Retinal pigment epithelium-secretome: A diabetic retinopathy perspective.

abstract：:Ocular trauma affects 20% of Americans in their lifetime and can cause permanent visual system damage. We have used a mouse model of ocular trauma (exposure to an air blast from a paintball gun) to examine pathways that trigger the resulting retinal damage and to develop treatment strategies that might ameliorate the ...

journal_title：Cytokine

authors： Jiang Y,Pagadala J,Miller DD,Steinle JJ

更新日期：2014-12-01 00:00:00

abstract：:We examined seasonal differences in whole blood cytokine production after endotoxin (LPS) stimulation in 17 healthy individuals from an urban area having normal sleep/wakefulness pattern. We used 500 pg/ml of LPS for incubation period of 4 h to stimulate 100 microl of whole blood of the same subjects in June, Septembe...

journal_title：Cytokine

authors： Myrianthefs P,Karatzas S,Venetsanou K,Grouzi E,Evagelopoulou P,Boutzouka E,Fildissis G,Spiliotopoulou I,Baltopoulos G

更新日期：2003-12-21 00:00:00

abstract：BACKGROUND:We aimed to investigate the use of novel serum biomarkers for predicting the recurrence and survival of patients with hepatitis B virus (HBV)-related early hepatocellular carcinoma (HCC) after hepatic resection or radiofrequency ablation (RFA). METHODS:One hundred and five patients with HBV-related HCC, who...

journal_title：Cytokine

authors： Cho HJ,Kim SS,Ahn SJ,Park SY,Park JH,Kim JK,Wang HJ,Cheong JY,Cho SW

更新日期：2015-06-01 00:00:00

abstract：:Non-Hodgkin's lymphomas (NHL) constitute a heterogenous group of mainly B-cell lymphoproliferative diseases with different patterns of clinical behaviour. Biological mechanisms leading to development of NHL are not clearly understood. Transforming growth factor-beta1 (TGF-beta1) influences B cell growth and developmen...

journal_title：Cytokine

authors： Mazur G,Bogunia-Kubik K,Wrobel T,Kuliczkowski K,Lange A

更新日期：2006-02-07 00:00:00

abstract：:As a result of the association between ionizing irradiation and the induction of inflammatory and fibrogenic cytokines, circulating levels of IL-1alpha, macrophage colony stimulating factor (M-CSF) and TGFbeta were measured in a group of 37 patients who presented with well-defined adenocarcinoma of the prostate and we...

journal_title：Cytokine

authors： Kovacs CJ,Daly BM,Evans MJ,Johnke RM,Lee TK,Karlsson UL,Allison R,Eaves GS,Biggs LM

更新日期：2003-09-21 00:00:00

abstract：:The induction of cytokine expression in monocytes/macrophages by bacterial endotoxin or lipopolysaccharide is a critical, highly regulated host defence response. The augmentation of LPS responses by interferon gamma (IFN-gamma), referred to as priming, is well established. However, the mechanism(s) by which priming oc...

journal_title：Cytokine

authors： Hayes MP,Freeman SL,Donnelly RP

更新日期：1995-07-01 00:00:00

abstract：:A large body of evidence supports the involvement of the immune system in the pathogenesis of multiple sclerosis (MS). Nevertheless, how the peripheral T-cells phenotypes are associated with factors such as the disability score, the effects of immunomodulatory treatments, or the activation period is poorly understood....

journal_title：Cytokine

authors： Sepulcre J,Sanchez-Ibarrola A,Moreno C,de Castro P

更新日期：2005-10-21 00:00:00

abstract：:Chemokines are small chemoattractant cytokines involved in normal and pathological immune processes. Although extensive nucleotide sequence data are available for human and murine chemokine cDNA sequences, very few data are currently available regarding rhesus macaque sequences. To increase our understanding of immune...

journal_title：Cytokine

authors： Basu S,Schaefer TM,Ghosh M,Fuller CL,Reinhart TA

更新日期：2002-05-07 00:00:00

abstract：:The aim of this study was to investigate the clinical relevance of lymphocyte-related serum miRNAs to the pathogenesis of acute graft-versus-host disease (aGVHD) and evaluate the predictive and prognosis value of miRNAs. Consecutive patients who received allogeneic peripheral blood stem cell transplantation (allo-PBSC...

journal_title：Cytokine

authors： Xie L,Zhou F,Liu X,Fang Y,Yu Z,Song N,Kong F

更新日期：2016-09-01 00:00:00

abstract：:The proper balance between IL-12p40-related cytokines controls the appearance of normal and pathological Th1 immune responses. In this study, we examined the inducible IL-12p40, IL-12p35 and IL-23p19 mRNA expression and protein production in human peripheral blood mononuclear cells (PBMC) and purified monocytes, isola...

