Abstract:
:Rheumatoid arthritis (RA) is a common autoimmune disease that is marked by a systemic inflammatory reaction and joint erosions. Elevated levels of B cell activating factor (BAFF) have been detected in the serum and synovial fluid of RA patients. Moreover, the levels of BAFF increase in cases of autoimmune disease and are correlated with the level of disease activity. As an innate cytokine mediator, BAFF affects the immune response of the synovial microenvironment. In this review, we consider recent observations of BAFF and its receptors in RA progression, as well as the effects of BAFF on the cell-cell interactions network. We also summarize the clinical development of BAFF antagonists for the treatment of RA.
journal_name
Cytokinejournal_title
Cytokineauthors
Wei F,Chang Y,Wei Wdoi
10.1016/j.cyto.2015.07.014subject
Has Abstractpub_date
2015-12-01 00:00:00pages
537-544issue
2eissn
1043-4666issn
1096-0023pii
S1043-4666(15)30024-7journal_volume
76pub_type
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