Abstract:
:Interleukin 2 (IL-2)- and IL-4-mediated stimulation of survival and growth, reflected by the induction of bcl2 and c-myc, respectively, depends on the integrity of the membrane-proximal region (S-region) in the IL-2 receptor beta-chain (IL-2R beta) and the haematopoietin homology box1-containing region of the IL-4 receptor alpha-chain (IL-4R alpha). In contrast to IL-4, IL-2 induces the expression of c-fos and c-jun family genes, mediated by the acidic region (A-region) within the cytoplasmic domain of IL-2R beta. A highly acidic motif is also present in IL-4R alpha, and evidence in favour and against its importance has been published. The authors have constructed chimeric receptors between IL-2R beta and IL-4R alpha by substitution of either the S-region or the A-region of IL-2R beta with sequences derived from IL-4R alpha. These chimeras were stably transfected into BA/F3 cells and assayed for the capacity to restore functions of IL-2 beta, such as growth mediation by IL-2 and the induction of proto-oncogenes (c-myc, c-junB and c-fos). Replacement of both the S- and A-region of IL-2R beta with IL-4R alpha derived regions of similar size and cytoplasmic location supported growth-stimulation by IL-2 as well as proto-oncogene induction. In contrast, all IL-2R functions were lost by exchange of the S-region with the corresponding part of IL-4R alpha. Induction of c-junB and c-fos RNA as an indicator of A-region function, however, was maintained in an IL-2R beta chimera containing the acidic box-bearing region of IL-4R alpha. These data indicate a functional role of the acidic region in the IL-4R alpha-chain.
journal_name
Cytokinejournal_title
Cytokineauthors
Deutsch HH,Chung J,Kalthoff FSdoi
10.1006/cyto.1997.0293subject
Has Abstractpub_date
1998-05-01 00:00:00pages
331-6issue
5eissn
1043-4666issn
1096-0023pii
S1043-4666(97)90293-3journal_volume
10pub_type
杂志文章相关文献
CYTOKINE文献大全abstract::Interleukin (IL)-4, IL-10, and IL-13 are T-helper2 cell derived cytokines, which are known to suppress pro-inflammatory cytokine production. The biologically related IL-4 and IL-13 have an impact on the development of atopic inflammation, whereas IL-10 is mostly supposed to be involved in fibrotic disorders or inflamm...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.01.007
更新日期:2006-02-21 00:00:00
abstract::Although G-CSF mobilized peripheral blood stem cell (PBSC) transplantation is commonly used in adults, bone marrow (BM) is still the preferred stem cell source in pediatric stem cell transplantation. Despite the fact that G-CSF is increasingly being used to enhance the hematopoietic stem/progenitor cell (HSPC) yield i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155407
更新日期:2020-12-28 00:00:00
abstract::Intestinal epithelial cells can be induced to secrete the chemokine interleukin (IL)-8 during inflammation. The PAR-2 receptor is believed to play a proinflammatory role and is expressed in gut epithelial cells. The aim was to investigate PAR-2 signaling in Caco-2 intestinal epithelial cells, with respect to chemokine...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2005.06.004
更新日期:2005-09-07 00:00:00
abstract::This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. Image duplication has been observed within Figure 1g-h. The corresponding author has been a...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.04.009
更新日期:2013-07-01 00:00:00
abstract::Studies have shown that following bacterial infection or endotoxin administration, immune functions are regulated differently in mice of different genetic background. Since the susceptibility to sepsis following trauma-hemorrhage is dependant on the severity of injury, it is important to determine whether genetic back...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2004.12.019
更新日期:2005-05-21 00:00:00
abstract::Neutrophil microparticles (NMs) are scarce in the circulation but are highly enriched at sites of inflammation and exert profound effects on immune cells. In the present study, we addressed whether NMs modulate cytokine-producing capacity of natural killer (NK) cells. NMs inhibited the production of IFN-γ and TNF-α bu...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.11.010
更新日期:2014-02-01 00:00:00
abstract::Over the last several years, there has been increasing interest in the role of proteins of the TIM (T cell immunoglobulin and mucin domain) family in regulating immune responses. Despite what the name suggests, proteins of this family function in a much more widespread manner than just on T cells, as we will discuss i...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2008.06.013
更新日期:2008-10-01 00:00:00
