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Human cancer cells have specifically lost the ability to induce the synergistic state caused by tumor necrosis factor plus interferon-beta.

Abstract：

:Tumor necrosis factor (TNF) and the members of the interferon (IFN) family are major inducible cytokines that function to counteract viral infections or cellular transformation. Recently, our lab has characterized a novel antiviral state which is induced in primary human fibroblasts by co-treatment with TNF plus IFNbeta. Here, we demonstrate that this synergistic state is both antiviral and cytostatic for primary human cells. Significantly, we observed that a wide spectrum of transformed human cancer cells have universally lost the ability to induce the TNF/IFNbeta synergistic state, as defined by three separate criteria. We hypothesize that the ability to induce the TNF/IFNbeta synergistic state is a unique feature of primary cells and is incompatible with cellular immortalization and/or transformation.

journal_name

Cytokine

journal_title

Cytokine

authors

Bartee E,McFadden G

doi

10.1016/j.cyto.2009.06.006

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

199-205

issue

3

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(09)00169-0

journal_volume

47

pub_type

杂志文章

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