当前位置： SCI文献检索 > CYTOKINE期刊下所有文献 > FK506 suppresses E-selectin, ICAM-1 and VCAM-1 expression on vascular endothelial cells by inhibiting tumor necrosis factor alpha secretion from peripheral blood mononuclear cells.

FK506 suppresses E-selectin, ICAM-1 and VCAM-1 expression on vascular endothelial cells by inhibiting tumor necrosis factor alpha secretion from peripheral blood mononuclear cells.

Abstract：

:FK506 suppresses activation of T cells; however, it down-regulates E-selectin, ICAM-1 and VCAM-1 expression in inflamed tissues. In this study, we investigated the effect of FK506 on expression of those adhesion molecules on human vascular endothelial cells (HMVEC). Culture supernatant from peripheral blood mononuclear cells (PBMC) stimulated with anti-CD3 plus anti-CD2 antibodies effectively induced the expression of E-selectin, ICAM-1 and VCAM-1 on HMVEC, and treatment with FK506 down-regulated their expression. Culture supernatant contained tumor necrosis factor (TNF) alpha and interleukin (IL)-1beta, which effectively induced adhesion molecules, and FK506 suppressed both cytokine secretions. TNFalpha content in culture supernatant was parallel to the induction of adhesion molecules by the culture supernatant. IL-1beta content was not enough to induce those adhesion molecules. Anti-TNFalpha antibody completely inhibited those expressions. FK506 did not inhibit either TNFalpha- or IL-1beta-induced expression of adhesion molecules, or viability of HMVEC. These results indicate that FK506 suppresses migration of inflammatory cells through the inhibition of TNFalpha secretion from leukocytes.

journal_name

Cytokine

journal_title

Cytokine

authors

Sasakawa T,Sasakawa Y,Masunaga T,Fujitsu T,Hirayama Y,Ohkubo Y,Mutoh S

doi

10.1016/j.cyto.2004.04.006

keywords:

subject

Has Abstract

pub_date

2005-01-21 00:00:00

pages

67-71

issue

2

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(04)00289-3

journal_volume

29

pub_type

杂志文章

相关文献

CYTOKINE文献大全
  • Interferonbeta-induced changes in metallothionein expression and subcellular distribution of zinc in HepG2 cells.

    abstract：:We evaluated the changes of metallothionein induction and cellular zinc distribution in HepG2 cells by interferonbeta treatment. Immunohistochemical staining of metallothionein was observed in the cytoplasm and nuclei of hepatocytes; which was observed predominantly in the cells treated with interferon and zinc compar...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2006.06.008

    authors： Nagamine T,Kusakabe T,Takada H,Nakazato K,Sakai T,Oikawa M,Satoh T,Arakawa K

    更新日期：2006-06-01 00:00:00

  • CK2 induced RIG-I drives metabolic adaptations in IFNγ-treated glioma cells.

    abstract：:Given the known anti-tumorigenic properties of IFNγ, its effect on glioma cell survival was investigated. Though IFNγ had no effect on glioma cell viability, it induced cell cycle arrest. This was accompanied by increased expression of p53 and retinoic acid inducible gene (RIG-I). While RIG-I had no effect on glioma c...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.10.009

    authors： Ghildiyal R,Sen E

    更新日期：2017-01-01 00:00:00

  • The IL-17 G-152A single nucleotide polymorphism is associated with pulmonary tuberculosis in northern Spain.

    abstract：BACKGROUND:Interleukin 17 (IL-17) is induced during the early stages of tuberculosis infection, playing an important role in the defense against mycobacterial infection. To date, only one study performed in Chinese Han population has found an association between IL-17F sequence variants and susceptibility to tuberculos...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.05.022

    authors： Ocejo-Vinyals JG,de Mateo EP,Hoz MÁ,Arroyo JL,Agüero R,Ausín F,Fariñas MC

    更新日期：2013-10-01 00:00:00

  • Gingival crevicular fluid levels of oncostatin M in periodontal conditions.

    abstract：OBJECTIVE:The initial study has reported the increased level of oncostatin M (OSM) in gingival crevicular fluid (GCF) of chronic periodontitis patients, and no study has reported its level in gingivitis patients. Therefore, the present study has been carried out to measure the level of OSM in gingival crevicular fluid ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.02.002

    authors： Thorat Manojkumar S,Pradeep AR,Garg G,Raju A

    更新日期：2010-06-01 00:00:00

  • Immune complexes, but not streptococcal cell walls or zymosan, cause chronic arthritis in mouse strains susceptible for collagen type II auto-immune arthritis.

