当前位置： SCI文献检索 > CYTOKINE期刊下所有文献 > The effects of soy supplementation on inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials.

The effects of soy supplementation on inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials.

Abstract：

BACKGROUND:Soy products contain several compounds with anti-inflammatory properties like genistein and daidzein which reported to act through different pathways. Present study conducted considering the inconsistent results and lack of any comprehensive review regarding randomized controlled trials which assess the effect of soy products on inflammatory markers. METHODS:Following electronic databases were searched up to March 2020: PubMed, Scopus, ISI web of science, and Cochrane Library All randomized trials which assessed the effect of soy product supplementation on c-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) were included for last analysis. Treatment effects were expressed as mean difference (MD) and the standard deviation (SD) of outcomes. To estimate the overall effect the random-effects model was employed. RESULTS:Finally, 51 randomized trial were included for present study. Last analysis showed that soy product supplementation lead to significant reduction in CRP (MD -0.27 mg/L; 95% CI: -0.51, -0.02, p = 0.028) but it did not affect IL-6 (MD 0.0 pg/ml; 95% CI: -0.06, 0.06, p = 0.970) and TNF-α (MD = -0.04 pg/ml; 95% CI: -0.11, 0.03, p = 0.252). Subgroup analysis showed that soy supplementation had a significant impact on decreasing IL-6 and TNF-α levels when studies had a long-term intervention (≥12 weeks) and used low dose isoflavone (<100 mg/day). CONCLUSION:In conclusion, present systematic review and meta-analysis found a significant reduction in CRP levels after soy supplementation whiles IL-6 and TNF-α did not affect.

journal_name

Cytokine

journal_title

Cytokine

authors

Asbaghi O,Yaghubi E,Nazarian B,Kelishadi MR,Khadem H,Moodi V,Naeini F,Ghaedi E

doi

10.1016/j.cyto.2020.155282

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

155282

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(20)30298-2

journal_volume

136

pub_type

杂志文章

相关文献

CYTOKINE文献大全
  • Impact of telmisartan on the inflammatory state in patients with coronary atherosclerosis--influence on IP-10, TNF-α and MCP-1.

    abstract：BACKGROUND:Hypertension is one of the most prominent risk factors for coronary artery disease (CAD). Treatment of hypertension is therefore important for reducing cardiovascular events and the progression of atherosclerosis. Several treatment strategies are common in clinical practice for example the use of ACE-blocker...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.02.001

    authors： Klinghammer L,Urschel K,Cicha I,Lewczuk P,Raaz-Schrauder D,Achenbach S,Garlichs CD

    更新日期：2013-05-01 00:00:00

  • Differential regulation of TNF-alpha, IL-6 and IL-10 in UVB-irradiated human keratinocytes via cyclic AMP/protein kinase A pathway.

    abstract：:Pro-inflammatory cytokines are important mediators of cutaneous cellular activities during many skin diseases. In the present study, we investigated the production of tumor necrosis factor-alpha (TNF-alpha), IL-6 and IL-10 by UVB-irradiated human keratinocytes NCTC 2544 cell line in the presence of cAMP-elevating agen...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/s1043-4666(03)00224-2

    authors： Grandjean-Laquerriere A,Le Naour R,Gangloff SC,Guenounou M

    更新日期：2003-08-21 00:00:00

  • Expression of MDC/CCL22 and its receptor CCR4 in rheumatoid arthritis, psoriatic arthritis and osteoarthritis.

    abstract：:The pathogenesis of rheumatoid arthritis (RA) and psoriatic arthritis (PsA) involves an abnormal chemokine regulation. The chemokine receptor CCR4 is necessary for T cell migration to the skin. We, therefore, studied if CCR4 and its ligand macrophage-derived chemokine (MDC/CCL22) could participate in spreading the dis...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2009.10.005

    authors： Flytlie HA,Hvid M,Lindgreen E,Kofod-Olsen E,Petersen EL,Jørgensen A,Deleuran M,Vestergaard C,Deleuran B

    更新日期：2010-01-01 00:00:00

  • In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant.

