Role of prostaglandins E1, E2 and F2 alpha in the brain in interleukin 1 beta-induced adrenocorticotropin secretion in the rat.


:It is well known that interleukin (IL)-1 is a potent activator of the hypothalamo-pituitary-adrenal axis in the rat. Many studies have reported that prostaglandins (PGs), especially PGE2, in the brain may mediate the IL-1 stimulation of corticotropin-releasing hormone release, which then leads to adrenocorticotropin (ACTH) secretion. However, a general consensus has yet to emerge regarding whether PGE2 is the only or the most important PG in the brain mediating IL-1-induced ACTH secretion in the rat. To address this question, we examined the effect of intracerebroventricular (icv) administration of antisera against PGE1, PGE2 or PGF2 alpha, or normal rabbit serum on the ACTH response induced by an icv injection of IL-1 beta in the rat. Each antibody or normal rabbit serum (as the control) was given icv 15 min before an icv administration of human recombinant IL-1 beta (50 ng). IL-1 beta produced a significant rise in plasma ACTH levels, and this response was significantly suppressed by either of the three PG antibodies. Interestingly, the inhibitory effect of anti-PGE2 antibody seemed to be somewhat weaker than those of the other two antibodies. We conclude that not only PGE2 but also PGE1 and PGF2 alpha in the brain may mediate the IL-1 beta stimulation of ACTH secretion in the rat.






Watanobe H,Sasaki S,Takebe K




Has Abstract


1995-10-01 00:00:00
















  • Altered plasma levels of βC and γC chain cytokines and post-treatment modulation in tuberculous lymphadenitis.

    abstract:BACKGROUND:Alterations in β common (βC) and γ common (γC) chain cytokines have been described in pulmonary tuberculosis. However, their role in tuberculous lymphadenitis (TBL) disease has not been assessed. METHODS:Thus, in the present study, we have examined the systemic levels of βC and γC chain cytokines in TBL, la...


    pub_type: 杂志文章


    authors: Kathamuthu GR,Moideen K,Sridhar R,Baskaran D,Babu S

    更新日期:2021-02-01 00:00:00

  • CCR7 signaling in pediatric opsoclonus-myoclonus: upregulated serum CCL21 expression is steroid-responsive.

    abstract::Identifying and blocking chemokine inflammatory mediators in pediatric opsoclonus-myoclonus syndrome (OMS) is critical to the treatment of this autoimmune, paraneoplastic, neurological disorder. In a prospective, case-control, clinico-scientific study of children with OMS compared to non-inflammatory neurological cont...


    pub_type: 杂志文章


    authors: Pranzatelli MR,Tate ED,McGee NR,Ransohoff RM

    更新日期:2013-10-01 00:00:00

  • Associations between inflammatory cytokines and organ damage in pediatric patients with hemophagocytic lymphohistiocytosis.

    abstract::Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal disease characterized by overwhelming inflammation response and multiple organ damage. Most of the clinical and laboratory manifestations of HLH are thought to be related to hypercytokinemia and organ infiltration with lymphocytes and histiocytes. The aim...


    pub_type: 杂志文章


    authors: Yang SL,Xu XJ,Tang YM,Song H,Xu WQ,Zhao FY,Shen DY

    更新日期:2016-09-01 00:00:00

  • Impact of telmisartan on the inflammatory state in patients with coronary atherosclerosis--influence on IP-10, TNF-α and MCP-1.

    abstract:BACKGROUND:Hypertension is one of the most prominent risk factors for coronary artery disease (CAD). Treatment of hypertension is therefore important for reducing cardiovascular events and the progression of atherosclerosis. Several treatment strategies are common in clinical practice for example the use of ACE-blocker...


    pub_type: 杂志文章


    authors: Klinghammer L,Urschel K,Cicha I,Lewczuk P,Raaz-Schrauder D,Achenbach S,Garlichs CD

    更新日期:2013-05-01 00:00:00

  • Regulation and role of interleukin 6 in wounded human epithelial keratinocytes.

    abstract::Dermal wounding is accompanied by inflammation and the resulting proinflammatory cytokines, including interleukin (IL)-6, are thought to play an important role in the repair process. IL-6 is produced by normal human keratinocytes to various dermatological diseases and we have recently shown it is also required for nor...


