Abstract:
:Staphylococcus aureus is one of the versatile Gram positive bacteria causing a range of diseases. Upon challenge, host immune cells recognize S. aureus and mount diverse immune responses including production of pro-inflammatory cytokines such as IL-1β and TNF-α. These cytokines are important mediators of inflammation which can be detected via various immunological methods such as enzyme linked immunosorbent assay (ELISA) and immunoblotting. In the current study, we found that a number of clinical isolates as well as laboratory strains of S. aureus exhibited cross reactivity with ELISA antibodies for murine IL-1β and TNF-α assays. This cross reactivity generates exaggerated false positive signals which can be a source of discrepancy for the understanding of real immune responses against S. aureus infection by host immune cells.
journal_name
Cytokinejournal_title
Cytokineauthors
Javed N,Xue G,Lu A,Xing Y,Iwakura Y,Xiao H,Lecoeur H,Späth GF,Meng Gdoi
10.1016/j.cyto.2016.03.007subject
Has Abstractpub_date
2016-05-01 00:00:00pages
101-8eissn
1043-4666issn
1096-0023pii
S1043-4666(16)30046-1journal_volume
81pub_type
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