Abstract:
:The genetic producibilities of T helper type 1 (Th1) and T helper type 2 (Th2) cytokines are associated with the prognosis of autoimmune thyroid diseases (AITDs). Interleukin (IL)-10 is considered to be a Th2 cytokine that can exhibit an anti-inflammatory role. Furthermore, IL-10 may be associated with the development of IgG4-related diseases, because IL-10 promotes IgG4 production by B cells. To evaluate the relationship between the functional -592 A/C polymorphism in the gene encoding IL-10 and the prognosis of AITDs, we genotyped this polymorphism in 57 patients with intractable GD, 43 patients with GD in remission, 63 patients with severe HD, 44 patients with untreated mild HD, and 62 healthy volunteers by the direct sequencing method. The CC genotype, which is associated with higher producibility of IL-10, was more frequent in patients with severe HD than in those with mild HD (p=0.0201). However, there were no significant differences in serum IgG4 levels between these two groups of HD patients or among 3 genotypes of this polymorphism. There were no significant differences in genotype and allele frequencies between the two GD groups, or between the controls and AITD patients. These data indicate that the functional -592 A/C polymorphism in the IL10 gene is associated with the severity of HD but not with serum IgG4 levels.
journal_name
Cytokinejournal_title
Cytokineauthors
Inoue N,Watanabe M,Wada M,Morita M,Hidaka Y,Iwatani Ydoi
10.1016/j.cyto.2013.05.014subject
Has Abstractpub_date
2013-10-01 00:00:00pages
370-4issue
1eissn
1043-4666issn
1096-0023pii
S1043-4666(13)00258-5journal_volume
64pub_type
杂志文章相关文献
CYTOKINE文献大全abstract:BACKGROUND:Secondhand smoke (SHS) exposure is a risk factor of respiratory, cardiovascular and inflammatory diseases, however its association with inflammatory markers among highly SHS exposed adolescents has not yet been explored. METHODS:Participants included in this study were a subset of 68 non-smoking adolescents...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.12.007
更新日期:2014-03-01 00:00:00
abstract::In hypertension studies, anti-inflammatory cytokine interleukin-10 (IL-10) has been shown to prevent angiotensin II (Ang II)-induced vasoconstriction and regulate vascular function by down-regulating pro-inflammatory cytokine and superoxide production in vascular cells. However, little is known about the mechanism beh...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2015.09.002
更新日期:2016-01-01 00:00:00
abstract::C-reactive protein (CRP) has been demonstrated to induce blood-brain barrier disruption (BBB) involving NAD(P)H-oxidase dependent oxidative stress. It is unclear why CRP affects the BBB and not other vascular beds following stroke. Therefore we examined CRP receptor and NAD(P)H-oxidase expression levels in bovine brai...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.02.011
更新日期:2010-05-01 00:00:00
abstract::Dendritic cell-based vaccines are considered as a new and promising immunotherapeutic approach for cancer treatment. However, the choice of optimal protocol of dendritic cell generation in vitro represents the major challenge. Here, we compared phenotype and functional characteristics of human monocyte-derived dendrit...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.07.258
更新日期:2015-01-01 00:00:00
abstract::The purpose of the study was to reassess the utility of transforming growth factor-beta-1 (TGF-beta1) together with dosimetric and tumor parameters as a predictor for radiation pneumonitis (RP). Of the 121 patients studied, 32 (26.4%) developed grade > or =1 RP, and 27 (22.3%) developed grade > or =2 RP. For the endpo...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.07.021
更新日期:2006-08-01 00:00:00
abstract::Interleukin (IL)-33 (or IL-1F11) was recently identified as a ligand for the orphan IL-1 receptor family member T1/ST2 (ST2). IL-33 belongs to the IL-1 cytokine family and, upon binding to ST2, induces intracellular signals similar to those utilized by IL-1. The effects of other IL-1 family cytokines are mediated by t...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.03.008
更新日期:2008-06-01 00:00:00
abstract::This study investigated changes in the myokines IL-1β, IL-6, and TNF-α, as well as HSP72, after endurance training and after a session of downhill running. Twenty-eight rats were allocated to four different groups: 1. Eight weeks of endurance training at 65-70% VO2max (Trained); 2. Endurance training and a single sess...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2015.03.013
更新日期:2015-06-01 00:00:00