    abstract：:In this study we investigated mechanisms involved in the chronic character of experimental collagen type II induced arthritis (CIA). We compared the knee joints of mouse strains which are prone to develop this autoimmune disease (DBA/1,B10RIII) with other nonsusceptible mouse strains (C57Bl/6,BALB/c) in their reaction...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1999.0503

    authors： Blom AB,van Lent PL,Holthuysen AE,van den Berg WB

    更新日期：1999-12-01 00:00:00

  • Interleukin-35 in idiopathic inflammatory myopathies.

    abstract：BACKGROUND:Interleukin-35 (IL-35) is a recently described heterodimeric cytokine that belongs to the IL-12 family and consists of p35 (IL-12a) and EBI3 (IL-27b) subunits. The expression of IL-35 in humans is inducible in response to inflammatory stimuli. Increased IL-35 levels were documented in several autoimmune infl...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2020.155350

    authors： Mann H,Kryštůfková O,Zámečník J,Háček J,Hulejová H,Filková M,Vencovský J,Šenolt L

    更新日期：2021-01-01 00:00:00

  • Interleukin-15 enhances the expansion and function of natural killer T cells from adult peripheral and umbilical cord blood.

    abstract：:Invariant natural killer T cells (iNKT cells) are innate-like non-conventional T cells restricted by the CD1d molecule that are unique in their ability to play a pivotal role in immune regulation. Deficient iNKT function has been reported in patients receiving umbilical cord blood (UCB) transplantation. We sought to d...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.09.015

    authors： Lin SJ,Huang YC,Cheng PJ,Lee PT,Hsiao HS,Kuo ML

    更新日期：2015-12-01 00:00:00

  • Polycyclic aromatic hydrocarbons induce IL-8 expression through nuclear factor kappaB activation in A549 cell line.

    abstract：:Air pollution causes increased cardiopulmonary morbidity and mortality. Airway inflammation plays a major role in the pathophysiology of many lung diseases. Proinflammatory cytokines, such as interleukin-8 (IL-8), are responsible in part for the initiation and maintenance of airway inflammation. Asbestos exposure and ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：

    authors： Pei XH,Nakanishi Y,Inoue H,Takayama K,Bai F,Hara N

    更新日期：2002-09-07 00:00:00

  • D-dopachrome tautomerase promotes IL-6 expression and inhibits adipogenesis in preadipocytes.

    abstract：:We previously identified D-dopachrome tautomerase (DDT) as a novel adipokine whose mRNA levels in adipocytes are negatively correlated with obesity-related clinical parameters, and which acts on adipocytes to regulate lipid metabolism. Here we investigated functions of DDT on preadipocytes. Recombinant DDT (rDDT) enha...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.07.037

    authors： Ishimoto K,Iwata T,Taniguchi H,Mizusawa N,Tanaka E,Yoshimoto K

    更新日期：2012-12-01 00:00:00

  • Cadmium induces interleukin-8 production via NF-kappaB activation in the human intestinal epithelial cell, Caco-2.

    abstract：:In the present study, we investigated the effect of CdCl2 on the inflammatory cytokines in human intestinal Caco-2 cells. The secretion of IL-8 from Caco-2 cells was significantly increased in a dose- and time-dependent manner, whereas the secretion of such other inflammatory cytokines as TNF-alpha and IFN-gamma was n...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2007.02.011

    authors： Hyun JS,Satsu H,Shimizu M

    更新日期：2007-01-01 00:00:00

  • IL-10 promotes resistance to apoptosis and metastatic potential in lung tumor cell lines.

    abstract：:Treatment of non-small cell lung carcinoma (NSCLC) remains at a disappointingly low success rate. Not only is metastatic spread common in NSCLC, but therapeutic success decreases dramatically once metastases are present. Understanding factors which contribute to poor prognosis in NSCLC is critical for development of m...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2009.11.015

    authors： Zeng L,O'Connor C,Zhang J,Kaplan AM,Cohen DA

    更新日期：2010-03-01 00:00:00

  • Retinal pigment epithelium-secretome: A diabetic retinopathy perspective.

    abstract：:Diabetic retinopathy is a major complication of diabetes mellitus that can lead to retinal vascular abnormalities and visual impairment. While retinal endothelial pathology is well studied, retinal pigment epithelium (RPE) layer modifications and the patho-physiological regulations are not widely understood. The RPE i...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2017.02.013

    authors： Ponnalagu M,Subramani M,Jayadev C,Shetty R,Das D

    更新日期：2017-07-01 00:00:00

  • Association of interleukin (IL)-4 variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms with susceptibility to pediatric autoimmune hepatitis type 1.

    abstract：OBJECTIVE:Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease mediated by an autoimmune reaction to hepatocytes, the present study aimed to assess the possible associations between interleukin-4 (IL-4) variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms and susceptibility to aut...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2018.01.009

    authors： Mansour AI,Behairy OG,Abd Almonaem ER,Abd-Rabuh RM,Ahmed IAE

    更新日期：2018-10-01 00:00:00

  • Enterovirus-induced production of pro-inflammatory and T-helper cytokines by human leukocytes.

