Interferon-alpha acutely impairs sleep in healthy humans.

abstract：:In order to understand the cellular disease mechanisms of osteoarthritic cartilage degeneration it is of primary importance to understand both the anabolic and the catabolic processes going on in parallel in the diseased tissue. In this study, we have applied cDNA-array technology (Clontech) to study gene expression p...

journal_title：Cytokine

authors： Aigner T,McKenna L,Zien A,Fan Z,Gebhard PM,Zimmer R

更新日期：2005-08-07 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection and hospitalization in infants. In spite of the enormous clinical burden caused by RSV infections, there remains no efficacious RSV vaccine. CD8 T cells mediate viral clearance as well as provide protection against a secondary ...

journal_title：Cytokine

authors： Schmidt ME,Varga SM

更新日期：2020-09-01 00:00:00

abstract：:Chronic liver injury causes liver regeneration, resulting in fibrosis. The proinflammatory cytokine tumor necrosis factor (TNF) is involved in the pathogenesis of many acute and chronic liver diseases. TNF has pleiotropic functions, but its role in liver fibrosis has not been clarified. Chronic repeated injection of C...

journal_title：Cytokine

authors： Sudo K,Yamada Y,Moriwaki H,Saito K,Seishima M

更新日期：2005-03-07 00:00:00

abstract：:Recently, we reported that extracellular ubiquitin functions as another agonist of CXC chemokine receptor (CXCR)4. Whereas the cognate CXCR4 ligand, stromal cell-derived factor (SDF)-1α, is also a CXCR7 agonist, ubiquitin does not bind to CXCR7. Because both ligands are present in the extracellular environment, co-act...

journal_title：Cytokine

authors： Tripathi A,Davis JD,Staren DM,Volkman BF,Majetschak M

更新日期：2014-02-01 00:00:00

abstract：CONTEXT:CTLA-4 is engaged on effector cells that may alter signal transduction and subsequently cytokine production. The transmission of longer repeats of (AT)(n) alleles of CTLA-4 is also associated with women undergoing recurrent miscarriage. The TNF-α known as an embryo-toxic cytokine is reported to be greater in pl...

journal_title：Cytokine

authors： Gupta R,Prakash S,Parveen F,Agrawal S

更新日期：2012-11-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) demonstrating pro-angiogenic activity promote new blood vessel formation in psoriatic lesions. The aim of this study was to evaluate the serum concentrations of VEGF, its soluble receptors (sVEGF R1 and R2) and VEGF content in scales of patients with psoriasis. To analyze poss...

journal_title：Cytokine

authors： Flisiak I,Zaniewski P,Rogalska M,Myśliwiec H,Jaroszewicz J,Chodynicka B

更新日期：2010-12-01 00:00:00

abstract：:D-dopachrome tautomerase (D-DT) is a newly described cytokine and a member of the macrophage migration inhibitory factor (MIF) protein superfamily. MIF is a broadly expressed pro-inflammatory cytokine that regulates both the innate and the adaptive immune response. MIF activates the MAP kinase cascade, modulates cell ...

journal_title：Cytokine

authors： Merk M,Mitchell RA,Endres S,Bucala R

更新日期：2012-07-01 00:00:00

abstract：:High-fat-fed C57Bl/6J FABP4/aP2 null mice develop obesity but not the related hyperglycemia or hyperinsulinemia characteristic of type II diabetes. FABP4/aP2 protein's function to bind fatty acids in the adipocytes may promote total body energy homeostasis by linking energy depots to the ability to express signaling m...

journal_title：Cytokine

authors： Witthuhn BA,Bernlohr DA

更新日期：2001-05-07 00:00:00

abstract：OBJECTIVE:To describe the relationship between the two mechanisms involved in sIL6R generation in rheumatoid arthritis (RA). METHOD:RA patients were selected from a group of subjects genotyped for the rs8192284 SNP, located at the proteolytic cleavage site of IL-6R. sIL6R and protease levels (ADAM17) were measured and...

journal_title：Cytokine

authors： Lamas JR,Rodríguez-Rodríguez L,Tornero-Esteban P,Villafuertes E,Hoyas J,Abasolo L,Varadé J,Alvarez-Lafuente R,Urcelay E,Fernández-Gutiérrez B

更新日期：2013-03-01 00:00:00

abstract：:Interleukin (IL)-4, IL-10, and IL-13 are T-helper2 cell derived cytokines, which are known to suppress pro-inflammatory cytokine production. The biologically related IL-4 and IL-13 have an impact on the development of atopic inflammation, whereas IL-10 is mostly supposed to be involved in fibrotic disorders or inflamm...

