Interferon gamma and prostaglandin in BSE-infected cattle.

Abstract:

:Suspect field cases of BSE infection (displaying clinical signs) were examined for possible alterations of cytokine/autacoid plasma levels and were compared to control cases (not displaying clinical signs of BSE infection). Interferon gamma (IFN-gamma) plasma levels were demonstrated as being elevated in all suspected field cases of BSE infection (irrespective of BSE status; determined via postmortem histopathological examination). We demonstrated that plasma IFN-gamma levels were significantly (P<0.005) higher in suspect cases of BSE infection than in control cases. BSE-positive prostaglandin-E(2), (PGE(2)) plasma levels were demonstrated as being elevated 1.25-fold above BSE-negative cases and 2.22-fold above control cases. No significant (P>0.5) increase in PGE(2)plasma levels was recorded between BSE-positive and -negative. IFN-gamma and PGE(2)plasma levels were examined using commercially available ELISA assay. The results presented in this publication are the first demonstration of alteration in immune state in animals with BSE.

journal_name

Cytokine

journal_title

Cytokine

authors

Murphy C,Breen C,Rogers M,Giese M

doi

10.1006/cyto.2000.0805

keywords:

subject

Has Abstract

pub_date

2001-02-07 00:00:00

pages

169-73

issue

3

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(00)90805-6

journal_volume

13

pub_type

杂志文章

相关文献

CYTOKINE文献大全
  • Gingival crevicular fluid levels of oncostatin M in periodontal conditions.

    abstract:OBJECTIVE:The initial study has reported the increased level of oncostatin M (OSM) in gingival crevicular fluid (GCF) of chronic periodontitis patients, and no study has reported its level in gingivitis patients. Therefore, the present study has been carried out to measure the level of OSM in gingival crevicular fluid ...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2010.02.002

    authors: Thorat Manojkumar S,Pradeep AR,Garg G,Raju A

    更新日期:2010-06-01 00:00:00

  • Presence of interleukin 10 (IL-10) in the ascites of patients with ovarian and other intra-abdominal cancers.

    abstract::Typically, ovarian cancer remains restricted to the peritoneal cavity. Because of this unique localization, the study of ovarian cancer is particularly suitable for immune analysis and for the development of immunotherapy. Here we report that peritoneal fluid from patients with ovarian or other intra-abdominal cancers...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/1043-4666(92)90082-3

    authors: Gotlieb WH,Abrams JS,Watson JM,Velu TJ,Berek JS,Martínez-Maza O

    更新日期:1992-09-01 00:00:00

  • TBXA2R rs4523 G allele is associated with decreased susceptibility to Kawasaki disease.

    abstract::Kawasaki disease is a multi-system vasculitis and a primary cause of acquired heart disease among children. Genetic factors may increase susceptibility to Kawasaki disease. TBXA2R is a G-protein-coupled receptor that participates in tissue inflammation and is associated with susceptibility to several diseases, but its...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2018.08.029

    authors: Che D,Pi L,Xu Y,Fu L,Zhou H,Wang Z,Huang P,Zhang L,Gu X

    更新日期:2018-11-01 00:00:00

  • Association of TNF-α but not IL-1β levels with the presence of Helicobacter pylori infection increased the risk of peptic ulcer development.

    abstract::Peptic ulcer is a lesion in the mucosa of the digestive tract affecting many people all around the world. Recent investigations have indicated that produced inflammatory cytokines such as TNF-α and IL-1β in response to gastric infection by Helicobacter pylori play an important role in the development of peptic ulcer. ...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2018.01.003

    authors: Tourani M,Habibzadeh M,Karkhah A,Shokri-Shirvani J,Barari L,Nouri HR

    更新日期:2018-10-01 00:00:00

  • Multiple cytokine secretion by IL-7-stimulated human T cells.