    abstract：:Enteroviruses are associated with chronic inflammatory and autoimmune diseases in humans. In these conditions, the cytokine network is supposed to have an important role in inflammation and modulation of the (auto)immune response. In the present study, we demonstrate that coxsackie virus B4 and poliovirus type 1 induc...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2000.0786

    authors： Vreugdenhil GR,Wijnands PG,Netea MG,van der Meer JW,Melchers WJ,Galama JM

    更新日期：2000-12-01 00:00:00

  • Homeopathic medicines cause Th1 predominance and induce spleen and megakaryocytes changes in BALB/c mice infected with Leishmania infantum.

    abstract：:The prevalence of Th1/Th2 response, spleen changes and megakaryocytes were investigated in BALB/c mice (n=138) infected with Leishmania infantum, and treated with Leishmania infantum 30× (10-30) biotherapy - BioLi30×. We performed controlled experiments using 8-to-12-week-old mice, infected with 5×107L. infantum proma...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2017.02.010

    authors： Cajueiro APB,Goma EP,Dos Santos HAM,Almeida Rodrigues I,Toma HK,Araújo SM,Bonamin LV,Gomes NBN,Castelo-Branco MTL,de Souza Dias EP,Dos Santos Pyrrho A,Holandino C

    更新日期：2017-07-01 00:00:00

  • The tertiary structure of γc cytokines dictates receptor sharing.

    abstract：:The γc family of cytokines comprising interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15 and IL-2 is an important group of 4-helix bundle cytokines that signals through receptors incorporating the common gamma chain (γc). These cytokines are involved in lymphocyte biology and their specific functions are contingent on bind...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2019.01.007

    authors： Reche PA

    更新日期：2019-04-01 00:00:00

  • IL 6 but not TNF is linked to coronary artery calcification in patients with chronic kidney disease.

    abstract：INTRODUCTION:Patients with chronic kidney disease (CKD) have a high risk of death mainly due to cardiovascular diseases (CVD). Early risk identification may allow interventions and prevention of fatal events. OBJECTIVES:The study aim was to assess the usefulness of selected CVD biomarkers as predictors of 5-year morta...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2019.04.002

    authors： Kamińska J,Stopiński M,Mucha K,Jędrzejczak A,Gołębiowski M,Niewczas MA,Pączek L,Foroncewicz B

    更新日期：2019-08-01 00:00:00

  • RETRACTED: Increases in inflammatory mediators in DRG implicate in the pathogenesis of painful neuropathy in Type 2 diabetes.

    abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. Image duplication has been observed within Figure 1g-h. The corresponding author has been a...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.04.009

    authors： Galloway C,Chattopadhyay M

    更新日期：2013-07-01 00:00:00

  • Insulin-like growth factor-1 binding protein 3 (IGFBP-3) promotes recovery from trauma-induced expression of inflammatory and apoptotic factors in retina.

    abstract：:Ocular trauma affects 20% of Americans in their lifetime and can cause permanent visual system damage. We have used a mouse model of ocular trauma (exposure to an air blast from a paintball gun) to examine pathways that trigger the resulting retinal damage and to develop treatment strategies that might ameliorate the ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2014.07.004

    authors： Jiang Y,Pagadala J,Miller DD,Steinle JJ

    更新日期：2014-12-01 00:00:00

  • Interleukin-12 as an adjuvant for induction of protective antibody responses.

    abstract：:Interleukin (IL)-12 is a pivotal cytokine that strongly stimulates Th1-associated cellular immunity. It is now recognized that IL-12 also activates humoral immunity to both T-dependent and T-independent antigens. This has let to considerable interest in exploiting IL-12 as a vaccine adjuvant for protection against var...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2010.06.011

    authors： Metzger DW

    更新日期：2010-10-01 00:00:00

  • CCAAT/enhancer binding protein is involved in the expression of the tumour necrosis factor gene in human monocytes.

    abstract：:Within the human TNF promoter we have identified two sites at positions -189 and -101 that show C/EBP specific binding of nuclear proteins from cells of the human monocytic line Mono Mac 6. Supershift analysis with anti C/EBP antibodies revealed that the complexes formed consist of both C/EBP alpha and C/EBP beta. Whe...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1996.0046

    authors： Wedel A,Sulski G,Ziegler-Heitbrock HW

    更新日期：1996-05-01 00:00:00

  • Serum vaspin levels in women with and without gestational diabetes mellitus during pregnancy and postpartum.

