Interleukin-15 interactions with interleukin-15 receptor complexes: characterization and species specificity.

Abstract:

:Interleukin (IL-) 2 and IL-15 share the IL-2 receptor betagamma c subunits (IL-2Rbetagamma c) but have specific, unique alpha receptor subunits. We studied species specificity of human (hu), simian (si), and mouse (mu) IL-15 and found that hu and si IL-15 behaved similarly in all systems investigated. Hu and mu IL-15 bound hu or mu IL-15Ralpha with equal high affinity in the presence or absence of IL-2Rbetagamma c and exhibited similar proliferative activities on cells containing all three subunits. However, quantitative differences were noted in the specific activity of hu and mu IL-15 in both in vitro and in vivo systems utilizing IL-2Rbetagamma c in the absence of IL-15Ralpha. These data show that hu IL-15 may be used in mouse model systems, however care must be taken when comparing the efficacy and toxicity of cytokines across species.

journal_name

Cytokine

journal_title

Cytokine

authors

Eisenman J,Ahdieh M,Beers C,Brasel K,Kennedy MK,Le T,Bonnert TP,Paxton RJ,Park LS

doi

10.1006/cyto.2002.1989

keywords:

subject

Has Abstract

pub_date

2002-11-07 00:00:00

pages

121-9

issue

3

eissn

1043-4666

issn

1096-0023

pii

S1043466602919897

journal_volume

20

pub_type

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