Abstract:
:C-reactive protein (CRP) has been demonstrated to induce blood-brain barrier disruption (BBB) involving NAD(P)H-oxidase dependent oxidative stress. It is unclear why CRP affects the BBB and not other vascular beds following stroke. Therefore we examined CRP receptor and NAD(P)H-oxidase expression levels in bovine brain- (BEC) and aortic endothelial cells. Dichlorodihydrofluorescein measurements revealed significantly higher CRP-induced reactive oxygen species (ROS) levels in BEC. Protein expression of the CRP-receptors CD16, CD32 and of the NAD(P)H-oxidase subunit p22phox were also significantly higher in BEC. In conclusion BEC show a higher vulnerability to CRP due to increased levels of CRP receptors and the NAD(P)H-oxidase.
journal_name
Cytokinejournal_title
Cytokineauthors
Closhen D,Bender B,Luhmann HJ,Kuhlmann CRdoi
10.1016/j.cyto.2010.02.011subject
Has Abstractpub_date
2010-05-01 00:00:00pages
117-20issue
2eissn
1043-4666issn
1096-0023pii
S1043-4666(10)00037-2journal_volume
50pub_type
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