Interleukin-1beta can mediate growth arrest and differentiation via the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells.

abstract：:In atherosclerotic plaques, macrophages (MAC) and smooth muscle cells (SMC) frequently reside in close proximity and resistin (Rs) and fractalkine (Fk) are present at increased levels, resistin being associated with CD68 macrophages and fractalkine predominantly associated with intimal SMC; however, their role in this...

journal_title：Cytokine

authors： Tucureanu MM,Butoi E,Gan AM,Stan D,Constantinescu CA,Calin M,Simionescu M,Manduteanu I

更新日期：2016-07-01 00:00:00

abstract：:Expression of cytokine genes, TNF-alpha, TNF-beta and IFN-gamma, in human astroglial cell lines and in fresh brain specimens was studied by PCR. mRNA transcripts of TNF-alpha could be detected in three out of five astrocytomas and neuroblastoma cell lines, and after stimulation with IL-1 beta/IFN-gamma or LPS/IFN-gamm...

journal_title：Cytokine

authors： Nitta T,Ebato M,Sato K,Okumura K

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:Cutaneous melanoma displays high morbidity and mortality rates. Isolated limb perfusion with melphalan (Mel) is used for the treatment of non-resectable, locally advanced extremity melanomas. When combined with tumor necrosis factor alpha (TNF-alpha) treatment, the complete response varies between 70% and 90...

journal_title：Cytokine

authors： de Lima VC,de Carvalho AF,Morato-Marques M,Hashimoto VL,Spilborghs GM,Marques SM,Landman G,Torres C,Braga Ribeiro K,Brentani H,Reis LF,Dias AA

更新日期：2013-05-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes including essential hypertension (EH). Associations of the IL-6 promoter region polymorphisms with circulating level of IL-6 have been reported in various studies. We detected the IL-6-597G/A polymorphism in 246 EH pati...

journal_title：Cytokine

authors： Gao SP,Pan M,Chen C,Ge LJ,Jiang MH,Luan H,Zheng JG,Deng XT,Pan HY,Zhu JH

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:Vascular endothelial growth factor (VEGF) is a potent stimulus of angiogenesis that has an important role in many human malignancies including prostate carcinoma (PCa). We evaluated the role of the functional VEGF polymorphisms as genetic markers for PCa susceptibility and prognosis. METHODS:The study inclu...

journal_title：Cytokine

authors： Sfar S,Hassen E,Saad H,Mosbah F,Chouchane L

更新日期：2006-07-01 00:00:00

abstract：:Three molecules, interleukin 1 (IL-1) receptor I (IL-1RI), IL-1 receptor II (IL-1RII or decoy) and IL-1 receptor accessory protein (IL-1R AcP or IL-1RIII), are involved in IL-1 binding and signal transduction. In addition, three homologous genes (T1/ST2, MyD88 and rsc786) have been identified. Expression of the signal...

journal_title：Cytokine

authors： Saccani S,Polentarutti N,Penton-Rol G,Sims JE,Mantovani A

更新日期：1998-10-01 00:00:00

abstract：:Interleukin 2 (IL-2) and interleukin 12 (IL-12) have potent anti-tumour activity as single agent therapy against several different murine and human tumours. Combining these cytokines may result in improved therapeutic effectiveness, however, the toxicity associated with simultaneous administration is prohibitive. This...

journal_title：Cytokine

authors： Kaufman HL,Swartout BG,Hörig H,Lubensky I

更新日期：2002-01-07 00:00:00

abstract：OBJECTIVE:We investigated the expression pattern and the role of inflammatory cytokines and their receptors in the placentas of pregnancy with HELLP syndrome. STUDY DESIGN:Placentas were collected after cesarean section, 10 from normal pregnancy and 10 from HELLP. The array was performed with GEArray Q Series Human In...

journal_title：Cytokine

authors： Tranquilli AL,Landi B,Corradetti A,Giannubilo SR,Sartini D,Pozzi V,Emanuelli M

更新日期：2007-11-01 00:00:00

abstract：:Exercise training is known to induce a molecular adaptation process involving inflammatory responses. However any time-of-day effect of exercise on inflammatory responses remains unknown. The aim of the present study was to investigate whether acute bouts of intense exercise performed at different times of the day wou...

journal_title：Cytokine

authors： Pledge D,Grosset JF,Onambélé-Pearson GL

更新日期：2011-08-01 00:00:00

abstract：:Recent studies have implicated leptin as a "stress" hormone and highlighted its association with increases in inflammatory cytokines, C-reactive protein and cortisol. In order to investigate the exact temporal leptin response to stress we undertook a detailed longitudinal study of circulating leptin concentrations dur...

journal_title：Cytokine

authors： Wallace AM,Sattar N,Mcmillan DC

更新日期：2000-07-01 00:00:00

abstract：:Dermal wounding is accompanied by inflammation and the resulting proinflammatory cytokines, including interleukin (IL)-6, are thought to play an important role in the repair process. IL-6 is produced by normal human keratinocytes to various dermatological diseases and we have recently shown it is also required for nor...

