Abstract:
:Colony stimulating factors (CSF) promote leukocyte survival by reducing apoptotic cell death. However, their effects on non-leukocyte cell types are unclear. Reduced apoptosis in colon epithelial cells is thought to contribute to the initiation of cancer. Here, we report diminished spontaneous apoptosis of human colon epithelial HT-29 cells in the presence of macrophage-CSF or granulocyte macrophage-CSF. Moreover, reduced apoptosis induced by sulindac sulfide was also observed with macrophage-CSF. Granulocyte-CSF failed to modify spontaneous or sulindac sulfide induced apoptosis. It seems, therefore, that the action of CSFs on apoptosis is not confined to haematopoietic cells but may be extended to stromal cells.
journal_name
Cytokinejournal_title
Cytokineauthors
Calatayud S,Warner TD,Breese EJ,Mitchell JAdoi
10.1006/cyto.2002.1999keywords:
subject
Has Abstractpub_date
2002-11-24 00:00:00pages
163-7issue
4eissn
1043-4666issn
1096-0023pii
S104346660291999Xjournal_volume
20pub_type
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