abstract::The regulation of local L-tryptophan concentrations by tryptophan-degrading enzyme, indoleamine 2,3-dioxygenase (IDO) induced by various stimuli such as interferon-γ (IFN-γ) is one of the key mechanisms in antimicrobial effect. Recently, IDO is also focused on an immunosuppressive mechanism shared by several different...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.04.022
更新日期:2012-08-01 00:00:00
abstract::The JAK-STAT3 signaling pathway is engaged by many cytokines and growth factor stimuli to control diverse biological processes including proliferation, angiogenesis, survival, immune modulation, and metabolism. For over two decades it has been accepted that STAT3-dependent biology is due to its potency as a transcript...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2016.05.019
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) contributes to type 2 diabetes (T2DM) pathogenesis, and genetic variations in VEGFA gene were suggested to influence VEGF secretion and T2DM pathogenesis. AIM:To evaluate the association of specific VEGFA variants with altered VEGF levels, and with T2DM among Tunisi...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.03.003
更新日期:2018-06-01 00:00:00
abstract::We have demonstrated that ingested murine interferon alpha (IFN-alpha) suppressed clinical relapse in chronic relapsing experimental autoimmune encephalomyelitis (CR-EAE), decreased inflammation and suppressed the adoptive transfer of EAE, and is a biological response modifier in patients with multiple sclerosis. We e...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1998.0450
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is the key regulator of angiogenesis in the development of various cancers. Previous studies have examined the relationship between VEGF gene promoter polymorphisms such as -2578C/A and -460C/T and bladder cancer risk; however, these results are inconclusive. Therefo...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155112
更新日期:2020-07-01 00:00:00
abstract::Interleukin-33 (IL-33) is a recently described member of the interleukin-1 (IL-1) family. It is produced by diverse cell types in response to a variety of stresses including hemorrhage and increased mechanical load. Though only relatively recently discovered, IL-33 has been shown to participate in several pathological...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.02.008
更新日期:2012-06-01 00:00:00
abstract::Cytokine balance alterations are responsible for some of the systemic and hepatic manifestations of alcoholism. The present study was aimed to evaluate the influence of both acute alcohol abstinence (in alcoholics) and acute alcohol intake (in healthy subjects) on serum IL-6, IL-8, IL-10, and IL-12 levels. Serum cytok...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0715
更新日期:2000-09-01 00:00:00
abstract::The γc family of cytokines comprising interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15 and IL-2 is an important group of 4-helix bundle cytokines that signals through receptors incorporating the common gamma chain (γc). These cytokines are involved in lymphocyte biology and their specific functions are contingent on bind...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2019.01.007
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:The effectual immune response is crucial to defeat viral infections. However, exuberant immune response with features of macrophage activation syndrome (MAS) lead detrimental consequences in COVID-19 patients. Interleukin (IL)-18 is one of the leading cytokines in MAS which has not been studied in COVID-19. ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155302
更新日期:2021-01-01 00:00:00
abstract::In hypertension studies, anti-inflammatory cytokine interleukin-10 (IL-10) has been shown to prevent angiotensin II (Ang II)-induced vasoconstriction and regulate vascular function by down-regulating pro-inflammatory cytokine and superoxide production in vascular cells. However, little is known about the mechanism beh...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2015.09.002
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Resveratrol has been reported to alleviate inflammatory responses and oxidative stress in mesangial cells and in several types of renal injury in animal models. Previously, the active resveratrol derivatives from the roots of Vitis thunbergii Sieb. & Zucc. (Vitaceae) were shown to have significant anti-pla...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.10.008
更新日期:2019-01-01 00:00:00
abstract::Ras expression has been suggested to be a marker for tumor aggressiveness of breast cancer. We previously showed that H-Ras, but not N-Ras, induced invasive/migratory phenotypes in MCF10A human breast epithelial cells. The present study aimed to determine the role of granulocyte colony-stimulating factor in H-Ras-indu...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.03.002
