Mechanism of regulation of autoimmunity by iNKT cells.

abstract：:The burst formation from human and murine burst forming unit-erythroid (BFU-E) requires the presence of erythropoietin (Epo) in semi-solid cultures of bone marrow cells. A number of haematopoietic factors are described that increase the burst number: interleukin 3 (IL-3), stem cell factor (SCF), granulocyte-macrophage...

journal_title：Cytokine

authors： Rodriguez MH,Arnaud S,Geay T,Mouchiroud G,Grasset MF,Blanchet JP

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease mediated by an autoimmune reaction to hepatocytes, the present study aimed to assess the possible associations between interleukin-4 (IL-4) variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms and susceptibility to aut...

journal_title：Cytokine

authors： Mansour AI,Behairy OG,Abd Almonaem ER,Abd-Rabuh RM,Ahmed IAE

更新日期：2018-10-01 00:00:00

abstract：:The objectives were to determine if blood IL-10 levels rise during the early stages of acute (wasting) pre-pubescent malnutrition in metabolically distinct murine models known to depress inflammatory immune competence and whether systemic IL-10 production is affected in these pathologies. Weanling C57BL/6J mice were a...

journal_title：Cytokine

authors： Monk JM,Woodward B

更新日期：2009-08-01 00:00:00

abstract：:Therapeutic plasmapheresis is a recognized medical procedure in which various techniques are used to separate and remove undesirable or excessively elevated plasma elements from blood. The main purpose of the procedure is to remove the substances responsible for the disease (autoantibodies, circulating immune complexe...

journal_title：Cytokine

authors： Zenti MG,Stefanutti C

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:Atherosclerosis is a chronic inflammatory disease regulated by T lymphocyte subsets. Recently, CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells and Th17 cells have been described as two distinct subsets and have the opposite effects on autoimmunity. Clinical observation has revealed that the Th17/Treg imbala...

journal_title：Cytokine

authors： Xie JJ,Wang J,Tang TT,Chen J,Gao XL,Yuan J,Zhou ZH,Liao MY,Yao R,Yu X,Wang D,Cheng Y,Liao YH,Cheng X

更新日期：2010-02-01 00:00:00

abstract：:We have cloned and performed the first functional characterization of the chemokine receptor, CCR3, of Cynomolgus monkey (Macaca fascicularis). The deduced amino acid sequence of the cloned Cynomolgus CCR3 was found to be more similar to that of a previously-reported Rhesus (Macaca mulatta) CCR3 (99.4%) than that of a...

journal_title：Cytokine

authors： Iino T,Sugimoto H,Watanabe A,Encinas JA,Liu N,Floeckner J,Bacon KB

更新日期：2002-09-21 00:00:00

abstract：:Platelet activation and platelet-derived cytokines contribute to the vascular inflammation and increased thrombotic activity known to occur in patients with sickle cell anemia (SCA). CD40 ligand (CD40L), a platelet-associated pro-inflammatory molecule that promotes endothelial cell activation, is elevated in the circu...

journal_title：Cytokine

authors： Garrido VT,Sonzogni L,Mtatiro SN,Costa FF,Conran N,Thein SL

更新日期：2017-09-01 00:00:00

abstract：:Although much research has been done related to biomarker discovery for tuberculosis infection, a set of biomarkers that can discriminate between active and latent TB diseases remains elusive. In the current study we correlate clinical aspects of TB disease with changes in the immune response as determined by biomarke...

journal_title：Cytokine

authors： Zambuzi FA,Cardoso-Silva PM,Espindola MS,Soares LS,Galvão-Lima LJ,Brauer VS,Gomes MS,Amaral LR,Schaller M,Bollela VR,Frantz FG

更新日期：2016-12-01 00:00:00

abstract：:In this study we investigated mechanisms involved in the chronic character of experimental collagen type II induced arthritis (CIA). We compared the knee joints of mouse strains which are prone to develop this autoimmune disease (DBA/1,B10RIII) with other nonsusceptible mouse strains (C57Bl/6,BALB/c) in their reaction...

journal_title：Cytokine

authors： Blom AB,van Lent PL,Holthuysen AE,van den Berg WB

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by a wide variety of autoantibodies, some of which are pathogenic. In recent years it has become more evident that the polyclonal B cell activation in SLE is T-cell dependent. The stimulation of the autoantibody producing B cells is li...

journal_title：Cytokine

authors： Sabry A,Sheashaa H,El-Husseini A,Mahmoud K,Eldahshan KF,George SK,Abdel-Khalek E,El-Shafey EM,Abo-Zenah H

更新日期：2006-08-01 00:00:00

abstract：:Epidemiological studies indicate a genetic contribution to colorectal cancer (CRC), but specific genetic variants remain unknown. Genome-wide association studies have identified rs4444235 at BMP4 as a new colorectal cancer (CRC) and colorectal adenoma (CRA) susceptibility locus in populations of European descent. Afte...