    abstract：:Most infections occur in early life, prompting development of novel adjuvanted vaccines to protect newborns and infants. Several Toll-like receptor (TLR) agonists (TLRAs) are components of licensed vaccine formulations or are in development as candidate adjuvants. However, the type and magnitude of immune responses to...

    journal_title：Cytokine

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.cyto.2016.04.001

    authors： van Haren SD,Ganapathi L,Bergelson I,Dowling DJ,Banks M,Samuels RC,Reed SG,Marshall JD,Levy O

    更新日期：2016-07-01 00:00:00

  • Duck interferon regulatory factor 7 (IRF7) can control duck Tembusu virus (DTMUV) infection by triggering type I interferon production and its signal transduction pathway.

    abstract：:Human interferon regulatory factor 7 (IRF7) plays an important role in the innate antiviral immune response. To date, the characteristics and functions of waterfowl IRF7 have not been clarified. This study reports the cDNA sequence, tissue distribution, and antiviral function of duck IRF7. The duck IRF7 gene has a 153...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2018.06.001

    authors： Chen S,Wang T,Liu P,Yang C,Wang M,Jia R,Zhu D,Liu M,Yang Q,Wu Y,Zhao X,Cheng A

    更新日期：2019-01-01 00:00:00

  • The increased maternal serum levels of IL-6 are associated with the severity and onset of preeclampsia.

    abstract：:Preeclampsia is a complex disease of pregnancy with both feto-placental and maternal factors contributing to its pathogenesis. Although the cause of this disease is uncertain, imbalance between pro-and anti-inflammatory cytokines has been implicated in the pathogenesis of preeclampsia. Increased levels of the inflamma...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.07.039

    authors： Xiao JP,Yin YX,Gao YF,Lau S,Shen F,Zhao M,Chen Q

    更新日期：2012-12-01 00:00:00

  • IL-10 production in mouse hepatocytes augmented by TGF-beta.

    abstract：:The supernatant from normal liver cell (Clone 1469) culture enhanced polyclonal antibody production in mouse spleen cells but not in human peripheral blood lymphocytes. The supernatants from transforming growth factor beta (TGF-beta)-treated C3H/HeN spleen cells augmented greatly polyclonal antibody responses compared...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1996.0112

    authors： Ishizaka S,Saito S,Yoshikawa M,Kimoto M,Nishiyama T

    更新日期：1996-11-01 00:00:00

  • Mechanisms of tumor necrosis factor-alpha-induced leaks in intestine epithelial barrier.

    abstract：PURPOSE:The aim of this study was to investigate the signaling mechanisms surrounding changes in tight junction (TJ) and the permeability of human intestinal epithelial cell induced by tumor necrosis factor-alpha (TNF-α). METHODS:To confirm that TNF-α induces epithelial barrier hyperpermeability by disrupting tight ju...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.04.008

    authors： He F,Peng J,Deng XL,Yang LF,Camara AD,Omran A,Wang GL,Wu LW,Zhang CL,Yin F

    更新日期：2012-08-01 00:00:00

  • Dysregulation of angiopoietin-Tie-2 axis in ugandan children hospitalized with pneumonia.

    abstract：OBJECTIVE:Pneumonia is the leading cause of death in children under 5, with the highest burden in resource-limited countries. Endothelial activation occurs in pneumonia and can be assessed using quantitative levels of biomarkers angiopoietin (Ang)-1 and Ang-2. We examined admission levels of Ang-1 and Ang-2 in pediatri...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2020.155175

    authors： Zhang R,Rai U,Ibrahim NBM,Amazouz Y,Soo J,Conroy AL,Namasopo S,Opoka RO,Bhargava R,Hawkes MT

    更新日期：2020-09-01 00:00:00

  • Direct contact with stimulated T cells induces the expression of IL-1beta and IL-1 receptor antagonist in human monocytes. Involvement of serine/threonine phosphatases in differential regulation.

    abstract：:Imbalance in the production of cytokines and their inhibitors plays a part in inflammation in chronic destructive diseases. Direct cell-cell contact with stimulated T cells markedly induces the production of pro-inflammatory cytokines and matrix metalloproteinases in monocytes. This study demonstrates that direct cont...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1997.0191

    authors： Vey E,Dayer JM,Burger D

    更新日期：1997-07-01 00:00:00

  • Interleukin-6 induced activation of a non-selective outward cation conductance in human cardiac fibroblasts.

