Neutrophil-activating peptide 1/interleukin 8 mRNA expression and protein secretion by human monocytes: effect of cyclosporin A.

abstract：AIMS:Interleukin-2 has a significant antitumor activity in some types of cancer, and has been associated with the development of atrial fibrillation (AF). In addition, IL-2 serum levels in recent onset AF have been related with pharmaceutical cardioversion outcomes. We evaluated the hypothesis that a relationship exist...

journal_title：Cytokine

authors： Cabrera-Bueno F,Medina-Palomo C,Ruiz-Salas A,Flores A,Rodríguez-Losada N,Barrera A,Jiménez-Navarro M,Alzueta J

更新日期：2015-05-01 00:00:00

abstract：:Dysregulation of cytokines synthesis is thought to play a role in the development of a number of age-related conditions, such as rheumatoid arthritis, osteoporosis, atherosclerosis, and others, but observational studies have led to contradictory results. We investigated potential familial influences on the plasma leve...

journal_title：Cytokine

authors： Pantsulaia I,Trofimov S,Kobyliansky E,Livshits G

更新日期：2002-08-07 00:00:00

abstract：:Lung cancer is a common malignant disease, nearly 2.09 million new patients occurred last year. Approximately 85% of the patients are classified as non-small-cell lung cancer (NSCLC). It is therefore important to identify new diagnostic and prognostic biomarkers for the early detection of this disease. The presented s...

journal_title：Cytokine

authors： Cai D,Xu Y,Ding R,Qiu K,Zhang R,Wang H,Huang L,Xie X,Yan H,Deng Y,Lin X,Shao J,Luo X,Duan C

更新日期：2020-02-01 00:00:00

abstract：:The aim of the present study was to verify the expression of tumour necrosis factor (TNF)-alpha mRNA by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) in unstimulated peripheral blood mononuclear cells (MNCs) of 15 relapsing-remitting multiple sclerosis (MS) patients who underwent treatment ...

journal_title：Cytokine

authors： Sarchielli P,Critelli A,Greco L,Sokola E,Floridi A,Gallai V

更新日期：2001-06-07 00:00:00

abstract：:Ocular trauma affects 20% of Americans in their lifetime and can cause permanent visual system damage. We have used a mouse model of ocular trauma (exposure to an air blast from a paintball gun) to examine pathways that trigger the resulting retinal damage and to develop treatment strategies that might ameliorate the ...

journal_title：Cytokine

authors： Jiang Y,Pagadala J,Miller DD,Steinle JJ

更新日期：2014-12-01 00:00:00

abstract：:HIV infection is associated with chronic inflammation in both non-treated and treated patients. TLR-dependent mechanisms are strongly involved in the maintenance of this inflammation. Indeed, the residual replication of HIV, the potential viral co-infections, or the products issued from microbial translocation provide...

journal_title：Cytokine

authors： Leite Pereira A,Tchitchek N,Marcos Lopez E,Lambotte O,Le Grand R,Cosma A

更新日期：2018-11-01 00:00:00

abstract：:Tumor necrosis factor (TNF) and the members of the interferon (IFN) family are major inducible cytokines that function to counteract viral infections or cellular transformation. Recently, our lab has characterized a novel antiviral state which is induced in primary human fibroblasts by co-treatment with TNF plus IFNbe...

journal_title：Cytokine

authors： Bartee E,McFadden G

更新日期：2009-09-01 00:00:00

abstract：:The gene for ISG12 (originally designated p27) was isolated as an oestrogen-induced gene. The authors undertook a comprehensive study using quantitative RT-PCR, in which we delineate the regulation of ISG12 by seven different cytokines including interferons and poly(I). poly(C) in seven human cell lines of different o...

journal_title：Cytokine

authors： Gjermandsen IM,Justesen J,Martensen PM

更新日期：2000-03-01 00:00:00

abstract：:The gene for C10, a member of the beta-chemokine family of cytokines, contains a novel second exon encoding a 16 amino acid sequence which is inserted into the amino-terminal region of the protein. We propose a model of C10 structure in which the sequence encoded by the second exon is located on the surface of the pro...

journal_title：Cytokine

authors： Berger MS,Taub DD,Orlofsky A,Kleyman TR,Coupaye-Gerard B,Eisner D,Cohen SA

更新日期：1996-06-01 00:00:00

abstract：:Although G-CSF mobilized peripheral blood stem cell (PBSC) transplantation is commonly used in adults, bone marrow (BM) is still the preferred stem cell source in pediatric stem cell transplantation. Despite the fact that G-CSF is increasingly being used to enhance the hematopoietic stem/progenitor cell (HSPC) yield i...

journal_title：Cytokine

authors： Aerts-Kaya F,Kilic E,Köse S,Aydin G,Cagnan I,Kuskonmaz B,Uckan-Cetinkaya D

