IL-7 receptor is expressed on adult pre-B-cell acute lymphoblastic leukemia and other B-cell derived neoplasms and correlates with expression of proliferation and survival markers.

abstract：:Most studies have shown that interleukin-1 (IL-1) acts as a helper or co-stimulator in T-lymphocyte activation and proliferation by mitogens or antigens. We describe here a stable subclone (D10S) of the murine D10.G4.1 helper T-cell which proliferates to subfemtomolar (attomolar) concentrations of IL-1 beta or alpha i...

journal_title：Cytokine

authors： Orencole SF,Dinarello CA

更新日期：1989-11-01 00:00:00

abstract：:Published data on the association between microRNA-146a (miR-146a) G/C polymorphism and cancer susceptibility are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 23 studies including 10,585 cases and 12,183 controls were used in the meta-analysis. Overal...

journal_title：Cytokine

authors： Qiu LX,He J,Wang MY,Zhang RX,Shi TY,Zhu ML,Mao C,Sun S,Lv FF,Zheng CL,Zhu XD

更新日期：2011-12-01 00:00:00

abstract：:A simple, generally applicable method to incorporate cytokine proteins into multilamellar liposomes is presented. A variety of human cytokines including granulocyte-macrophage colony stimulating factor (GM-CSF), interleukins 1 alpha, 2 and 6 (IL-1 alpha, IL-2, IL-6) and interferon-gamma (IFN-gamma) were incorporated i...

journal_title：Cytokine

authors： Anderson PM,Hanson DC,Hasz DE,Halet MR,Blazar BR,Ochoa AC

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:The aetiology of postdialysis fatigue (PDF), an intermittent but debilitating fatigue occurring after haemodialysis (HD) treatment, is still unclear. In other inflammatory diseases, increasing evidence points toward the involvement of the immune system in the onset of fatigue symptoms. Altered serum levels o...

journal_title：Cytokine

authors： Brys A,Stasio ED,Lenaert B,Picca A,Calvani R,Marzetti E,Gambaro G,Bossola M

更新日期：2020-11-01 00:00:00

abstract：:The expression of oncostatin M and leukemia inhibitory factor (LIF), JAK-STAT activators and members of the interleukin-6 family of cytokines, were examined in a series of primary ovarian carcinomas using immunohistochemistry. The malignant epithelial cells of all 29 ovarian carcinomas examined expressed oncostatin M;...

journal_title：Cytokine

authors： Savarese TM,Campbell CL,McQuain C,Mitchell K,Guardiani R,Quesenberry PJ,Nelson BE

更新日期：2002-03-21 00:00:00

abstract：:Chronic elevation of circulating Interleukin-6 (IL-6) is observed in elderly individuals as well as in several illnesses, including chronic kidney diseases. A number of cells and tissues possess the ability to metabolize significant amounts of IL-6 in vitro. However, information on signals and mechanisms by which IL-6...

journal_title：Cytokine

authors： Garibotto G,Sofia A,Balbi M,Procopio V,Villaggio B,Tarroni A,Di Martino M,Cappelli V,Gandolfo MT,Valli A,Verzola D

更新日期：2007-01-01 00:00:00

abstract：:CoPoIFN-α is a recombinant non-naturally occurring porcine interferon-α (IFN-α). It was designed by scanning 17 porcine IFN-α nonallelic subtypes and assigning the most frequently occurring amino acid in each position. We used a porcine IFN-α (PoIFN-α) derived from domestic pig as a control. Both porcine IFN-α genes w...

journal_title：Cytokine

authors： Huang L,Cao RB,Wang N,Liu K,Wei JC,Isahg H,Song LJ,Zuo WY,Zhou B,Wang WW,Mao X,Chen PY

更新日期：2012-01-01 00:00:00

abstract：:Leptin is considered an adipokine, however, cultured myocytes have also been found to release leptin. Therefore, as proof-of-concept we investigated if human skeletal muscle synthesized leptin by measuring leptin in skeletal muscle biopsies. Following this, we quantified human skeletal muscle and adipose tissue leptin...

journal_title：Cytokine

authors： Wolsk E,Mygind H,Grøndahl TS,Pedersen BK,van Hall G

更新日期：2012-12-01 00:00:00

abstract：:In this study two different aspects of tumour necrosis factor alpha (TNF-alpha) and interleukin 1 (IL-1) in locally induced murine streptococcal cell wall arthritis (SCW) were investigated. First, the kinetics and interdependence of TNF-alpha and IL-1 release; and second; their involvement in inflammation and cartilag...

journal_title：Cytokine

authors： Kuiper S,Joosten LA,Bendele AM,Edwards CK 3rd,Arntz OJ,Helsen MM,Van de Loo FA,Van den Berg WB

更新日期：1998-09-01 00:00:00

abstract：:X-linked lymphoproliferative syndrome (XLP) is a rare primary immunodeficiency characterized by increased vulnerability to Epstein-Barr virus infection. XLP type 1 is caused by mutations in SH2D1A, whereas X-linked inhibitor of apoptosis (XIAP) encoded by XIAP/BIRC4 is mutated in XLP type 2. In XIAP deficiency, hemoph...