journal_title：Cytokine

authors： Zhou L,Xie J,Gu EL,Huang Y,Qu Y,Xu AP,Zhu Y,Wang H

更新日期：2015-04-01 00:00:00

abstract：:The possibility has been suggested that interferon (IFN)-λs can be induced rapidly for restricting respiratory viral infection in asthmatic mice and may modulate Th2-related immune responses that underlie the pathogenesis of asthma. We sought to determine the in vivo contribution of IFN-λs on decrease of Th2 cytokines...

journal_title：Cytokine

authors： Won J,Gil CH,Jo A,Kim HJ

更新日期：2019-07-01 00:00:00

abstract：:CoPoIFN-α is a recombinant non-naturally occurring porcine interferon-α (IFN-α). It was designed by scanning 17 porcine IFN-α nonallelic subtypes and assigning the most frequently occurring amino acid in each position. We used a porcine IFN-α (PoIFN-α) derived from domestic pig as a control. Both porcine IFN-α genes w...

journal_title：Cytokine

authors： Huang L,Cao RB,Wang N,Liu K,Wei JC,Isahg H,Song LJ,Zuo WY,Zhou B,Wang WW,Mao X,Chen PY

更新日期：2012-01-01 00:00:00

abstract：:In a previous work we demonstrated that monoclonal antibody (mAb) 8C2 recognized a human granulocyte-colony stimulating factor (hG-CSF) region left unmasked after binding to placenta receptors, whereas mAb 6E3 defined a receptor-buried epitope. Herein we examined the role of these antigenic regions on the proliferativ...

journal_title：Cytokine

authors： Marino VJ,Sterin-Prync AE,Roguin LP

更新日期：2003-04-01 00:00:00

abstract：:T cells and T cell derived cytokines are involved in the complex pathogenesis of asthma. The role of the cytokine IL-18 however, is not clearly defined so far. On the one hand side IL-18 induces Th1-type cytokines and thereby might counter-regulate Th2-mediated allergic asthma. On the other hand IL-18 also bears pro-i...

journal_title：Cytokine

authors： Hartwig C,Tschernig T,Mazzega M,Braun A,Neumann D

更新日期：2008-06-01 00:00:00

abstract：:The authors have shown previously that in addition to its survival effects on neurons and glia, ciliary neurotrophic factor (CNTF) induced potent cachectic effects and acute phase proteins when present in the peripheral circulation at concentrations of < or = 10 ng/ml. These effects did not depend upon the induction o...

journal_title：Cytokine

authors： Henderson JT,Mullen BJ,Roder JC

更新日期：1996-10-01 00:00:00

abstract：:We investigated the effects of two low doses of interferon-alpha (IFN-alpha) on nocturnal sleep in 18 healthy men by means of polysomnographic sleep recordings. At 1900h, human recombinant IFN-alpha (1000 or 10000 U/kg body weight) or placebo was administered subcutaneously. Between 2300h and 0700h subjects were allow...

journal_title：Cytokine

authors： Späth-Schwalbe E,Lange T,Perras B,Fehm HL,Born J

更新日期：2000-05-01 00:00:00

abstract：:The in vivo influence of recombinant human erythropoietin (rhEpo) and iron on human neutrophil (PMN) antimicrobial function was assessed. A total of 21 preterm infants were randomized to receive either 200 U/kg/other day of rHuEPO+12 mg/kg/day of iron (EPO+high Fe, seven infants) or 200 U/kg/other day of rhEPO+4 mg/kg...

journal_title：Cytokine

authors： Soubasi V,Roilides E,Tsantali C,Mussafiris K,Tsakiris D,Kremenopoulos G

更新日期：1999-01-01 00:00:00

abstract：:The chemokine eotaxin (CCL11) is a key player in the trafficking of eosinophils to normal tissues and in the tissue eosinophilia associated with human allergic disease. We have recently cloned equine eotaxin and here we report the production of rEq eotaxin, with and without a C-terminal fusion peptide, in a novel expr...

journal_title：Cytokine

authors： Benarafa C,Collins ME,Hamblin AS,Sabroe I,Cunningham FM

更新日期：2002-07-07 00:00:00

abstract：:This study was aimed to evaluate the effects on some inflammatory markers of two dialytic treatments [bicarbonate dialysis (BHD) and hemodiafiltration (HDF)] in patients with severe chronic kidney disease. We evaluated: blood glucose, homeostasis model assessment insulin resistance index, homocistein (Hcs), high sensi...

journal_title：Cytokine

authors： Derosa G,Libetta C,Esposito P,Borettaz I,Tinelli C,D'angelo A,Maffioli P