    abstract：:Although vaspin is regarded an insulin-sensitizing adipokine, its role in gestational diabetes mellitus (GDM) is currently unknown. We aimed to evaluate serum vaspin levels and their correlation with insulin resistance in women with and without GDM. Forty-four women with GDM [GDM Group - 20 managed with diet only (GDM...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.09.006

    authors： Gkiomisi A,Makedou KG,Anastasilakis AD,Polyzos SA,Kourtis A,Gerou S,Gavana E,Dagklis T,Rousso D,Giannoulis C

    更新日期：2013-01-01 00:00:00

  • Effects of two different dialytic treatments on inflammatory markers in people with end-stage renal disease with and without type 2 diabetes mellitus.

    abstract：:This study was aimed to evaluate the effects on some inflammatory markers of two dialytic treatments [bicarbonate dialysis (BHD) and hemodiafiltration (HDF)] in patients with severe chronic kidney disease. We evaluated: blood glucose, homeostasis model assessment insulin resistance index, homocistein (Hcs), high sensi...

    journal_title：Cytokine

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.cyto.2016.12.026

    authors： Derosa G,Libetta C,Esposito P,Borettaz I,Tinelli C,D'angelo A,Maffioli P

    更新日期：2017-04-01 00:00:00

  • Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit.

    abstract：:It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2017.11.010

    authors： Palumbo ML,Di Rosso ME,Simon EH,Gonzalez Murano MR,Genaro AM

    更新日期：2018-07-01 00:00:00

  • Effects of hypothermia and re-warming on the inflammatory response in a murine multiple hit model of trauma.

    abstract：INTRODUCTION:Although, hypothermia is a frequent event after trauma, it is unclear whether its beneficial or detrimental effects are more important. This study aims to quantify the effects of hypothermia and re-warming on the inflammatory response after fracture/hemorrhage and subsequent fracture stabilization with res...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2005.06.008

    authors： Hildebrand F,van Griensven M,Giannoudis P,Luerig A,Harwood P,Harms O,Fehr M,Krettek C,Pape HC

    更新日期：2005-09-07 00:00:00

  • G-CSF-induced evacuation of sinusoidal NK cells and the facilitation of liver regeneration in a partial hepatectomy.

    abstract：:Since liver regeneration after partial hepatectomy (PHx) is known to improve by pretreatment with recombinant human G-CSF (rhG-CSF), we investigated the mechanism by evaluating the distribution and activity of sinusoidal NK cells. F344 rats were treated with rhG-CSF (250 microg/kg/day) for 5 days before PHx. Pretreatm...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2006.04.001

    authors： Oishi K,Hayamizu K,Aihaiti X,Itamoto T,Arihiro K,Asahara T

    更新日期：2006-04-01 00:00:00

  • Interferon-γ induces biphasic changes in caldesmon localization as well as adherens junction organization and expression in HUVECs.

    abstract：:Endothelial barrier dysfunction leads to increased endothelial permeability and is an early step in the development of vascular inflammatory diseases such as atherosclerosis. Interferon-γ (IFN-γ), a proinflammatory cytokine, is known to cause increased endothelial permeability. However, the mechanisms by which IFN-γ d...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2018.06.010

    authors： Ng CT,Fong LY,Yong YK,Hakim MN,Ahmad Z

    更新日期：2018-11-01 00:00:00

  • Modification of biological responses to interleukin-1 by agents that perturb signal transduction pathways.

    abstract：:In this study we have examined the effect of agents known to perturb certain signal transduction pathways on the biological responses of target cells to stimulation with interleukin-1 (IL-1). In the murine thymoma cell line EL4, IL-1 stimulation results in the secretion of interleukin-2 (IL-2), which was subsequently ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(91)90009-3

    authors： Rollins P,Witham S,Ray K,Thompson N,Sadler H,Smithers N,Grenfell S,Solari R

    更新日期：1991-01-01 00:00:00

  • Human cancer cells have specifically lost the ability to induce the synergistic state caused by tumor necrosis factor plus interferon-beta.

    abstract：:Tumor necrosis factor (TNF) and the members of the interferon (IFN) family are major inducible cytokines that function to counteract viral infections or cellular transformation. Recently, our lab has characterized a novel antiviral state which is induced in primary human fibroblasts by co-treatment with TNF plus IFNbe...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2009.06.006

    authors： Bartee E,McFadden G

    更新日期：2009-09-01 00:00:00

  • Plasma inflammatory cytokine response to surgical trauma in chronic depressed patients.

    abstract：:We investigated inflammatory cytokine response in chronic depressed patients during abdominal surgery. Twenty-five major depressed patients (Group D) and twenty-five patients (Group C) as the control were studied. Plasma interleukin 6 (IL-6), interleukin 8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha) concentrat...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2000.0802

    authors： Kudoh A,Katagai H,Takazawa T

    更新日期：2001-01-21 00:00:00