Epidermal growth factor, insulin-like growth factor-1 and basic fibroblast growth factor modulate the cytostatic effect of tumour necrosis factor-alpha on the breast cancer cell line, T47D.

abstract：:TNF-related apoptosis inducing ligand (TRAIL) plasma levels was measured in plasma samples obtained 1h (time 1) and 2-3 days (time 2) after delivery in a group of healthy women (n=17) who underwent cesarean delivery, and showed a significantly increase from time 1 (39.3 pg/ml median; 41.2 ± 15.9 mean ± SD) to time 2 (...

journal_title：Cytokine

authors： Zauli G,Monasta L,Vecchi Brumatti L,Agnoletto C,Volpi P,Secchiero P

更新日期：2013-10-01 00:00:00

abstract：:The gene for ISG12 (originally designated p27) was isolated as an oestrogen-induced gene. The authors undertook a comprehensive study using quantitative RT-PCR, in which we delineate the regulation of ISG12 by seven different cytokines including interferons and poly(I). poly(C) in seven human cell lines of different o...

journal_title：Cytokine

authors： Gjermandsen IM,Justesen J,Martensen PM

更新日期：2000-03-01 00:00:00

abstract：:Dendritic cell-based vaccines are considered as a new and promising immunotherapeutic approach for cancer treatment. However, the choice of optimal protocol of dendritic cell generation in vitro represents the major challenge. Here, we compared phenotype and functional characteristics of human monocyte-derived dendrit...

journal_title：Cytokine

authors： Leplina OY,Tyrinova TV,Tikhonova MA,Ostanin AA,Chernykh ER

更新日期：2015-01-01 00:00:00

abstract：:The self-renewal capacity of germline derived stem cells (GSCs) makes them an ideal source for research and use in clinics. Despite the presence of active gene network similarities between embryonic stem cells (ESCs) and GSCs, there are unanswered questions regarding the roles of evolutionary conserved genes in GSCs. ...

journal_title：Cytokine

authors： Farshchian M,Matin MM,Armant O,Geerts D,Dastpak M,Nakhaei-Rad S,Tajeran M,Jebelli A,Shahriyari M,Bahrami M,Fallah A,Yaghoobi V,Mirahmadi M,Abbaszadegan MR,Bahrami AR

更新日期：2018-06-01 00:00:00

abstract：:Purpose suppressor of cytokine signaling 1 (SOCS-1) is inducible feedback inhibitors of cytokine signaling and involved in viral infection through regulation of both innate and adaptive immunity. In this study, we firstly cloned SOCS-1 (goSOCS-1) from duck Tembusu virus (DTMUV) infected goose. The full-length sequence...

journal_title：Cytokine

authors： Zhang W,Chen S,Zhang J,Wu Z,Wang M,Jia R,Zhu D,Liu M,Sun K,Yang Q,Wu Y,Chen X,Cheng A

更新日期：2017-05-01 00:00:00

abstract：:Thalidomide has antiangiogenic and immunomodulatory effects, mediated by several cytokines such as vascular endothelial growth factor (VEGF), fibroblastic growth factor (FGF-2), hepatocyte growth factor (HGF), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). Although extramedullary plasmacytomas (EMP)...

journal_title：Cytokine

authors： Rosiñol L,Cibeira MT,Segarra M,Cid MC,Filella X,Aymerich M,Rozman M,Arenillas L,Esteve J,Bladé J,Montserrat E

更新日期：2004-05-21 00:00:00

abstract：BACKGROUND:Dysregulated production of TNF has been implicated in the pathogenesis and severity of inflammatory rheumatic diseases, many of which show age-related increased incidence. Ageing is also associated with changes in the immune system including higher systemic levels of pro-inflammatory cytokines. Methylation o...

journal_title：Cytokine

authors： Gowers IR,Walters K,Kiss-Toth E,Read RC,Duff GW,Wilson AG

更新日期：2011-12-01 00:00:00

abstract：AIM:How irreversible electroporation (IRE) affect immune status is still kept unknown. This preclinical study is to investigate its local and systemic immune reaction both on tumor-bearing and tumor free animals. METHODS:Liver ablation was performed by a standard IRE instrument and proposal. Altogether 57 tumor bearin...

journal_title：Cytokine

authors： Chen X,Ren Z,Yin S,Xu Y,Guo D,Xie H,Zhou L,Wu L,Jiang J,Li H,Sun J,Zheng S

更新日期：2017-05-01 00:00:00

abstract：:Atherosclerosis is an inflammatory disease of the vasculature regulated by cytokines. Macrophages play a crucial role at all stages of this disease, including regulation of foam cell formation, the inflammatory response and stability of atherosclerotic plaques. For example, matrix metalloproteinases produced by macrop...

journal_title：Cytokine

authors： Ashlin TG,Kwan AP,Ramji DP

更新日期：2013-10-01 00:00:00

abstract：:The in vivo influence of recombinant human erythropoietin (rhEpo) and iron on human neutrophil (PMN) antimicrobial function was assessed. A total of 21 preterm infants were randomized to receive either 200 U/kg/other day of rHuEPO+12 mg/kg/day of iron (EPO+high Fe, seven infants) or 200 U/kg/other day of rhEPO+4 mg/kg...

