Role of prostaglandins E1, E2 and F2 alpha in the brain in interleukin 1 beta-induced adrenocorticotropin secretion in the rat.


:It is well known that interleukin (IL)-1 is a potent activator of the hypothalamo-pituitary-adrenal axis in the rat. Many studies have reported that prostaglandins (PGs), especially PGE2, in the brain may mediate the IL-1 stimulation of corticotropin-releasing hormone release, which then leads to adrenocorticotropin (ACTH) secretion. However, a general consensus has yet to emerge regarding whether PGE2 is the only or the most important PG in the brain mediating IL-1-induced ACTH secretion in the rat. To address this question, we examined the effect of intracerebroventricular (icv) administration of antisera against PGE1, PGE2 or PGF2 alpha, or normal rabbit serum on the ACTH response induced by an icv injection of IL-1 beta in the rat. Each antibody or normal rabbit serum (as the control) was given icv 15 min before an icv administration of human recombinant IL-1 beta (50 ng). IL-1 beta produced a significant rise in plasma ACTH levels, and this response was significantly suppressed by either of the three PG antibodies. Interestingly, the inhibitory effect of anti-PGE2 antibody seemed to be somewhat weaker than those of the other two antibodies. We conclude that not only PGE2 but also PGE1 and PGF2 alpha in the brain may mediate the IL-1 beta stimulation of ACTH secretion in the rat.






Watanobe H,Sasaki S,Takebe K




Has Abstract


1995-10-01 00:00:00
















  • Association of TNF-α-(308(GG)), IL-10(-819(TT)), IL-10(-1082(GG)) and IL-1R1(+1970(CC)) genotypes with the susceptibility and progression of leprosy in North Indian population.

    abstract::Leprosy is an infectious disease caused by M. leprae. We analyzed 48 cytokine polymorphisms in 13 (pro as well as anti-inflammatory) cytokine genes using PCR-SSP assay in 102 leprosy patients and 120 healthy controls with intent to find out a link between cytokine polymorphisms and disease susceptibility. TNF-α (-308)...


    pub_type: 杂志文章


    authors: Tarique M,Naqvi RA,Santosh KV,Kamal VK,Khanna N,Rao DN

    更新日期:2015-05-01 00:00:00

  • Facultative heterochromatin formation at the IL-1 beta promoter in LPS tolerance and sepsis.

    abstract::The clinical phenotype in sepsis that is observed as LPS tolerance is determined by silencing of pro-inflammatory genes like IL-1 beta (IL-1β). This study shows that facultative heterochromatin (fHC) silences IL-1β expression during sepsis, where we find dephosphorylated histone H3 serine 10 and increased binding of h...


    pub_type: 杂志文章


    authors: Yoza BK,McCall CE

    更新日期:2011-02-01 00:00:00

  • Bullous pemphigoid: interaction of interleukin 5, anti-basement membrane zone antibodies and eosinophils. A preliminary observation. .

    abstract::Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by the presence of autoantibodies to normal components of the hemidesmosome (BPAg1 and BPAg2). Histology of skin lesions demonstrate a subepidermal vesicle and a predominantly eosinophilic dermal cellular infiltrate. Interleukin 5 (IL-5) pl...


    pub_type: 杂志文章


    authors: Engineer L,Bhol K,Kumari S,Razzaque Ahmed A

    更新日期:2001-01-07 00:00:00

  • Expression of canine interleukin-4 in canine chondrocytes inhibits inflammatory cascade through STAT6.

    abstract::Interleukin-4 (IL-4) is a pleiotropic cytokine with broad spectrum of biological effects on target cells. This study deals with the mammalian expression of canine IL-4 (cIL-4) in canine articular chondrocytes (CAC) and its ability to down-regulate pro-inflammatory cytokines, enzyme mediators and their catabolites. We ...


    pub_type: 杂志文章


    authors: Rachakonda PS,Rai MF,Manning K,Schmidt MF

    更新日期:2008-10-01 00:00:00

  • Serum resistin in older patients with hip fracture: Relationship with comorbidity and biochemical determinants of bone metabolism.