更新日期：2020-12-28 00:00:00

abstract：:Asthma and type I diabetes are major causes of chronic illness in childhood which, according to the current paradigm, have mutually antagonistic immunopathologies. Nonetheless, the disorders appear to preferably coexist both on population and individual levels. To assess whether children with asthma and type I diabete...

journal_title：Cytokine

authors： Kainonen E,Rautava S,Korkeamäki M,Isolauri E

更新日期：2006-05-01 00:00:00

abstract：:Studies have shown that following bacterial infection or endotoxin administration, immune functions are regulated differently in mice of different genetic background. Since the susceptibility to sepsis following trauma-hemorrhage is dependant on the severity of injury, it is important to determine whether genetic back...

journal_title：Cytokine

authors： Matsutani T,Anantha Samy TS,Kang SC,Bland KI,Chaudry IH

更新日期：2005-05-21 00:00:00

abstract：BACKGROUND:It has been demonstrated that cardiac fibroblasts of the human heart have several myocyte-like features, induced by inflammation. OBJECTIVES:This study analyzed the changes of the expressed currents in the basal condition and in the presence of interleukin-6 in cultured human cardiac fibroblasts. METHODS:H...

journal_title：Cytokine

authors： Mitrokhin V,Kazanski V,Kalsin V,Mladenov M,Kamkin A

更新日期：2017-09-01 00:00:00

abstract：:Cytokine profiles were studied during 19 episodes of chemotherapy-induced neutropenia in 17 patients with haematological malignancies. Circulating concentrations of interleukin 1 alpha (IL-1 alpha), tumour necrosis factor alpha (TNF-alpha) and IL-1 receptor antagonist (IL-1ra) were measured before chemotherapy and the...

journal_title：Cytokine

authors： Denecker NE,Kullberg BJ,Drenth JP,Raemaekers JM,Van der Meer JW

更新日期：1997-09-01 00:00:00

abstract：:Specific high titre polyclonal antibodies rapidly obtained by intralymphnode immunization of rabbits with recombinant M-CSF and LIF (< 60 micrograms/animal) have been used to develop specific, accurate and sensitive EIAs. The same batch of purified anti-M-CSF or anti-LIF Igs has been used for the coating of 96-well pl...

journal_title：Cytokine

authors： Fixe P,Lorgeot V,Le Meur Y,Coupey L,Heymann D,Godard A,Praloran V

更新日期：1996-07-01 00:00:00

abstract：:The purpose of these studies was to test whether pentoxifylline, a drug that can inhibit the production and action of cytokines hypothesized to be endogenous pyrogens (for example, interleukin 1 and tumor necrosis factor [TNF]), is antipyretic. We also tested the effects of pentoxifylline on plasma activities of inter...

journal_title：Cytokine

authors： LeMay LG,Vander AJ,Kluger MJ

更新日期：1990-07-01 00:00:00

abstract：:Imbalance in the production of cytokines and their inhibitors plays a part in inflammation in chronic destructive diseases. Direct cell-cell contact with stimulated T cells markedly induces the production of pro-inflammatory cytokines and matrix metalloproteinases in monocytes. This study demonstrates that direct cont...

journal_title：Cytokine

authors： Vey E,Dayer JM,Burger D

更新日期：1997-07-01 00:00:00

abstract：:Published data on the association between CYP1A1 gene polymorphism and ovarian cancer risk are conflicting and heterogeneous. To derive a more precise estimation of the relationship, a meta-analysis was performed. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were performed for heterozygous, homozyg...

journal_title：Cytokine

authors： Huang M,Chen Q,Xiao J,Zhao X,Liu C

更新日期：2012-04-01 00:00:00

abstract：:Although physical therapy has been shown to be an effective method for treatment of rheumatoid arthritis, a thorough investigation on the impact of mechanical signals upon the complex cytokine network associated with pathogenesis has not yet been conducted. In the current study, our research group investigated the eff...

journal_title：Cytokine

authors： Bader RA,Wagoner KL

更新日期：2010-07-01 00:00:00

abstract：:Numerous proteins are cleaved or "shed" from their membrane-bound form. One such protein, tumour necrosis factor alpha (TNF-alpha), is synthesized as a type 2 transmembrane protein. Recently, a human protease responsible for this shedding, the TNF-alpha converting enzyme (TACE/ADAM17), was isolated. TACE/ADAM17 is a m...

journal_title：Cytokine

authors： Cerretti DP,Poindexter K,Castner BJ,Means G,Copeland NG,Gilbert DJ,Jenkins NA,Black RA,Nelson N

