Strongyloides venezuelensis-infection alters the profile of cytokines and liver inflammation in mice co-infected with Schistosoma mansoni.

abstract：:Patients admitted to a medical intensive care unit (ICU) are characterized by an activated immune system and exhibit a high mortality rate irrespective of the underlying cause of admission. Interleukin (IL)-33 has been shown to be protective in experimental sepsis models and it has been demonstrated that circulating l...

journal_title：Cytokine

authors： Krychtiuk KA,Stojkovic S,Lenz M,Brekalo M,Huber K,Wojta J,Heinz G,Demyanets S,Speidl WS

更新日期：2018-03-01 00:00:00

abstract：:Large amounts of anti-inflammatory mediators, such as interleukin (IL)-10, are produced and found early in the course of sepsis. We explore the role of IL-10 on neutrophil (PMN) activation/function using an in vitro model. Isolated human PMN were pre-incubated with lipopolysaccharide (LPS) and/or IL-10 for 18h. Subseq...

journal_title：Cytokine

authors： Martire-Greco D,Rodriguez-Rodrigues N,Landoni VI,Rearte B,Isturiz MA,Fernández GC

更新日期：2013-06-01 00:00:00

abstract：:The regulation of local L-tryptophan concentrations by tryptophan-degrading enzyme, indoleamine 2,3-dioxygenase (IDO) induced by various stimuli such as interferon-γ (IFN-γ) is one of the key mechanisms in antimicrobial effect. Recently, IDO is also focused on an immunosuppressive mechanism shared by several different...

journal_title：Cytokine

authors： Murakami Y,Hoshi M,Hara A,Takemura M,Arioka Y,Yamamoto Y,Matsunami H,Funato T,Seishima M,Saito K

更新日期：2012-08-01 00:00:00

abstract：:Dysregulation of cytokines synthesis is thought to play a role in the development of a number of age-related conditions, such as rheumatoid arthritis, osteoporosis, atherosclerosis, and others, but observational studies have led to contradictory results. We investigated potential familial influences on the plasma leve...

journal_title：Cytokine

authors： Pantsulaia I,Trofimov S,Kobyliansky E,Livshits G

更新日期：2002-08-07 00:00:00

abstract：:The pleiotropic cytokine, interleukin-6 (IL-6), has emerged in recent years as a key regulator of the transition from innate to adaptive immunity through its ability to modulate leukocyte recruitment at inflammatory sites. This review highlights a newly identified role for IL-6 trans-signaling, initiated by an agonist...

journal_title：Cytokine

authors： Vardam TD,Zhou L,Appenheimer MM,Chen Q,Wang WC,Baumann H,Evans SS

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by a wide variety of autoantibodies, some of which are pathogenic. In recent years it has become more evident that the polyclonal B cell activation in SLE is T-cell dependent. The stimulation of the autoantibody producing B cells is li...

journal_title：Cytokine

authors： Sabry A,Sheashaa H,El-Husseini A,Mahmoud K,Eldahshan KF,George SK,Abdel-Khalek E,El-Shafey EM,Abo-Zenah H

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Bronchial asthma (BA) is a chronic disease of the airways. The great majority of BA exacerbations are associated with respiratory viral infections. Recent findings point out a possible role of proinflammatory cytokine interleukin-33 (IL-33) in the development of atopic diseases. Although, little is known abo...

journal_title：Cytokine

authors： Nikonova A,Shilovskiy I,Galitskaya M,Sokolova A,Sundukova M,Dmitrieva-Posocco O,Mitin A,Komogorova V,Litvina M,Sharova N,Zhernov Y,Kudlay D,Dvornikov A,Kurbacheva O,Khaitov R,Khaitov M

更新日期：2021-02-01 00:00:00

abstract：:Staphylococcus aureus is one of the versatile Gram positive bacteria causing a range of diseases. Upon challenge, host immune cells recognize S. aureus and mount diverse immune responses including production of pro-inflammatory cytokines such as IL-1β and TNF-α. These cytokines are important mediators of inflammation ...

journal_title：Cytokine

authors： Javed N,Xue G,Lu A,Xing Y,Iwakura Y,Xiao H,Lecoeur H,Späth GF,Meng G

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVES:Vascular endothelial growth factor (VEGF) is a potent stimulus of angiogenesis that has an important role in many human malignancies including prostate carcinoma (PCa). We evaluated the role of the functional VEGF polymorphisms as genetic markers for PCa susceptibility and prognosis. METHODS:The study inclu...

journal_title：Cytokine

authors： Sfar S,Hassen E,Saad H,Mosbah F,Chouchane L

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVES:In pregnancy, the placental contribution of cytokines to maternal immunosuppression has been established, however their role in normal maternal blood pressure regulation has not been identified. We investigate the contribution of interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha) to the vasod...

