack of any comprehensive review regarding randomized controlled trials which assess the effe...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155282
更新日期:2020-12-01 00:00:00
abstract::The present study demonstrates that liposomes coated with synthesized neoglycolipids constructed from mannotriose and dipalmitoylphosphatidylethanolamine (Man3-DPPE) activate peritoneal macrophages (PEMs) to up-regulate expression of co-stimulatory molecules and preferentially secrete IL-12. Injection of Man3-DPPE-coa...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.10.005
更新日期:2007-12-01 00:00:00
abstract::In a previous work we demonstrated that monoclonal antibody (mAb) 8C2 recognized a human granulocyte-colony stimulating factor (hG-CSF) region left unmasked after binding to placenta receptors, whereas mAb 6E3 defined a receptor-buried epitope. Herein we examined the role of these antigenic regions on the proliferativ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/s1043-4666(03)00099-1
更新日期:2003-04-01 00:00:00