Abstract:
:High-fat-fed C57Bl/6J FABP4/aP2 null mice develop obesity but not the related hyperglycemia or hyperinsulinemia characteristic of type II diabetes. FABP4/aP2 protein's function to bind fatty acids in the adipocytes may promote total body energy homeostasis by linking energy depots to the ability to express signaling molecules similar to leptin. To test this hypothesis, proteomic analysis of serum proteins from high-fat-fed wild-type and FABP4/aP2 null mice revealed that the GDF-3/Vgr-2 protein, a bone morphogenetic protein, was upregulated in C57Bl/6J FABP4/aP2 null mice. The increase in serum GDF-3/Vgr-2 protein was correlated with a 27-fold increase in adipose GDF-3/Vgr-2 mRNA. In contrast, leptin expression was unaltered between FABP4/aP2 null and wild-type animals. The expression of GDF-3/Vgr-2 mRNA was not substantially different in adipose tissue of db/db and tb/tb mice compared to wild-type controls. The expression of GDF-3/Vgr-2 mRNA was dependent upon the age and diet of the animals, declining as a function of age in high-fat-fed wild-type animals while increasing in the FABP4/aP2 null strain. These results identify GDF-3/Vgr-2 as an age- and fat-regulated, adipose-derived cytokine suggesting a linkage between adipocyte fatty acid metabolism and the expression of the bone morphogenetic family of differentiation regulators.
journal_name
Cytokinejournal_title
Cytokineauthors
Witthuhn BA,Bernlohr DAdoi
10.1006/cyto.2001.0864keywords:
subject
Has Abstractpub_date
2001-05-07 00:00:00pages
129-35issue
3eissn
1043-4666issn
1096-0023pii
S1043-4666(01)90864-6journal_volume
14pub_type
杂志文章相关文献
CYTOKINE文献大全abstract::The protective effect of interleukin 1 alpha (IL-1 alpha) in mice with acetaminophen (AAP)-induced hepatitis was investigated. IL-1 alpha had a significant protective effect if given 2 or more hours (up to 24 hours) before AAP; it significantly reduced mortality of mice and decreased serum transaminase level. The maxi...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(93)90004-o
更新日期:1993-05-01 00:00:00
abstract::Invariant NKT (iNKT) cells have been extensively studied throughout the last decade due to their ability to polarize and amplify the downstream immune response. Only recently however, have the various mechanisms underlying NKT cell activation begun to unfold. iNKT cells have the ability to respond as innate immune cel...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2010.04.016
更新日期:2010-09-01 00:00:00
abstract::Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection and hospitalization in infants. In spite of the enormous clinical burden caused by RSV infections, there remains no efficacious RSV vaccine. CD8 T cells mediate viral clearance as well as provide protection against a secondary ...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2018.07.012
更新日期:2020-09-01 00:00:00
abstract::Dysregulation of cytokines synthesis is thought to play a role in the development of a number of age-related conditions, such as rheumatoid arthritis, osteoporosis, atherosclerosis, and others, but observational studies have led to contradictory results. We investigated potential familial influences on the plasma leve...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2002.1959
更新日期:2002-08-07 00:00:00
abstract::In order to study structure-function relationships of the M(r) 55,000 subunit of the murine IL-2R (p55 IL-2R) by epitope mapping, we have expressed the p55 IL-2R molecule in a cell-free translation system. Under these in vitro conditions, we detected the expected p55 IL-2R polypeptide initiated at Met 1 and, in additi...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(92)90066-z
更新日期:1992-07-01 00:00:00
abstract::Dermal wounding is accompanied by inflammation and the resulting proinflammatory cytokines, including interleukin (IL)-6, are thought to play an important role in the repair process. IL-6 is produced by normal human keratinocytes to various dermatological diseases and we have recently shown it is also required for nor...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2001.0946
更新日期:2001-09-21 00:00:00
abstract:OBJECTIVE:Oxidative stress is involved in several maternal conditions characterized both by an increase in free radicals synthesis and a parallel decrease in the antioxidant activity. Parturition induces considerable oxidative stress and many inflammatory mediators, among which HMGB1, are involved from the beginning of...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.03.019
更新日期:2018-08-01 00:00:00