journal_title：Cytokine

authors： Orange S,Rasko JE,Thompson JF,Vaughan J,Olive E,Pedler M,Horvath JS,Hennessy A

更新日期：2005-02-21 00:00:00

abstract：AIMS:At present, there are few studies on the relationship between circulating irisin levels and gestational diabetes mellitus (GDM), and the results are inconsistent. Therefore, this study conducts a systematic review and meta-analysis to comprehensively discuss the role of irisin in the occurrence and development of ...

journal_title：Cytokine

authors： Cui L,Qiao T,Xu F,Li Z,Chen T,Su H,Chen G,Zhang L,Xu D,Zhang X

更新日期：2020-02-01 00:00:00

abstract：:The genetic producibilities of T helper type 1 (Th1) and T helper type 2 (Th2) cytokines are associated with the prognosis of autoimmune thyroid diseases (AITDs). Interleukin (IL)-10 is considered to be a Th2 cytokine that can exhibit an anti-inflammatory role. Furthermore, IL-10 may be associated with the development...

journal_title：Cytokine

authors： Inoue N,Watanabe M,Wada M,Morita M,Hidaka Y,Iwatani Y

更新日期：2013-10-01 00:00:00

abstract：:This study was conducted to compare the secretion of TGF-beta isoforms by human ovarian carcinoma (OVCA) cell lines (n=12) and human peritoneal mesothelial cells (HPMC;n=6) and to examine the regulation of their production by inflammatory cytokines. TGF-beta isoforms were furthermore analysed in OVCA-associated asciti...

journal_title：Cytokine

authors： Abendstein B,Stadlmann S,Knabbe C,Buck M,Müller-Holzner E,Zeimet AG,Marth C,Obrist P,Krugmann J,Offner FA

更新日期：2000-07-01 00:00:00

abstract：:IL-1 family members regulate innate immune responses, are produced by gestation-associated tissues, and have a role in healthy and adverse pregnancy outcomes. To better understand their role at the materno-fetal interface we used a human tissue explant model to map lipopolysaccharide (LPS)-stimulated production of IL-...

journal_title：Cytokine

authors： Scott LM,Bryant AH,Rees A,Down B,Jones RH,Thornton CA

更新日期：2017-11-01 00:00:00

abstract：:Osteoclasts, the main protagonists involved in bone resorption mechanisms, are generally considered to be of haematopoietic origin, although the exact nature of the primary osteoclastic stem cells is still unknown. In vitro cellular models developed to study the different events of osteoclastic differentiation have re...

journal_title：Cytokine

authors： Heymann D,Guicheux J,Gouin F,Passuti N,Daculsi G

更新日期：1998-03-01 00:00:00

abstract：:The induction of cytokine expression in monocytes/macrophages by bacterial endotoxin or lipopolysaccharide is a critical, highly regulated host defence response. The augmentation of LPS responses by interferon gamma (IFN-gamma), referred to as priming, is well established. However, the mechanism(s) by which priming oc...

journal_title：Cytokine

authors： Hayes MP,Freeman SL,Donnelly RP

更新日期：1995-07-01 00:00:00

abstract：:Antigen (Ag)-stimulated mast cells induce synthesis and production of cytokines including tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 with proinflammatory and immune regulatory properties. Expression of TNF-alpha and IL-6 was regulated by a transcription factor, nuclear factor (NF)-kappaB. The iridoid gly...

journal_title：Cytokine

authors： Jeong HJ,Koo HN,Na HJ,Kim MS,Hong SH,Eom JW,Kim KS,Shin TY,Kim HM

更新日期：2002-06-07 00:00:00

abstract：BACKGROUND:It has been demonstrated that cardiac fibroblasts of the human heart have several myocyte-like features, induced by inflammation. OBJECTIVES:This study analyzed the changes of the expressed currents in the basal condition and in the presence of interleukin-6 in cultured human cardiac fibroblasts. METHODS:H...

journal_title：Cytokine

authors： Mitrokhin V,Kazanski V,Kalsin V,Mladenov M,Kamkin A

更新日期：2017-09-01 00:00:00

abstract：:Pro-inflammatory cytokines are important mediators of cutaneous cellular activities during many skin diseases. In the present study, we investigated the production of tumor necrosis factor-alpha (TNF-alpha), IL-6 and IL-10 by UVB-irradiated human keratinocytes NCTC 2544 cell line in the presence of cAMP-elevating agen...

journal_title：Cytokine

authors： Grandjean-Laquerriere A,Le Naour R,Gangloff SC,Guenounou M

更新日期：2003-08-21 00:00:00

abstract：:Cell death and innate immunity are ancient evolutionary conserved processes that utilize a dazzling number of related molecular effectors and parallel signal transduction mechanisms. The investigation of the molecular mechanisms linking the sensing of a danger signal (pathogens or tissue damage) to the induction of an...