journal_title：Cytokine

authors： Dobreva ZG,Stanilova SA,Miteva LD

更新日期：2008-07-01 00:00:00

abstract：:Human milk is a complex biological fluid. It contains many nutrients, anti-infectious and biologically active substance. Human milk also contains many angiogenic polypeptides. We have determined four of these: Vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF), insulin-like growth factor...

journal_title：Cytokine

authors： Ozgurtas T,Aydin I,Turan O,Koc E,Hirfanoglu IM,Acikel CH,Akyol M,Erbil MK

更新日期：2010-05-01 00:00:00

abstract：:The possibility has been suggested that interferon (IFN)-λs can be induced rapidly for restricting respiratory viral infection in asthmatic mice and may modulate Th2-related immune responses that underlie the pathogenesis of asthma. We sought to determine the in vivo contribution of IFN-λs on decrease of Th2 cytokines...

journal_title：Cytokine

authors： Won J,Gil CH,Jo A,Kim HJ

更新日期：2019-07-01 00:00:00

abstract：:Measuring T-cell production of intracellular cytokines by flow cytometry enables specific monitoring of airway inflammation and response to therapies in chronic lung diseases including chronic obstructive pulmonary disease (COPD). We have previously shown that T cells in the airways of ex- and current- smoker COPD pat...

journal_title：Cytokine

authors： Hodge G,Reynolds PN,Holmes M,Hodge S

更新日期：2012-12-01 00:00:00

abstract：:The effect of ether lipid 1-O-Octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine (ET-18-OCH3), platelet activating factor (PAF) and carbamyl activating factor (CPAF) on the release of IL-6 in human thymic epithelium cultivated in vitro was studied. ET-18-OCH3 significantly increased the release of IL-6, giving the gre...

journal_title：Cytokine

authors： Cardile V,Mascarucci P,De Simoni MG,Jiang X,Bindoni M

更新日期：1996-09-01 00:00:00

abstract：:Interleukin-1beta (IL-1beta) is a pleiotropic cytokine that can induce several cellular signal transduction pathways. Here, we show that IL-1beta can induce cell cycle arrest and differentiation in the human medullary thyroid carcinoma (MTC) cell line, TT. IL-1beta induces cell cycle arrest accompanied by morphologica...

journal_title：Cytokine

authors： Park JI,Strock CJ,Ball DW,Nelkin BD

更新日期：2005-02-07 00:00:00

abstract：AIMS:At present, there are few studies on the relationship between circulating irisin levels and gestational diabetes mellitus (GDM), and the results are inconsistent. Therefore, this study conducts a systematic review and meta-analysis to comprehensively discuss the role of irisin in the occurrence and development of ...

journal_title：Cytokine

authors： Cui L,Qiao T,Xu F,Li Z,Chen T,Su H,Chen G,Zhang L,Xu D,Zhang X

更新日期：2020-02-01 00:00:00

abstract：:Interleukin-21 (IL-21) is overproduced in human intestines affected by inflammatory bowel disease (IBD) and in the gut of mice with DSS-induced colitis. IL-21-deficient mice are largely protected against DSS-induced colitis, indicating that IL-21 plays a key role in the development of IBD. We previously identified a n...

journal_title：Cytokine

authors： Araki A,Nara H,Rahman M,Onoda T,Li J,Juliana FM,Jin L,Murata K,Takeda Y,Asao H

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:Oxidative stress is involved in several maternal conditions characterized both by an increase in free radicals synthesis and a parallel decrease in the antioxidant activity. Parturition induces considerable oxidative stress and many inflammatory mediators, among which HMGB1, are involved from the beginning of...

journal_title：Cytokine

authors： D'Angelo G,Marseglia L,Granese R,Di Benedetto A,Giacobbe A,Impellizzeri P,Alibrandi A,Ferro E,Palmara A,Manti S,Arrigo T,Salpietro C,Buonocore G,Reiter RJ,Gitto E

更新日期：2018-08-01 00:00:00

abstract：:Myeloma is a neoplasm thought to "home" to bone marrow. However, evidence for bone-marrow-specific receptors or adhesion molecules expressed on myeloma cells is scanty. Initial myeloma expansion is thought to be due to IL-6 and/or related cytokines. Previous determinations of cytokine expression in bone marrow were pe...

journal_title：Cytokine

authors： Barton BE,Murphy TF

更新日期：2000-10-01 00:00:00

abstract：:Estrogens have been associated with risk for epithelial ovarian cancer (OVCA). Both IL-6 and IL-8 are also likely involved in the progression of OVCA. In order to discover the underline molecular mechanism, we investigated the modulation of estrogen and two cytokines in the growth and progression of epithelial OVCA. I...

