Abstract:
:Osteoclasts, the main protagonists involved in bone resorption mechanisms, are generally considered to be of haematopoietic origin, although the exact nature of the primary osteoclastic stem cells is still unknown. In vitro cellular models developed to study the different events of osteoclastic differentiation have revealed that not only several cell types (osteoblasts, monocytes, lymphocytes, etc.) but also many soluble factors (cytokines, hormones, vitamins, ions, etc.) and extracellular matrix elements (osteopontin, osteocalcin, etc.) are involved in osteoclastic differentiation and activation. This article provides an exhaustive review of recent knowledge on the origin of the osteoclast and the main substances involved in the osteoclastogenesis and activation of these cells.
journal_name
Cytokinejournal_title
Cytokineauthors
Heymann D,Guicheux J,Gouin F,Passuti N,Daculsi Gdoi
10.1006/cyto.1997.0277subject
Has Abstractpub_date
1998-03-01 00:00:00pages
155-68issue
3eissn
1043-4666issn
1096-0023pii
S1043-4666(97)90277-5journal_volume
10pub_type
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