Impaired production of IL-12 in systemic lupus erythematosus. III: deficient IL-12 p40 gene expression and cross-regulation of IL-12, IL-10 and IFN-gamma gene expression.

abstract：:The effect of epidermal growth factor (EGF), basic fibroblast growth factor (bFGF) and insulin-like growth factor-1 (IGF-1) on the cytostatic activity of tumour necrosis factor-alpha (TNF-alpha) was studied on the breast cancer cell line, T47D. TNF-alpha completely blocked the potent growth-promoting activity of all t...

journal_title：Cytokine

authors： Pusztai L,Lewis CE,McGee JO

更新日期：1993-03-01 00:00:00

abstract：:Cisplatin is commonly prescribed for the treatment of various solid tumors but its use is limited due to certain side effects and renal injury is a true example. Oxidative stress and inflammation may contribute to the cisplatin induced nephrotoxicity. Accordingly, we evaluated the effect of oral vanillin intake (100mg...

journal_title：Cytokine

authors： Elseweidy MM,Askar ME,Elswefy SE,Shawky M

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:HIV rapid progressors (RPs) present with a rapid decline of CD4+ T cells within a few years of infection. Determining the underlying mechanisms throughout this decline is important to identify prognostic biomarkers and intervention strategies. Determining the numbers of CD4+ and CD8+ T cells is essential for...

journal_title：Cytokine

authors： Ding ZD,Zheng JF,Song CB,Fu YJ,Xu JJ,Jiang YJ,Shang H,Zhang ZN

更新日期：2020-01-01 00:00:00

abstract：:The kynurenine pathway (KP) is the major metabolic route of tryptophan (Trp) metabolism. Indoleamine 2,3-dioxygenase (IDO1), the enzyme responsible for the first and rate-limiting step in the pathway, as well as other enzymes in the pathway, have been shown to be highly regulated by cytokines. Hence, the KP has been i...

journal_title：Cytokine

authors： Baumgartner R,Forteza MJ,Ketelhuth DFJ

更新日期：2019-10-01 00:00:00

abstract：:The proinflammatory cytokines TNFalpha and IL-1beta are thought to play a role in the mechanism of septic vasodilatory shock. Most evidence indicate that the vascular effects these cytokines are mediated through increased expression of inducible nitric oxide synthase, whereas several animal studies report a more rapid...

journal_title：Cytokine

authors： Pickkers P,Netea MG,van der Meer JW,Smits P

更新日期：2002-12-07 00:00:00

abstract：:The purpose of the study was to reassess the utility of transforming growth factor-beta-1 (TGF-beta1) together with dosimetric and tumor parameters as a predictor for radiation pneumonitis (RP). Of the 121 patients studied, 32 (26.4%) developed grade > or =1 RP, and 27 (22.3%) developed grade > or =2 RP. For the endpo...

journal_title：Cytokine

authors： Evans ES,Kocak Z,Zhou SM,Kahn DA,Huang H,Hollis DR,Light KL,Anscher MS,Marks LB

更新日期：2006-08-01 00:00:00

abstract：:The N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP), a unique cytokine present in human granulocytes, was determined to be: Pyroglu-Leu-Lys-X-Tyr-Thr-X-Lys-Glu-Pro-Met-Thr-Ser(Thr)-Ala-Ala... This sequence showed no significant homology with any other protein when used in database searches...

journal_title：Cytokine

authors： Ridge RJ,Sloane NH

更新日期：1996-01-01 00:00:00

abstract：:The present study was aimed at defining the activity of human and mouse monocyte chemotactic protein-1 (MCP-1) on homologous and heterologous mononuclear phagocytes. Human natural and recombinant MCP-1 and mouse natural MCP-1/JE were tested as chemoattractants on human blood monocytes and mouse peritoneal macrophages....

journal_title：Cytokine

authors： Luini W,Sozzani S,Van Damme J,Mantovani A

更新日期：1994-01-01 00:00:00

abstract：:In order to study structure-function relationships of the M(r) 55,000 subunit of the murine IL-2R (p55 IL-2R) by epitope mapping, we have expressed the p55 IL-2R molecule in a cell-free translation system. Under these in vitro conditions, we detected the expected p55 IL-2R polypeptide initiated at Met 1 and, in additi...

journal_title：Cytokine

authors： Lorenzo F,Jaulin C,Jankovic DL,Theze J

更新日期：1992-07-01 00:00:00

abstract：:We examined seasonal differences in whole blood cytokine production after endotoxin (LPS) stimulation in 17 healthy individuals from an urban area having normal sleep/wakefulness pattern. We used 500 pg/ml of LPS for incubation period of 4 h to stimulate 100 microl of whole blood of the same subjects in June, Septembe...