    abstract：BACKGROUND:It has been demonstrated that cardiac fibroblasts of the human heart have several myocyte-like features, induced by inflammation. OBJECTIVES:This study analyzed the changes of the expressed currents in the basal condition and in the presence of interleukin-6 in cultured human cardiac fibroblasts. METHODS:H...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2017.06.004

    authors： Mitrokhin V,Kazanski V,Kalsin V,Mladenov M,Kamkin A

    更新日期：2017-09-01 00:00:00

  • Plasma interleukin-1beta concentration is associated with stroke in sickle cell disease.

    abstract：:The pathogenesis of sickle cell disease (HbSS), which has numerous complications including stroke, involves inflammation resulting in alteration of plasma inflammatory protein concentration. We investigated HbSS children with abnormal cerebral blood flow detected by trans-cranial Doppler ultrasound (TCD) who participa...

    journal_title：Cytokine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.cyto.2009.10.002

    authors： Asare K,Gee BE,Stiles JK,Wilson NO,Driss A,Quarshie A,Adams RJ,Kutlar A,Hibbert JM

    更新日期：2010-01-01 00:00:00

  • Interferon gamma induces actin polymerization, Rac1 activation and down regulates phagocytosis in human monocytic cells.

    abstract：:IFNγ is a potent activator and IL-10 a powerful inhibitor of macrophage functions. However, neither all cellular functions are enhanced by IFNγ nor IL-10 inhibits all cellular responses. Thus, FcγRs-mediated phagocytosis in monocyte-derived macrophages (MDM) increases after IL-10 treatment, and decreases after treatme...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2011.11.008

    authors： Frausto-Del-Río D,Soto-Cruz I,Garay-Canales C,Ambriz X,Soldevila G,Carretero-Ortega J,Vázquez-Prado J,Ortega E

    更新日期：2012-01-01 00:00:00

  • CK2 induced RIG-I drives metabolic adaptations in IFNγ-treated glioma cells.

    abstract：:Given the known anti-tumorigenic properties of IFNγ, its effect on glioma cell survival was investigated. Though IFNγ had no effect on glioma cell viability, it induced cell cycle arrest. This was accompanied by increased expression of p53 and retinoic acid inducible gene (RIG-I). While RIG-I had no effect on glioma c...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.10.009

    authors： Ghildiyal R,Sen E

    更新日期：2017-01-01 00:00:00

  • Multiple cytokine analysis in gastroschisis: Association with adverse outcomes including fetal brain damage.

    abstract：OBJECTIVES:To investigate the distribution of multiple cytokines in gastroschisis and reveal its association with clinical outcomes, including gastrointestinal disorders and fetal brain damage caused by chronic inflammation in gastroschisis. METHODS:We obtained amniotic fluid and arterial cord blood from 10 patients w...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2020.155406

    authors： Owaki T,Imai K,Miki R,Niwa Y,Kotani T,Nakano-Kobayashi T,Ushida T,Kajiyama H

    更新日期：2021-02-01 00:00:00

  • IL6-174 G/C gene polymorphism and its relation to serum IL6 in Egyptian children with community-acquired pneumonia.

    abstract：:Cytokines are involved in the pathogenesis of community acquired pneumonia (CAP). The aim of this study is to investigate the association of IL6-174 G/C gene polymorphism with CAP in Egyptian children, to assess its effect on CAP outcome and to determine its effect on the serum IL6 levels in these children. IL6-174 G/...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2014.02.013

    authors： Zidan HE,Elbehedy RM,Azab SF

    更新日期：2014-06-01 00:00:00

  • VEGF gene therapy cooperatively recruits molecules from the immune system and stimulates cell homing and angiogenesis in refractory angina.

    abstract：BACKGROUND:New vessels are formed in response to stimuli from angiogenic factors, a process in which paracrine signaling is fundamental. OBJECTIVE:To investigate the cooperative paracrine signaling profile in response to Vascular Endothelial Growth Factor (VEGF) gene therapy in patients with coronary artery disease (C...