journal_title：Cytokine

authors： Soubasi V,Roilides E,Tsantali C,Mussafiris K,Tsakiris D,Kremenopoulos G

更新日期：1999-01-01 00:00:00

abstract：:Acute respiratory distress syndrome following an acute lung injury (ALI) is a life threatening inflammatory condition predominantly characterized by vascular protein leakage, neutrophil recruitment and overexpression of proinflammatory cytokines. Pulmonary and systemic bacterial infections are the major cause of ALI w...

journal_title：Cytokine

authors： Trivedi J,Shaikh J,Chavan N,Thorve D,Chaudhary B,Karade A,Gupta S,Patel A,Bhagwat S

更新日期：2020-05-01 00:00:00

abstract：:Thrombopoietin (TPO) plays a pivotal role in megakaryopoiesis. TPO initiates its biological effects by binding to its receptor Mpl. A recombinant protein consisting of a carrier Fc domain linked to multiple Mpl-binding domains was constructed, and is called AMG531. To define the biological activity of AMG531, we exami...

journal_title：Cytokine

authors： Broudy VC,Lin NL

更新日期：2004-01-21 00:00:00

abstract：:Tumor Necrosis Factor alpha (TNFα, TNF) is a key mediator and regulator of mammalian immune responses in healthy organisms and in diseased conditions. TNF governs development of the immune system, cell survival signaling pathways, proliferation and regulates metabolic processes. Whereas TNF-induced NF-κB and MAP pro-s...

journal_title：Cytokine

authors： Varfolomeev E,Vucic D

更新日期：2018-01-01 00:00:00

abstract：:Tumour necrosis factor alpha (TNF-alpha) plays an important role in orchestrating inflammatory responses with the vascular endothelium as main target cell type, and was found to promote migration of endothelial cells, as occurs in wound healing processes. Substantial evidence exists that endothelial cell migration in ...

journal_title：Cytokine

authors： van Rijen HV,van Kempen MJ,Postma S,Jongsma HJ

更新日期：1998-04-01 00:00:00

abstract：:The authors describe the design and validation of a competitive RT-PCR method for the efficient and reproducible quantitation of mRNA molecules of IFN-gamma, TNF-alpha, IL-4 and IL-10 in mouse spleen RNA extracts. Before being subjected to RT-PCR, the RNA extracts were supplemented with internal control RNAs (IC-RNAs)...

journal_title：Cytokine

authors： Zhou NM,Matthys P,Polacek C,Fiten P,Sato A,Billiau A,Froyen G

更新日期：1997-03-01 00:00:00

abstract：:Asthma and type I diabetes are major causes of chronic illness in childhood which, according to the current paradigm, have mutually antagonistic immunopathologies. Nonetheless, the disorders appear to preferably coexist both on population and individual levels. To assess whether children with asthma and type I diabete...

journal_title：Cytokine

authors： Kainonen E,Rautava S,Korkeamäki M,Isolauri E

更新日期：2006-05-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis is stimulated during immune and inflammatory processes. Interleukin 1beta (IL-1beta) and lipopolysaccharide (LPS) are known to be potent stimulators of this axis. During postnatal development, the rat seems to be hyporesponsive to many stimuli. The effects of repeated syst...

journal_title：Cytokine

authors： Bumiller A,Götz F,Rohde W,Dörner G

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Interleukin (IL)-17A is proinflammatory cytokine produced by Th17 cells, which play key, but sometimes inconsistent role in autoimmunity and cancer. Polymorphic variants in IL-17A gene were differentially associated with susceptibility to cancer, including colorectal cancer (CRC). AIM:We investigated the as...

journal_title：Cytokine

authors： Bedoui SA,Barbirou M,Stayoussef M,Dallel M,Mokrani A,Makni L,Mezlini A,Bouhaouala B,Yacoubi-Loueslati B,Almawi WY

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Egypt has a high prevalence of hepatitis C virus (HCV) infection. Limitations of the current HCV treatment in children are low rate of sustained virological response, significant side effects and high expenses, making prediction of treatment response crucial. AIM:This study aimed to investigate association ...

journal_title：Cytokine

authors： Rady NH,Darwish RK,Mogahed EA,Mandour IA,Abo Youssef H,Sharaf SA,El-Karaksy HM

更新日期：2015-10-01 00:00:00

abstract：:We have isolated and sequenced a cDNA that contains the coding sequence of porcine interleukin 18 (IL-18) and the recombinant protein of porcine IL-18 was expressed using the baculovirus system. The open reading frame (ORF) of the porcine IL-18 cDNA is 579 base pairs (bp) in length and encodes 192 amino acids. The pre...