    abstract:OBJECTIVES:To determine the relationship of serum resistin concentrations to biochemical determinants of bone metabolism, comorbidity and outcomes in patients with hip fracture (HF). METHODS:In 256 consecutive patients (mean age 81.9±7.8 years; 71.1% women) serum levels of resistin (determined by ELISA), biochemical p...


    pub_type: 杂志文章


    authors: Fisher A,Southcott E,Li R,Srikusalanukul W,Davis M,Smith P

    更新日期:2011-11-01 00:00:00

  • Interleukin-7 augments CD8+ T cells function and promotes viral clearance in chronic hepatitis C virus infection.

    abstract::Interleukin (IL)-7 is a potent proliferation, activation, and survival cytokine for CD8+ T cells to improve viral and tumor specific CD8+ T cell responses. However, the role of IL-7 in regulation of dysfunctional hepatitis C virus (HCV)-specific CD8+ T cells was not fully elucidated. Thus, a total of 53 patients with ...


    pub_type: 杂志文章


    authors: Hou H,Kang Y,Zeng Y,Li Y,Shang J

    更新日期:2018-02-01 00:00:00

  • IL-17/Th17 targeting: on the road to prevent chronic destructive arthritis?

    abstract::Interleukin-17A (IL-17A) contributes to the pathogenesis of arthritis. Data from experimental arthritis indicate IL-17 receptor signaling as a critical pathway in turning an acute synovitis into a chronic destructive arthritis. The identification of six IL-17 family members (IL-17A-F) may extend the role of this novel...


    pub_type: 杂志文章,评审


    authors: Lubberts E

    更新日期:2008-02-01 00:00:00

  • Periapical fluid RANKL and IL-8 are differentially regulated in pulpitis and apical periodontitis.

    abstract::The dental pulp space can become infected due to a breach in the surrounding hard tissues. This leads to inflammation of the pulp (pulpitis), soft tissue breakdown, and finally to bone loss around the root apex (apical periodontitis). The succession of the molecular events leading to apical periodontitis is currently ...


    pub_type: 杂志文章


    authors: Rechenberg DK,Bostanci N,Zehnder M,Belibasakis GN

    更新日期:2014-09-01 00:00:00

  • Distinct roles for p42/p44 and p38 mitogen-activated protein kinases in the induction of IL-2 by IL-1.

    abstract::Interleukin 1 (IL-1) activates p42/p44 and p38 mitogen-activated protein kinases (MAP kinases) in target cells. Here we have used two specific inhibitors, PD98059 which inhibits MAP kinase kinase (MEK), and SB203580 which inhibits p38 MAP kinase to explore the involvement of these kinases in the induction of IL-2 by I...


    pub_type: 杂志文章


    authors: Matthews JS,O'Neill LA

    更新日期:1999-09-01 00:00:00

  • Longitudinal analysis of serum interleukin-18 in patients with familial Mediterranean fever carrying MEFV mutations in exon 10.

    abstract:BACKGROUND:Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in the MEFV gene. Mutations in exon 10 are associated with typical FMF phenotypes, and patients with exon 10 mutations have higher serum levels of interleukin (IL)-18 both during attacks and afebrile phases, compared to tho...


    pub_type: 杂志文章


    authors: Wada T,Toma T,Miyazawa H,Koizumi E,Shirahashi T,Matsuda Y,Yachie A

    更新日期:2018-04-01 00:00:00

  • IL-4 up-regulates epidermal chemotactic, angiogenic, and pro-inflammatory genes and down-regulates antimicrobial genes in vivo and in vitro: relevant in the pathogenesis of atopic dermatitis.

    abstract::Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Although the pathogenesis of AD is not fully understood, we and others have shown that IL-4 plays a key role. In this study we aimed to identify keratinocyte genes regulated by IL-4 that may play important roles in the pathophysiology of AD. HaCat c...