    pub_type: 杂志文章


    authors: Sugawara T,Gallucci RM,Simeonova PP,Luster MI

    更新日期:2001-09-21 00:00:00

  • Preferential production of IL-12 by peritoneal macrophages activated by liposomes prepared from neoglycolipids containing oligomannose residues.

    abstract::The present study demonstrates that liposomes coated with synthesized neoglycolipids constructed from mannotriose and dipalmitoylphosphatidylethanolamine (Man3-DPPE) activate peritoneal macrophages (PEMs) to up-regulate expression of co-stimulatory molecules and preferentially secrete IL-12. Injection of Man3-DPPE-coa...


    pub_type: 杂志文章


    authors: Takagi H,Furuya N,Kojima N

    更新日期:2007-12-01 00:00:00

  • Vascular endothelial growth factor: therapeutic possibilities and challenges for the treatment of ischemia.

    abstract::Vascular endothelial growth factor (VEGF) is a notable chemokine that plays critical roles in angiogenesis and vasculogenesis. The contemporary body of literature contains a substantial amount of information regarding its chemical properties as well as its fundamental role in vascular development. Studies strongly ind...


    pub_type: 杂志文章,评审


    authors: Crafts TD,Jensen AR,Blocher-Smith EC,Markel TA

    更新日期:2015-02-01 00:00:00

  • The association between common genetic variant of microRNA-146a and cancer susceptibility.

    abstract::Published data on the association between microRNA-146a (miR-146a) G/C polymorphism and cancer susceptibility are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 23 studies including 10,585 cases and 12,183 controls were used in the meta-analysis. Overal...


    pub_type: 杂志文章,meta分析


    authors: Qiu LX,He J,Wang MY,Zhang RX,Shi TY,Zhu ML,Mao C,Sun S,Lv FF,Zheng CL,Zhu XD

    更新日期:2011-12-01 00:00:00

  • The design and recombinant protein expression of a consensus porcine interferon: CoPoIFN-α.

    abstract::CoPoIFN-α is a recombinant non-naturally occurring porcine interferon-α (IFN-α). It was designed by scanning 17 porcine IFN-α nonallelic subtypes and assigning the most frequently occurring amino acid in each position. We used a porcine IFN-α (PoIFN-α) derived from domestic pig as a control. Both porcine IFN-α genes w...


    pub_type: 杂志文章


    authors: Huang L,Cao RB,Wang N,Liu K,Wei JC,Isahg H,Song LJ,Zuo WY,Zhou B,Wang WW,Mao X,Chen PY

    更新日期:2012-01-01 00:00:00

  • Interleukin-15 interactions with interleukin-15 receptor complexes: characterization and species specificity.

    abstract::Interleukin (IL-) 2 and IL-15 share the IL-2 receptor betagamma c subunits (IL-2Rbetagamma c) but have specific, unique alpha receptor subunits. We studied species specificity of human (hu), simian (si), and mouse (mu) IL-15 and found that hu and si IL-15 behaved similarly in all systems investigated. Hu and mu IL-15 ...


    pub_type: 杂志文章


    authors: Eisenman J,Ahdieh M,Beers C,Brasel K,Kennedy MK,Le T,Bonnert TP,Paxton RJ,Park LS

    更新日期:2002-11-07 00:00:00

  • Low extracellular pH stimulates the production of IL-1β by human monocytes.

    abstract::The development of acidic environments is a hallmark of inflammatory processes of different etiology. We have previously shown that transient exposure to acidic conditions, similar to those encountered in vivo, induces the activation of neutrophils and the phenotypic maturation of dendritic cells. We here report that ...


    pub_type: 杂志文章


    authors: Jancic CC,Cabrini M,Gabelloni ML,Rodríguez Rodrigues C,Salamone G,Trevani AS,Geffner J

    更新日期:2012-02-01 00:00:00

  • The effect of interleukin 1 alpha on acetaminophen-induced hepatotoxicity.

