当前位置： SCI文献检索 > CYTOKINE期刊下所有文献 > Molecular regulation of inflammation and cell death.

Molecular regulation of inflammation and cell death.

Abstract：

:Cell death and innate immunity are ancient evolutionary conserved processes that utilize a dazzling number of related molecular effectors and parallel signal transduction mechanisms. The investigation of the molecular mechanisms linking the sensing of a danger signal (pathogens or tissue damage) to the induction of an inflammatory response has witnessed a renaissance in the last few years. This was initiated by the identification of pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and more recently cytosolic Nod-like receptors (NLRs), that brought innate immunity to center stage and opened the field to the study of signal transduction pathways, adaptors and central effectors linked to PRRs. This led to the characterization of the inflammasome, a macromolecular complex, scaffolded by NLRs, that recruits and activates inflammatory caspases, which are essential effectors in inflammation and cell death responses. In this review, we describe the molecular pathways of cell death and innate immunity with a focus on recent advancements in both fields and an emphasis on the striking analogies between NLR innate immunity and mitochondrial apoptosis pathways.

journal_name

Cytokine

journal_title

Cytokine

authors

Yeretssian G,Labbé K,Saleh M

doi

10.1016/j.cyto.2008.07.015

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

380-90

issue

3

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(08)00227-5

journal_volume

43

pub_type

杂志文章,评审

相关文献

CYTOKINE文献大全
  • Lack of tumor necrosis factor receptor type 1 inhibits liver fibrosis induced by carbon tetrachloride in mice.

    abstract：:Chronic liver injury causes liver regeneration, resulting in fibrosis. The proinflammatory cytokine tumor necrosis factor (TNF) is involved in the pathogenesis of many acute and chronic liver diseases. TNF has pleiotropic functions, but its role in liver fibrosis has not been clarified. Chronic repeated injection of C...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2004.11.001

    authors： Sudo K,Yamada Y,Moriwaki H,Saito K,Seishima M

    更新日期：2005-03-07 00:00:00

  • Erythroid differentiation regulator (EDR), a novel, highly conserved factor I. Induction of haemoglobin synthesis in erythroleukaemic cells.

    abstract：:In serum-free WEHI-3 supernatants an activity was detected inducing haemoglobin synthesis in human and murine erythroleukaemia cell lines. The absolute numbers of benzidine-positive cells induced with either DMSO or WEHI-3-conditioned medium were comparable. Terminal differentiation was not observed. An expression lib...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2004.02.005

    authors： Dörmer P,Spitzer E,Frankenberger M,Kremmer E

    更新日期：2004-06-21 00:00:00

  • Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxin.

    abstract：:Although tumor necrosis factor (TNF) and interleukin 6 (IL 6) are purported to be important mediators of inflammatory responses following trauma, it is not known if the serum levels of these cytokines are altered by simple hemorrhage. The objective of this study therefore was to determine whether or not: 1) there is a...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(90)90012-i

    authors： Ayala A,Perrin MM,Meldrum DR,Ertel W,Chaudry IH

    更新日期：1990-05-01 00:00:00

  • Aberrant production of IL-13 by T cells promotes exocrinopathy in Id3 knockout mice.

    abstract：:Elevated levels of the cytokine IL-13 has been found to be associated with autoimmune diseases, including Sjögren's Syndrome. However, whether IL-13 plays a causative role in disease development is not known and cannot be easily studied in humans. Our previous work has shown that levels of IL-13 are elevated in Id3 kn...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2014.06.009

    authors： Belle I,Mahlios J,McKenzie A,Zhuang Y

    更新日期：2014-10-01 00:00:00

  • Interferonbeta-induced changes in metallothionein expression and subcellular distribution of zinc in HepG2 cells.

    abstract：:We evaluated the changes of metallothionein induction and cellular zinc distribution in HepG2 cells by interferonbeta treatment. Immunohistochemical staining of metallothionein was observed in the cytoplasm and nuclei of hepatocytes; which was observed predominantly in the cells treated with interferon and zinc compar...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2006.06.008

    authors： Nagamine T,Kusakabe T,Takada H,Nakazato K,Sakai T,Oikawa M,Satoh T,Arakawa K

    更新日期：2006-06-01 00:00:00

  • Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes.

    abstract：:The N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP), a unique cytokine present in human granulocytes, was determined to be: Pyroglu-Leu-Lys-X-Tyr-Thr-X-Lys-Glu-Pro-Met-Thr-Ser(Thr)-Ala-Ala... This sequence showed no significant homology with any other protein when used in database searches...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1996.0001

    authors： Ridge RJ,Sloane NH

    更新日期：1996-01-01 00:00:00

  • Identification of the IL-33 protein segment that controls subcellular localization, extracellular secretion, and functional maturation.

