Abstract:
:In the atopic allergic individual, challenge with allergen elicits manifestations of both the humoral (IgE-mediated or early-phase reaction) and the cell-mediated immune response (late-phase reaction). Detailed study of late-phase cell-mediated events is confounded by the effects of the earlier IgE-mediated response which results in mast cell and basophil activation. Thus the relative contributions to allergic inflammation of individual cell types, such as T cells and eosinophils, are difficult to define. In this review we describe experiments, largely from our own group, in which we have attempted to dissociate early and late allergic reactions. To this end, cell-mediated responses were induced in the absence of preceding IgE-mediated events, by the delivery of synthetic peptides representing T cell epitopes of the allergen. Activation of T cells resulted in airway narrowing and an increase in airway reactivity to non-specific stimuli. Furthermore, we describe the induction of antigen-specific hyporesponsiveness or "tolerance" following intradermal, but not mucosal, peptide delivery. The induction of peptide-induced hyporesponsiveness could be temporally dissociated from the initial T cell activation resulting in bronchoconstriction and likely occurred through a different mechanism. Analysis of in vitro allergen responses of peripheral blood cells revealed that hyporesponsiveness was associated with reductions in both Th1 and Th2 cytokines, together with a concomitant increase in the regulatory cytokine IL-10. We conclude that activation of T cells in vivo may result in manifestations of chronic allergic inflammation including bronchoconstriction and hyperreactivity. Additionally, when administered systemically at low dose, peptides may induce long-lasting hyporesponsiveness in the T cell compartment, through a mechanism that is associated with induction of IL-10.
journal_name
Cytokinejournal_title
Cytokineauthors
Smith TR,Larché Mdoi
10.1016/j.cyto.2004.07.001keywords:
subject
Has Abstractpub_date
2004-10-21 00:00:00pages
49-54issue
2eissn
1043-4666issn
1096-0023pii
S1043-4666(04)00203-0journal_volume
28pub_type
杂志文章,评审相关文献
CYTOKINE文献大全abstract:BACKGROUND:The anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody was significantly associated with dermatomyositis associated with interstitial lung disease (DM-ILD) and poor survival in patients. However, there was no convenient and accurate biomarker can predict the poor prognosis of anti-MDA5 posi...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155209
更新日期:2020-11-01 00:00:00
abstract::Fifty-five adult patients with primary bone tumour, 27 benign and 28 malignant tumours, were assayed for leukaemia inhibitory factor (LIF) in urine and serum samples. Supernatant was obtained from primary tumour tissue cultures in 24 cases (14 benign, 10 malignant tumours). LIF was found in 11 urine samples (16.7%, 1 ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0264
更新日期:1998-02-01 00:00:00
abstract::It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.11.010
更新日期:2018-07-01 00:00:00
abstract::IL-12p70 is a proinflammatory cytokine secreted by dendritic cells, monocytes and macrophages. It plays a crucial role in cell-mediated immunity by inducing proliferation of T cell and natural killer cells, and enhancing their cytotoxic activity. In adaptive immune response, it acts on naive T cells to differentiate i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.03.021
更新日期:2013-06-01 00:00:00
abstract::Along with several other aspects of Chagas disease, the mechanisms responsible for the different clinical outcomes observed in chronic infected individuals have not yet been clarified. It is believed that the host immune response to the parasite plays an important role in the development of the pathology. Therefore, t...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.01.008
更新日期:2012-05-01 00:00:00
abstract::Invariant NKT (iNKT) cells have been extensively studied throughout the last decade due to their ability to polarize and amplify the downstream immune response. Only recently however, have the various mechanisms underlying NKT cell activation begun to unfold. iNKT cells have the ability to respond as innate immune cel...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2010.04.016
更新日期:2010-09-01 00:00:00
abstract::Following recent attention focused on IL-32 as an important component involved in the inflammatory cytokine network, we speculated that IL-32's action on IFN-γ and IFN-γ secreting T cell subsets may help sustain the immune activation and dysregulation found in patients with HIV-1 achieving viral suppression. To explor...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2019.01.012
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder which presents with abdominal pain and alterations of the bowel habits. The pathophysiology of IBS is not well-recognized. Low grade inflammation has been suggested as one of the underlying mechanisms of IBS. Variations in the ci...