    abstract::The protective effect of interleukin 1 alpha (IL-1 alpha) in mice with acetaminophen (AAP)-induced hepatitis was investigated. IL-1 alpha had a significant protective effect if given 2 or more hours (up to 24 hours) before AAP; it significantly reduced mortality of mice and decreased serum transaminase level. The maxi...


    pub_type: 杂志文章


    authors: Renić M,Culo F,Bilić A,Bukovec Z,Sabolović D,Zupanović Z

    更新日期:1993-05-01 00:00:00

  • Inflammations mediators and circulating levels of matrix metalloproteinases: Biomarkers of diabetes in Tunisians metabolic syndrome patients.

    abstract:AIMS:This study investigates the relationships between matrix metalloproteinases, inflammations mediators and type 2 diabetes mellitus in Tunisians metabolic syndrome (Mets) patients. METHODS:The study has included 239 MetS patients and 247 controls. Mets was defined according to the NCEP-ATPIII report. Mets patients ...


    pub_type: 杂志文章


    authors: Zayani Y,El Golli N,Zidi W,Guizani I,Boussairi S,Aloui S,Ayadi I,Ftouhi B,Feki M,Ben Romdhane N,Ben Sliman H,Allal-Elasmi M,Kaabachi N

    更新日期:2016-10-01 00:00:00

  • IL-4, but not IL-13, modulates TARC (thymus and activation-regulated chemokine)/CCL17 and IP-10 (interferon-induced protein of 10kDA)/CXCL10 release by TNF-alpha and IFN-gamma in HaCaT cell line.

    abstract::It is known that both interleukin-4 (IL-4) and IL-13 are produced by Th2-type cells and share similar biological functions with each other. However, recently accumulated evidences have revealed that IL-4 may be involved in the Th1-type response. Both thymus and activation-regulated chemokine (TARC/CCL17), a ligand for...


    pub_type: 杂志文章


    authors: Kakinuma T,Nakamura K,Wakugawa M,Yano S,Saeki H,Torii H,Komine M,Asahina A,Tamaki K

    更新日期:2002-10-07 00:00:00

  • Human neutrophils produce IL-12, IL-10, PGE2 and LTB4 in response to Paracoccidioides brasiliensis. Involvement of TLR2, mannose receptor and dectin-1.

    abstract::The functions of phagocytic cells against pathogens are initiated by the interaction between membrane receptors and molecular structures which compose the cell wall of these microorganisms. Thus our study aimed to identify the neutrophil receptors involved in the recognition of different strains of Paracoccidioides br...


    pub_type: 杂志文章


    authors: Balderramas HA,Penitenti M,Rodrigues DR,Bachiega TF,Fernandes RK,Ikoma MR,Dias-Melicio LA,Oliveira SL,Soares ÂM

    更新日期:2014-05-01 00:00:00

  • Evaluation of the biological activities of the IL-15 superagonist complex, ALT-803, following intravenous versus subcutaneous administration in murine models.

    abstract::ALT-803 is a fusion protein complex consisting of an interleukin (IL)-15 superagonist and a dimeric IL-15 receptor alpha sushi domain IgG1 Fc fusion protein. When administered to mice, ALT-803 is capable of inducing natural killer (NK) and CD8+ T cell proliferation and activation, and effectively promoting potent anti...


    pub_type: 杂志文章


    authors: Liu B,Jones M,Kong L,Noel T,Jeng EK,Shi S,England CG,Alter S,Miller JS,Cai W,Rhode PR,Wong HC

    更新日期:2018-07-01 00:00:00

  • CXCL5 gene polymorphisms are related to systemic concentrations and leukocyte production of epithelial neutrophil-activating peptide (ENA-78).

    abstract::Data exist linking elevated epithelial neutrophil activating peptide (ENA-78) concentrations with myriad inflammatory conditions. ENA-78 is encoded by the CXCL5 gene which has recently been shown to be polymorphic in nature (rs352046 and rs425535). No functional data on these polymorphisms exist. We investigated wheth...


    pub_type: 杂志文章


    authors: Zineh I,Aquilante CL,Langaee TY,Beitelshees AL,Arant CB,Wessel TR,Schofield RS