    abstract：:Proteolytic activation of the IL-33 precursor, full-length interleukin-33 (FLIL33), at multiple sites within the sensor domain (aa 95-109) yields several functionally mature (MIL33) forms. Unlike nuclear FLIL33, intracellular MIL33 occurs in the cytoplasm, is secreted from source cells, and exerts biological effects b...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2019.02.015

    authors： Luzina IG,Clerman A,Fishelevich R,Todd NW,Lockatell V,Atamas SP

    更新日期：2019-07-01 00:00:00

  • Chemokine/cytokine profiling after rituximab: reciprocal expression of BCA-1/CXCL13 and BAFF in childhood OMS.

    abstract：:The aim of the study was to test the hypothesis that B-cell repopulation following rituximab (anti-CD20) therapy is orchestrated by chemokines and non-chemokine cytokines. Twenty-five children with opsoclonus-myoclonus syndrome (OMS) received rituximab with or without conventional agents. A comprehensive panel of 40 c...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.12.004

    authors： Pranzatelli MR,Tate ED,Travelstead AL,Verhulst SJ

    更新日期：2011-03-01 00:00:00

  • The effects of IgG and immune complexes on the endotoxin-induced cytokine response.

    abstract：:Cytokine induction following stimulation by endotoxin (LPS) was investigated in human peripheral whole blood. Blood cells were suspended in autologous plasma diluted in basal medium (BM-plasma) or Compound Sodium Lactate Solution (CSL-plasma), or in autologous serum diluted in CSL. Induction of interleukin 1 beta, int...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(94)90020-5

    authors： Yentis SM,Gooding RP,Riches PG

    更新日期：1994-05-01 00:00:00

  • IL-33 stimulates expression of the GPR84 (EX33) fatty acid receptor gene and of cytokine and chemokine genes in human adipocytes.

    abstract：:Expression of GPCR fatty acid sensor/receptor genes in adipocytes is modulated by inflammatory mediators, particularly IL-1β. In this study we examined whether the IL-1 gene superfamily member, IL-33, also regulates expression of the fatty acid receptor genes in adipocytes. Human fat cells, differentiated from preadip...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2018.05.008

    authors： Zaibi MS,Kępczyńska MA,Harikumar P,Alomar SY,Trayhurn P

    更新日期：2018-10-01 00:00:00

  • Atherogenic cytokines and chemokines in chronic hepatitis C are not associated with the presence of cardiovascular diseases.

    abstract：:There appears to be an associative link between chronic hepatitis C (CHC) and cardiovascular diseases (CVDs). However, the exact nature of the relationship between CHC and CVDs has not been elucidated. We investigated the presence of CVDs and the clinical and laboratory alterations associated with these diseases in CH...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2018.12.005

    authors： Santos TPS,Pereira MM,Schinoni MI,Sampaio GP,Aras R Jr,Atta MLS,Atta AM

    更新日期：2019-03-01 00:00:00

  • The treatment of propofol induced the TGF-β1 expression in human endothelial cells to suppress endocytosis activities of monocytes.

    abstract：:Propofol anesthesia and sedation are known to downregulate the functions of many hematopoietic cells, such as macrophages and neutrophils, in vivo. However, the effects of propofol on secretion of the regulatory cytokine transforming growth factor β1 (TGF-β1) in vivo are unknown. In this study, the effects of propofol...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.08.001

    authors： Li CH,Lee RP,Lin YL,Lin CS,Hsu BG,Tseng FJ,Chen YC,Liao KW,Yang FL

    更新日期：2010-12-01 00:00:00

  • Associations between inflammatory cytokines and organ damage in pediatric patients with hemophagocytic lymphohistiocytosis.

    abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal disease characterized by overwhelming inflammation response and multiple organ damage. Most of the clinical and laboratory manifestations of HLH are thought to be related to hypercytokinemia and organ infiltration with lymphocytes and histiocytes. The aim...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2016.05.022

    authors： Yang SL,Xu XJ,Tang YM,Song H,Xu WQ,Zhao FY,Shen DY

    更新日期：2016-09-01 00:00:00

  • Cytokines in liposomes: preliminary studies with IL-1, IL-2, IL-6, GM-CSF and interferon-gamma.

    abstract：:A simple, generally applicable method to incorporate cytokine proteins into multilamellar liposomes is presented. A variety of human cytokines including granulocyte-macrophage colony stimulating factor (GM-CSF), interleukins 1 alpha, 2 and 6 (IL-1 alpha, IL-2, IL-6) and interferon-gamma (IFN-gamma) were incorporated i...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(94)90014-0

    authors： Anderson PM,Hanson DC,Hasz DE,Halet MR,Blazar BR,Ochoa AC

    更新日期：1994-01-01 00:00:00

  • Cytokines modulate endothelial cell intracellular signal transduction required for VCAM-1-dependent lymphocyte transendothelial migration.