journal_title：Cytokine

authors： Sugawara T,Gallucci RM,Simeonova PP,Luster MI

更新日期：2001-09-21 00:00:00

abstract：:The interleukin (IL)-7 receptor (IL-7R) is expressed on human pre-B but not mature B-cells. We hypothesised that aberrant expression of IL-7R contributes to B-cell oncogenesis. Surface expression of IL-7R components CD127 and CD132, and intracellular Ki-67 and Bcl-2 were examined by flow cytometry on peripheral blood ...

journal_title：Cytokine

authors： Sasson SC,Smith S,Seddiki N,Zaunders JJ,Bryant A,Koelsch KK,Weatherall C,Munier ML,McGinley C,Yeung J,Mulligan SP,Moore J,Cooper DA,Milliken S,Kelleher AD

更新日期：2010-04-01 00:00:00

abstract：:Purpose suppressor of cytokine signaling 1 (SOCS-1) is inducible feedback inhibitors of cytokine signaling and involved in viral infection through regulation of both innate and adaptive immunity. In this study, we firstly cloned SOCS-1 (goSOCS-1) from duck Tembusu virus (DTMUV) infected goose. The full-length sequence...

journal_title：Cytokine

authors： Zhang W,Chen S,Zhang J,Wu Z,Wang M,Jia R,Zhu D,Liu M,Sun K,Yang Q,Wu Y,Chen X,Cheng A

更新日期：2017-05-01 00:00:00

abstract：:The hypothesis that IL-10, in addition to down-regulating pro-inflammatory activities of macrophages, induces an alternative state of macrophage reactivity was tested. We therefore conducted a systematic search for genes induced by IL-10 using the method of suppression subtractive hybridisation. Of an initial 1,300 ca...

journal_title：Cytokine

authors： Stumpo R,Kauer M,Martin S,Kolb H

更新日期：2003-10-01 00:00:00

abstract：:We investigated whether healthy young (age ≤ 40) and elderly (age ≥ 65) people infected with cytomegalovirus (CMV) had similar levels of CD8(+) T cell cytokine production and proliferation in response to an immunodominant CMV pp65 peptide pool given the role of CD8(+) T cells in controlling viral infection and the ass...

journal_title：Cytokine

authors： Shin MS,Lee JS,Lee N,Lee WW,Kim SH,Kang I

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Immuno-inflammation plays an important role in the pathophysiological process of sepsis-associated acute hepatic injury (AHI). Interleukin 27 (IL-27) is an important inflammatory regulator; however, its role in this condition is not clear. METHODS:The clinical data and IL-27 serum levels in sepsis patients ...

journal_title：Cytokine

authors： Fan J,Zhang YC,Zheng DF,Zhang M,Liu H,He M,Wu ZJ

更新日期：2020-03-01 00:00:00

abstract：:Preeclampsia is a common disease of pregnancy characterised by maternal hypertension and proteinuria. Abnormal placentation in early pregnancy and abnormal cytokine and anti-angiogenic factor expression are thought to contribute to the clinical syndrome of endothelial dysfunction evident in the second half of gestatio...

journal_title：Cytokine

authors： Sunderland NS,Thomson SE,Heffernan SJ,Lim S,Thompson J,Ogle R,McKenzie P,Kirwan PJ,Makris A,Hennessy A

更新日期：2011-11-01 00:00:00

abstract：:Periodontitis is the most prevalent infectious disease caused by periodontopathic bacteria and is also a chronic inflammatory disease. Gingival crevicular fluid (GCF) is an inflammatory exudate that seeps into the gingival crevices or periodontal pockets around teeth with inflamed gingiva, and contains various materia...

journal_title：Cytokine

authors： Yoshimoto T,Fujita T,Kajiya M,Matsuda S,Ouhara K,Shiba H,Kurihara H

更新日期：2015-09-01 00:00:00

abstract：:L-buthionine-S,R-sulfoximine (BSO), an inhibitor of GSH synthesis, decreased IL-1 beta-induced nitrite release in rat islets and purified rat beta cells, nitrite formation and iNOS gene promoter activity in insulinoma cells, and iNOS mRNA expression in rat islets. The thiol depletor diethyl maleate (DEM) and an inhibi...

journal_title：Cytokine

authors： Nikulina MA,Andersen HU,Karlsen AE,Darville MI,Eizirik DL,Mandrup-Poulsen T

更新日期：2000-09-01 00:00:00

abstract：:The specificity of leukocyte trafficking in inflammation is controlled by the interactions of chemokines with chemokine receptors. Reliable structure-function studies of chemokine-receptor interactions would benefit from cell lines that express consistent high levels of chemokine receptors. We describe herein two new ...