    更新日期:2006-03-07 00:00:00

  • Tumor Necrosis Factor-α, Interleukins-12(p40), 6, and 10 levels in cerebrospinal fluid and outcome prediction in Ossimi sheep with encephalitic listeriosis.

    abstract::Encephalitic listeriosis in sheep is a life-threatening disease. However, little is known about the cytokine response and their predictive value in this disease. The aim of present study was to assess the prognostic significance of Tumor Necrosis Factor-α (TNF-α), Interleukin-12(p40) (IL-12 p40), Interleukin-6 (IL-6),...


    pub_type: 杂志文章


    authors: Abdlla OA,Elboshy ME,Reisha EF,Gadlla HA,El-Khodery SA

    更新日期:2015-06-01 00:00:00

  • Expression of TNF-alpha mRNA by peripheral blood mononuclear cells of multiple sclerosis patients treated with IFN-beta 1A.

    abstract::The aim of the present study was to verify the expression of tumour necrosis factor (TNF)-alpha mRNA by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) in unstimulated peripheral blood mononuclear cells (MNCs) of 15 relapsing-remitting multiple sclerosis (MS) patients who underwent treatment ...


    pub_type: 杂志文章


    authors: Sarchielli P,Critelli A,Greco L,Sokola E,Floridi A,Gallai V

    更新日期:2001-06-07 00:00:00

  • Upregulation of osteopontin expression via the interaction of macrophages and fibroblasts under IL-1b stimulation.

    abstract:BACKGROUND:Fibrosis is attributed to dysregulation of tissue-remodeling. In remodeling areas, fibroblasts and macrophages actively make contact with each other. Osteopontin (OPN) is a pro-fibrotic molecule, whose expression is upregulated by interleukin (IL)-1β via secretion of its downstream cytokines, such as IL-6. H...


    pub_type: 杂志文章


    authors: Shimodaira T,Matsuda K,Uchibori T,Sugano M,Uehara T,Honda T

    更新日期:2018-10-01 00:00:00

  • Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue.

    abstract::CC Chemokine ligand 22 (Ccl22) is a selective, high affinity ligand at the CC chemokine receptor 4 (Ccr4). We have identified cDNAs encoding both ligand and receptor of the Ccl22-Ccr4 pair in cDNA libraries of the anterior hypothalamus/pre-optic area (AH/POA) by PCR. The AH/POA is the key brain region where endogenous...


    pub_type: 杂志文章


    authors: Osborn O,Sanchez-Alavez M,Dubins JS,Gonzalez AS,Morrison B,Hadcock JR,Bartfai T

    更新日期:2011-03-01 00:00:00

  • FK506 suppresses E-selectin, ICAM-1 and VCAM-1 expression on vascular endothelial cells by inhibiting tumor necrosis factor alpha secretion from peripheral blood mononuclear cells.

    abstract::FK506 suppresses activation of T cells; however, it down-regulates E-selectin, ICAM-1 and VCAM-1 expression in inflamed tissues. In this study, we investigated the effect of FK506 on expression of those adhesion molecules on human vascular endothelial cells (HMVEC). Culture supernatant from peripheral blood mononuclea...


    pub_type: 杂志文章


    authors: Sasakawa T,Sasakawa Y,Masunaga T,Fujitsu T,Hirayama Y,Ohkubo Y,Mutoh S

    更新日期:2005-01-21 00:00:00

  • Association between VEGF gene promoter polymorphisms and bladder cancer: An updated meta-analysis.

    abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is the key regulator of angiogenesis in the development of various cancers. Previous studies have examined the relationship between VEGF gene promoter polymorphisms such as -2578C/A and -460C/T and bladder cancer risk; however, these results are inconclusive. Therefo...


    pub_type: 杂志文章


    authors: Chen CH,Ho CH,Kuan-Hua Huang S,Shen CH,Wu CC,Wang YH

    更新日期:2020-07-01 00:00:00

  • Effects of repeated injections of interleukin 1beta or lipopolysaccharide on the HPA axis in the newborn rat.

    abstract::The hypothalamic-pituitary-adrenal (HPA) axis is stimulated during immune and inflammatory processes. Interleukin 1beta (IL-1beta) and lipopolysaccharide (LPS) are known to be potent stimulators of this axis. During postnatal development, the rat seems to be hyporesponsive to many stimuli. The effects of repeated syst...