abstract::The kynurenine pathway (KP) is the major metabolic route of tryptophan (Trp) metabolism. Indoleamine 2,3-dioxygenase (IDO1), the enzyme responsible for the first and rate-limiting step in the pathway, as well as other enzymes in the pathway, have been shown to be highly regulated by cytokines. Hence, the KP has been i...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2017.09.004
更新日期:2019-10-01 00:00:00
abstract::TNF-alpha, IL-1, IL-6 and TGF-beta are important macrophage-derived mediators which play the pleiotropic role in inflammatory, metabolic, hematopoietic and immunologic processes. Studies have shown that haemorrhagic shock without significant tissue trauma induces profound immunosuppression which is associated with ele...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1995.1002
更新日期:1995-01-01 00:00:00
abstract:UNLABELLED:Hyperoxia exposure can inhibit alveolar growth in the neonatal lung through induction of p21/p53 pathways and is a risk factor for the development of bronchopulmonary dysplasia (BPD) in preterm infants. We previously found that activation of nuclear factor erythroid 2 p45-related factor (Nrf2) improved survi...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.09.021
更新日期:2014-01-01 00:00:00
abstract::Interleukin-1beta (IL-1beta) is a pleiotropic cytokine that can induce several cellular signal transduction pathways. Here, we show that IL-1beta can induce cell cycle arrest and differentiation in the human medullary thyroid carcinoma (MTC) cell line, TT. IL-1beta induces cell cycle arrest accompanied by morphologica...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2004.10.005
更新日期:2005-02-07 00:00:00
abstract:BACKGROUND AND AIM:Interleukin-22 (IL-22), plays a vital role in the mucosal repair of inflammatory bowel disease (IBD). Serum levels of IL-22 and IL-22 binding protein (IL-22BP), a soluble inhibitory IL-22 receptor, were measured in patients with IBD to investigate the profile of IL-22 in the systemic circulation. ME...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155264
更新日期:2020-12-01 00:00:00
abstract::In the family of cytokines and cytokine receptors, alternative splicing of pre-mRNA is a frequently observed process that generates different protein isoforms from a single genetic locus. The splicing-derived cytokine receptor protein isoforms are mostly soluble receptors or show alterations in their cytoplasmic domai...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0777
更新日期:2000-11-01 00:00:00
abstract::Epidemiological studies indicate a genetic contribution to colorectal cancer (CRC), but specific genetic variants remain unknown. Genome-wide association studies have identified rs4444235 at BMP4 as a new colorectal cancer (CRC) and colorectal adenoma (CRA) susceptibility locus in populations of European descent. Afte...
journal_title:Cytokine
pub_type: 杂志文章,meta分析
doi:10.1016/j.cyto.2014.12.021
更新日期:2015-04-01 00:00:00
abstract::Visfatin is an important adipokines, which are expressed in different tissues including ovary of mammals. The postnatal ovary in rodents undergoes dramatic changes of intra-ovarian factors in relation to proliferation and apoptosis. There are studies which showed that gonadal visfatin changes in postnatal life. Howeve...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2021.155422
更新日期:2021-01-18 00:00:00
abstract::The effect of ether lipid 1-O-Octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine (ET-18-OCH3), platelet activating factor (PAF) and carbamyl activating factor (CPAF) on the release of IL-6 in human thymic epithelium cultivated in vitro was studied. ET-18-OCH3 significantly increased the release of IL-6, giving the gre...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0092
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVE:To describe the relationship between the two mechanisms involved in sIL6R generation in rheumatoid arthritis (RA). METHOD:RA patients were selected from a group of subjects genotyped for the rs8192284 SNP, located at the proteolytic cleavage site of IL-6R. sIL6R and protease levels (ADAM17) were measured and...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.12.025
更新日期:2013-03-01 00:00:00
abstract::The objectives were to determine if blood IL-10 levels rise during the early stages of acute (wasting) pre-pubescent malnutrition in metabolically distinct murine models known to depress inflammatory immune competence and whether systemic IL-10 production is affected in these pathologies. Weanling C57BL/6J mice were a...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.05.015
更新日期:2009-08-01 00:00:00
abstract::Autoantibodies against a variety of growth factors and cytokines are present in preparations of pooled normal human IgG, such as IVIg. The present study demonstrated that healthy Danish blood donors produced high concentrations of anti-IL-10 IgG antibodies that bound IL-10 with extremely high avidity. The antibodies w...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.06.009
