Abstract:
:Acute respiratory distress syndrome following an acute lung injury (ALI) is a life threatening inflammatory condition predominantly characterized by vascular protein leakage, neutrophil recruitment and overexpression of proinflammatory cytokines. Pulmonary and systemic bacterial infections are the major cause of ALI wherein the bacterial cell components play a crucial role. Macrolide/ketolide antibiotics are reported to possess immunomodulatory activity; as a result improved survival has been noted in pneumonia patients. Hence immunomodulatory activity of nafithromycin, a novel lactone ketolide antibacterial agent was assessed in the murine LPS induced ALI model. Vehicle, nafithromycin (100 mg/kg), azithromycin (600 mg/kg) and dexamethasone (20 mg/kg) were administered orally, 1 h prior to LPS challenge and bronchoalveolar lavage (BAL) fluid was collected thereafter at 18, 24 and 48 h to determine the total cell count, total protein, myeloperoxidase (MPO), tumor necrosis factor (TNF)-α and interleukin (IL)-6. Results from the current study showed that pretreatment with nafithromycin significantly reduced the total cell count, total protein, MPO, TNF-α and IL-6 levels in BAL fluid compared to LPS control group. Histopathological evaluations also suggest significant reduction in neutrophil infiltration by nafithromycin. Dexamethasone, a positive reference standard as expected exhibited potent anti-inflammatory activity. The immunomodulatory effect of nafithromycin at dose of 100 mg/kg was comparable to azithromycin dosed at 600 mg/kg. As a result of immunomodulatory activity, nafithromycin is expected to provide additional clinical benefits by resolving the secondary complications associated with severe pneumonia and thereby improving survival in such patients.
journal_name
Cytokinejournal_title
Cytokineauthors
Trivedi J,Shaikh J,Chavan N,Thorve D,Chaudhary B,Karade A,Gupta S,Patel A,Bhagwat Sdoi
10.1016/j.cyto.2020.155049subject
Has Abstractpub_date
2020-05-01 00:00:00pages
155049eissn
1043-4666issn
1096-0023pii
S1043-4666(20)30065-Xjournal_volume
129pub_type
杂志文章相关文献
CYTOKINE文献大全abstract::Our aim was to explore the putative beneficial effects of low-to-moderate intensity exercise training program in patients with irritable bowel syndrome (IBS). This study evaluated the changes in blood oxidative stress status, inflammatory biomarkers and IBS severity symptoms following 24 weeks of moderate aerobic exer...
journal_title:Cytokine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.cyto.2017.12.016
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:HIV-1 and HIV-2 are two related viruses with distinct clinical outcomes, where HIV-1 is more pathogenic and transmissible than HIV-2. The pathogenesis of both infections is influenced by the dysregulation and deterioration of the adaptive immune system. However, their effects on the responsiveness of innate ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.03.003
更新日期:2009-06-01 00:00:00
abstract::We investigated the effects of two low doses of interferon-alpha (IFN-alpha) on nocturnal sleep in 18 healthy men by means of polysomnographic sleep recordings. At 1900h, human recombinant IFN-alpha (1000 or 10000 U/kg body weight) or placebo was administered subcutaneously. Between 2300h and 0700h subjects were allow...
journal_title:Cytokine
pub_type: 临床试验,杂志文章
doi:10.1006/cyto.1999.0587
更新日期:2000-05-01 00:00:00
abstract:CONTEXT:CTLA-4 is engaged on effector cells that may alter signal transduction and subsequently cytokine production. The transmission of longer repeats of (AT)(n) alleles of CTLA-4 is also associated with women undergoing recurrent miscarriage. The TNF-α known as an embryo-toxic cytokine is reported to be greater in pl...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.05.018
更新日期:2012-11-01 00:00:00
abstract::The present study aimed to assess the kinetics of cytokine release and compare the accuracy of serum biomarkers for the diagnosis of macrophage activation syndrome (MAS) associated with Kawasaki disease (KD). Serum neopterin, interleukin (IL)-18, IL-6 and soluble tumour necrosis factor receptor type I (sTNFR-I) and sT...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2019.03.001
更新日期:2019-07-01 00:00:00
abstract::The hyper-inflammatory response is thought to be a major cause of acute respiratory distress syndrome (ARDS) in patients with COVID-19. Although multiple cytokines are reportedly associated with disease severity, the key mediators of SARS-CoV-2 induced cytokine storm and their predictive values have not been fully elu...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155365
更新日期:2021-02-01 00:00:00
abstract::Tumour necrosis factor (TNF) is a major mediator in septic shock and several inflammatory diseases such as hepatitis. Galactosamine (GalN) sensitises experimental animals for TNF and the combination TNF/GalN leads to a lethal inflammatory hepatitis. We describe that a single injection of lipopolysaccharide (LPS), inte...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2001.0912
更新日期:2001-07-21 00:00:00
abstract::The present study demonstrates that liposomes coated with synthesized neoglycolipids constructed from mannotriose and dipalmitoylphosphatidylethanolamine (Man3-DPPE) activate peritoneal macrophages (PEMs) to up-regulate expression of co-stimulatory molecules and preferentially secrete IL-12. Injection of Man3-DPPE-coa...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.10.005
更新日期:2007-12-01 00:00:00
abstract::Previous studies identified the variant IFNG +874A/T (rs2430561) in the first intron of the gene in association with mycobacterial infection, especially tuberculosis and leprosy. The aim of this investigation was to analyze the protective role of the T allele in relation to leprosy using a meta-analysis evaluation. Th...
