Stat3-dependent induction of interleukin-3 receptor expression in leukemia inhibitory factor-stimulated M1 mouse leukemia cells.

abstract：BACKGROUND:Immuno-inflammation plays an important role in the pathophysiological process of sepsis-associated acute hepatic injury (AHI). Interleukin 27 (IL-27) is an important inflammatory regulator; however, its role in this condition is not clear. METHODS:The clinical data and IL-27 serum levels in sepsis patients ...

journal_title：Cytokine

authors： Fan J,Zhang YC,Zheng DF,Zhang M,Liu H,He M,Wu ZJ

更新日期：2020-03-01 00:00:00

abstract：:Cytokines are involved in the pathogenesis of community acquired pneumonia (CAP). The aim of this study is to investigate the association of IL6-174 G/C gene polymorphism with CAP in Egyptian children, to assess its effect on CAP outcome and to determine its effect on the serum IL6 levels in these children. IL6-174 G/...

journal_title：Cytokine

authors： Zidan HE,Elbehedy RM,Azab SF

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:This case-control study aimed to evaluate the ability to use a panel of IL-31, IL-1ß and NLRP3 to differentiate sepsis from systemic inflammatory response syndrome (SIRS) and to predict septic shock. METHODS:Serum levels of IL-31, IL-1ß and NLRP3 were measured by ELISA in 149 participants; 38 with sepsis, 51 w...

journal_title：Cytokine

authors： Watany MM,Elmazny MI,Nasif EM

更新日期：2020-07-01 00:00:00

abstract：:Antigen (Ag)-stimulated mast cells induce synthesis and production of cytokines including tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 with proinflammatory and immune regulatory properties. Expression of TNF-alpha and IL-6 was regulated by a transcription factor, nuclear factor (NF)-kappaB. The iridoid gly...

journal_title：Cytokine

authors： Jeong HJ,Koo HN,Na HJ,Kim MS,Hong SH,Eom JW,Kim KS,Shin TY,Kim HM

更新日期：2002-06-07 00:00:00

abstract：BACKGROUND:Cardiac surgery is associated with inflammatory responses that are known to affect its outcome. The present study was designed to define whether post-operative release of interleukin (IL)-6, 8 and tumor necrosis factor-alpha (TNF-alpha) is related to the presence of a certain allele in functional polymorphis...

journal_title：Cytokine

authors： Wang Z,Shao J,Zhou Q,Liu J,Zhu Y,Yang J,Wei M

更新日期：2010-06-01 00:00:00

abstract：:Exercise training is known to induce a molecular adaptation process involving inflammatory responses. However any time-of-day effect of exercise on inflammatory responses remains unknown. The aim of the present study was to investigate whether acute bouts of intense exercise performed at different times of the day wou...

journal_title：Cytokine

authors： Pledge D,Grosset JF,Onambélé-Pearson GL

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Adiponectin is an anti-atherogenic insulin-sensitizer hormone whose plasma concentration is lower in patients with metabolic syndrome (MS). Visceral adiposity, including epicardial adipose tissue (EAT), is closely related to the development of MS and coronary artery disease (CAD). We sought to study whether ...

journal_title：Cytokine

authors： Teijeira-Fernandez E,Eiras S,Shamagian LG,Somoza AS,Delgado C,Gonzalez-Juanatey JR

更新日期：2011-05-01 00:00:00

abstract：:The purpose of these studies was to test whether pentoxifylline, a drug that can inhibit the production and action of cytokines hypothesized to be endogenous pyrogens (for example, interleukin 1 and tumor necrosis factor [TNF]), is antipyretic. We also tested the effects of pentoxifylline on plasma activities of inter...

journal_title：Cytokine

authors： LeMay LG,Vander AJ,Kluger MJ

更新日期：1990-07-01 00:00:00

abstract：:Periodontitis is the most prevalent infectious disease caused by periodontopathic bacteria and is also a chronic inflammatory disease. Gingival crevicular fluid (GCF) is an inflammatory exudate that seeps into the gingival crevices or periodontal pockets around teeth with inflamed gingiva, and contains various materia...

journal_title：Cytokine

authors： Yoshimoto T,Fujita T,Kajiya M,Matsuda S,Ouhara K,Shiba H,Kurihara H

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Bronchial asthma (BA) is a chronic disease of the airways. The great majority of BA exacerbations are associated with respiratory viral infections. Recent findings point out a possible role of proinflammatory cytokine interleukin-33 (IL-33) in the development of atopic diseases. Although, little is known abo...

journal_title：Cytokine

authors： Nikonova A,Shilovskiy I,Galitskaya M,Sokolova A,Sundukova M,Dmitrieva-Posocco O,Mitin A,Komogorova V,Litvina M,Sharova N,Zhernov Y,Kudlay D,Dvornikov A,Kurbacheva O,Khaitov R,Khaitov M

