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The treatment of propofol induced the TGF-β1 expression in human endothelial cells to suppress endocytosis activities of monocytes.

Abstract：

:Propofol anesthesia and sedation are known to downregulate the functions of many hematopoietic cells, such as macrophages and neutrophils, in vivo. However, the effects of propofol on secretion of the regulatory cytokine transforming growth factor β1 (TGF-β1) in vivo are unknown. In this study, the effects of propofol on TGF-β1 expression in human peripheral blood mononuclear cells, umbilical vein endothelial cells (HUVECs), lymphocytes (Jurkat) and monocytes (THP-1) were tested. Moreover, these sera were also tested for regulatory activity on monocyte endocytosis with or without treatment with the TGF-β1 pathway inhibitor SB431542. Propofol raised levels of both total and activated TGF-β1 in propofol-treated patient sera after surgical operations. Furthermore, propofol induced secretion of latent TGF-β1 in HUVEC cells and enhanced TGF-β1 activation in THP-1 and Jurkat cells in vitro. Additionally, sera from propofol-treated patients suppressed monocyte endocytosis ex vivo, an effect that was abrogated by the TGF-β1 pathway inhibitor SB431542.

journal_name

Cytokine

journal_title

Cytokine

authors

Li CH,Lee RP,Lin YL,Lin CS,Hsu BG,Tseng FJ,Chen YC,Liao KW,Yang FL

doi

10.1016/j.cyto.2010.08.001

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

203-9

issue

3

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(10)00631-9

journal_volume

52

pub_type

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