abstract::Chemokines are small chemoattractant cytokines involved in normal and pathological immune processes. Although extensive nucleotide sequence data are available for human and murine chemokine cDNA sequences, very few data are currently available regarding rhesus macaque sequences. To increase our understanding of immune...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2002.0875
更新日期:2002-05-07 00:00:00
abstract::We investigated the effects of human interleukin 10 (IL-10) on the antibacterial and antifungal activities of human neutrophils (PMNs) against Staphylococcus aureus and Candida albicans. Incubation of PMNs from healthy volunteers with 20-100 ng/ml of IL-10 at 37 degrees C for 1 h suppressed phagocytosis of serum-opson...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1999.0567
更新日期:2000-04-01 00:00:00
abstract::Long-term exposure to biomass-burning smoke (BS) is associated with chronic obstructive pulmonary disease (COPD), asthma, and other chronic inflammatory lung diseases. BS results from such processes as the burning of wood for indoor cooking and heating, with women and children having the highest exposure rate. This st...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155089
更新日期:2020-07-01 00:00:00
abstract::Clara cell protein (CC16) is an endogenous anti-inflammatory agent. It is produced mainly in the respiratory and urogenital tracts. CC16 has been quantified in serum, but not in cerebrospinal fluid (CSF). The aim of this study was to examine CSF CC16 in relation to age, gender and serum CC16, and to examine CC16 level...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0318
更新日期:1998-06-01 00:00:00
abstract::Interleukin-8 (IL-8/CXCL8) is widely expressed in fetal tissues although inflammatory changes are not seen. Circulating IL-8 is comprised of an endothelial-derived [ala-IL-8](77) isoform and another, more potent [ser-IL-8](72) secreted by most other cells; [ala-IL-8](77) can be converted into [ser-IL-8](72) by proteol...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.12.022
更新日期:2009-04-01 00:00:00
abstract::Increased levels of serum IgE have been described in gliadin-intolerant patients; however, biological mechanisms implicated in this immunoglobulin production remained unknown. In this study, we demonstrated that in vitro crude gliadins and gliadin lysates (Glilys) promoted the IL-4-induced IgE production by human peri...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/s1043-4666(03)00100-5
更新日期:2003-03-21 00:00:00
abstract:OBJECTIVE:The initial study has reported the increased level of oncostatin M (OSM) in gingival crevicular fluid (GCF) of chronic periodontitis patients, and no study has reported its level in gingivitis patients. Therefore, the present study has been carried out to measure the level of OSM in gingival crevicular fluid ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.02.002
更新日期:2010-06-01 00:00:00
abstract::TLR2 is a toll-like receptor protein which is involved in innate immune responses. TLR2 recognize several virus, fungal and bacterial pathogens, upon their uptake cause internalization and cellular activation. During this process several cytokines participate including interleukins, IL6 and IL12. Interestingly, TLR2 i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2016.05.007
更新日期:2016-07-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) regulate the structural integrity of the extracellular matrix (ECM). Constitutive expression of human TIMP-3 in human DLD colon carcinoma cells renewed serum-responses and inhibited tumour formation in nude mice. To elucidate the mecha...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0233
更新日期:1997-10-01 00:00:00
abstract::Although numerous studies have shown that visfatin is linked to several cancers, its prognostic value is still unclear. This first comprehensive meta-analysis was performed to evaluate the prognostic effect of visfatin in cancer patients. A systematic search was conducted for relevant studies in health-related electro...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2019.154964
更新日期:2020-03-01 00:00:00
abstract::The regulation of local L-tryptophan concentrations by tryptophan-degrading enzyme, indoleamine 2,3-dioxygenase (IDO) induced by various stimuli such as interferon-γ (IFN-γ) is one of the key mechanisms in antimicrobial effect. Recently, IDO is also focused on an immunosuppressive mechanism shared by several different...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.04.022
更新日期:2012-08-01 00:00:00
abstract::Interleukin (IL)-6, a multifunctional cytokine, is widely used as an index for illnesses such as inflammatory and autoimmune disorders, coronary artery disease, neurological disease, and gestational problems. It is thus very important to be able to precisely quantify the level of IL-6 for disease diagnosis and any sub...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.04.004