    pub_type: 杂志文章


    authors: Bao L,Shi VY,Chan LS

    更新日期:2013-02-01 00:00:00

  • Disruption of thrombo-inflammatory response and activation of a distinct cytokine cluster after subarachnoid hemorrhage.

    abstract:BACKGROUND:Unregulated inflammatory and thrombotic responses have been proposed to be important causes of early brain injury and worse clinical outcomes after subarachnoid hemorrhage (SAH). OBJECTIVE:We hypothesize that SAH is characterized by an increased inflammatory and thrombotic state and disruption of associatio...


    pub_type: 杂志文章


    authors: Savarraj JP,McGuire MF,Parsha K,Hergenroeder G,Bajgur S,Ahn S,Zhu L,Espino E,Chang T,Blackburn S,Kim DH,Dash P,Choi HA

    更新日期:2018-11-01 00:00:00

  • Upregulation of neuropilin-1 by basic fibroblast growth factor enhances vascular smooth muscle cell migration in response to VEGF.

    abstract::Neuropilin-1 (NRP-1) is a co-receptor for vascular endothelial growth factor (VEGF). During neovascularization, vascular smooth muscle cells (VSMCs) and pericytes modulate the function of endothelial cells. Factors that mediate NRP-1 in human VSMCs (hVSMCs) remain to be elucidated. We studied various angiogenic cytoki...


    pub_type: 杂志文章


    authors: Liu W,Parikh AA,Stoeltzing O,Fan F,McCarty MF,Wey J,Hicklin DJ,Ellis LM

    更新日期:2005-12-07 00:00:00

  • Low serum interleukin-6 levels as a predictive marker of recurrence in patients with hepatitis B virus related hepatocellular carcinoma who underwent curative treatment.

    abstract:BACKGROUND:We aimed to investigate the use of novel serum biomarkers for predicting the recurrence and survival of patients with hepatitis B virus (HBV)-related early hepatocellular carcinoma (HCC) after hepatic resection or radiofrequency ablation (RFA). METHODS:One hundred and five patients with HBV-related HCC, who...


    pub_type: 杂志文章


    authors: Cho HJ,Kim SS,Ahn SJ,Park SY,Park JH,Kim JK,Wang HJ,Cheong JY,Cho SW

    更新日期:2015-06-01 00:00:00

  • Monitoring of IL-10 in the serum of patients with advanced ovarian cancer: results from a prospective pilot-study.

    abstract:OBJECTIVES:The fact that ovarian cancer remains confined to the peritoneal cavity even in advanced stages has allowed us to surmise that local immunosuppressive factors could be involved in the tumor biology of ovarian cancer. In this context, IL-10 can be one of the key factors. By studying the kinetics of IL-10 conce...


    pub_type: 杂志文章


    authors: Mustea A,Braicu EI,Koensgen D,Yuan S,Sun PM,Stamatian F,Lichtenegger W,Chen FC,Chekerov R,Sehouli J

    更新日期:2009-01-01 00:00:00

  • Conundrums in leishmaniasis.

    abstract::Parasites of the genus Leishmania cause the disease leishmaniasis. As the sandfly vector transfers the promastigotes into the skin of the human host, the infection is either cured or exacerbated. In the process, there emerge several unsolved paradoxes of leishmaniasis. Chronologically, as the infections starts in skin...


    pub_type: 杂志文章


    authors: Saha B,Bhattacharjee S,Sarkar A,Bhor R,Pai K,Bodhale N

    更新日期:2020-09-29 00:00:00

  • Potential gingival crevicular fluid and serum biomarkers by stage of HIV infection.

    abstract:OBJECTIVE:This study evaluates the potential of gingival crevicular fluid and serum cytokines as HIV stage biomarkers. METHODS:Gingival crevicular fluid (GCF) and serum samples from 78 HIV-positive adult male subjects (cases) and 39 HIV-negative male subjects (controls) from Mexico were examined for 17 cytokines using...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Elizondo JE,Rocha-Pizaña MD,Treviño AC,Violant D,Álvarez MM,Rivas-Estilla AM