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Hypertension is one of the most prominent risk factors for coronary artery disease (CAD). Treatment of hypertension is therefore important for reducing cardiovascular events and the progression of atherosclerosis. Several treatment strategies are common in clinical practice for example the use of ACE-blocker...

journal_title：Cytokine

authors： Klinghammer L,Urschel K,Cicha I,Lewczuk P,Raaz-Schrauder D,Achenbach S,Garlichs CD

更新日期：2013-05-01 00:00:00

abstract：:Inflammatory bowel diseases are characterized by dysregulated immune response to the normal microflora and structural and functional changes of the enteric nervous system which occur in inflamed as well as non-inflamed areas of the bowel. This study describes the changes in the expression of nerve growth factor (NGF) ...

journal_title：Cytokine

authors： Barada KA,Mourad FH,Sawah SI,Khoury C,Safieh-Garabedian B,Nassar CF,Tawil A,Jurjus A,Saadé NE

更新日期：2007-03-01 00:00:00

abstract：:The purpose of this study was to determine if vitamin D status before supplementation influences the cytokine response after supplemental vitamin D. Forty-six reportedly healthy adults (mean(SD); age, 32(7) y; body mass index (BMI), 25.3(4.5) kg/m(2); serum 25-hydroxyvitamin D (25(OH)D), 34.8(12.2) ng/mL) were randoml...

journal_title：Cytokine

authors： Barker T,Rogers VE,Levy M,Templeton J,Goldfine H,Schneider ED,Dixon BM,Henriksen VT,Weaver LK

更新日期：2015-02-01 00:00:00

abstract：:Human milk is a complex biological fluid. It contains many nutrients, anti-infectious and biologically active substance. Human milk also contains many angiogenic polypeptides. We have determined four of these: Vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF), insulin-like growth factor...

journal_title：Cytokine

authors： Ozgurtas T,Aydin I,Turan O,Koc E,Hirfanoglu IM,Acikel CH,Akyol M,Erbil MK

更新日期：2010-05-01 00:00:00

abstract：:To clarify the biological significance of tumour necrosis factor alpha (TNF-alpha) precursor, we analysed its expression at the primed and triggered stages using human monocyte-like cell line THP-1. To prime them, THP-1 cells were treated with either recombinant human interferon gamma (rIFN-gamma) or recombinant human...

journal_title：Cytokine

authors： Tanabe Y,Kitahara-Tanabe N,Mizuno D,Soma GI

更新日期：1994-07-01 00:00:00

abstract：:A recombinant human GM-CSF-EPO hybrid protein named MEN 11300 was administered biweekly for a total of 6 weeks to rhesus monkeys in order to evaluate its pharmacokinetic behaviour, tolerability and immunogenicity. In this primate species a strong antibody response was induced which neutralized the in vitro biological ...

journal_title：Cytokine

authors： Coscarella A,Liddi R,Di Loreto M,Bach S,Faiella A,van der Meide PH,Mele A,De Santis R

更新日期：1998-12-01 00:00:00

abstract：:Interactions between interleukin 8 (IL-8) and endothelial cells play an important role in the emigration of mononuclear cells from the blood into areas of inflammation. We examined the ability of specific second-line antirheumatic drugs to regulate (IL-8) gene expression and protein secretion in interleukin 1 (IL-1) s...

journal_title：Cytokine

authors： Deleuran B,Kristensen M,Paludan K,Zachariae C,Larsen CG,Zachariae E,Thestrup-Pedersen K

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Soy products contain several compounds with anti-inflammatory properties like genistein and daidzein which reported to act through different pathways. Present study conducted considering the inconsistent results and lack of any comprehensive review regarding randomized controlled trials which assess the effe...

journal_title：Cytokine

authors： Asbaghi O,Yaghubi E,Nazarian B,Kelishadi MR,Khadem H,Moodi V,Naeini F,Ghaedi E

更新日期：2020-12-01 00:00:00

abstract：:The aim of the study was to test the hypothesis that B-cell repopulation following rituximab (anti-CD20) therapy is orchestrated by chemokines and non-chemokine cytokines. Twenty-five children with opsoclonus-myoclonus syndrome (OMS) received rituximab with or without conventional agents. A comprehensive panel of 40 c...

journal_title：Cytokine

authors： Pranzatelli MR,Tate ED,Travelstead AL,Verhulst SJ

更新日期：2011-03-01 00:00:00

abstract：:We have studied the effects of rhTGF-beta2, dexamethanosome (dex) and 1,25(OH)2D3 on human bone marrow stromal (HBMS) cells in long-term culture. A fraction on HBMS expressed type I collagen (Col I) and osteopontin, and transient treatment (48 h) with dex increased the number of alkaline phosphatase (ALP) positive cel...

journal_title：Cytokine

authors： Fromigué O,Marie PJ,Lomri A

更新日期：1997-08-01 00:00:00