更新日期:2011-07-01 00:00:00
abstract::Interleukin (IL)-12 is a pivotal cytokine that strongly stimulates Th1-associated cellular immunity. It is now recognized that IL-12 also activates humoral immunity to both T-dependent and T-independent antigens. This has let to considerable interest in exploiting IL-12 as a vaccine adjuvant for protection against var...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2010.06.011
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:The fact that ovarian cancer remains confined to the peritoneal cavity even in advanced stages has allowed us to surmise that local immunosuppressive factors could be involved in the tumor biology of ovarian cancer. In this context, IL-10 can be one of the key factors. By studying the kinetics of IL-10 conce...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.10.019
更新日期:2009-01-01 00:00:00
abstract::Vascular smooth muscle cells (VSMC) may be programmed by nutrient deprivation. We found that after 2 and 12 h exposure to 75% reduced amino acids, the release of basic fibroblast growth factor (bFGF) and transforming growth factor beta1 (TGF beta 1) from VSMC was significantly greater than that from cells maintained i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0710
更新日期:2000-09-01 00:00:00
abstract::Using different binding assays we examined the interaction of the cytokine interleukin 4 (IL-4) with basement membrane. Equilibrium binding analysis revealed a high-affinity site characterized by a dissociation constant (Kd) of 0.3 nM. This interaction was confirmed by native polyacrylamide gel electrophoresis, which ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0142
更新日期:1997-02-01 00:00:00
abstract::Leishmania major, the causative agent of zoonotic cutaneous leishmaniasis shows heterogeneity and diverse clinical manifestations in different areas of infection and experimental models. Such polymorphism may cause difficulties in selection of reliable strains for development of prophylaxes. Hence, the aim of this stu...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2015.05.022
更新日期:2015-12-01 00:00:00
abstract::The purpose of the study was to reassess the utility of transforming growth factor-beta-1 (TGF-beta1) together with dosimetric and tumor parameters as a predictor for radiation pneumonitis (RP). Of the 121 patients studied, 32 (26.4%) developed grade > or =1 RP, and 27 (22.3%) developed grade > or =2 RP. For the endpo...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.07.021
更新日期:2006-08-01 00:00:00
abstract::Tumour necrosis factor alpha (TNF-alpha) plays an important role in orchestrating inflammatory responses with the vascular endothelium as main target cell type, and was found to promote migration of endothelial cells, as occurs in wound healing processes. Substantial evidence exists that endothelial cell migration in ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0287
更新日期:1998-04-01 00:00:00
abstract::The burst formation from human and murine burst forming unit-erythroid (BFU-E) requires the presence of erythropoietin (Epo) in semi-solid cultures of bone marrow cells. A number of haematopoietic factors are described that increase the burst number: interleukin 3 (IL-3), stem cell factor (SCF), granulocyte-macrophage...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1998.0335
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:Among all cytokines involved in the pathogenesis and in the progression of psoriasis, Tumor Necrosis Factor (TNF)-alpha and interleukin (IL)-17 play a pivotal role. OBJECTIVE:The aim of the present study was to mimic a psoriatic microenvironment and to investigate the early effects of TNF-alpha and IL-17 in...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.03.003
更新日期:2014-07-01 00:00:00
abstract::Tumor necrosis factor (TNF) and the members of the interferon (IFN) family are major inducible cytokines that function to counteract viral infections or cellular transformation. Recently, our lab has characterized a novel antiviral state which is induced in primary human fibroblasts by co-treatment with TNF plus IFNbe...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.06.006
更新日期:2009-09-01 00:00:00
abstract::Although physical therapy has been shown to be an effective method for treatment of rheumatoid arthritis, a thorough investigation on the impact of mechanical signals upon the complex cytokine network associated with pathogenesis has not yet been conducted. In the current study, our research group investigated the eff...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.03.015
更新日期:2010-07-01 00:00:00