journal_title:Cytokine
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.cyto.2017.08.017
更新日期:2017-11-01 00:00:00
abstract::Expression of GPCR fatty acid sensor/receptor genes in adipocytes is modulated by inflammatory mediators, particularly IL-1β. In this study we examined whether the IL-1 gene superfamily member, IL-33, also regulates expression of the fatty acid receptor genes in adipocytes. Human fat cells, differentiated from preadip...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.05.008
更新日期:2018-10-01 00:00:00
abstract::Candida albicans is an opportunistic fungal pathogen that colonizes human gastro-intestinal mucosal tissues. Its effect on the immune response in intestinal epithelial cells and on the intestinal mucosal barrier are not yet fully understood. In this study, we investigated Caco-2 cells, a monolayer model of intestinal ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2019.154882
更新日期:2020-02-01 00:00:00
abstract::The activation of STAT1 and STAT3 in response to SEB was analyzed in spleen of Balb/c mice. The intraperitoneal injection of the superantigen SEB activated STAT1 and STAT3 in spleen. Activated STAT1 almost completely disappeared in 24 h even though activated STAT3 was present for more than 48 h after SEB injection. Cy...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2003.09.006
更新日期:2004-01-07 00:00:00
abstract:BACKGROUND:Interleukin 17 (IL-17) is induced during the early stages of tuberculosis infection, playing an important role in the defense against mycobacterial infection. To date, only one study performed in Chinese Han population has found an association between IL-17F sequence variants and susceptibility to tuberculos...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.05.022
更新日期:2013-10-01 00:00:00
abstract::In this study we have examined the effect of agents known to perturb certain signal transduction pathways on the biological responses of target cells to stimulation with interleukin-1 (IL-1). In the murine thymoma cell line EL4, IL-1 stimulation results in the secretion of interleukin-2 (IL-2), which was subsequently ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(91)90009-3
更新日期:1991-01-01 00:00:00
abstract::The objectives were to determine if blood IL-10 levels rise during the early stages of acute (wasting) pre-pubescent malnutrition in metabolically distinct murine models known to depress inflammatory immune competence and whether systemic IL-10 production is affected in these pathologies. Weanling C57BL/6J mice were a...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.05.015
更新日期:2009-08-01 00:00:00
abstract::Interactions between interleukin 8 (IL-8) and endothelial cells play an important role in the emigration of mononuclear cells from the blood into areas of inflammation. We examined the ability of specific second-line antirheumatic drugs to regulate (IL-8) gene expression and protein secretion in interleukin 1 (IL-1) s...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(92)90085-6
更新日期:1992-09-01 00:00:00
abstract::Metabolic syndrome poses a major threat on human health affecting the quality of life. Adipose tissue is an important organ which plays a crucial role in the pathogenesis of metabolic syndrome. Adipocytokines secreted by the adipose tissue plays a critical role in storage, food intake, energy expenditure, lipid and gl...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2019.154735
更新日期:2019-09-01 00:00:00
abstract::Preeclampsia is a complex disease of pregnancy with both feto-placental and maternal factors contributing to its pathogenesis. Although the cause of this disease is uncertain, imbalance between pro-and anti-inflammatory cytokines has been implicated in the pathogenesis of preeclampsia. Increased levels of the inflamma...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.07.039
更新日期:2012-12-01 00:00:00
abstract::We had earlier shown that human foetal epithelial cells (WISH), growth-inhibited by interferon gamma (IFNgamma), were reversibly detained at a point prior to DNA synthesis. In the present study, we determined the window of action of IFNgamma in the G1 phase duration and the exact point of detention of WISH cells in ce...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.02.013
更新日期:2007-02-01 00:00:00
abstract::We previously identified D-dopachrome tautomerase (DDT) as a novel adipokine whose mRNA levels in adipocytes are negatively correlated with obesity-related clinical parameters, and which acts on adipocytes to regulate lipid metabolism. Here we investigated functions of DDT on preadipocytes. Recombinant DDT (rDDT) enha...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.07.037