journal_title：Cytokine

authors： Wada T,Kanegane H,Ohta K,Katoh F,Imamura T,Nakazawa Y,Miyashita R,Hara J,Hamamoto K,Yang X,Filipovich AH,Marsh RA,Yachie A

更新日期：2014-01-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a molecule with plethora of functions such as regulation of immune response, hormone-like, enzymatic and chaperone-like activity. Further, MIF is a major participant in glucose homeostasis since it is an autocrine stimulator of insulin secretion. MIF absence in male knoc...

journal_title：Cytokine

authors： Vujicic M,Senerovic L,Nikolic I,Saksida T,Stosic-Grujicic S,Stojanovic I

更新日期：2014-09-01 00:00:00

abstract：:Suspect field cases of BSE infection (displaying clinical signs) were examined for possible alterations of cytokine/autacoid plasma levels and were compared to control cases (not displaying clinical signs of BSE infection). Interferon gamma (IFN-gamma) plasma levels were demonstrated as being elevated in all suspected...

journal_title：Cytokine

authors： Murphy C,Breen C,Rogers M,Giese M

更新日期：2001-02-07 00:00:00

abstract：:Leishmania major, the causative agent of zoonotic cutaneous leishmaniasis shows heterogeneity and diverse clinical manifestations in different areas of infection and experimental models. Such polymorphism may cause difficulties in selection of reliable strains for development of prophylaxes. Hence, the aim of this stu...

journal_title：Cytokine

authors： Darabi S,Khaze V,Riazi-Rad F,Darabi H,Bahrami F,Ajdary S,Alimohammadian MH

更新日期：2015-12-01 00:00:00

abstract：:Colony stimulating factors (CSF) promote leukocyte survival by reducing apoptotic cell death. However, their effects on non-leukocyte cell types are unclear. Reduced apoptosis in colon epithelial cells is thought to contribute to the initiation of cancer. Here, we report diminished spontaneous apoptosis of human colon...

journal_title：Cytokine

authors： Calatayud S,Warner TD,Breese EJ,Mitchell JA

更新日期：2002-11-24 00:00:00

abstract：:Cytokine induction following stimulation by endotoxin (LPS) was investigated in human peripheral whole blood. Blood cells were suspended in autologous plasma diluted in basal medium (BM-plasma) or Compound Sodium Lactate Solution (CSL-plasma), or in autologous serum diluted in CSL. Induction of interleukin 1 beta, int...

journal_title：Cytokine

authors： Yentis SM,Gooding RP,Riches PG

更新日期：1994-05-01 00:00:00

abstract：:Among New Mexican Hispanic women, breast cancer is detected at a more advanced stage than compared to Non-Hispanic White women. One central factor that has been little studied is the role of critical cytokines. We genotyped incident breast cancer cases and their age-, gender- and smoking-matched controls (N=40 matched...

journal_title：Cytokine

authors： Erdei E,Kang H,Meisner A,White K,Pickett G,Baca C,Royce M,Berwick M

更新日期：2010-07-01 00:00:00

abstract：:Tumor necrosis factor (TNF) and the members of the interferon (IFN) family are major inducible cytokines that function to counteract viral infections or cellular transformation. Recently, our lab has characterized a novel antiviral state which is induced in primary human fibroblasts by co-treatment with TNF plus IFNbe...

journal_title：Cytokine

authors： Bartee E,McFadden G

更新日期：2009-09-01 00:00:00

abstract：:Interleukin (IL)-7 stimulation improves virus- and tumor-specific CD8+ T cell responses. However, the role of IL-7 in modulation of dysfunctional CD8+ T cells in hepatocellular carcinoma (HCC) was not completely understood. In this study, a total of 37 HLA-A2 restricted patients with HCC and 16 healthy individuals wer...

journal_title：Cytokine

authors： Teng D,Ding L,Cai B,Luo Q,Wang H

更新日期：2019-06-01 00:00:00

abstract：:The transforming growth factor-beta 1 (TGFβ1) and NFκB pathways are important regulators of epidermal homeostasis, inflammatory responses and carcinogenesis. Previous studies have shown extensive crosstalk between these pathways that is cell type and context dependent, but this has not been well-characterized in epide...

journal_title：Cytokine

authors： Hogan KA,Ravindran A,Podolsky MA,Glick AB

更新日期：2013-12-01 00:00:00

abstract：:Castration-refractory prostate cancer (CRPC) is treated with taxane-based chemotherapy, but eventually becomes drug resistant. It is thus essential to identify novel therapeutic targets for taxane resistance in CRPC patients. We investigated the role of the chemokine (C-C motif) receptor 1 (CCR1) and its ligand, chemo...

journal_title：Cytokine

authors： Kato T,Fujita Y,Nakane K,Mizutani K,Terazawa R,Ehara H,Kanimoto Y,Kojima T,Nozawa Y,Deguchi T,Ito M