journal_title：Cytokine

authors： Muneta Y,Mori Y,Shimoji Y,Yokomizo Y

更新日期：2000-06-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF) is expressed on the cell surface as a transmembrane form (tmTNF), that can be released as a soluble form (solTNF) via proteolytic cleavage. These two types of TNF exert their biological functions by binding to one of two TNF receptors, TNFR1 or TNFR2. However, the biological function ...

journal_title：Cytokine

authors： Shibata H,Abe Y,Yoshioka Y,Nomura T,Sato M,Kayamuro H,Kawara T,Arita S,Furuya T,Nagano K,Yoshikawa T,Kamada H,Tsunoda S,Tsutsumi Y

更新日期：2010-04-01 00:00:00

abstract：:Studies have shown that following bacterial infection or endotoxin administration, immune functions are regulated differently in mice of different genetic background. Since the susceptibility to sepsis following trauma-hemorrhage is dependant on the severity of injury, it is important to determine whether genetic back...

journal_title：Cytokine

authors： Matsutani T,Anantha Samy TS,Kang SC,Bland KI,Chaudry IH

更新日期：2005-05-21 00:00:00

abstract：:Muscle wasting is a decline in skeletal muscle mass and function that is associated with aging, obesity, and a spectrum of pathologies including cancer. Cancer-associated wasting not only reduces quality of life, but also directly impacts cancer mortality, chemotherapeutic efficacy, and surgical outcomes. There is an ...

journal_title：Cytokine

authors： Hogan KA,Cho DS,Arneson PC,Samani A,Palines P,Yang Y,Doles JD

更新日期：2018-07-01 00:00:00

abstract：:CC Chemokine ligand 22 (Ccl22) is a selective, high affinity ligand at the CC chemokine receptor 4 (Ccr4). We have identified cDNAs encoding both ligand and receptor of the Ccl22-Ccr4 pair in cDNA libraries of the anterior hypothalamus/pre-optic area (AH/POA) by PCR. The AH/POA is the key brain region where endogenous...

journal_title：Cytokine

authors： Osborn O,Sanchez-Alavez M,Dubins JS,Gonzalez AS,Morrison B,Hadcock JR,Bartfai T

更新日期：2011-03-01 00:00:00

abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. Image duplication has been observed within Figure 1g-h. The corresponding author has been a...

journal_title：Cytokine

authors： Galloway C,Chattopadhyay M

更新日期：2013-07-01 00:00:00

abstract：:Circulating interleukin (IL)-6 and IL-10 concentrations can be elevated following the surgically induced trauma of total knee arthroplasty (TKA). An exaggerated increase in IL-6 relative to IL-10 (i.e., IL-6/IL-10 ratio) associates with trauma severity and indicative of pro-inflammatory predominance. Although various ...

journal_title：Cytokine

authors： Barker T,Henriksen VT,Rogers VE,Trawick RH,Momberger NG,Lynn Rasmussen G

更新日期：2021-01-23 00:00:00

abstract：:Interleukin (IL-) 2 and IL-15 share the IL-2 receptor betagamma c subunits (IL-2Rbetagamma c) but have specific, unique alpha receptor subunits. We studied species specificity of human (hu), simian (si), and mouse (mu) IL-15 and found that hu and si IL-15 behaved similarly in all systems investigated. Hu and mu IL-15 ...

journal_title：Cytokine

authors： Eisenman J,Ahdieh M,Beers C,Brasel K,Kennedy MK,Le T,Bonnert TP,Paxton RJ,Park LS

更新日期：2002-11-07 00:00:00

abstract：BACKGROUND:Although transforming growth factor-beta (TGF-beta), a growth regulator of hepatocytes, induces cell death under pathological conditions, responsiveness of hepatocytes to hypoxic stimulus has not been fully defined. This study aimed at investigating the role of TGF-beta1 in hypoxia-induced hepatotoxicity usi...

journal_title：Cytokine

authors： Kao YH,Jawan B,Goto S,Pan MC,Lin YC,Sun CK,Hsu LW,Tai MH,Cheng YF,Nakano T,Wang CS,Huang CJ,Chen CL

更新日期：2009-07-01 00:00:00

abstract：:Recent evidence indicates that the rate of progression of the HIV-1 disease is significantly reduced in thalassaemia major patients upon treatment with high doses of desferrioxamine (DFX). The authors have previously demonstrated that in vitro exposure of mononuclear cells to DFX decreases the bioavailability of tumou...

journal_title：Cytokine

authors： Bellocq A,Israël-Biet D,Cadranel J,Perez J,Fouqueray B,Kanfer A,Girot R,Baud L

更新日期：1999-02-01 00:00:00

abstract：:Azidothymidine (AZT)-induced anemia in mice can be reversed by the administration of IGF-IL-3 (fusion protein of insulin-like growth factor II (IGF II) and interleukin 3). Although interleukin 3 (IL-3) and erythropoietin (EPO) are known to act synergistically on hematopoietic cell proliferation in vitro, injection of ...

journal_title：Cytokine

authors： DiFalco MR,Congote LF

更新日期：2002-04-07 00:00:00