    pub_type: 杂志文章


    authors: Bumiller A,Götz F,Rohde W,Dörner G

    更新日期:1999-03-01 00:00:00

  • Low-to-moderate intensity aerobic exercise training modulates irritable bowel syndrome through antioxidative and inflammatory mechanisms in women: Results of a randomized controlled trial.

    abstract::Our aim was to explore the putative beneficial effects of low-to-moderate intensity exercise training program in patients with irritable bowel syndrome (IBS). This study evaluated the changes in blood oxidative stress status, inflammatory biomarkers and IBS severity symptoms following 24 weeks of moderate aerobic exer...


    pub_type: 杂志文章,随机对照试验


    authors: Hajizadeh Maleki B,Tartibian B,Mooren FC,FitzGerald LZ,Krüger K,Chehrazi M,Malandish A

    更新日期:2018-02-01 00:00:00

  • LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain.

    abstract::The eph family is the largest subfamily of receptor tyrosine kinases (RTKs). Members of this subfamily display specific expression in the developing and adult brain. Recently, cDNAs encoding membrane bound ligands for these receptors have been identified which we have termed LERKs (ligand for eph-related kinases). We ...


    pub_type: 杂志文章


    authors: Kozlosky CJ,VandenBos T,Park L,Cerretti DP,Carpenter MK

    更新日期:1997-08-01 00:00:00

  • Chronic inflammation and hemodialysis reduce immune competence of peripheral blood leukocytes in end-stage renal failure patients.

    abstract::Immunoincompetence is a profound problem in end-stage renal failure patients undergoing hemodialysis, and chronic inflammation with altered serum levels of inflammation markers has been reported. Gene expression patterns have had little relevance for leukocyte research so far because of limitations in transcript level...


    pub_type: 杂志文章


    authors: Knerr K,Füth R,Hemsen P,Mohné W,Heinig A,Kleophas W,Scherbaum WA,Martin S

    更新日期:2005-05-07 00:00:00

  • Levels of pro- and anti-inflammatory cytokines in cystic fibrosis patients with or without gingivitis.

    abstract:BACKGROUND:Inflammatory periodontal diseases are caused by interaction between gram negative, anaerobic bacteria and host response. Persistent infection of Pseudomonas aeruginosa in cystic fibrosis (CF) patients also cause increased pro-inflammatory response and the imbalance of pro- and anti-inflammatory response in b...


    pub_type: 杂志文章


    authors: Duruel O,Berker E,Özşin-Özler C,Gharibzadeh-Hızal M,Gürpınar Ö,Eryılmaz-Polat S,Ataman-Duruel ET,Tan Ç,Karabulut E,Tekçiçek M,Eser ÖK,Kiper N,Tezcan İ

    更新日期:2020-03-01 00:00:00

  • Different roles of tumour necrosis factor alpha and interleukin 1 in murine streptococcal cell wall arthritis.

    abstract::In this study two different aspects of tumour necrosis factor alpha (TNF-alpha) and interleukin 1 (IL-1) in locally induced murine streptococcal cell wall arthritis (SCW) were investigated. First, the kinetics and interdependence of TNF-alpha and IL-1 release; and second; their involvement in inflammation and cartilag...


    pub_type: 杂志文章


    authors: Kuiper S,Joosten LA,Bendele AM,Edwards CK 3rd,Arntz OJ,Helsen MM,Van de Loo FA,Van den Berg WB

    更新日期:1998-09-01 00:00:00

  • Expression of cytokines and their receptors by psoriatic fibroblasts. II. decreased TNF receptor expression.

    abstract::Psoriatic fibroblasts produce enhanced amounts of IL-6 in vitro. This state of activation may reflect an altered expression of cytokine receptors, involved in auto/paracrine induction of IL-6. Cultures of dermal fibroblasts derived from lesional psoriatic (PP) and normal control (NN) skin were therefore analysed for t...


    pub_type: 杂志文章


    authors: Debets R,Hegmans JP,Buurman WA,Benner R,Prens EP

    更新日期:1996-01-01 00:00:00