更新日期：2013-10-01 00:00:00

abstract：:Cartilage-specific extracellular matrix synthesis is the prerequisite for chondrocyte survival and cartilage function, but is affected by the pro-inflammatory cytokine TNF-alpha in arthritis. The aim of the present study was to characterize whether the immunoregulatory cytokine IL-10 might modulate cartilage matrix an...

journal_title：Cytokine

authors： Müller RD,John T,Kohl B,Oberholzer A,Gust T,Hostmann A,Hellmuth M,Laface D,Hutchins B,Laube G,Veh RW,Tschoeke SK,Ertel W,Schulze-Tanzil G

更新日期：2008-12-01 00:00:00

abstract：:The in vivo influence of recombinant human erythropoietin (rhEpo) and iron on human neutrophil (PMN) antimicrobial function was assessed. A total of 21 preterm infants were randomized to receive either 200 U/kg/other day of rHuEPO+12 mg/kg/day of iron (EPO+high Fe, seven infants) or 200 U/kg/other day of rhEPO+4 mg/kg...

journal_title：Cytokine

authors： Soubasi V,Roilides E,Tsantali C,Mussafiris K,Tsakiris D,Kremenopoulos G

更新日期：1999-01-01 00:00:00

abstract：:We recently reported an association between interleukin-6 (IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study was to investigate this association in a larger cohort of subjects, affected by either aggressive or chronic periodontitis. Five IL6 SNPs were analyzed in 765 su...

journal_title：Cytokine

authors： Nibali L,D'Aiuto F,Donos N,Griffiths GS,Parkar M,Tonetti MS,Humphries SE,Brett PM

更新日期：2009-01-01 00:00:00

abstract：:In order to study structure-function relationships of the M(r) 55,000 subunit of the murine IL-2R (p55 IL-2R) by epitope mapping, we have expressed the p55 IL-2R molecule in a cell-free translation system. Under these in vitro conditions, we detected the expected p55 IL-2R polypeptide initiated at Met 1 and, in additi...

journal_title：Cytokine

authors： Lorenzo F,Jaulin C,Jankovic DL,Theze J

更新日期：1992-07-01 00:00:00

abstract：:Intraarticular injection of zymosan (1 mg) into the knee joints of male Wistar rats led to infiltration of neutrophils and monocytes, joint swelling and elevation of tumour necrosis factor (TNF-alpha) in joint lavage fluids. Neutrophil infiltration was maximal at 5 h after induction of arthritis but had declined by 24...

journal_title：Cytokine

authors： Pettipher ER,Salter ED

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:Cutaneous melanoma displays high morbidity and mortality rates. Isolated limb perfusion with melphalan (Mel) is used for the treatment of non-resectable, locally advanced extremity melanomas. When combined with tumor necrosis factor alpha (TNF-alpha) treatment, the complete response varies between 70% and 90...

journal_title：Cytokine

authors： de Lima VC,de Carvalho AF,Morato-Marques M,Hashimoto VL,Spilborghs GM,Marques SM,Landman G,Torres C,Braga Ribeiro K,Brentani H,Reis LF,Dias AA

更新日期：2013-05-01 00:00:00

abstract：:The eph family is the largest subfamily of receptor tyrosine kinases (RTKs). Members of this subfamily display specific expression in the developing and adult brain. Recently, cDNAs encoding membrane bound ligands for these receptors have been identified which we have termed LERKs (ligand for eph-related kinases). We ...

journal_title：Cytokine

authors： Kozlosky CJ,VandenBos T,Park L,Cerretti DP,Carpenter MK

更新日期：1997-08-01 00:00:00

abstract：:Dendritic cell-based vaccines are considered as a new and promising immunotherapeutic approach for cancer treatment. However, the choice of optimal protocol of dendritic cell generation in vitro represents the major challenge. Here, we compared phenotype and functional characteristics of human monocyte-derived dendrit...

journal_title：Cytokine

authors： Leplina OY,Tyrinova TV,Tikhonova MA,Ostanin AA,Chernykh ER

更新日期：2015-01-01 00:00:00

abstract：:Intestinal epithelial cells can be induced to secrete the chemokine interleukin (IL)-8 during inflammation. The PAR-2 receptor is believed to play a proinflammatory role and is expressed in gut epithelial cells. The aim was to investigate PAR-2 signaling in Caco-2 intestinal epithelial cells, with respect to chemokine...

journal_title：Cytokine

authors： Fyfe M,Bergström M,Aspengren S,Peterson A

更新日期：2005-09-07 00:00:00

abstract：:We investigated whether healthy young (age ≤ 40) and elderly (age ≥ 65) people infected with cytomegalovirus (CMV) had similar levels of CD8(+) T cell cytokine production and proliferation in response to an immunodominant CMV pp65 peptide pool given the role of CD8(+) T cells in controlling viral infection and the ass...

journal_title：Cytokine

authors： Shin MS,Lee JS,Lee N,Lee WW,Kim SH,Kang I

更新日期：2013-02-01 00:00:00