journal_title：Cytokine

authors： Myrianthefs P,Karatzas S,Venetsanou K,Grouzi E,Evagelopoulou P,Boutzouka E,Fildissis G,Spiliotopoulou I,Baltopoulos G

更新日期：2003-12-21 00:00:00

abstract：:It is known that both interleukin-4 (IL-4) and IL-13 are produced by Th2-type cells and share similar biological functions with each other. However, recently accumulated evidences have revealed that IL-4 may be involved in the Th1-type response. Both thymus and activation-regulated chemokine (TARC/CCL17), a ligand for...

journal_title：Cytokine

authors： Kakinuma T,Nakamura K,Wakugawa M,Yano S,Saeki H,Torii H,Komine M,Asahina A,Tamaki K

更新日期：2002-10-07 00:00:00

abstract：:Leishmania major, the causative agent of zoonotic cutaneous leishmaniasis shows heterogeneity and diverse clinical manifestations in different areas of infection and experimental models. Such polymorphism may cause difficulties in selection of reliable strains for development of prophylaxes. Hence, the aim of this stu...

journal_title：Cytokine

authors： Darabi S,Khaze V,Riazi-Rad F,Darabi H,Bahrami F,Ajdary S,Alimohammadian MH

更新日期：2015-12-01 00:00:00

abstract：:The chemokine eotaxin (CCL11) is a key player in the trafficking of eosinophils to normal tissues and in the tissue eosinophilia associated with human allergic disease. We have recently cloned equine eotaxin and here we report the production of rEq eotaxin, with and without a C-terminal fusion peptide, in a novel expr...

journal_title：Cytokine

authors： Benarafa C,Collins ME,Hamblin AS,Sabroe I,Cunningham FM

更新日期：2002-07-07 00:00:00

abstract：OBJECTIVE:Functions of the Th9 cells and its signature cytokine IL-9 in human autoimmune diseases is currently under extensive research. Here we are reporting new functions of IL-9-receptor (IL-9R); its regulatory role on (i) FLS (fibroblast like synoviocyte) biology and (ii) pannus formation in rheumatoid arthritis (R...

journal_title：Cytokine

authors： Raychaudhuri SK,Abria C,Maverakis EM,Raychaudhuri SP

更新日期：2018-11-01 00:00:00

abstract：:Pregnancy in sickle cell disease is a problem due to the adverse outcomes related to the disease. Research into the role of chemokines in sickle cell disease is available, but studies investigating the disease in pregnancy are scarce. Our data show the chemokine profiles of pregnant women with sickle cell disease comp...

journal_title：Cytokine

authors： Hazin-Costa MF,da Silva Aráujo A,Guerra GL,da Matta MC,Torres LC,Souza AI

更新日期：2019-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a notable chemokine that plays critical roles in angiogenesis and vasculogenesis. The contemporary body of literature contains a substantial amount of information regarding its chemical properties as well as its fundamental role in vascular development. Studies strongly ind...

journal_title：Cytokine

authors： Crafts TD,Jensen AR,Blocher-Smith EC,Markel TA

更新日期：2015-02-01 00:00:00

abstract：:Functional diversity of the memory T-cell-derived cytokine IL-17 was explored at the receptor level. IL-17 inhibited TNF-induced chemokine Rantes expression in human synovial fibroblasts and mouse lung fibroblasts. This inhibitory activity of IL-17 (IC50=0.2 ng/ml) was 6-fold more potent than its stimulatory activity ...

journal_title：Cytokine

authors： Schnyder B,Schnyder-Candrian S,Pansky A,Schmitz ML,Heim M,Ryffel B,Moser R

更新日期：2005-08-07 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a fast-growing cancer characterized by high occurrences of nodal and distant metastases and poor prognosis. It is therefore important to identify new serum biomarkers for the early diagnosis and prognostic prediction of this disease. The present study identifies biomarkers in NPC pati...

journal_title：Cytokine

authors： Gong D,Li Z,Ding R,Cheng M,Huang H,Liu A,Kang M,He H,Xu Y,Shao J,Wang Y,Duan C

更新日期：2019-06-01 00:00:00

abstract：:We have examined the effects of various antioxidants and inhibitors of redox-sensitive signal transduction pathways on induction of interleukin 8 (IL-8) gene by NO in monocytic U937 cells. We have observed that nitrosoglutathione or another NO-generating compound spermine NONOate caused significant accumulation of IL-...

journal_title：Cytokine

authors： Turpaev K,Litvinov D,Justesen J

更新日期：2003-07-01 00:00:00

abstract：:Colony stimulating factors (CSF) promote leukocyte survival by reducing apoptotic cell death. However, their effects on non-leukocyte cell types are unclear. Reduced apoptosis in colon epithelial cells is thought to contribute to the initiation of cancer. Here, we report diminished spontaneous apoptosis of human colon...