    更新日期:2017-03-01 00:00:00

  • A meta-analysis of tumor necrosis factor-alpha, interleukin-6, and interleukin-10 in preeclampsia.

    abstract::Inflammation may play a major role in the pathogenesis of preeclampsia (PE). In this meta-analysis, we determined whether maternal polymorphisms and serum concentrations of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) were associated with PE. All studies investigating the assoc...


    pub_type: 杂志文章,meta分析


    authors: Xie C,Yao MZ,Liu JB,Xiong LK

    更新日期:2011-12-01 00:00:00

  • Circularly permuted interleukin 4 retains proliferative and binding activity.

    abstract::In human interleukin 4(IL-4), the carboxyl and amino termini of the 129 amino acid hormone are close to each other and this region is believed to be important for binding to the IL-4 receptor (IL-4r). We constructed plasmids encoding circularly permuted IL-4 mutants with the peptide Gly-Gly-Asn-Gly-Gly (GGNGG) joining...


    pub_type: 杂志文章


    authors: Kreitman RJ,Puri RK,McPhie P,Pastan I

    更新日期:1995-05-01 00:00:00

  • Tumour necrosis factor alpha alters the expression of connexin43, connexin40, and connexin37 in human umbilical vein endothelial cells.

    abstract::Tumour necrosis factor alpha (TNF-alpha) plays an important role in orchestrating inflammatory responses with the vascular endothelium as main target cell type, and was found to promote migration of endothelial cells, as occurs in wound healing processes. Substantial evidence exists that endothelial cell migration in ...


    pub_type: 杂志文章


    authors: van Rijen HV,van Kempen MJ,Postma S,Jongsma HJ

    更新日期:1998-04-01 00:00:00

  • Supplemental vitamin D increases serum cytokines in those with initially low 25-hydroxyvitamin D: a randomized, double blind, placebo-controlled study.

    abstract::The purpose of this study was to determine if vitamin D status before supplementation influences the cytokine response after supplemental vitamin D. Forty-six reportedly healthy adults (mean(SD); age, 32(7) y; body mass index (BMI), 25.3(4.5) kg/m(2); serum 25-hydroxyvitamin D (25(OH)D), 34.8(12.2) ng/mL) were randoml...


    pub_type: 杂志文章,随机对照试验


    authors: Barker T,Rogers VE,Levy M,Templeton J,Goldfine H,Schneider ED,Dixon BM,Henriksen VT,Weaver LK

    更新日期:2015-02-01 00:00:00

  • The design and recombinant protein expression of a consensus porcine interferon: CoPoIFN-α.

    abstract::CoPoIFN-α is a recombinant non-naturally occurring porcine interferon-α (IFN-α). It was designed by scanning 17 porcine IFN-α nonallelic subtypes and assigning the most frequently occurring amino acid in each position. We used a porcine IFN-α (PoIFN-α) derived from domestic pig as a control. Both porcine IFN-α genes w...


    pub_type: 杂志文章


    authors: Huang L,Cao RB,Wang N,Liu K,Wei JC,Isahg H,Song LJ,Zuo WY,Zhou B,Wang WW,Mao X,Chen PY

    更新日期:2012-01-01 00:00:00

  • Interferon alpha induces generation of semi-mature dendritic cells with high pro-inflammatory and cytotoxic potential.

    abstract::Dendritic cell-based vaccines are considered as a new and promising immunotherapeutic approach for cancer treatment. However, the choice of optimal protocol of dendritic cell generation in vitro represents the major challenge. Here, we compared phenotype and functional characteristics of human monocyte-derived dendrit...


    pub_type: 杂志文章


    authors: Leplina OY,Tyrinova TV,Tikhonova MA,Ostanin AA,Chernykh ER

    更新日期:2015-01-01 00:00:00

  • Molecular regulation of inflammation and cell death.

    abstract::Cell death and innate immunity are ancient evolutionary conserved processes that utilize a dazzling number of related molecular effectors and parallel signal transduction mechanisms. The investigation of the molecular mechanisms linking the sensing of a danger signal (pathogens or tissue damage) to the induction of an...


