当前位置： SCI文献检索 > CYTOKINE期刊下所有文献 > TBXA2R rs4523 G allele is associated with decreased susceptibility to Kawasaki disease.

TBXA2R rs4523 G allele is associated with decreased susceptibility to Kawasaki disease.

Abstract：

:Kawasaki disease is a multi-system vasculitis and a primary cause of acquired heart disease among children. Genetic factors may increase susceptibility to Kawasaki disease. TBXA2R is a G-protein-coupled receptor that participates in tissue inflammation and is associated with susceptibility to several diseases, but its relevance in Kawasaki disease is unclear. We genotyped TBXA2R (rs1131882 and rs4523) in 694 Kawasaki disease cases and 657 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the intensity of the associations. We found a significantly decreased risk of Kawasaki disease associated with TBXA2R rs4523 G variant genotypes (AG vs AA: adjusted OR = 0.788, 95%CI = 0.626-0.993; GG vs AA: adjusted OR = 0.459, 95%CI = 0.258-0.815; AG/GG vs AA: adjusted OR = 0.744, 95%CI = 0.595-0.929; GG vs AG/AA: adjusted OR = 0.497, 95% CI = 0.281-0.879). In the combined analysis of the two single-nucleotide polymorphisms (SNPs), we found that individuals with two unfavorable genotypes exhibited decreased risk for Kawasaki disease (adjusted OR = 0.754, 95%CI = 0.577-0.985) compared with those who did not have or one unfavorable genotypes. This cumulative effect on protection is effect-genotype dose-dependent (ptrend = 0.022). Moreover, the combined analysis indicated that the two unfavorable genotypes were associated with a decreased risk of Kawasaki disease in children 12-60 months of age, females and the subgroup with non-coronary artery lesion (NCAL) formation compared with those who did not have or one unfavorable genotypes. In conclusion, the TBXA2R rs4523 G allele may contribute to protection against Kawasaki disease and decreased risk of coronary artery aneurysm complications in a southern Chinese population.

journal_name

Cytokine

journal_title

Cytokine

authors

Che D,Pi L,Xu Y,Fu L,Zhou H,Wang Z,Huang P,Zhang L,Gu X

doi

10.1016/j.cyto.2018.08.029

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

216-221

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(18)30364-8

journal_volume

111

pub_type

杂志文章

相关文献

CYTOKINE文献大全
  • Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome.

    abstract：:Recently, differences in the levels of various chemokines and cytokines were reported in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as compared with controls. Moreover, the analyte profile differed between chronic ME/CFS patients of long duration versus patients with disease of less than...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.11.018

    authors： Landi A,Broadhurst D,Vernon SD,Tyrrell DL,Houghton M

    更新日期：2016-02-01 00:00:00

  • IL-7 receptor is expressed on adult pre-B-cell acute lymphoblastic leukemia and other B-cell derived neoplasms and correlates with expression of proliferation and survival markers.

    abstract：:The interleukin (IL)-7 receptor (IL-7R) is expressed on human pre-B but not mature B-cells. We hypothesised that aberrant expression of IL-7R contributes to B-cell oncogenesis. Surface expression of IL-7R components CD127 and CD132, and intracellular Ki-67 and Bcl-2 were examined by flow cytometry on peripheral blood ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2009.12.001

    authors： Sasson SC,Smith S,Seddiki N,Zaunders JJ,Bryant A,Koelsch KK,Weatherall C,Munier ML,McGinley C,Yeung J,Mulligan SP,Moore J,Cooper DA,Milliken S,Kelleher AD

    更新日期：2010-04-01 00:00:00

  • Association of VEGF genetic polymorphisms with prostate carcinoma risk and clinical outcome.

    abstract：OBJECTIVES:Vascular endothelial growth factor (VEGF) is a potent stimulus of angiogenesis that has an important role in many human malignancies including prostate carcinoma (PCa). We evaluated the role of the functional VEGF polymorphisms as genetic markers for PCa susceptibility and prognosis. METHODS:The study inclu...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2006.07.003

    authors： Sfar S,Hassen E,Saad H,Mosbah F,Chouchane L

    更新日期：2006-07-01 00:00:00

  • Clara cell protein: concentrations in cerebrospinal fluid, serum and amniotic fluid.