    journal_title：Cytokine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.cyto.2016.12.005

    authors： Eibel B,Markoski MM,Rodrigues CG,Dipp T,de Salles FB,Giusti II,Nardi NB,Plentz RD,Kalil RA

    更新日期：2017-03-01 00:00:00

  • Modulation of PGE(2) and TNFalpha by nitric oxide and LPS-activated RAW 264.7 cells.

    abstract：:Prostaglandins (PGs), the arachidonic acid (AA) metabolites of the cyclooxygenase (COX) pathway, and the cytokine TNFalpha play major roles in inflammation and they are synthesised mainly by macrophages. Their syntheses have been shown to be regulated by several factors, including nitric oxide, a further important mac...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2002.1955

    authors： Guastadisegni C,Nicolini A,Balduzzi M,Ajmone-Cat MA,Minghetti L

    更新日期：2002-08-21 00:00:00

  • Effects of hypothermia and re-warming on the inflammatory response in a murine multiple hit model of trauma.

    abstract：INTRODUCTION:Although, hypothermia is a frequent event after trauma, it is unclear whether its beneficial or detrimental effects are more important. This study aims to quantify the effects of hypothermia and re-warming on the inflammatory response after fracture/hemorrhage and subsequent fracture stabilization with res...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2005.06.008

    authors： Hildebrand F,van Griensven M,Giannoudis P,Luerig A,Harwood P,Harms O,Fehr M,Krettek C,Pape HC

    更新日期：2005-09-07 00:00:00

  • Effect of antioxidants on apoptosis and cytokine release in fetal rat Type II pneumocytes exposed to hyperoxia and nitric oxide.

    abstract：:The response of the fetal rat Type II pneumocyte (FTIIP), the stem cell of the alveolar epithelium, to hyperoxia would be helpful to understand the effects of oxygen-induced injury to the developing lung. Our goals were to evaluate the effect of antioxidants (AO) on apoptosis and release of cytokines in freshly isolat...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2004.06.001

    authors： Johnson-Varghese L,Brodsky N,Bhandari V

    更新日期：2004-10-07 00:00:00

  • TGF-beta1 increases microbial clearance but worsens lung injury during Escherichia coli pneumonia in rats.

    abstract：:We investigated the effects of either intravenous (IV) or intrabronchial (IB) treatment with transforming growth factor beta1 (TGF-beta1) during bacterial pneumonia in rats. Immediately following IB Escherichia coli inoculation (T0), animals (n=270) were randomized to receive a single treatment with human recombinant ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2003.07.003

    authors： Cui X,Zeni F,Vodovitz Y,Correa-de-Araujo R,Quezado M,Roberts A,Wahl S,Danner RL,Banks SM,Gerstenberger E,Fitz Y,Natanson C,Eichacker PQ

    更新日期：2003-11-21 00:00:00

  • Local levels of interleukin-1beta, -4, -6 and tumor necrosis factor alpha in an experimental model of murine osteomyelitis due to staphylococcus aureus.

    abstract：:The purpose of this study is to evaluate local levels of interleukin-1 beta (IL-1 beta), -4 (IL-4), -6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha), in a model of murine osteomyelitis due to Staphylococcus aureus. Cytokine levels in supernatants derived from bone homogenates were determined by enzyme-linked im...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2002.1039

    authors： Yoshii T,Magara S,Miyai D,Nishimura H,Kuroki E,Furudoi S,Komori T,Ohbayashi C

    更新日期：2002-07-21 00:00:00

  • Differential effect of rapamycin and cyclosporin A in proliferation in a murine T cell line expressing either intermediate or high affinity receptor for IL-2.

    abstract：:It has been reported that rapamycin (rap), cyclosporin A (CsA) and FK506 have immunosuppressive effect during the activation process of murine T cells. These drugs were investigated for their suppressive effect on a murine T cell line expressing intermediate (TS1 beta) or high (TS1 alpha beta) affinity IL-2R. Rap and ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1995.0033

    authors： Rebollo A,Mérida I,Gómez J,Pitton C,Silva A,Martínez C,García A

    更新日期：1995-04-01 00:00:00

  • Stat3-dependent induction of interleukin-3 receptor expression in leukemia inhibitory factor-stimulated M1 mouse leukemia cells.