    pub_type: 杂志文章,评审


    authors: Yeretssian G,Labbé K,Saleh M

    更新日期:2008-09-01 00:00:00

  • Expression of leukocyte chemotactic cytokines in myocardial tissue.

    abstract::Cytotoxic action of leukocytes may be involved in the pathogenesis of inflammatory heart muscle disorders. We investigated the expression of rat leukocyte chemotactic cytokines--cytokine induced neutrophil chemoattractant (CINC) and JE--in cultured neonatal rat cardiac myocytes; CINC belongs to the interleukin 8 (IL-8...


    pub_type: 杂志文章


    authors: Seino Y,Ikeda U,Sekiguchi H,Morita M,Konishi K,Kasahara T,Shimada K

    更新日期:1995-04-01 00:00:00

  • Serum levels of interleukin-2 predict the recurrence of atrial fibrillation after pulmonary vein ablation.

    abstract:AIMS:Interleukin-2 has a significant antitumor activity in some types of cancer, and has been associated with the development of atrial fibrillation (AF). In addition, IL-2 serum levels in recent onset AF have been related with pharmaceutical cardioversion outcomes. We evaluated the hypothesis that a relationship exist...


    pub_type: 杂志文章


    authors: Cabrera-Bueno F,Medina-Palomo C,Ruiz-Salas A,Flores A,Rodríguez-Losada N,Barrera A,Jiménez-Navarro M,Alzueta J

    更新日期:2015-05-01 00:00:00

  • Lack of tumor necrosis factor receptor type 1 inhibits liver fibrosis induced by carbon tetrachloride in mice.

    abstract::Chronic liver injury causes liver regeneration, resulting in fibrosis. The proinflammatory cytokine tumor necrosis factor (TNF) is involved in the pathogenesis of many acute and chronic liver diseases. TNF has pleiotropic functions, but its role in liver fibrosis has not been clarified. Chronic repeated injection of C...


    pub_type: 杂志文章


    authors: Sudo K,Yamada Y,Moriwaki H,Saito K,Seishima M

    更新日期:2005-03-07 00:00:00

  • Identification of the IL-33 protein segment that controls subcellular localization, extracellular secretion, and functional maturation.

    abstract::Proteolytic activation of the IL-33 precursor, full-length interleukin-33 (FLIL33), at multiple sites within the sensor domain (aa 95-109) yields several functionally mature (MIL33) forms. Unlike nuclear FLIL33, intracellular MIL33 occurs in the cytoplasm, is secreted from source cells, and exerts biological effects b...


    pub_type: 杂志文章


    authors: Luzina IG,Clerman A,Fishelevich R,Todd NW,Lockatell V,Atamas SP

    更新日期:2019-07-01 00:00:00

  • TBXA2R rs4523 G allele is associated with decreased susceptibility to Kawasaki disease.

    abstract::Kawasaki disease is a multi-system vasculitis and a primary cause of acquired heart disease among children. Genetic factors may increase susceptibility to Kawasaki disease. TBXA2R is a G-protein-coupled receptor that participates in tissue inflammation and is associated with susceptibility to several diseases, but its...


    pub_type: 杂志文章


    authors: Che D,Pi L,Xu Y,Fu L,Zhou H,Wang Z,Huang P,Zhang L,Gu X

    更新日期:2018-11-01 00:00:00

  • Inter-individual and intra-individual variability in TNF-alpha production by human peripheral blood cells in vitro.

    abstract:BACKGROUND:Two assays--isolated peripheral blood mononuclear cells (PBMC) and a whole blood assay (WBA)--are commonly used to study TNF-alpha production by an individual in order to distinguish between high and low cytokine producers. We assessed the reliability and reproducibility of these assays. METHODS:The PBMC as...


    pub_type: 杂志文章


    authors: Bakiyeva LT,Brooks RA,Rushton N

    更新日期:2005-04-07 00:00:00