    abstract：:Clara cell protein (CC16) is an endogenous anti-inflammatory agent. It is produced mainly in the respiratory and urogenital tracts. CC16 has been quantified in serum, but not in cerebrospinal fluid (CSF). The aim of this study was to examine CSF CC16 in relation to age, gender and serum CC16, and to examine CC16 level...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1997.0318

    authors： De Jongh R,Vranken J,Kenis G,Bosmans E,Maes M,Stans G,De Ley M,Heylen R

    更新日期：1998-06-01 00:00:00

  • Shark cartilage extract induces cytokines expression and release in endothelial cells and induces E-selectin, plasminogen and t-PA genes expression through an antioxidant-sensitive mechanism.

    abstract：:Neovastat® is a standardized extract of marine cartilage, an avascular tissue, which contains many biologically active molecules and has multiple antiangiogenic properties. In addition to VEGFR2 and MMPs inhibition, shark cartilage extract (SCE) has recently been shown to induce tissue plasminogen activator gene (PLAT...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.08.035

    authors： Simard B,Ratel D,Dupré I,Pautre V,Berger F

    更新日期：2013-01-01 00:00:00

  • GD1a modulates GM-CSF-induced cell proliferation.

    abstract：:Gangliosides have been extensively described to be involved in the proliferation and differentiation of various cell types, such including hematopoietic cells. Our previous studies on murine models of stroma-mediated myelopoiesis have shown that gangliosides are required for optimal capacity of stromal cells to suppor...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2011.08.032

    authors： Santos AX,Maia JE,Crespo PM,Pettenuzzo LF,Daniotti JL,Barbé-Tuana FM,Martins LM,Trindade VM,Borojevic R,Guma FC

    更新日期：2011-12-01 00:00:00

  • Reciprocal regulation of 17beta-estradiol, interleukin-6 and interleukin-8 during growth and progression of epithelial ovarian cancer.

    abstract：:Estrogens have been associated with risk for epithelial ovarian cancer (OVCA). Both IL-6 and IL-8 are also likely involved in the progression of OVCA. In order to discover the underline molecular mechanism, we investigated the modulation of estrogen and two cytokines in the growth and progression of epithelial OVCA. I...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2009.03.013

    authors： Yang J,Wang Y,Gao Y,Shao J,Zhang XJ,Yao Z

    更新日期：2009-06-01 00:00:00

  • Wheat gliadin promotes the interleukin-4-induced IgE production by normal human peripheral mononuclear cells through a redox-dependent mechanism.

    abstract：:Increased levels of serum IgE have been described in gliadin-intolerant patients; however, biological mechanisms implicated in this immunoglobulin production remained unknown. In this study, we demonstrated that in vitro crude gliadins and gliadin lysates (Glilys) promoted the IL-4-induced IgE production by human peri...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/s1043-4666(03)00100-5

    authors： Dugas B,Dugas N,Conti M,Calenda A,Pino P,Thomas Y,Mazier D,Vouldoukis I

    更新日期：2003-03-21 00:00:00

  • Influence of acute alcohol intake and alcohol withdrawal on circulating levels of IL-6, IL-8, IL-10 and IL-12.

    abstract：:Cytokine balance alterations are responsible for some of the systemic and hepatic manifestations of alcoholism. The present study was aimed to evaluate the influence of both acute alcohol abstinence (in alcoholics) and acute alcohol intake (in healthy subjects) on serum IL-6, IL-8, IL-10, and IL-12 levels. Serum cytok...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2000.0715

    authors： González-Quintela A,Dominguez-Santalla MJ,Pérez LF,Vidal C,Lojo S,Barrio E

    更新日期：2000-09-01 00:00:00

  • Does transforming growth factor-beta1 predict for radiation-induced pneumonitis in patients treated for lung cancer?