    abstract：:Vascular cell adhesion molecule-1 (VCAM-1) activates endothelial cell NADPH oxidase which catalyzes production of reactive oxygen species (ROS). This activity is required for VCAM-1-dependent lymphocyte migration. The focus of our study was to determine whether these VCAM-1-dependent functions are modulated by cytokin...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2001.0922

    authors： Tudor KS,Hess KL,Cook-Mills JM

    更新日期：2001-08-21 00:00:00

  • Intracellular localization of the p35 subunit of murine IL-12.

    abstract：:Production of interleukin-12 (IL-12), a heterodimer of p35 and p40 subunits, is limited by p35 expression. A long and a short murine p35 mRNA potentially encoding proteins differing in pre-sequence size are produced. Increased pre-sequence size could convert a cleaved signal peptide to an uncleaved signal peptide, rai...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/s1043-4666(03)00016-4

    authors： Vaidyanathan H,Zhou Y,Petro TM,Schwartzbach SD

    更新日期：2003-02-07 00:00:00

  • Interferon-gamma associated cytokines and chemokines produced by spleen cells from Brucella-immune mice.

    abstract：:It is known that interferon (IFN)-gamma plays a critical role in protection against brucellosis. In this study we have investigated several cytokines and chemokines that are associated with IFN-gamma for potential in vitro correlates of protection. We cultured spleen cells in vitro from mice immunized orally with a li...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2004.12.009

    authors： Paranavitana C,Zelazowska E,Izadjoo M,Hoover D

    更新日期：2005-04-21 00:00:00

  • Scatter factor affects major changes in the cytoskeletal organization of epithelial cells.

    abstract：:The effects of scatter factor on the cytoskeleton of MDCK and PtK2 cells are described. During the first 6 h after the addition of scatter factor, MDCK cells were found to increase their projected areas twofold, as well as the number and size of their F-actin stress fibers. In contrast PtK2 cells showed no change in t...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(91)90498-3

    authors： Dowrick PG,Prescott AR,Warn RM

    更新日期：1991-07-01 00:00:00

  • FK506 suppresses E-selectin, ICAM-1 and VCAM-1 expression on vascular endothelial cells by inhibiting tumor necrosis factor alpha secretion from peripheral blood mononuclear cells.

    abstract：:FK506 suppresses activation of T cells; however, it down-regulates E-selectin, ICAM-1 and VCAM-1 expression in inflamed tissues. In this study, we investigated the effect of FK506 on expression of those adhesion molecules on human vascular endothelial cells (HMVEC). Culture supernatant from peripheral blood mononuclea...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2004.04.006

    authors： Sasakawa T,Sasakawa Y,Masunaga T,Fujitsu T,Hirayama Y,Ohkubo Y,Mutoh S

    更新日期：2005-01-21 00:00:00

  • Polycyclic aromatic hydrocarbons induce IL-8 expression through nuclear factor kappaB activation in A549 cell line.

    abstract：:Air pollution causes increased cardiopulmonary morbidity and mortality. Airway inflammation plays a major role in the pathophysiology of many lung diseases. Proinflammatory cytokines, such as interleukin-8 (IL-8), are responsible in part for the initiation and maintenance of airway inflammation. Asbestos exposure and ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：

    authors： Pei XH,Nakanishi Y,Inoue H,Takayama K,Bai F,Hara N

    更新日期：2002-09-07 00:00:00

  • Interleukin 10 suppresses phagocytic and antihyphal activities of human neutrophils.

    abstract：:We investigated the effects of human interleukin 10 (IL-10) on the antibacterial and antifungal activities of human neutrophils (PMNs) against Staphylococcus aureus and Candida albicans. Incubation of PMNs from healthy volunteers with 20-100 ng/ml of IL-10 at 37 degrees C for 1 h suppressed phagocytosis of serum-opson...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1999.0567

    authors： Roilides E,Katsifa H,Tsaparidou S,Stergiopoulou T,Panteliadis C,Walsh TJ

    更新日期：2000-04-01 00:00:00

  • A competitive RT-PCR method for the quantitative analysis of cytokine mRNAs in mouse tissues.

    abstract：:The authors describe the design and validation of a competitive RT-PCR method for the efficient and reproducible quantitation of mRNA molecules of IFN-gamma, TNF-alpha, IL-4 and IL-10 in mouse spleen RNA extracts. Before being subjected to RT-PCR, the RNA extracts were supplemented with internal control RNAs (IC-RNAs)...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1996.0156

    authors： Zhou NM,Matthys P,Polacek C,Fiten P,Sato A,Billiau A,Froyen G

    更新日期：1997-03-01 00:00:00

  • A rapid activation assay for human eosinophils based on adhesion to immobilized ICAM-1, VCAM-1 and IgG.