    abstract：:M1 mouse leukemia cells differentiate to macrophages/monocytes by the stimulation of interleukin-6 (IL-6)/leukemia inhibitory factor (LIF). To identify new LIF-induced genes, we have performed representational difference analysis using M1 cells and cloned mouse interleukin-3 (IL-3) receptor beta subunit gene. The mRNA...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2003.10.009

    authors： Iwamoto T,Senga T,Adachi K,Hamaguchi M

    更新日期：2004-02-07 00:00:00

  • Elevated circulating osteoprotegerin and reduced matrix-metalloprotease-9 in post-menopausal women with chronic Hepatitis C virus infection.

    abstract：:The failure of the immune response to clear the Hepatitis C virus (HCV) results in chronic inflammation that leads to liver cirrhosis. In general, women have a better prognosis than men and this may be associated with increased levels of anti-inflammatory mediators that are positively regulated by female sex hormones....

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.07.006

    authors： Nanda KS,Brady JJ,Murray BF,Sullivan O,Fearon U,McKenna MJ,Hegarty JE,O'Farrelly C,Ryan EJ

    更新日期：2012-11-01 00:00:00

  • IL-10 -592A/C polymorphism is associated with severity of Hashimoto's disease.

    abstract：:The genetic producibilities of T helper type 1 (Th1) and T helper type 2 (Th2) cytokines are associated with the prognosis of autoimmune thyroid diseases (AITDs). Interleukin (IL)-10 is considered to be a Th2 cytokine that can exhibit an anti-inflammatory role. Furthermore, IL-10 may be associated with the development...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.05.014

    authors： Inoue N,Watanabe M,Wada M,Morita M,Hidaka Y,Iwatani Y

    更新日期：2013-10-01 00:00:00

  • Mitochondrial STAT3: Powering up a potent factor.

    abstract：:The JAK-STAT3 signaling pathway is engaged by many cytokines and growth factor stimuli to control diverse biological processes including proliferation, angiogenesis, survival, immune modulation, and metabolism. For over two decades it has been accepted that STAT3-dependent biology is due to its potency as a transcript...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2016.05.019

    authors： Garama DJ,White CL,Balic JJ,Gough DJ

    更新日期：2016-11-01 00:00:00

  • Physical training prior to myocardial infarction potentializes stem cell therapy, SDF-1/CXCR4 axis activation and inhibits the vasoconstrictor response in hypertensive rats.

    abstract：:Stem cell therapy is a promising strategy for recovering of injured cardiac tissue after acute myocardial infarction. The effects promoted by preventive physical training, beneficial for regeneration, are not yet understood on stem cell homing. In the present study, we evaluated the effect of preventive physical train...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2019.154912

    authors： Schaun MI,Kristochek M,Dias LD,Peres TR,Lehnen AM,Irigoyen MC,Markoski MM

    更新日期：2020-02-01 00:00:00

  • Proinflammatory cytokines (TNF-alpha and IL-6) in Egyptian patients with SLE: its correlation with disease activity.

    abstract：BACKGROUND:Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by a wide variety of autoantibodies, some of which are pathogenic. In recent years it has become more evident that the polyclonal B cell activation in SLE is T-cell dependent. The stimulation of the autoantibody producing B cells is li...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2006.07.023

    authors： Sabry A,Sheashaa H,El-Husseini A,Mahmoud K,Eldahshan KF,George SK,Abdel-Khalek E,El-Shafey EM,Abo-Zenah H

    更新日期：2006-08-01 00:00:00

  • Production of tumour necrosis factor alpha by primary cultured rat alveolar epithelial cells.

    abstract：:Tumour necrosis factor alpha(TNF-alpha) is one of the most important pro-inflammatory cytokines, which plays an important role in host defense and acute inflammation related to tissue injury. The major source of TNF-alpha has been shown to be immune cells such as macrophages and neutrophils. In the present study, we d...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1999.0656

    authors： McRitchie DI,Isowa N,Edelson JD,Xavier AM,Cai L,Man HY,Wang YT,Keshavjee SH,Slutsky AS,Liu M

    更新日期：2000-06-01 00:00:00