    abstract：:The purpose of the study was to reassess the utility of transforming growth factor-beta-1 (TGF-beta1) together with dosimetric and tumor parameters as a predictor for radiation pneumonitis (RP). Of the 121 patients studied, 32 (26.4%) developed grade > or =1 RP, and 27 (22.3%) developed grade > or =2 RP. For the endpo...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2006.07.021

    authors： Evans ES,Kocak Z,Zhou SM,Kahn DA,Huang H,Hollis DR,Light KL,Anscher MS,Marks LB

    更新日期：2006-08-01 00:00:00

  • The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33.

    abstract：:Interleukin (IL)-33 (or IL-1F11) was recently identified as a ligand for the orphan IL-1 receptor family member T1/ST2 (ST2). IL-33 belongs to the IL-1 cytokine family and, upon binding to ST2, induces intracellular signals similar to those utilized by IL-1. The effects of other IL-1 family cytokines are mediated by t...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2008.03.008

    authors： Palmer G,Lipsky BP,Smithgall MD,Meininger D,Siu S,Talabot-Ayer D,Gabay C,Smith DE

    更新日期：2008-06-01 00:00:00

  • IL-10 induces gene expression in macrophages: partial overlap with IL-5 but not with IL-4 induced genes.

    abstract：:The hypothesis that IL-10, in addition to down-regulating pro-inflammatory activities of macrophages, induces an alternative state of macrophage reactivity was tested. We therefore conducted a systematic search for genes induced by IL-10 using the method of suppression subtractive hybridisation. Of an initial 1,300 ca...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/s1043-4666(03)00270-9

    authors： Stumpo R,Kauer M,Martin S,Kolb H

    更新日期：2003-10-01 00:00:00

  • Polycyclic aromatic hydrocarbons induce IL-8 expression through nuclear factor kappaB activation in A549 cell line.

    abstract：:Air pollution causes increased cardiopulmonary morbidity and mortality. Airway inflammation plays a major role in the pathophysiology of many lung diseases. Proinflammatory cytokines, such as interleukin-8 (IL-8), are responsible in part for the initiation and maintenance of airway inflammation. Asbestos exposure and ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：

    authors： Pei XH,Nakanishi Y,Inoue H,Takayama K,Bai F,Hara N

    更新日期：2002-09-07 00:00:00

  • Prolactin modulates cytokine production induced by culture filtrate proteins of M. bovis through different signaling mechanisms in THP1 cells.

    abstract：:The immunomodulatory functions of prolactin (PRL) are well recognized. Augmented PRL plasma levels were observed in patients with advanced tuberculosis (TB). Recently, we have reported that LPS and Mycobacterium bovis (M. bovis) induced differential expression of PRL receptor (PRLR) isoforms in THP-1 cells and bovine ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2014.08.006

    authors： Martínez-Neri PA,López-Rincón G,Mancilla-Jiménez R,del Toro-Arreola S,Muñoz-Valle JF,Fafutis-Morris M,Bueno-Topete MR,Estrada-Chávez C,Pereira-Suárez AL

    更新日期：2015-01-01 00:00:00

  • An inter-correlated cytokine network identified at the center of cytokine storm predicted COVID-19 prognosis.

    abstract：:The hyper-inflammatory response is thought to be a major cause of acute respiratory distress syndrome (ARDS) in patients with COVID-19. Although multiple cytokines are reportedly associated with disease severity, the key mediators of SARS-CoV-2 induced cytokine storm and their predictive values have not been fully elu...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2020.155365

    authors： Liu Y,Chen D,Hou J,Li H,Cao D,Guo M,Ling Y,Gao M,Zhou Y,Wan Y,Zhu Z

    更新日期：2021-02-01 00:00:00

  • Toll-like receptor signalling in liver disease: ER stress the missing link?

    abstract：:Toll-like receptors induce a complex inflammatory response that can function to alert the body to infection, neutralize pathogens and repair damaged tissues. Toll-like receptors are expressed on kupffer, endothelial, dendritic, biliary epithelial, hepatic stellate cells, and hepatocytes in the liver. The endoplasmic r...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2012.04.003

    authors： Lawless MW,Greene CM

    更新日期：2012-08-01 00:00:00

  • Visfatin protein may be responsible for suppression of proliferation and apoptosis in the infantile mice ovary.