journal_title：Cytokine

authors： Yang J,Wang Y,Gao Y,Shao J,Zhang XJ,Yao Z

更新日期：2009-06-01 00:00:00

abstract：:Prostaglandins (PGs), the arachidonic acid (AA) metabolites of the cyclooxygenase (COX) pathway, and the cytokine TNFalpha play major roles in inflammation and they are synthesised mainly by macrophages. Their syntheses have been shown to be regulated by several factors, including nitric oxide, a further important mac...

journal_title：Cytokine

authors： Guastadisegni C,Nicolini A,Balduzzi M,Ajmone-Cat MA,Minghetti L

更新日期：2002-08-21 00:00:00

abstract：BACKGROUND:Resistin is a novel cysteine-rich protein that plays a role in the development of insulin resistance and atherosclerosis in rodents, while its role in humans is unclear. C-reactive protein (CRP) is an important risk predictor for coronary heart disease, and it can also modify the expression of genes involved...

journal_title：Cytokine

authors： Hu WL,Qiao SB,Li JJ

更新日期：2007-12-01 00:00:00

abstract：:The present study aimed to assess the kinetics of cytokine release and compare the accuracy of serum biomarkers for the diagnosis of macrophage activation syndrome (MAS) associated with Kawasaki disease (KD). Serum neopterin, interleukin (IL)-18, IL-6 and soluble tumour necrosis factor receptor type I (sTNFR-I) and sT...

journal_title：Cytokine

authors： Jinkawa A,Shimizu M,Nishida K,Kaneko S,Usami M,Sakumura N,Irabu H,Takakuwa M,Inoue N,Mizuta M,Ikawa Y,Fujita S,Yachie A

更新日期：2019-07-01 00:00:00

abstract：:Human co-infection by helminth species is frequent, but their consequences are mostly unknown. Here, we investigate the impact of Strongyloides venezuelensis co-infection on the immune response, schistosome burden, and the associated pathology of schistosomiasis in mice. Co-infection did not alter the schistosome para...

journal_title：Cytokine

authors： de Rezende MC,Moreira JMP,Fernandes LLM,Rodrigues VF,Negrão-Corrêa D

更新日期：2020-03-01 00:00:00

abstract：AIMS:There is interest in using blood C-reactive protein (CRP) to predict adverse prognosis outcomes patients with type 2 diabetes. This meta-analysis aimed to investigate the association between elevated baseline CRP level and unfavorable outcomes in type 2 diabetes patients. MATERIALS/METHODS:PubMed and Embase datab...

journal_title：Cytokine

authors： Tian R,Tian M,Wang L,Qian H,Zhang S,Pang H,Liu Z,Fang L,Shen Z

更新日期：2019-05-01 00:00:00

abstract：:Interleukin (IL)-12 is a pivotal cytokine that strongly stimulates Th1-associated cellular immunity. It is now recognized that IL-12 also activates humoral immunity to both T-dependent and T-independent antigens. This has let to considerable interest in exploiting IL-12 as a vaccine adjuvant for protection against var...

journal_title：Cytokine

authors： Metzger DW

更新日期：2010-10-01 00:00:00

abstract：:The human interferon alpha-receptor (IFNAR gene product or IFN alpha R protein) was expressed in hamster CHO cells and in mouse A9 cells. The response of the IFN alpha R cDNA transfectants to human IFNs was studied by measuring induction of (2'-5') A synthetase (2'-5' AS). In the murine cells, the IFN alpha R protein ...

journal_title：Cytokine

authors： Abramovich C,Chebath J,Revel M

更新日期：1994-07-01 00:00:00

abstract：:We had earlier shown that human foetal epithelial cells (WISH), growth-inhibited by interferon gamma (IFNgamma), were reversibly detained at a point prior to DNA synthesis. In the present study, we determined the window of action of IFNgamma in the G1 phase duration and the exact point of detention of WISH cells in ce...

journal_title：Cytokine

authors： Vashistha S,Patil S,Joshi C,Ajitkumar P

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:The effectual immune response is crucial to defeat viral infections. However, exuberant immune response with features of macrophage activation syndrome (MAS) lead detrimental consequences in COVID-19 patients. Interleukin (IL)-18 is one of the leading cytokines in MAS which has not been studied in COVID-19. ...

journal_title：Cytokine

authors： Satış H,Özger HS,Aysert Yıldız P,Hızel K,Gulbahar Ö,Erbaş G,Aygencel G,Guzel Tunccan O,Öztürk MA,Dizbay M,Tufan A

更新日期：2021-01-01 00:00:00

abstract：:Cisplatin is commonly prescribed for the treatment of various solid tumors but its use is limited due to certain side effects and renal injury is a true example. Oxidative stress and inflammation may contribute to the cisplatin induced nephrotoxicity. Accordingly, we evaluated the effect of oral vanillin intake (100mg...

journal_title：Cytokine

authors： Elseweidy MM,Askar ME,Elswefy SE,Shawky M

更新日期：2017-11-01 00:00:00