    abstract::The induction of cytokine secretion by human peripheral blood (PB) T cells was examined. Highly purified T cells stimulated with interleukin 7 (IL-7), in the absence of co-mitogen, secreted IL-2, IL-4, IL-6 and interferon gamma (IFN-gamma) upon restimulation with phorbol ester and ionomycin. In contrast, induction of ...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/1043-4666(92)90006-d

    authors: Armitage RJ,Macduff BM,Ziegler SF,Grabstein KH

    更新日期:1992-11-01 00:00:00

  • Intracellular localization of the p35 subunit of murine IL-12.

    abstract::Production of interleukin-12 (IL-12), a heterodimer of p35 and p40 subunits, is limited by p35 expression. A long and a short murine p35 mRNA potentially encoding proteins differing in pre-sequence size are produced. Increased pre-sequence size could convert a cleaved signal peptide to an uncleaved signal peptide, rai...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/s1043-4666(03)00016-4

    authors: Vaidyanathan H,Zhou Y,Petro TM,Schwartzbach SD

    更新日期:2003-02-07 00:00:00

  • Ureaplasma species modulate cell adhesion molecules and growth factors in human brain microvascular endothelial cells.

    abstract::Ureaplasma species (spp.) are considered commensals of the adult urogenital tract, but may cause chorioamnionitis and preterm birth as well as sepsis and meningitis in neonates. Pathomechanisms in Ureaplasma-driven neuroinflammation are largely unknown. This study addressed mRNA and protein expression of intercellular...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2019.154737

    authors: Silwedel C,Speer CP,Haarmann A,Fehrholz M,Claus H,Schlegel N,Glaser K

    更新日期:2019-09-01 00:00:00

  • Hypocholesterolemia and dysregulated production of angiopoietin-like proteins in sickle cell anemia patients.

    abstract::Angiopoietin-like proteins (ANGPTL) are responsible for inhibiting lipoprotein lipase activity, and ANGPTL3 and ANGPTL4 deficiencies have been shown to lower lipoprotein levels in animal models and in humans carrying loss-of-function mutations. Sickle cell anemia (SCA) is a hereditary hemolytic anemia characterized by...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2019.04.014

    authors: Vendrame F,Olops L,Saad STO,Costa FF,Fertrin KY

    更新日期:2019-08-01 00:00:00

  • Expression of interferon-γ, interferon-α and related genes in individuals with Down syndrome and periodontitis.

    abstract:BACKGROUND:Recently, attenuation of anti-inflammatory and increase of pro-inflammatory mediators was demonstrated in individuals with Down syndrome (DS) in comparison with euploid patients during periodontal disease (PD), suggesting a shift to a more aggressive inflammation in DS. AIM:To determine the influence of DS ...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2012.08.020

    authors: Tanaka MH,Giro EM,Cavalcante LB,Pires JR,Apponi LH,Valentini SR,Spolidório DM,Capela MV,Rossa C Jr,Scarel-Caminaga RM

    更新日期:2012-12-01 00:00:00

  • Alternative splicing and proteolytic rupture contribute to the generation of soluble IL-6 receptors (sIL-6R) in rheumatoid arthritis.

    abstract:OBJECTIVE:To describe the relationship between the two mechanisms involved in sIL6R generation in rheumatoid arthritis (RA). METHOD:RA patients were selected from a group of subjects genotyped for the rs8192284 SNP, located at the proteolytic cleavage site of IL-6R. sIL6R and protease levels (ADAM17) were measured and...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2012.12.025

    authors: Lamas JR,Rodríguez-Rodríguez L,Tornero-Esteban P,Villafuertes E,Hoyas J,Abasolo L,Varadé J,Alvarez-Lafuente R,Urcelay E,Fernández-Gutiérrez B

    更新日期:2013-03-01 00:00:00

  • Expression of leukocyte chemotactic cytokines in myocardial tissue.