更新日期:2010-07-01 00:00:00
abstract::The effects of scatter factor on the cytoskeleton of MDCK and PtK2 cells are described. During the first 6 h after the addition of scatter factor, MDCK cells were found to increase their projected areas twofold, as well as the number and size of their F-actin stress fibers. In contrast PtK2 cells showed no change in t...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(91)90498-3
更新日期:1991-07-01 00:00:00
abstract::Stem cell therapy is a promising strategy for recovering of injured cardiac tissue after acute myocardial infarction. The effects promoted by preventive physical training, beneficial for regeneration, are not yet understood on stem cell homing. In the present study, we evaluated the effect of preventive physical train...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2019.154912
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Two assays--isolated peripheral blood mononuclear cells (PBMC) and a whole blood assay (WBA)--are commonly used to study TNF-alpha production by an individual in order to distinguish between high and low cytokine producers. We assessed the reliability and reproducibility of these assays. METHODS:The PBMC as...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2004.11.011
更新日期:2005-04-07 00:00:00
abstract:BACKGROUND:Resistin is a novel cysteine-rich protein that plays a role in the development of insulin resistance and atherosclerosis in rodents, while its role in humans is unclear. C-reactive protein (CRP) is an important risk predictor for coronary heart disease, and it can also modify the expression of genes involved...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.09.011
更新日期:2007-12-01 00:00:00
abstract::The predominant pathological features in the central nervous system (CNS) in multiple sclerosis (MS) are perivascular inflammation and demyelination. The cells in the inflammatory cuff consist mainly of T lymphocytes and macrophages. Cytokines produced by inflammatory cells within the CNS have the potential to enhance...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/s1043-4666(05)80008-0
更新日期:1993-11-01 00:00:00
abstract::There are limited and conflicting studies investigating the role of the angiopoietin family in human thyroid cancer development and progression. We have investigated cytokines angiopoietin-1, -2 and their receptor (Tie-2), known to be involved in angiogenesis, in the serum of 52 thyroid cancer patients (21 cases of pa...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.02.008
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:The balance of several cytokines likely influences the resolution of glomerulonephritis. Monocyte chemoattractant protein-1(MCP-1) is a chemokine that promotes renal inflammation whereas epidermal growth factor (EGF) stimulates protective responses. Previously, high urine MCP-1(MCP-1) and low urine EGF (EGF)...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.01.015
更新日期:2018-04-01 00:00:00
abstract::Among New Mexican Hispanic women, breast cancer is detected at a more advanced stage than compared to Non-Hispanic White women. One central factor that has been little studied is the role of critical cytokines. We genotyped incident breast cancer cases and their age-, gender- and smoking-matched controls (N=40 matched...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.03.014
更新日期:2010-07-01 00:00:00
abstract::Cytokines are key mediators of immune responses to autoantigens, tumor antigens and foreign antigens including pathogens and transplant antigens. The cytokines are produced by a variety of immune and non-immune cells and are dynamically regulated. Remarkably, during toxic and septic shock syndromes, anaphylactic shock...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155320
更新日期:2020-10-27 00:00:00
abstract::Human interleukin-6 (IL-6) secreted by cytokine- or endotoxin-induced fibroblasts, monocytes, keratinocytes, endometrial stromal cells, and endothelial cells, when analyzed under denaturing and reducing conditions, consists of a set of differentially modified phosphoglycoproteins of molecular mass in the range from 23...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(91)90018-9
更新日期:1991-05-01 00:00:00
abstract::IL-1 family members regulate innate immune responses, are produced by gestation-associated tissues, and have a role in healthy and adverse pregnancy outcomes. To better understand their role at the materno-fetal interface we used a human tissue explant model to map lipopolysaccharide (LPS)-stimulated production of IL-...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.07.005
更新日期:2017-11-01 00:00:00