更新日期:2010-09-01 00:00:00
abstract::The dental pulp space can become infected due to a breach in the surrounding hard tissues. This leads to inflammation of the pulp (pulpitis), soft tissue breakdown, and finally to bone loss around the root apex (apical periodontitis). The succession of the molecular events leading to apical periodontitis is currently ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.05.014
更新日期:2014-09-01 00:00:00
abstract:AIMS:At present, there are few studies on the relationship between circulating irisin levels and gestational diabetes mellitus (GDM), and the results are inconsistent. Therefore, this study conducts a systematic review and meta-analysis to comprehensively discuss the role of irisin in the occurrence and development of ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2019.154924
更新日期:2020-02-01 00:00:00
abstract::There appears to be an associative link between chronic hepatitis C (CHC) and cardiovascular diseases (CVDs). However, the exact nature of the relationship between CHC and CVDs has not been elucidated. We investigated the presence of CVDs and the clinical and laboratory alterations associated with these diseases in CH...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.12.005
更新日期:2019-03-01 00:00:00
abstract::In this study two different aspects of tumour necrosis factor alpha (TNF-alpha) and interleukin 1 (IL-1) in locally induced murine streptococcal cell wall arthritis (SCW) were investigated. First, the kinetics and interdependence of TNF-alpha and IL-1 release; and second; their involvement in inflammation and cartilag...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1998.0372
更新日期:1998-09-01 00:00:00
abstract::Hepatitis C virus (HCV) chronic infection causes severe cellular immune dysfunction. Here, we investigated the production of Th17-associated cytokines by peripheral blood mononuclear cells (PBMCs) of untreated patients with HCV, patients presenting an early virologic response (EVR) after 12weeks of treatment with inte...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.09.015
更新日期:2018-02-01 00:00:00
abstract::Malignant tumours are usually accompanied by an immune response. Chemokines such as MCP-1 have been claimed to be potent inducers of such tumour-associated reactions. In the present study MCP-1 mRNA was quantified by competitive reverse transcription polymerase reaction and localised by in situ hybridisation in renal ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0823
更新日期:2001-02-21 00:00:00
abstract::Most infections occur in early life, prompting development of novel adjuvanted vaccines to protect newborns and infants. Several Toll-like receptor (TLR) agonists (TLRAs) are components of licensed vaccine formulations or are in development as candidate adjuvants. However, the type and magnitude of immune responses to...
journal_title:Cytokine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.cyto.2016.04.001
更新日期:2016-07-01 00:00:00
abstract::Epithelial cell apoptosis triggered cooperatively by multiple cytokines contributes to the injury induced by inflammatory responses in the lung and elsewhere. Here we show that interferon-gamma (IFN-gamma) sensitizes A549 cells, human lung epithelial cells, to cytokine-mediated apoptosis by upregulating caspase-8 expr...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2003.2008
更新日期:2002-12-21 00:00:00
abstract::The gene for C10, a member of the beta-chemokine family of cytokines, contains a novel second exon encoding a 16 amino acid sequence which is inserted into the amino-terminal region of the protein. We propose a model of C10 structure in which the sequence encoded by the second exon is located on the surface of the pro...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0060
更新日期:1996-06-01 00:00:00
abstract::Radiation exposure results in an inflammatory reaction with acute as well as subacute consequences. Leukocyte infiltration is one of the predominant early histological changes and involves both cytokines and adhesion molecules. Endothelial cells play a key role in this reaction. We have previously shown the increased ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1999.0497
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:Soy products contain several compounds with anti-inflammatory properties like genistein and daidzein which reported to act through different pathways. Present study conducted considering the inconsistent results and lack of any comprehensive review regarding randomized controlled trials which assess the effe...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155282
更新日期:2020-12-01 00:00:00