    abstract::Cytotoxic action of leukocytes may be involved in the pathogenesis of inflammatory heart muscle disorders. We investigated the expression of rat leukocyte chemotactic cytokines--cytokine induced neutrophil chemoattractant (CINC) and JE--in cultured neonatal rat cardiac myocytes; CINC belongs to the interleukin 8 (IL-8...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.1995.0037

    authors: Seino Y,Ikeda U,Sekiguchi H,Morita M,Konishi K,Kasahara T,Shimada K

    更新日期:1995-04-01 00:00:00

  • Atherogenic cytokines and chemokines in chronic hepatitis C are not associated with the presence of cardiovascular diseases.

    abstract::There appears to be an associative link between chronic hepatitis C (CHC) and cardiovascular diseases (CVDs). However, the exact nature of the relationship between CHC and CVDs has not been elucidated. We investigated the presence of CVDs and the clinical and laboratory alterations associated with these diseases in CH...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2018.12.005

    authors: Santos TPS,Pereira MM,Schinoni MI,Sampaio GP,Aras R Jr,Atta MLS,Atta AM

    更新日期:2019-03-01 00:00:00

  • Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations.

    abstract::Emerging evidence indicates that chemokine receptor expression patterns are critical in determining the spectrum of action of the chemokines. We have analysed the expression patterns of 17 chemokine receptors and two orphan chemokine receptor-like genes in various freshly prepared human peripheral blood leucocyte popu...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.2000.0851

    authors: Patel L,Charlton SJ,Chambers JK,Macphee CH

    更新日期:2001-04-07 00:00:00

  • Elevated blood interleukin-10 levels and undiminished systemic interleukin-10 production rate prevail throughout acute protein-energy malnutrition in the weanling mouse.

    abstract::The objectives were to determine if blood IL-10 levels rise during the early stages of acute (wasting) pre-pubescent malnutrition in metabolically distinct murine models known to depress inflammatory immune competence and whether systemic IL-10 production is affected in these pathologies. Weanling C57BL/6J mice were a...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2009.05.015

    authors: Monk JM,Woodward B

    更新日期:2009-08-01 00:00:00

  • Cytokine mRNA expression in inflammatory multiple sclerosis lesions: detection by non-radioactive in situ hybridization.

    abstract::The predominant pathological features in the central nervous system (CNS) in multiple sclerosis (MS) are perivascular inflammation and demyelination. The cells in the inflammatory cuff consist mainly of T lymphocytes and macrophages. Cytokines produced by inflammatory cells within the CNS have the potential to enhance...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/s1043-4666(05)80008-0

    authors: Woodroofe MN,Cuzner ML

    更新日期:1993-11-01 00:00:00

  • Synergism between lipopolysaccharide and interferon gamma in the regulation of lipoprotein lipase in macrophages.

    abstract::The regulation of macrophage lipoprotein lipase (LPL) by cytokines is potentially of crucial importance in the pathogenesis of atherosclerosis and in septic shock. The effect of combinations of lipopolysaccharide (LPS) and cytokines on the expression of LPL in macrophages was studied using the murine J774.2 cell line....

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.1998.0447

    authors: Tengku-Muhammad TS,Hughes TR,Cryer A,Ramji DP

    更新日期:1999-06-01 00:00:00

  • The effects of pentoxifylline on lipopolysaccharide (LPS) fever, plasma interleukin 6 (IL 6), and tumor necrosis factor (TNF) in the rat.

    abstract::The purpose of these studies was to test whether pentoxifylline, a drug that can inhibit the production and action of cytokines hypothesized to be endogenous pyrogens (for example, interleukin 1 and tumor necrosis factor [TNF]), is antipyretic. We also tested the effects of pentoxifylline on plasma activities of inter...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/1043-4666(90)90032-o

    authors: LeMay LG,Vander AJ,Kluger MJ

    更新日期:1990-07-01 00:00:00

  • Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome.