    abstract：:Visfatin is an important adipokines, which are expressed in different tissues including ovary of mammals. The postnatal ovary in rodents undergoes dramatic changes of intra-ovarian factors in relation to proliferation and apoptosis. There are studies which showed that gonadal visfatin changes in postnatal life. Howeve...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2021.155422

    authors： Annie L,Gurusubramanian G,Kumar Roy V

    更新日期：2021-01-18 00:00:00

  • Involvement of G(i) proteins and Src tyrosine kinase in TNFalpha production induced by lipopolysaccharide, group B Streptococci and Staphylococcus aureus.

    abstract：:Previous studies have suggested that heterotrimeric G(i) proteins, Src tyrosine kinase and phosphatidylinositol-3 kinase (PI3 Kinase) are involved in signaling events induced by lipopolysaccharide (LPS) leading to pro-inflammatory cytokines gene expression. To investigate the involvement of these mediators in Gram-pos...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/s1043-4666(03)00122-4

    authors： Fan H,Teti G,Ashton S,Guyton K,Tempel GE,Halushka PV,Cook JA

    更新日期：2003-06-07 00:00:00

  • Nitric oxide synthesis in rat mesangial cells induced by cytokines.

    abstract：:The production of nitric oxide (NO) is increased in experimental nephritis, with NO thought to be an important mediator of cell damage. The cytokines interleukin 1 beta (IL-1 beta), IL-6, IL-8, monocyte chemotactic protein-1 (MCP-1) and transforming growth factor-beta (TGF-beta) are released from mesangial cells in vi...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(94)90047-7

    authors： Ikeda M,Ikeda U,Ohkawa F,Shimada K,Kano S

    更新日期：1994-11-01 00:00:00

  • Serological signatures of clinical cure following successful treatment with sodium stibogluconate in Ethiopian visceral leishmaniasis.

    abstract：BACKGROUND:In Ethiopia, visceral leishmaniasis (VL) is a growing public health threat. Among the key challenges in VL control in Ethiopia is lack of an effective test of cure. The recommended test of cure is parasite detection. As sterile cure is not expected with the current widely used drugs, the value of parasite de...

    journal_title：Cytokine

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.cyto.2016.11.016

    authors： Gadisa E,Tasew G,Abera A,Gelaye W,Chanyalew M,Abebe M,Laskay T,Aseffa A

    更新日期：2017-03-01 00:00:00

  • Expression of tumour necrosis factor-alpha, -beta and interferon-gamma genes within human neuroglial tumour cells and brain specimens.

    abstract：:Expression of cytokine genes, TNF-alpha, TNF-beta and IFN-gamma, in human astroglial cell lines and in fresh brain specimens was studied by PCR. mRNA transcripts of TNF-alpha could be detected in three out of five astrocytomas and neuroblastoma cell lines, and after stimulation with IL-1 beta/IFN-gamma or LPS/IFN-gamm...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(94)90039-6

    authors： Nitta T,Ebato M,Sato K,Okumura K

    更新日期：1994-03-01 00:00:00

  • Interferon gamma and prostaglandin in BSE-infected cattle.

    abstract：:Suspect field cases of BSE infection (displaying clinical signs) were examined for possible alterations of cytokine/autacoid plasma levels and were compared to control cases (not displaying clinical signs of BSE infection). Interferon gamma (IFN-gamma) plasma levels were demonstrated as being elevated in all suspected...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2000.0805

    authors： Murphy C,Breen C,Rogers M,Giese M

    更新日期：2001-02-07 00:00:00

  • Plasma levels and leucocyte RNA expression of adipokines in young patients with coronary artery disease, in metabolic syndrome and healthy controls.

    abstract：OBJECTIVES:Little is known about the role of adipokines in the pathogenesis of coronary artery disease in young patients. The aims of this study were to compare serum levels of adipokines and expression of adipokines in peripheral blood leukocytes in patients with premature coronary artery disease (CAD), metabolic synd...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2017.03.016

    authors： Smékal A,Václavík J,Stejskal D,Benešová K,Jarkovský J,Svobodová G,Richterová R,Švesták M,Táborský M