更新日期：2021-02-01 00:00:00

abstract：:The effect of epidermal growth factor (EGF), basic fibroblast growth factor (bFGF) and insulin-like growth factor-1 (IGF-1) on the cytostatic activity of tumour necrosis factor-alpha (TNF-alpha) was studied on the breast cancer cell line, T47D. TNF-alpha completely blocked the potent growth-promoting activity of all t...

journal_title：Cytokine

authors： Pusztai L,Lewis CE,McGee JO

更新日期：1993-03-01 00:00:00

abstract：:Circulating interleukin (IL)-6 and IL-10 concentrations can be elevated following the surgically induced trauma of total knee arthroplasty (TKA). An exaggerated increase in IL-6 relative to IL-10 (i.e., IL-6/IL-10 ratio) associates with trauma severity and indicative of pro-inflammatory predominance. Although various ...

journal_title：Cytokine

authors： Barker T,Henriksen VT,Rogers VE,Trawick RH,Momberger NG,Lynn Rasmussen G

更新日期：2021-01-23 00:00:00

abstract：:Cytokine balance alterations are responsible for some of the systemic and hepatic manifestations of alcoholism. The present study was aimed to evaluate the influence of both acute alcohol abstinence (in alcoholics) and acute alcohol intake (in healthy subjects) on serum IL-6, IL-8, IL-10, and IL-12 levels. Serum cytok...

journal_title：Cytokine

authors： González-Quintela A,Dominguez-Santalla MJ,Pérez LF,Vidal C,Lojo S,Barrio E

更新日期：2000-09-01 00:00:00

abstract：:Tumor Necrosis Factor alpha (TNFα, TNF) is a key mediator and regulator of mammalian immune responses in healthy organisms and in diseased conditions. TNF governs development of the immune system, cell survival signaling pathways, proliferation and regulates metabolic processes. Whereas TNF-induced NF-κB and MAP pro-s...

journal_title：Cytokine

authors： Varfolomeev E,Vucic D

更新日期：2018-01-01 00:00:00

abstract：:IL-12p70 is a proinflammatory cytokine secreted by dendritic cells, monocytes and macrophages. It plays a crucial role in cell-mediated immunity by inducing proliferation of T cell and natural killer cells, and enhancing their cytotoxic activity. In adaptive immune response, it acts on naive T cells to differentiate i...

journal_title：Cytokine

authors： Chen IF,Khan J,Noma N,Hadlaq E,Teich S,Benoliel R,Eliav E

更新日期：2013-06-01 00:00:00

abstract：:Bone tissue is continually being remodelled according to physiological circumstances. Two main cell populations (osteoblasts and osteoclasts) are involved in this process, and cellular activities (including cell differentiation) are modulated by hormones, cytokines and growth factors. Within the last 20 years, many fa...

journal_title：Cytokine

authors： Heymann D,Rousselle AV

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:Tumor necrosis factor (TNFα) is a proinflammatory cytokine and has been a target for intervention in human sepsis. However, inhibition of TNF-α with a high dose of a TNF-receptor fusion protein in patients with septic shock worsened patient survival. This study was designed to investigate whether blocking TNF-α...

journal_title：Cytokine

authors： Tsay TB,Yang MC,Chen PH,Lai KH,Huang HT,Hsu CM,Chen LW

更新日期：2013-07-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a molecule with plethora of functions such as regulation of immune response, hormone-like, enzymatic and chaperone-like activity. Further, MIF is a major participant in glucose homeostasis since it is an autocrine stimulator of insulin secretion. MIF absence in male knoc...

journal_title：Cytokine

authors： Vujicic M,Senerovic L,Nikolic I,Saksida T,Stosic-Grujicic S,Stojanovic I

更新日期：2014-09-01 00:00:00

abstract：:Tumour necrosis factor alpha(TNF-alpha) is one of the most important pro-inflammatory cytokines, which plays an important role in host defense and acute inflammation related to tissue injury. The major source of TNF-alpha has been shown to be immune cells such as macrophages and neutrophils. In the present study, we d...

journal_title：Cytokine

authors： McRitchie DI,Isowa N,Edelson JD,Xavier AM,Cai L,Man HY,Wang YT,Keshavjee SH,Slutsky AS,Liu M

更新日期：2000-06-01 00:00:00

abstract：:An anti-inflammatory cytokine, interleukin-10 (IL-10) exerts inhibitory effects on vascular inflammation. Chemokines promote vascular inflammation and play a pathogenic role in the development and maintenance of hypertension. However, chemokine CCL5 has down-regulatory effects on angiotensin II (Ang II)-induced hypert...