    abstract::Recently, differences in the levels of various chemokines and cytokines were reported in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as compared with controls. Moreover, the analyte profile differed between chronic ME/CFS patients of long duration versus patients with disease of less than...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2015.11.018

    authors: Landi A,Broadhurst D,Vernon SD,Tyrrell DL,Houghton M

    更新日期:2016-02-01 00:00:00

  • Blocking TNF-α enhances Pseudomonas aeruginosa-induced mortality in burn mice through induction of IL-1β.

    abstract:PURPOSE:Tumor necrosis factor (TNFα) is a proinflammatory cytokine and has been a target for intervention in human sepsis. However, inhibition of TNF-α with a high dose of a TNF-receptor fusion protein in patients with septic shock worsened patient survival. This study was designed to investigate whether blocking TNF-α...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2013.04.002

    authors: Tsay TB,Yang MC,Chen PH,Lai KH,Huang HT,Hsu CM,Chen LW

    更新日期:2013-07-01 00:00:00

  • Influence of recombinant human erythropoietin on neutrophil function in premature neonates.

    abstract::The in vivo influence of recombinant human erythropoietin (rhEpo) and iron on human neutrophil (PMN) antimicrobial function was assessed. A total of 21 preterm infants were randomized to receive either 200 U/kg/other day of rHuEPO+12 mg/kg/day of iron (EPO+high Fe, seven infants) or 200 U/kg/other day of rhEPO+4 mg/kg...

    journal_title:Cytokine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1006/cyto.1998.0393

    authors: Soubasi V,Roilides E,Tsantali C,Mussafiris K,Tsakiris D,Kremenopoulos G

    更新日期:1999-01-01 00:00:00

  • Multiple cytokine analysis in gastroschisis: Association with adverse outcomes including fetal brain damage.

    abstract:OBJECTIVES:To investigate the distribution of multiple cytokines in gastroschisis and reveal its association with clinical outcomes, including gastrointestinal disorders and fetal brain damage caused by chronic inflammation in gastroschisis. METHODS:We obtained amniotic fluid and arterial cord blood from 10 patients w...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2020.155406

    authors: Owaki T,Imai K,Miki R,Niwa Y,Kotani T,Nakano-Kobayashi T,Ushida T,Kajiyama H

    更新日期:2021-02-01 00:00:00

  • Increased interleukin-4 and decreased interferon-γ levels in serum of children with asthma.

    abstract:BACKGROUND AND PURPOSE:Immune and inflammatory responses, mediated by cytokines, play important roles in the pathophysiology of asthma. These responses are associated with over expression of T helper (Th)-2 cytokine, particularly interleukin (IL)-4 and IL-5, and decreased expression of Th-1 cytokine, IL-2 and IFN-γ. We...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2011.05.011

    authors: Lama M,Chatterjee M,Nayak CR,Chaudhuri TK

    更新日期:2011-09-01 00:00:00

  • Molecular cloning, characterization and expression analysis of an IL-21 homologue from Tetraodon nigroviridis.

    abstract::Interleukin-21 (IL-21) is an important immune cytokine that was well characterized in human and mammals, but little is known in fish. In present study, an IL-21 homologue was cloned and well characterized from Tetraodon nigroviridis. The full-length Tetraodon IL-21 cDNA was 849bp in size, containing an open reading fr...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2006.07.010

    authors: Wang HJ,Xiang LX,Shao JZ,Jia S

    更新日期:2006-08-01 00:00:00

  • IL-4, but not IL-13, modulates TARC (thymus and activation-regulated chemokine)/CCL17 and IP-10 (interferon-induced protein of 10kDA)/CXCL10 release by TNF-alpha and IFN-gamma in HaCaT cell line.