journal_title：Cytokine

authors： Parody TR,Stone MJ

更新日期：2004-07-07 00:00:00

abstract：:As a result of the association between ionizing irradiation and the induction of inflammatory and fibrogenic cytokines, circulating levels of IL-1alpha, macrophage colony stimulating factor (M-CSF) and TGFbeta were measured in a group of 37 patients who presented with well-defined adenocarcinoma of the prostate and we...

journal_title：Cytokine

authors： Kovacs CJ,Daly BM,Evans MJ,Johnke RM,Lee TK,Karlsson UL,Allison R,Eaves GS,Biggs LM

更新日期：2003-09-21 00:00:00

abstract：:Interferon (IFN)-alpha and -beta are important antiviral mediators. IFN-alpha is widely used for the treatment of chronic hepatitis B. In our previous studies, a subtype of woodchuck IFN-alpha (wIFN-alpha) was characterized and has been shown to be active in suppressing the replication of woodchuck hepatitis virus (WH...

journal_title：Cytokine

authors： Lu Y,Xu Y,Yang D,Kemper T,Roggendorf M,Lu M

更新日期：2008-02-01 00:00:00

abstract：:Fifty-five adult patients with primary bone tumour, 27 benign and 28 malignant tumours, were assayed for leukaemia inhibitory factor (LIF) in urine and serum samples. Supernatant was obtained from primary tumour tissue cultures in 24 cases (14 benign, 10 malignant tumours). LIF was found in 11 urine samples (16.7%, 1 ...

journal_title：Cytokine

authors： Gouin F,Heymann D,Raher S,De Groote D,Passuti N,Daculsi G,Godard A

更新日期：1998-02-01 00:00:00

abstract：:Psoriatic fibroblasts produce enhanced amounts of IL-6 in vitro. This state of activation may reflect an altered expression of cytokine receptors, involved in auto/paracrine induction of IL-6. Cultures of dermal fibroblasts derived from lesional psoriatic (PP) and normal control (NN) skin were therefore analysed for t...

journal_title：Cytokine

authors： Debets R,Hegmans JP,Buurman WA,Benner R,Prens EP

更新日期：1996-01-01 00:00:00

abstract：:To clarify the biological significance of tumour necrosis factor alpha (TNF-alpha) precursor, we analysed its expression at the primed and triggered stages using human monocyte-like cell line THP-1. To prime them, THP-1 cells were treated with either recombinant human interferon gamma (rIFN-gamma) or recombinant human...

journal_title：Cytokine

authors： Tanabe Y,Kitahara-Tanabe N,Mizuno D,Soma GI

更新日期：1994-07-01 00:00:00

abstract：:Invariant Natural Killer T (iNKT) cells represent a population of innate T lymphocytes which act as 'first-responders' to infection. While they have long been considered a versatile cell, capable of secretion of multiple cytokines upon activation, recent evidence now indicates that distinct lineages of iNKT cells with...

journal_title：Cytokine

authors： Buechel HM,Stradner MH,D'Cruz LM

更新日期：2015-04-01 00:00:00

abstract：:BAFF is associated with various immunological diseases. Previously, we have reported that mouse B cell activating factor (mBAFF) expression was dependent on nuclear localization of co-activator, p300 and the activation of transcription factors including NF-κB and CREB. Here, we investigated whether transcription facto...

journal_title：Cytokine

authors： Lee GH,Lee MH,Yoon YD,Kang JS,Pyo S,Moon EY

更新日期：2012-07-01 00:00:00

abstract：:Interleukin (IL)-6, a multifunctional cytokine, is widely used as an index for illnesses such as inflammatory and autoimmune disorders, coronary artery disease, neurological disease, and gestational problems. It is thus very important to be able to precisely quantify the level of IL-6 for disease diagnosis and any sub...

journal_title：Cytokine

authors： Chou TH,Chuang CY,Wu CM

更新日期：2010-07-01 00:00:00

abstract：:Thalidomide has antiangiogenic and immunomodulatory effects, mediated by several cytokines such as vascular endothelial growth factor (VEGF), fibroblastic growth factor (FGF-2), hepatocyte growth factor (HGF), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). Although extramedullary plasmacytomas (EMP)...

journal_title：Cytokine

authors： Rosiñol L,Cibeira MT,Segarra M,Cid MC,Filella X,Aymerich M,Rozman M,Arenillas L,Esteve J,Bladé J,Montserrat E

更新日期：2004-05-21 00:00:00

abstract：:The objective of this study was to investigate the effects of the cytokines IFN-alpha, IL-6 and IL-10 present in the serum of systemic lupus erythematosus (SLE) patients on the differentiation and maturation of DCs derived from CD34(+) hematopoietic precursor cells (HPCs). CD34(+) HPCs cultured in SLE serum containing...

journal_title：Cytokine

authors： Zhang R,Xing M,Ji X,Gu L,Yang X,Wang H,Jiang P

更新日期：2010-05-01 00:00:00