journal_title：Cytokine

authors： Kim HY,Kim HS

更新日期：2014-07-01 00:00:00

abstract：:The effects of scatter factor on the cytoskeleton of MDCK and PtK2 cells are described. During the first 6 h after the addition of scatter factor, MDCK cells were found to increase their projected areas twofold, as well as the number and size of their F-actin stress fibers. In contrast PtK2 cells showed no change in t...

journal_title：Cytokine

authors： Dowrick PG,Prescott AR,Warn RM

更新日期：1991-07-01 00:00:00

abstract：:Interleukin (IL)-4, IL-10, and IL-13 are T-helper2 cell derived cytokines, which are known to suppress pro-inflammatory cytokine production. The biologically related IL-4 and IL-13 have an impact on the development of atopic inflammation, whereas IL-10 is mostly supposed to be involved in fibrotic disorders or inflamm...

journal_title：Cytokine

authors： Hocke AC,Ermert M,Althoff A,Brell B,N'Guessan PD,Suttorp N,Ermert L

更新日期：2006-02-21 00:00:00

abstract：:Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by the presence of autoantibodies to normal components of the hemidesmosome (BPAg1 and BPAg2). Histology of skin lesions demonstrate a subepidermal vesicle and a predominantly eosinophilic dermal cellular infiltrate. Interleukin 5 (IL-5) pl...

journal_title：Cytokine

authors： Engineer L,Bhol K,Kumari S,Razzaque Ahmed A

更新日期：2001-01-07 00:00:00

abstract：:Hepatitis C virus (HCV) chronic infection causes severe cellular immune dysfunction. Here, we investigated the production of Th17-associated cytokines by peripheral blood mononuclear cells (PBMCs) of untreated patients with HCV, patients presenting an early virologic response (EVR) after 12weeks of treatment with inte...

journal_title：Cytokine

authors： Cabral MS,Santos TPS,Santos PL,Schinoni MI,Oliveira IS,Pereira AB,Atta AM,Sousa-Atta MLB

更新日期：2018-02-01 00:00:00

abstract：:Endothelial barrier dysfunction leads to increased endothelial permeability and is an early step in the development of vascular inflammatory diseases such as atherosclerosis. Interferon-γ (IFN-γ), a proinflammatory cytokine, is known to cause increased endothelial permeability. However, the mechanisms by which IFN-γ d...

journal_title：Cytokine

authors： Ng CT,Fong LY,Yong YK,Hakim MN,Ahmad Z

更新日期：2018-11-01 00:00:00

abstract：:Colony stimulating factors (CSF) promote leukocyte survival by reducing apoptotic cell death. However, their effects on non-leukocyte cell types are unclear. Reduced apoptosis in colon epithelial cells is thought to contribute to the initiation of cancer. Here, we report diminished spontaneous apoptosis of human colon...

journal_title：Cytokine

authors： Calatayud S,Warner TD,Breese EJ,Mitchell JA

更新日期：2002-11-24 00:00:00

abstract：:Dysregulation of cytokines synthesis is thought to play a role in the development of a number of age-related conditions, such as rheumatoid arthritis, osteoporosis, atherosclerosis, and others, but observational studies have led to contradictory results. We investigated potential familial influences on the plasma leve...

journal_title：Cytokine

authors： Pantsulaia I,Trofimov S,Kobyliansky E,Livshits G

更新日期：2002-08-07 00:00:00

abstract：:Cytokine mRNA expression was analyzed by reverse transcriptase (RT)/PCR in extensively purified normal peripheral CD4+CD45R T cell subsets. Both CD45RA+ and CD45 RO+ populations produced mRNAs for interleukin (IL)-2, IL-2 receptor (alpha chain), IL-6 receptor and tumour necrosis factor (TNF)-beta within 3-4 h of activ...

journal_title：Cytokine

authors： Beckman I,Shepherd K,Dimopoulos K,Ahern M,Firgaira F,Bradley J

更新日期：1994-03-01 00:00:00

abstract：:Along with several other aspects of Chagas disease, the mechanisms responsible for the different clinical outcomes observed in chronic infected individuals have not yet been clarified. It is believed that the host immune response to the parasite plays an important role in the development of the pathology. Therefore, t...

journal_title：Cytokine

authors： de Melo AS,de Lorena VM,de Moura Braz SC,Docena C,de Miranda Gomes Y

更新日期：2012-05-01 00:00:00

abstract：:Interleukin 1 (IL-1) activates p42/p44 and p38 mitogen-activated protein kinases (MAP kinases) in target cells. Here we have used two specific inhibitors, PD98059 which inhibits MAP kinase kinase (MEK), and SB203580 which inhibits p38 MAP kinase to explore the involvement of these kinases in the induction of IL-2 by I...

journal_title：Cytokine

authors： Matthews JS,O'Neill LA

更新日期：1999-09-01 00:00:00