journal_title:Cytokine
pub_type: 杂志文章,meta分析
doi:10.1016/j.cyto.2013.12.002
更新日期:2014-02-01 00:00:00
abstract::During the quarter of a century since TNF was isolated, much knowledge has been gained of the identity of other ligands besides TNF in the TNF cytokine family, and of the proximal signaling molecules that these ligands activate. The numerous laboratories contributing to this advance have approached TNF research from v...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2013.05.027
更新日期:2013-09-01 00:00:00
abstract::Burn injury is associated with profound inflammation and activation of the innate immune system involving gammadelta T-cells. Similarly, Toll-like receptors (TLR) are associated with activation of the innate immune response; however, it is unclear whether TLR expression is altered in gammadelta T-cells after major bur...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.09.001
更新日期:2008-12-01 00:00:00
abstract::Neutrophil-activating peptide 1/interleukin 8 (NAP-1/IL-8) is a recently described cytokine with potent chemotactic activity for human neutrophil granulocytes (PMN) and T cells. In psoriasis, a chronic hyperproliferative and inflammatory skin disorder, PMN and T cells are found as prominent cells in the inflammatory i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(91)90500-d
更新日期:1991-07-01 00:00:00
abstract::The kynurenine pathway (KP) is the major metabolic route of tryptophan (Trp) metabolism. Indoleamine 2,3-dioxygenase (IDO1), the enzyme responsible for the first and rate-limiting step in the pathway, as well as other enzymes in the pathway, have been shown to be highly regulated by cytokines. Hence, the KP has been i...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2017.09.004
更新日期:2019-10-01 00:00:00
abstract::Obesity is closely associated with increased production of pro-inflammatory adipokines, including interleukin (IL)-6, plasminogen activator inhibitor (PAI)-1, and adipose-tissue-derived monocyte chemoattractant protein (MCP)-1, which contribute to chronic and low-grade inflammation in adipose tissue. Harpagoside, a ma...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2015.05.015
更新日期:2015-12-01 00:00:00
abstract::Thrombopoietin (TPO) plays a pivotal role in megakaryopoiesis. TPO initiates its biological effects by binding to its receptor Mpl. A recombinant protein consisting of a carrier Fc domain linked to multiple Mpl-binding domains was constructed, and is called AMG531. To define the biological activity of AMG531, we exami...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2003.05.001
更新日期:2004-01-21 00:00:00
abstract::Atherosclerosis is an inflammatory disease of the vasculature regulated by cytokines. Macrophages play a crucial role at all stages of this disease, including regulation of foam cell formation, the inflammatory response and stability of atherosclerotic plaques. For example, matrix metalloproteinases produced by macrop...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.06.315
更新日期:2013-10-01 00:00:00
abstract::Interferon (IFN)-alpha and -beta are important antiviral mediators. IFN-alpha is widely used for the treatment of chronic hepatitis B. In our previous studies, a subtype of woodchuck IFN-alpha (wIFN-alpha) was characterized and has been shown to be active in suppressing the replication of woodchuck hepatitis virus (WH...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.11.002
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:The aetiology of postdialysis fatigue (PDF), an intermittent but debilitating fatigue occurring after haemodialysis (HD) treatment, is still unclear. In other inflammatory diseases, increasing evidence points toward the involvement of the immune system in the onset of fatigue symptoms. Altered serum levels o...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155223
更新日期:2020-11-01 00:00:00
abstract::Leptin is considered an adipokine, however, cultured myocytes have also been found to release leptin. Therefore, as proof-of-concept we investigated if human skeletal muscle synthesized leptin by measuring leptin in skeletal muscle biopsies. Following this, we quantified human skeletal muscle and adipose tissue leptin...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.08.021
