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Plasma leptin, but not resistin, TNF-α and adiponectin, is associated with echocardiographic parameters of cardiac remodeling in patients with coronary artery disease.

Abstract：

:The aim of this research was to assess the relationship between plasma adiponectin, leptin, resistin, tumor necrosis factor alpha (TNF-α) levels and echocardiographic parameters of ventricular remodeling in patients with coronary artery disease, without acute myocardial infarction. The study population consisted of 49 patients with echocardiographic measurements performed. After adjustment for age, gender, body mass index, systolic and diastolic blood pressure, and glycaemia, adiponectin was statistically significant associated with interventricular septum thickness (β = -0.304), left ventricular posterior wall thickness (β = -0.402), left ventricular end diastolic diameter (LVEDD; β = 0.385) and left ventricular relative wall thickness (β = -0.448, p < .05 for all). The associations were no longer significant when only patients without diabetes were included in the analysis. Leptin was associated with LVEDD (β = -0.354) and left ventricular relative wall thickness (β = 0.385, p < .05 for all). No associations between resistin, TNF-α and echocardiographic left ventricular parameters assessed were found in these patients. In conclusion, in patients with coronary artery disease and without acute myocardial infarction leptin may represent a potential mechanism of adverse cardiac remodeling. Resistin and TNF-α might not be involved in ventricular remodeling in these patients.

journal_name

Cytokine

journal_title

Cytokine

authors

Farcaş AD,Rusu A,Stoia MA,Vida-Simiti LA

doi

10.1016/j.cyto.2018.01.002

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

46-49

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(18)30002-4

journal_volume

103

pub_type

临床试验,杂志文章

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