更新日期:2012-12-01 00:00:00
abstract::Although vaspin is regarded an insulin-sensitizing adipokine, its role in gestational diabetes mellitus (GDM) is currently unknown. We aimed to evaluate serum vaspin levels and their correlation with insulin resistance in women with and without GDM. Forty-four women with GDM [GDM Group - 20 managed with diet only (GDM...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.09.006
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:We investigated the expression pattern and the role of inflammatory cytokines and their receptors in the placentas of pregnancy with HELLP syndrome. STUDY DESIGN:Placentas were collected after cesarean section, 10 from normal pregnancy and 10 from HELLP. The array was performed with GEArray Q Series Human In...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.08.010
更新日期:2007-11-01 00:00:00
abstract::Functional diversity of the memory T-cell-derived cytokine IL-17 was explored at the receptor level. IL-17 inhibited TNF-induced chemokine Rantes expression in human synovial fibroblasts and mouse lung fibroblasts. This inhibitory activity of IL-17 (IC50=0.2 ng/ml) was 6-fold more potent than its stimulatory activity ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2005.02.012
更新日期:2005-08-07 00:00:00
abstract:OBJECTIVES:The fact that ovarian cancer remains confined to the peritoneal cavity even in advanced stages has allowed us to surmise that local immunosuppressive factors could be involved in the tumor biology of ovarian cancer. In this context, IL-10 can be one of the key factors. By studying the kinetics of IL-10 conce...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.10.019
更新日期:2009-01-01 00:00:00
abstract::The aim of the study was to characterize and to quantify peripheral and tissue. IL-35- and IL-37-producing cells in Inflammatory Bowel Disease (IBD) patients. We studied a total of 38 active UC, 31 inactive UC, 17 active CD, and 13 inactive CD and 50 non-inflamed tissues as control group. Gene expression was measured ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2015.04.009
更新日期:2015-10-01 00:00:00
abstract::Although tumor necrosis factor (TNF) and interleukin 6 (IL 6) are purported to be important mediators of inflammatory responses following trauma, it is not known if the serum levels of these cytokines are altered by simple hemorrhage. The objective of this study therefore was to determine whether or not: 1) there is a...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(90)90012-i
更新日期:1990-05-01 00:00:00
abstract::Previously, two binding sites for interleukin 5 (IL-5) were identified on the IL-5 receptor alpha chain (IL-5Ralpha). They are located within the CD loop of the first fibronectin type III (FnIII)-like domain and the EF loop of the second FnIII-like domain. The first binding site was identified by exploiting the differ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1999.0663
更新日期:2000-07-01 00:00:00
abstract::Neutrophil-activating peptide 1/interleukin 8 (NAP-1/IL-8) is a recently described cytokine with potent chemotactic activity for human neutrophil granulocytes (PMN) and T cells. In psoriasis, a chronic hyperproliferative and inflammatory skin disorder, PMN and T cells are found as prominent cells in the inflammatory i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(91)90500-d
更新日期:1991-07-01 00:00:00
abstract::We have examined the effects of various antioxidants and inhibitors of redox-sensitive signal transduction pathways on induction of interleukin 8 (IL-8) gene by NO in monocytic U937 cells. We have observed that nitrosoglutathione or another NO-generating compound spermine NONOate caused significant accumulation of IL-...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/s1043-4666(03)00114-5
更新日期:2003-07-01 00:00:00
abstract::Vascular smooth muscle cells (VSMC) may be programmed by nutrient deprivation. We found that after 2 and 12 h exposure to 75% reduced amino acids, the release of basic fibroblast growth factor (bFGF) and transforming growth factor beta1 (TGF beta 1) from VSMC was significantly greater than that from cells maintained i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0710
更新日期:2000-09-01 00:00:00
abstract:RATIONALE:Sarcoidosis is an idiopathic granulomatous disorder with heterogeneous clinical manifestations and variable prognosis. Monitoring disease activity is important to identify patients requiring treatment. Several cytokines have previously been shown to be elevated in the serum of patients with sarcoidosis and ma...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.07.010
更新日期:2013-10-01 00:00:00