journal_title：Cytokine

authors： Yeretssian G,Labbé K,Saleh M

更新日期：2008-09-01 00:00:00

abstract：:Increasing evidence shows that inflammation plays critical roles in the tumorigenesis of bladder cancer. Fibroblast growth factor 12 (FGF12), a kind of inflammatory cytokine, is located in the region of 3q28 that has been demonstrated to be a bladder cancer risk locus by genome wide association study (GWAS). In this s...

journal_title：Cytokine

authors： Wu J,Huang H,Huang Q,Qiu R,Huang M,Meng D

更新日期：2020-12-01 00:00:00

abstract：:The interleukin (IL)-7 receptor (IL-7R) is expressed on human pre-B but not mature B-cells. We hypothesised that aberrant expression of IL-7R contributes to B-cell oncogenesis. Surface expression of IL-7R components CD127 and CD132, and intracellular Ki-67 and Bcl-2 were examined by flow cytometry on peripheral blood ...

journal_title：Cytokine

authors： Sasson SC,Smith S,Seddiki N,Zaunders JJ,Bryant A,Koelsch KK,Weatherall C,Munier ML,McGinley C,Yeung J,Mulligan SP,Moore J,Cooper DA,Milliken S,Kelleher AD

更新日期：2010-04-01 00:00:00

abstract：:Among New Mexican Hispanic women, breast cancer is detected at a more advanced stage than compared to Non-Hispanic White women. One central factor that has been little studied is the role of critical cytokines. We genotyped incident breast cancer cases and their age-, gender- and smoking-matched controls (N=40 matched...

journal_title：Cytokine

authors： Erdei E,Kang H,Meisner A,White K,Pickett G,Baca C,Royce M,Berwick M

更新日期：2010-07-01 00:00:00

abstract：:Stimulation of Ca2+ permeable TRPM3 (transient receptor potential melastatin-3) channels with the steroid ligand pregnenolone sulfate activates stimulus-responsive transcription factors, including the transcription factor AP-1 (activator protein-1). As part of a search for AP-1-regulated target genes we analyzed the g...

journal_title：Cytokine

authors： Rubil S,Lesch A,Mukaida N,Thiel G

更新日期：2018-03-01 00:00:00

abstract：:The N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP), a unique cytokine present in human granulocytes, was determined to be: Pyroglu-Leu-Lys-X-Tyr-Thr-X-Lys-Glu-Pro-Met-Thr-Ser(Thr)-Ala-Ala... This sequence showed no significant homology with any other protein when used in database searches...

journal_title：Cytokine

authors： Ridge RJ,Sloane NH

更新日期：1996-01-01 00:00:00

abstract：:There are indications that bone regulatory and immune systems are closely related. Of special interest in this context is the acute otitis media (AOM), which mainly affects immunologically immature patients and, when complicated, involves bone tissue. To explore host responses in bone tissue during Haemophilus influen...

journal_title：Cytokine

authors： Melhus A,Ryan AF

更新日期：2004-03-21 00:00:00

abstract：OBJECTIVE:Epicardial adipose tissue (EAT) produces a wide range of adipokines and has recently been linked to the physiopathology of cardiovascular (CV) and metabolic diseases. We aimed to study whether EAT and subcutaneous (SAT) adiponectin and leptin expression levels are associated with CV complications during long-...

journal_title：Cytokine

authors： Teijeira-Fernandez E,Eiras S,Salgado Somoza A,Gonzalez-Juanatey JR

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:In Ethiopia, visceral leishmaniasis (VL) is a growing public health threat. Among the key challenges in VL control in Ethiopia is lack of an effective test of cure. The recommended test of cure is parasite detection. As sterile cure is not expected with the current widely used drugs, the value of parasite de...

journal_title：Cytokine

authors： Gadisa E,Tasew G,Abera A,Gelaye W,Chanyalew M,Abebe M,Laskay T,Aseffa A

更新日期：2017-03-01 00:00:00

abstract：:Along with several other aspects of Chagas disease, the mechanisms responsible for the different clinical outcomes observed in chronic infected individuals have not yet been clarified. It is believed that the host immune response to the parasite plays an important role in the development of the pathology. Therefore, t...

journal_title：Cytokine

authors： de Melo AS,de Lorena VM,de Moura Braz SC,Docena C,de Miranda Gomes Y

更新日期：2012-05-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection and hospitalization in infants. In spite of the enormous clinical burden caused by RSV infections, there remains no efficacious RSV vaccine. CD8 T cells mediate viral clearance as well as provide protection against a secondary ...

journal_title：Cytokine

authors： Schmidt ME,Varga SM

更新日期：2020-09-01 00:00:00