Abstract:
OBJECTIVE:Oxidative stress is involved in several maternal conditions characterized both by an increase in free radicals synthesis and a parallel decrease in the antioxidant activity. Parturition induces considerable oxidative stress and many inflammatory mediators, among which HMGB1, are involved from the beginning of pregnancy to the birth of the infant. We evaluated serum cord blood HMGB1 levels in a population of neonates to investigate correlation with mode of delivery, as well as the influence of labour. SETTING AND PATIENTS:The study subjects were 325 neonates delivered at University Hospital "G. Martino" of Messina over an 18-month period. Following cord separation, venous blood sampling was performed on umbelical cords. RESULTS:In the cord venous blood, we found HMGB1 values significantly more elevated in spontaneous vaginal group when compared to elective or emergency caesarean section group. Regarding labour, umbilical cord venous blood HMGB1 levels were significantly higher in the spontaneous and induced labour group, compared to non-labouring women. CONCLUSION:These results could highlight a possible role of HMGB1 during birth time related to mode of delivery and labour.
journal_name
Cytokinejournal_title
Cytokineauthors
D'Angelo G,Marseglia L,Granese R,Di Benedetto A,Giacobbe A,Impellizzeri P,Alibrandi A,Ferro E,Palmara A,Manti S,Arrigo T,Salpietro C,Buonocore G,Reiter RJ,Gitto Edoi
10.1016/j.cyto.2018.03.019subject
Has Abstractpub_date
2018-08-01 00:00:00pages
53-56eissn
1043-4666issn
1096-0023pii
S1043-4666(18)30105-4journal_volume
108pub_type
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