journal_title：Cytokine

authors： Calatayud S,Warner TD,Breese EJ,Mitchell JA

更新日期：2002-11-24 00:00:00

abstract：:The development of acidic environments is a hallmark of inflammatory processes of different etiology. We have previously shown that transient exposure to acidic conditions, similar to those encountered in vivo, induces the activation of neutrophils and the phenotypic maturation of dendritic cells. We here report that ...

journal_title：Cytokine

authors： Jancic CC,Cabrini M,Gabelloni ML,Rodríguez Rodrigues C,Salamone G,Trevani AS,Geffner J

更新日期：2012-02-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes including essential hypertension (EH). Associations of the IL-6 promoter region polymorphisms with circulating level of IL-6 have been reported in various studies. We detected the IL-6-597G/A polymorphism in 246 EH pati...

journal_title：Cytokine

authors： Gao SP,Pan M,Chen C,Ge LJ,Jiang MH,Luan H,Zheng JG,Deng XT,Pan HY,Zhu JH

更新日期：2011-07-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) is the major cytokine involved in the control of neutrophil development. G-CSF activates the special receptor, the G-CSF receptor (GCSF-R), which subsequently triggers multiple signaling events. To obtain more interactive molecules with GCSF-R and to further understand the...

journal_title：Cytokine

authors： Yuan X,Shan Y,Zhao Z,Chen J,Cong Y

更新日期：2006-02-21 00:00:00

abstract：:Interleukin 1alpha (IL-1alpha), a pleiotropic cytokine with multiple anti-tumour activities, has been investigated in our laboratory for its potential to serve as an immunotherapeutic agent. In the present study, an attempt was made to direct IL-1alpha to macrophages, in order to induce their immunoregulatory activiti...

journal_title：Cytokine

authors： Mullerad J,Cohen S,Voronov E,Apte RN

更新日期：2000-11-01 00:00:00

abstract：:Organ failure is associated with increased mortality and morbidity in patients with systemic inflammatory response syndrome. Previously, we showed that a short course of infusion of a hydrogen sulfide (H(2)S) donor reduced metabolism with concurrent reduction of lung injury. Here, we hypothesize that prolonged H(2)S i...

journal_title：Cytokine

authors： Aslami H,Beurskens CJ,de Beer FM,Kuipers MT,Roelofs JJ,Hegeman MA,Van der Sluijs KF,Schultz MJ,Juffermans NP

更新日期：2013-02-01 00:00:00

abstract：:Interleukin-4 (IL-4) is a pleiotropic cytokine with broad spectrum of biological effects on target cells. This study deals with the mammalian expression of canine IL-4 (cIL-4) in canine articular chondrocytes (CAC) and its ability to down-regulate pro-inflammatory cytokines, enzyme mediators and their catabolites. We ...

journal_title：Cytokine

authors： Rachakonda PS,Rai MF,Manning K,Schmidt MF

更新日期：2008-10-01 00:00:00

abstract：:This study investigated changes in the myokines IL-1β, IL-6, and TNF-α, as well as HSP72, after endurance training and after a session of downhill running. Twenty-eight rats were allocated to four different groups: 1. Eight weeks of endurance training at 65-70% VO2max (Trained); 2. Endurance training and a single sess...

journal_title：Cytokine

authors： Isanejad A,Saraf ZH,Mahdavi M,Gharakhanlou R,Shamsi MM,Paulsen G

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Granulocyte colony-stimulating factor (G-CSF) is the standard-of-care therapy for chemotherapy-associated neutropenia in patients with malignancies. Recent case reports have implied that G-CSF treatment may be associated with the development of aortitis, but the precise nature of the relationship is unclear....

journal_title：Cytokine

authors： Oshima Y,Takahashi S,Tani K,Tojo A

更新日期：2019-07-01 00:00:00

abstract：:Neuregulin-4 (Nrg4) is a novel adipokine associated with obesity, hyperglycemia, insulin resistance, dislipidemia, inflammation, and oxidative stress in mice and humans. However, no report has demonstrated the relationship of circulating Nrg4 with diabetic peripheral neuropathy (DPN). The objective of our study was to...

journal_title：Cytokine

authors： Yan P,Xu Y,Zhang Z,Gao C,Zhu J,Li H,Wan Q

更新日期：2019-01-01 00:00:00

abstract：:The authors evaluated the relationship between hormonal and cytokine responses after surgery. Patients who underwent thoracic oesophagectomy (O group; n = 7), pulmonary lobectomy (P group; n = 5), modified mastectomy (M group; n = 5) and laparoscopic cholecystectomy (LC group; n = 7), were randomly selected. Circulati...

journal_title：Cytokine

authors： Yamauchi H,Kobayashi E,Yoshida T,Kiyozaki H,Hozumi Y,Kohiyama R,Suminaga Y,Sakurabayashi I,Fujimura A,Miyata M

更新日期：1998-07-01 00:00:00