journal_title：Cytokine

authors： Hocke AC,Ermert M,Althoff A,Brell B,N'Guessan PD,Suttorp N,Ermert L

更新日期：2006-02-21 00:00:00

abstract：OBJECTIVES:The fact that ovarian cancer remains confined to the peritoneal cavity even in advanced stages has allowed us to surmise that local immunosuppressive factors could be involved in the tumor biology of ovarian cancer. In this context, IL-10 can be one of the key factors. By studying the kinetics of IL-10 conce...

journal_title：Cytokine

authors： Mustea A,Braicu EI,Koensgen D,Yuan S,Sun PM,Stamatian F,Lichtenegger W,Chen FC,Chekerov R,Sehouli J

更新日期：2009-01-01 00:00:00

abstract：:Patients admitted to a medical intensive care unit (ICU) are characterized by an activated immune system and exhibit a high mortality rate irrespective of the underlying cause of admission. Interleukin (IL)-33 has been shown to be protective in experimental sepsis models and it has been demonstrated that circulating l...

journal_title：Cytokine

authors： Krychtiuk KA,Stojkovic S,Lenz M,Brekalo M,Huber K,Wojta J,Heinz G,Demyanets S,Speidl WS

更新日期：2018-03-01 00:00:00

abstract：:During the quarter of a century since TNF was isolated, much knowledge has been gained of the identity of other ligands besides TNF in the TNF cytokine family, and of the proximal signaling molecules that these ligands activate. The numerous laboratories contributing to this advance have approached TNF research from v...

journal_title：Cytokine

authors： Wallach D

更新日期：2013-09-01 00:00:00

abstract：:Injection of tumour necrosis factor (TNF) in animals causes severe liver cell toxicity, especially when D-(+)-galactosamine (GalN) is co-administered. After challenge with TNF/GalN, serum complement activity (CH50 and APCH50) decreased dramatically, suggesting strong activation of both the classical and the alternativ...

journal_title：Cytokine

authors： Libert C,Wielockx B,Grijalba B,Van Molle W,Kremmer E,Colten HR,Fiers W,Brouckaert P

更新日期：1999-08-01 00:00:00

abstract：:Pregnancy in sickle cell disease is a problem due to the adverse outcomes related to the disease. Research into the role of chemokines in sickle cell disease is available, but studies investigating the disease in pregnancy are scarce. Our data show the chemokine profiles of pregnant women with sickle cell disease comp...

journal_title：Cytokine

authors： Hazin-Costa MF,da Silva Aráujo A,Guerra GL,da Matta MC,Torres LC,Souza AI

更新日期：2019-01-01 00:00:00

abstract：:Although tumor necrosis factor (TNF) and interleukin 6 (IL 6) are purported to be important mediators of inflammatory responses following trauma, it is not known if the serum levels of these cytokines are altered by simple hemorrhage. The objective of this study therefore was to determine whether or not: 1) there is a...

journal_title：Cytokine

authors： Ayala A,Perrin MM,Meldrum DR,Ertel W,Chaudry IH

更新日期：1990-05-01 00:00:00

abstract：:Numerous proteins are cleaved or "shed" from their membrane-bound form. One such protein, tumour necrosis factor alpha (TNF-alpha), is synthesized as a type 2 transmembrane protein. Recently, a human protease responsible for this shedding, the TNF-alpha converting enzyme (TACE/ADAM17), was isolated. TACE/ADAM17 is a m...

journal_title：Cytokine

authors： Cerretti DP,Poindexter K,Castner BJ,Means G,Copeland NG,Gilbert DJ,Jenkins NA,Black RA,Nelson N

更新日期：1999-08-01 00:00:00

abstract：:Inhibition of inflammation is one of the possible therapeutic approaches for Insulin resistance (IR) during type 2 diabetes mellitus (T2DM). In the current study we investigated the effects of palmitate and chicoric acid (CA) on inflammation in peripheral blood mononuclear cells (PBMCs) of newly diagnosed T2DM patient...

journal_title：Cytokine

authors： Sadeghabadi ZA,Ziamajidi N,Abbasalipourkabir R,Mohseni R,Borzouei S

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Interleukin (IL)-4 and IL-10 are viewed mainly as anti-inflammatory cytokines. Yet, high concentrations have also been associated with inflammation-related diseases in newborns. METHODS:We measured the concentrations of IL-4 and IL-10, as well as IL-8 and ICAM-1 in blood specimens collected on postnatal day...

journal_title：Cytokine

authors： Leviton A,Joseph RM,Allred EN,Fichorova RN,O'Shea TM,Kuban KKC,Dammann O

更新日期：2018-10-01 00:00:00

abstract：RATIONALE:Inflammation exacerbates a number of deleterious effects on the heart, most notable being left ventricular dysfunction (LVD). A promoter polymorphism of the NFKB1 gene (encodes p50 subunit) results in lower protein levels of NFkB p50 subunits, which in its dimmer (p50) form has anti-inflammatory effects. The ...