    更新日期：2019-10-01 00:00:00

  • Dissimilar cytokine patterns in different human liver and colon cancer cell lines.

    abstract：:An accurate and simultaneous estimate of cellular levels of a large cytokine number is very useful to obtain information about an organ dysfunction leading to cancer because through the understanding of the evolution of cytokine patterns we can recognize and predict the disease progression. Cancer cell lines are commo...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.09.002

    authors： Guerriero E,Capone F,Rusolo F,Colonna G,Castello G,Costantini S

    更新日期：2013-11-01 00:00:00

  • Monitoring of IL-10 in the serum of patients with advanced ovarian cancer: results from a prospective pilot-study.

    abstract：OBJECTIVES:The fact that ovarian cancer remains confined to the peritoneal cavity even in advanced stages has allowed us to surmise that local immunosuppressive factors could be involved in the tumor biology of ovarian cancer. In this context, IL-10 can be one of the key factors. By studying the kinetics of IL-10 conce...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2008.10.019

    authors： Mustea A,Braicu EI,Koensgen D,Yuan S,Sun PM,Stamatian F,Lichtenegger W,Chen FC,Chekerov R,Sehouli J

    更新日期：2009-01-01 00:00:00

  • Comparative moleculo-immunological analysis of swamp- and riverine-type water buffaloes responses.

    abstract：:This moleculo-epidemiological and immunological study through cytokine response assessment was done to know the dynamics of cytokines in the initiation, persistence and association to physiological changes of a particular pathogen in water buffaloes. This is important to understand the magnitude and behavior of diseas...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2009.02.006

    authors： Mingala CN,Konnai S,Cruz LC,Onuma M,Ohashi K

    更新日期：2009-05-01 00:00:00

  • Immune complexes, but not streptococcal cell walls or zymosan, cause chronic arthritis in mouse strains susceptible for collagen type II auto-immune arthritis.

    abstract：:In this study we investigated mechanisms involved in the chronic character of experimental collagen type II induced arthritis (CIA). We compared the knee joints of mouse strains which are prone to develop this autoimmune disease (DBA/1,B10RIII) with other nonsusceptible mouse strains (C57Bl/6,BALB/c) in their reaction...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1999.0503

    authors： Blom AB,van Lent PL,Holthuysen AE,van den Berg WB

    更新日期：1999-12-01 00:00:00

  • Strongyloides venezuelensis-infection alters the profile of cytokines and liver inflammation in mice co-infected with Schistosoma mansoni.

    abstract：:Human co-infection by helminth species is frequent, but their consequences are mostly unknown. Here, we investigate the impact of Strongyloides venezuelensis co-infection on the immune response, schistosome burden, and the associated pathology of schistosomiasis in mice. Co-infection did not alter the schistosome para...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2019.154931

    authors： de Rezende MC,Moreira JMP,Fernandes LLM,Rodrigues VF,Negrão-Corrêa D

    更新日期：2020-03-01 00:00:00

  • Ingested interferon alpha induces Mx mRNA.

    abstract：:We have demonstrated that ingested murine interferon alpha (IFN-alpha) suppressed clinical relapse in chronic relapsing experimental autoimmune encephalomyelitis (CR-EAE), decreased inflammation and suppressed the adoptive transfer of EAE, and is a biological response modifier in patients with multiple sclerosis. We e...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1998.0450

    authors： Brod SA,Nelson L,Jin R,Wolinsky JS

    更新日期：1999-07-01 00:00:00

  • Altered chemokine receptor expression in the peripheral blood lymphocytes in polymyositis and dermatomyositis.

    abstract：OBJECTIVE:To examine the expression of chemokine receptors in different peripheral blood T-cell subsets in patients with polymyositis (PM) and dermatomyositis (DM). METHODS:We used flow cytometry to measure the frequencies of chemokinereceptors CXCR3 and CCR4 expression in the CD4+ or CD8+ lymphocytes. Enzyme linked i...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2017.08.018

    authors： Zhu Z,Yang C,Wang J,Feng Q,Chen Q,Yang P

    更新日期：2017-11-01 00:00:00