更新日期：1999-08-01 00:00:00

abstract：:A recombinant human GM-CSF-EPO hybrid protein named MEN 11300 was administered biweekly for a total of 6 weeks to rhesus monkeys in order to evaluate its pharmacokinetic behaviour, tolerability and immunogenicity. In this primate species a strong antibody response was induced which neutralized the in vitro biological ...

journal_title：Cytokine

authors： Coscarella A,Liddi R,Di Loreto M,Bach S,Faiella A,van der Meide PH,Mele A,De Santis R

更新日期：1998-12-01 00:00:00

abstract：:Kawasaki disease is a multi-system vasculitis and a primary cause of acquired heart disease among children. Genetic factors may increase susceptibility to Kawasaki disease. TBXA2R is a G-protein-coupled receptor that participates in tissue inflammation and is associated with susceptibility to several diseases, but its...

journal_title：Cytokine

authors： Che D,Pi L,Xu Y,Fu L,Zhou H,Wang Z,Huang P,Zhang L,Gu X

更新日期：2018-11-01 00:00:00

abstract：:Previous studies have suggested that heterotrimeric G(i) proteins, Src tyrosine kinase and phosphatidylinositol-3 kinase (PI3 Kinase) are involved in signaling events induced by lipopolysaccharide (LPS) leading to pro-inflammatory cytokines gene expression. To investigate the involvement of these mediators in Gram-pos...

journal_title：Cytokine

authors： Fan H,Teti G,Ashton S,Guyton K,Tempel GE,Halushka PV,Cook JA

更新日期：2003-06-07 00:00:00

abstract：:Inflammatory bowel disease is a disease that reflects a disequilibrium in host-commensal homeostasis. T-bet-/-xRAG2-/- deficient mice develop a spontaneous juvenile ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota that is dendritic cell and TNF-alpha driven [schematized in Fig....

journal_title：Cytokine

authors： Garrett WS,Glimcher LH

更新日期：2009-10-01 00:00:00

abstract：:Ras expression has been suggested to be a marker for tumor aggressiveness of breast cancer. We previously showed that H-Ras, but not N-Ras, induced invasive/migratory phenotypes in MCF10A human breast epithelial cells. The present study aimed to determine the role of granulocyte colony-stimulating factor in H-Ras-indu...

journal_title：Cytokine

authors： Park S,Kim ES,Noh DY,Hwang KT,Moon A

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:To examine the expression of chemokine receptors in different peripheral blood T-cell subsets in patients with polymyositis (PM) and dermatomyositis (DM). METHODS:We used flow cytometry to measure the frequencies of chemokinereceptors CXCR3 and CCR4 expression in the CD4+ or CD8+ lymphocytes. Enzyme linked i...

journal_title：Cytokine

authors： Zhu Z,Yang C,Wang J,Feng Q,Chen Q,Yang P

更新日期：2017-11-01 00:00:00

abstract：:In the present study, we investigated the effect of CdCl2 on the inflammatory cytokines in human intestinal Caco-2 cells. The secretion of IL-8 from Caco-2 cells was significantly increased in a dose- and time-dependent manner, whereas the secretion of such other inflammatory cytokines as TNF-alpha and IFN-gamma was n...

journal_title：Cytokine

authors： Hyun JS,Satsu H,Shimizu M

更新日期：2007-01-01 00:00:00

abstract：:Thalidomide has antiangiogenic and immunomodulatory effects, mediated by several cytokines such as vascular endothelial growth factor (VEGF), fibroblastic growth factor (FGF-2), hepatocyte growth factor (HGF), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). Although extramedullary plasmacytomas (EMP)...

journal_title：Cytokine

authors： Rosiñol L,Cibeira MT,Segarra M,Cid MC,Filella X,Aymerich M,Rozman M,Arenillas L,Esteve J,Bladé J,Montserrat E

更新日期：2004-05-21 00:00:00

abstract：:This study investigated changes in the myokines IL-1β, IL-6, and TNF-α, as well as HSP72, after endurance training and after a session of downhill running. Twenty-eight rats were allocated to four different groups: 1. Eight weeks of endurance training at 65-70% VO2max (Trained); 2. Endurance training and a single sess...

journal_title：Cytokine

authors： Isanejad A,Saraf ZH,Mahdavi M,Gharakhanlou R,Shamsi MM,Paulsen G

更新日期：2015-06-01 00:00:00

abstract：:Cardiotrophin-1 (CT-1) can induce expression of the protective heat shock proteins (hsps) in cardiac cells. We show here that, unlike the stress induced accumulation of hsps, the effect of CT-1 is not accompanied by increased hsp mRNA levels and is insensitive to the RNA synthesis inhibitor actinomycin D, suggesting t...

journal_title：Cytokine

authors： Railson J,Lawrence K,Stephanou A,Brar B,Pennica D,Latchman D

更新日期：2000-11-01 00:00:00