journal_title：Cytokine

authors： Mishra A,Srivastava A,Mittal T,Garg N,Mittal B

更新日期：2013-03-01 00:00:00

abstract：:Monocytes/macrophages (Mphi) play a pivotal role in the persistence of chronic inflammation and local tissue destruction in diseases such as rheumatoid arthritis and atherosclerosis. The production by Mphi of cytokines, chemokines, metalloproteinases and their inhibitors is an essential component in this process, whic...

journal_title：Cytokine

authors： Meier CA,Chicheportiche R,Juge-Aubry CE,Dreyer MG,Dayer JM

更新日期：2002-06-21 00:00:00

abstract：:Bone tissue is continually being remodelled according to physiological circumstances. Two main cell populations (osteoblasts and osteoclasts) are involved in this process, and cellular activities (including cell differentiation) are modulated by hormones, cytokines and growth factors. Within the last 20 years, many fa...

journal_title：Cytokine

authors： Heymann D,Rousselle AV

更新日期：2000-10-01 00:00:00

abstract：:We have examined the effects of various antioxidants and inhibitors of redox-sensitive signal transduction pathways on induction of interleukin 8 (IL-8) gene by NO in monocytic U937 cells. We have observed that nitrosoglutathione or another NO-generating compound spermine NONOate caused significant accumulation of IL-...

journal_title：Cytokine

authors： Turpaev K,Litvinov D,Justesen J

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Immune and inflammatory responses, mediated by cytokines, play important roles in the pathophysiology of asthma. These responses are associated with over expression of T helper (Th)-2 cytokine, particularly interleukin (IL)-4 and IL-5, and decreased expression of Th-1 cytokine, IL-2 and IFN-γ. We...

journal_title：Cytokine

authors： Lama M,Chatterjee M,Nayak CR,Chaudhuri TK

更新日期：2011-09-01 00:00:00

abstract：:Interleukin 1 (IL-1) activates p42/p44 and p38 mitogen-activated protein kinases (MAP kinases) in target cells. Here we have used two specific inhibitors, PD98059 which inhibits MAP kinase kinase (MEK), and SB203580 which inhibits p38 MAP kinase to explore the involvement of these kinases in the induction of IL-2 by I...

journal_title：Cytokine

authors： Matthews JS,O'Neill LA

更新日期：1999-09-01 00:00:00

abstract：RATIONALE:Sarcoidosis is an idiopathic granulomatous disorder with heterogeneous clinical manifestations and variable prognosis. Monitoring disease activity is important to identify patients requiring treatment. Several cytokines have previously been shown to be elevated in the serum of patients with sarcoidosis and ma...

journal_title：Cytokine

authors： Geyer AI,Kraus T,Roberts M,Wisnivesky J,Eber CD,Hiensch R,Moran TM

更新日期：2013-10-01 00:00:00

abstract：:Recent evidence indicates that the rate of progression of the HIV-1 disease is significantly reduced in thalassaemia major patients upon treatment with high doses of desferrioxamine (DFX). The authors have previously demonstrated that in vitro exposure of mononuclear cells to DFX decreases the bioavailability of tumou...

journal_title：Cytokine

authors： Bellocq A,Israël-Biet D,Cadranel J,Perez J,Fouqueray B,Kanfer A,Girot R,Baud L

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Two assays--isolated peripheral blood mononuclear cells (PBMC) and a whole blood assay (WBA)--are commonly used to study TNF-alpha production by an individual in order to distinguish between high and low cytokine producers. We assessed the reliability and reproducibility of these assays. METHODS:The PBMC as...

journal_title：Cytokine

authors： Bakiyeva LT,Brooks RA,Rushton N

更新日期：2005-04-07 00:00:00

abstract：:Stimulation of Ca2+ permeable TRPM3 (transient receptor potential melastatin-3) channels with the steroid ligand pregnenolone sulfate activates stimulus-responsive transcription factors, including the transcription factor AP-1 (activator protein-1). As part of a search for AP-1-regulated target genes we analyzed the g...

journal_title：Cytokine

authors： Rubil S,Lesch A,Mukaida N,Thiel G

更新日期：2018-03-01 00:00:00

abstract：:Circulating interleukin (IL)-6 and IL-10 concentrations can be elevated following the surgically induced trauma of total knee arthroplasty (TKA). An exaggerated increase in IL-6 relative to IL-10 (i.e., IL-6/IL-10 ratio) associates with trauma severity and indicative of pro-inflammatory predominance. Although various ...

journal_title：Cytokine

authors： Barker T,Henriksen VT,Rogers VE,Trawick RH,Momberger NG,Lynn Rasmussen G

更新日期：2021-01-23 00:00:00