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the signaling mechanisms surrounding changes in tight junction (TJ) and the permeability of human intestinal epithelial cell induced by tumor necrosis factor-alpha (TNF-α). METHODS:To confirm that TNF-α induces epithelial barrier hyperpermeability by disrupting tight ju...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.04.008
更新日期:2012-08-01 00:00:00
abstract::Neuropilin-1 (NRP-1) is a co-receptor for vascular endothelial growth factor (VEGF). During neovascularization, vascular smooth muscle cells (VSMCs) and pericytes modulate the function of endothelial cells. Factors that mediate NRP-1 in human VSMCs (hVSMCs) remain to be elucidated. We studied various angiogenic cytoki...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2005.09.009
更新日期:2005-12-07 00:00:00
abstract::Interactions between interleukin 8 (IL-8) and endothelial cells play an important role in the emigration of mononuclear cells from the blood into areas of inflammation. We examined the ability of specific second-line antirheumatic drugs to regulate (IL-8) gene expression and protein secretion in interleukin 1 (IL-1) s...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(92)90085-6
更新日期:1992-09-01 00:00:00
abstract::Cartilage-specific extracellular matrix synthesis is the prerequisite for chondrocyte survival and cartilage function, but is affected by the pro-inflammatory cytokine TNF-alpha in arthritis. The aim of the present study was to characterize whether the immunoregulatory cytokine IL-10 might modulate cartilage matrix an...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.10.012
更新日期:2008-12-01 00:00:00
abstract::The human interferon alpha-receptor (IFNAR gene product or IFN alpha R protein) was expressed in hamster CHO cells and in mouse A9 cells. The response of the IFN alpha R cDNA transfectants to human IFNs was studied by measuring induction of (2'-5') A synthetase (2'-5' AS). In the murine cells, the IFN alpha R protein ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(94)90066-3
更新日期:1994-07-01 00:00:00
abstract::In a previous work we demonstrated that monoclonal antibody (mAb) 8C2 recognized a human granulocyte-colony stimulating factor (hG-CSF) region left unmasked after binding to placenta receptors, whereas mAb 6E3 defined a receptor-buried epitope. Herein we examined the role of these antigenic regions on the proliferativ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/s1043-4666(03)00099-1
更新日期:2003-04-01 00:00:00
abstract::Interleukin-21 (IL-21) is overproduced in human intestines affected by inflammatory bowel disease (IBD) and in the gut of mice with DSS-induced colitis. IL-21-deficient mice are largely protected against DSS-induced colitis, indicating that IL-21 plays a key role in the development of IBD. We previously identified a n...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.03.006
更新日期:2013-05-01 00:00:00
abstract::Cytokines are key mediators of immune responses to autoantigens, tumor antigens and foreign antigens including pathogens and transplant antigens. The cytokines are produced by a variety of immune and non-immune cells and are dynamically regulated. Remarkably, during toxic and septic shock syndromes, anaphylactic shock...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155320
更新日期:2020-10-27 00:00:00
abstract::Proteolytic activation of the IL-33 precursor, full-length interleukin-33 (FLIL33), at multiple sites within the sensor domain (aa 95-109) yields several functionally mature (MIL33) forms. Unlike nuclear FLIL33, intracellular MIL33 occurs in the cytoplasm, is secreted from source cells, and exerts biological effects b...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2019.02.015
更新日期:2019-07-01 00:00:00
abstract::Oncostatin M (OSM) and leukaemia inhibitory factor (LIF) exhibit pleiotropic biological activities and share many structural and genetic features. The two cytokines bind with high affinity to the same receptor (LIF/OSM receptor), which consists of the LIF receptor alpha chain (LIFRalpha) and the signal transduction un...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1999.0550
更新日期:2000-02-01 00:00:00
abstract:AIMS:There is interest in using blood C-reactive protein (CRP) to predict adverse prognosis outcomes patients with type 2 diabetes. This meta-analysis aimed to investigate the association between elevated baseline CRP level and unfavorable outcomes in type 2 diabetes patients. MATERIALS/METHODS:PubMed and Embase datab...
journal_title:Cytokine
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.cyto.2019.02.005
更新日期:2019-05-01 00:00:00