Abstract:
OBJECTIVE:We investigated the expression pattern and the role of inflammatory cytokines and their receptors in the placentas of pregnancy with HELLP syndrome. STUDY DESIGN:Placentas were collected after cesarean section, 10 from normal pregnancy and 10 from HELLP. The array was performed with GEArray Q Series Human Inflammatory Cytokines & Receptors Gene Array HS-015. The data were confirmed by quantitative real-time PCR. The Student's t test was used for statistical analysis. RESULTS:Macroarray analysis identified 14 cytokines differentially expressed. PCR confirmed that only IL-10, IL-6-receptor, and TGF-beta3 were increased, whilst CCL18, CXCL5, and IL-16 were significantly decreased, in HELLP. CONCLUSION:The regulation of cytokines involved in angiogenesis and adaptive immune responses may be critical for the placental vascular dysfunction. Our data support the hypothesis that HELLP syndrome could be a placental inflammatory response which leads to a systemic and endothelial dysfunction.
journal_name
Cytokinejournal_title
Cytokineauthors
Tranquilli AL,Landi B,Corradetti A,Giannubilo SR,Sartini D,Pozzi V,Emanuelli Mdoi
10.1016/j.cyto.2007.08.010subject
Has Abstractpub_date
2007-11-01 00:00:00pages
82-8issue
2eissn
1043-4666issn
1096-0023pii
S1043-4666(07)00378-Xjournal_volume
40pub_type
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