当前位置： SCI文献检索 > CYTOKINE期刊下所有文献 > Characterization of the cDNA and gene for mouse tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and its location to mouse chromosome 12 and human chromosome 2p25.

Characterization of the cDNA and gene for mouse tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and its location to mouse chromosome 12 and human chromosome 2p25.

Abstract：

:Numerous proteins are cleaved or "shed" from their membrane-bound form. One such protein, tumour necrosis factor alpha (TNF-alpha), is synthesized as a type 2 transmembrane protein. Recently, a human protease responsible for this shedding, the TNF-alpha converting enzyme (TACE/ADAM17), was isolated. TACE/ADAM17 is a member of the adamalysin class of zinc-binding metalloproteases or ADAM (a disintegrin and metalloprotease). We report the isolation and characterization of the mouse TACE/ADAM17 cDNA and gene. Mouse TACE/ADAM17 has a 92% amino-acid identity with the human protein and was ubiquitously expressed. A recombinant form of the protease is found to cleave a peptide representing the cleavage site of precursor mouse TNF-alpha. An alternatively spliced form of mouse TACE/ADAM17 was found that would produce a soluble protein. The gene for TACE/ADAM17 is approximately 50 kb and contains 19 exons. Chromosomal mapping places TACE/ADAM17 on mouse chromosome 12 and human chromosome 2p25.

journal_name

Cytokine

journal_title

Cytokine

authors

Cerretti DP,Poindexter K,Castner BJ,Means G,Copeland NG,Gilbert DJ,Jenkins NA,Black RA,Nelson N

doi

10.1006/cyto.1998.0466

keywords:

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

541-51

issue

8

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(98)90466-5

journal_volume

11

pub_type

杂志文章

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