    abstract：:Interleukin 5 (IL-5) is a T-cell derived cytokine that induces eosinophil growth and differentiation in both mouse and human bone marrow cultures. Elevated levels of IL-5 as well as eosinophils have been detected in the sputum and Bronchoalveolar lavage (BAL) fluids of asthmatics. Since the recruitment of inflammatory...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1996.0034

    authors： Fattah D,Page KR,Bezbaruah S,Priest RC,Horgan CM,Solari R

    更新日期：1996-03-01 00:00:00

  • Ureaplasma species modulate cell adhesion molecules and growth factors in human brain microvascular endothelial cells.

    abstract：:Ureaplasma species (spp.) are considered commensals of the adult urogenital tract, but may cause chorioamnionitis and preterm birth as well as sepsis and meningitis in neonates. Pathomechanisms in Ureaplasma-driven neuroinflammation are largely unknown. This study addressed mRNA and protein expression of intercellular...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2019.154737

    authors： Silwedel C,Speer CP,Haarmann A,Fehrholz M,Claus H,Schlegel N,Glaser K

    更新日期：2019-09-01 00:00:00

  • Differences in the inducible gene expression and protein production of IL-12p40, IL-12p70 and IL-23: involvement of p38 and JNK kinase pathways.

    abstract：:The proper balance between IL-12p40-related cytokines controls the appearance of normal and pathological Th1 immune responses. In this study, we examined the inducible IL-12p40, IL-12p35 and IL-23p19 mRNA expression and protein production in human peripheral blood mononuclear cells (PBMC) and purified monocytes, isola...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2008.04.003

    authors： Dobreva ZG,Stanilova SA,Miteva LD

    更新日期：2008-07-01 00:00:00

  • Decreased interleukin-18 response in asthmatic children with severe Mycoplasma pneumoniae pneumonia.

    abstract：PURPOSE:Mycoplasma pneumoniae (M. pneumoniae) is a common causative agent of pneumonia in children. The aim of this study is to determine whether there is any difference in selected cytokine or chemokines response in asthmatic children compared to non-asthmatic children during acute M. pneumoniae pneumonia. METHODS:Se...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2011.02.008

    authors： Chung HL,Shin JY,Ju M,Kim WT,Kim SG

    更新日期：2011-05-01 00:00:00

  • The pneumotoxicant paraquat induces IL-8 mRNA in human mononuclear cells and pulmonary epithelial cells.

    abstract：:Paraquat (PQ) is a herbicide which is highly pneumotoxic by generating reactive oxygen intermediates (ROI). Pro-inflammatory cytokines, particularly IL-1 and TNF, have been implicated in some ROI-mediated pathologies, including bleomycin toxicity and ischaemia/reperfusion injury. We have studied the effect of PQ on th...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(93)90045-7

    authors： Bianchi M,Fantuzzi G,Bertini R,Perin L,Salmona M,Ghezzi P

    更新日期：1993-09-01 00:00:00

  • The local liver ablation with pulsed electric field stimulate systemic immune reaction against hepatocellular carcinoma (HCC) with time-dependent cytokine profile.

    abstract：AIM:How irreversible electroporation (IRE) affect immune status is still kept unknown. This preclinical study is to investigate its local and systemic immune reaction both on tumor-bearing and tumor free animals. METHODS:Liver ablation was performed by a standard IRE instrument and proposal. Altogether 57 tumor bearin...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2017.05.003

    authors： Chen X,Ren Z,Yin S,Xu Y,Guo D,Xie H,Zhou L,Wu L,Jiang J,Li H,Sun J,Zheng S

    更新日期：2017-05-01 00:00:00

  • Prognostic value of visfatin in various human malignancies: A systematic review and meta-analysis.

    abstract：:Although numerous studies have shown that visfatin is linked to several cancers, its prognostic value is still unclear. This first comprehensive meta-analysis was performed to evaluate the prognostic effect of visfatin in cancer patients. A systematic search was conducted for relevant studies in health-related electro...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2019.154964

    authors： Mohammadi M,Moradi A,Farhadi J,Akbari A,Pourmandi S,Mehrad-Majd H

    更新日期：2020-03-01 00:00:00

  • Cytokine-mediated FOXO3a phosphorylation suppresses FasL expression in hemopoietic cell lines: investigations of the role of Fas in apoptosis due to cytokine starvation.

    abstract：:We have investigated phosphatidylinositol 3-kinase (PI3K)-dependent survival signalling pathways using several cytokines in three different hemopoietic cell lines, MC/9, FDC-P1, and TF-1. Cytokines caused PI3K- and PKB-dependent phosphorylation of FOXO3a (previously known as FKHRL1) at three distinct sites. Following ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2007.05.004

    authors： Behzad H,Jamil S,Denny TA,Duronio V

    更新日期：2007-05-01 00:00:00