    abstract::It is known that both interleukin-4 (IL-4) and IL-13 are produced by Th2-type cells and share similar biological functions with each other. However, recently accumulated evidences have revealed that IL-4 may be involved in the Th1-type response. Both thymus and activation-regulated chemokine (TARC/CCL17), a ligand for...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.2002.1965

    authors: Kakinuma T,Nakamura K,Wakugawa M,Yano S,Saeki H,Torii H,Komine M,Asahina A,Tamaki K

    更新日期:2002-10-07 00:00:00

  • The mediating role of the visceral fat area in the correlation between the serum osteocalcin levels and a prolonged QTc interval.

    abstract:AIMS:Osteocalcin, a bone-derived factor, could be a feasible marker for metabolic disorders and adverse cardiovascular outcomes. This study aimed to explore the correlation between serum osteocalcin levels and correct QT interval (QTc) interval prolongation, a risk factor of cardiac morbidity and mortality. METHODS:We...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2020.155261

    authors: Xu Y,Wang Y,Ma X,Xiao Y,Wang Y,Bao Y

    更新日期:2020-12-01 00:00:00

  • Adiponectin signaling and its role in bone metabolism.

    abstract::Adiponectin, the most prevalent adipo-cytokine in plasma plays critical metabolic and anti-inflammatory roles is fast emerging as an important molecular target for the treatment of metabolic disorders. Adiponectin action is critical in multiple organs including cardio-vascular system, muscle, liver, adipose tissue, br...

    journal_title:Cytokine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cyto.2018.06.012

    authors: Pal China S,Sanyal S,Chattopadhyay N

    更新日期:2018-12-01 00:00:00

  • Effect of MG132, a proteasome inhibitor, on the expression of growth related oncogene protein-alpha in human umbilical vein endothelial cells.

    abstract::Growth related oncogene protein-alpha (GRO-alpha) is a member of C-X-C chemokine and plays an important role in inflammatory responses. Expression of GRO gene family is regulated by a number of factors at both transcriptional and posttranscriptional levels. In the present study, we have addressed the possible regulati...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/s1043-4666(03)00271-0

    authors: Shibata T,Imaizumi T,Matsumiya T,Tamo W,Hatakeyama M,Yoshida H,Munakata H,Fukuda I,Satoh K

    更新日期:2003-11-07 00:00:00

  • The role of complement activation in tumour necrosis factor-induced lethal hepatitis.

    abstract::Injection of tumour necrosis factor (TNF) in animals causes severe liver cell toxicity, especially when D-(+)-galactosamine (GalN) is co-administered. After challenge with TNF/GalN, serum complement activity (CH50 and APCH50) decreased dramatically, suggesting strong activation of both the classical and the alternativ...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.1998.0462

    authors: Libert C,Wielockx B,Grijalba B,Van Molle W,Kremmer E,Colten HR,Fiers W,Brouckaert P

    更新日期:1999-08-01 00:00:00

  • Procalcitonin and calcitonin gene-related peptide decrease LPS-induced tnf production by human circulating blood cells.

    abstract::The pathogenesis of septic shock is mainly due to unregulated tumour necrosis factor-alpha (TNF-alpha) production. Procalcitonin (PCT) and calcitonin gene-related peptide (CGRP) are alternative transcription products of the calcitonin gene. Since high PCT levels have been described in human sepsis, and since CGRP inhi...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.1999.0607

    authors: Monneret G,Pachot A,Laroche B,Picollet J,Bienvenu J

    更新日期:2000-06-01 00:00:00

  • Interleukin-6 and perioperative thermoregulation and HPA-axis activation.

    abstract::Surgery is followed by an acute-phase response, including hypothalamo-pituitary-adrenal (HPA)-axis activation and fever. Considering its physiological properties and its behaviour in plasma after stress and surgery, the pro-inflammatory cytokine interleukin (IL)-6 is a putative candidate in eliciting these stress-rela...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/s1043-4666(03)00093-0

    authors: De Jongh RF,Vissers KC,Booij LH,De Jongh KL,Vincken P,Meert TF

    更新日期:2003-03-07 00:00:00