当前位置： SCI文献检索 > CYTOKINE期刊下所有文献 > Leptin as a predictive marker for metabolic syndrome.

Leptin as a predictive marker for metabolic syndrome.

Abstract：

:Metabolic syndrome poses a major threat on human health affecting the quality of life. Adipose tissue is an important organ which plays a crucial role in the pathogenesis of metabolic syndrome. Adipocytokines secreted by the adipose tissue plays a critical role in storage, food intake, energy expenditure, lipid and glucose metabolism. Leptin is primarily involved in regulating food intake, body weight and energy homeostasis through neuroendocrine functions. Contemporary research suggests that leptin also influences insulin sensitivity and lipid metabolism. High leptin concentrations are directly associated with the obesity subsequent development of metabolic disease sequelae such as insulin resistance, type 2 diabetes and cardiovascular diseases. Elucidation of the mechanism of action of leptin would help to develop novel therapeutic approaches for there metabolic disorders like obesity and diabetes. This review provides an updated 'state-of-the-art' about the leptin and its role in the pathophysiology of metabolic syndrome at the molecular level.

journal_name

Cytokine

journal_title

Cytokine

authors

Ghadge AA,Khaire AA

doi

10.1016/j.cyto.2019.154735

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

154735

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(19)30144-9

journal_volume

121

pub_type

杂志文章,评审

相关文献

CYTOKINE文献大全
  • TGF-beta1 gene polymorphisms influence the course of the disease in non-Hodgkin's lymphoma patients.

    abstract：:Non-Hodgkin's lymphomas (NHL) constitute a heterogenous group of mainly B-cell lymphoproliferative diseases with different patterns of clinical behaviour. Biological mechanisms leading to development of NHL are not clearly understood. Transforming growth factor-beta1 (TGF-beta1) influences B cell growth and developmen...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2005.12.010

    authors： Mazur G,Bogunia-Kubik K,Wrobel T,Kuliczkowski K,Lange A

    更新日期：2006-02-07 00:00:00

  • Systemic blood osteopontin, endostatin, and E-selectin concentrations after vertical banding surgery in severely obese adults.

    abstract：BACKGROUND:Obesity is associated with endothelial dysfunction and increased inflammation as well as with expansion of the capillary bed in regional adipose deposits, and a balance between these factors is involved in angiogenesis. Osteopontin (OPN) is a proinflammatory cytokine involved in regulating immune processes a...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2011.03.020

    authors： Komorowski J,Jankiewicz-Wika J,Kolomecki K,Cywinski J,Piestrzeniewicz K,Swiętoslawski J,Stepien H

    更新日期：2011-07-01 00:00:00

  • Longitudinal analysis of serum interleukin-18 in patients with familial Mediterranean fever carrying MEFV mutations in exon 10.

    abstract：BACKGROUND:Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in the MEFV gene. Mutations in exon 10 are associated with typical FMF phenotypes, and patients with exon 10 mutations have higher serum levels of interleukin (IL)-18 both during attacks and afebrile phases, compared to tho...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2017.10.007

    authors： Wada T,Toma T,Miyazawa H,Koizumi E,Shirahashi T,Matsuda Y,Yachie A

    更新日期：2018-04-01 00:00:00

  • Modulation of endotoxin stimulated interleukin-6 production in monocytes and Kupffer cells by S-adenosylmethionine (SAMe).

    abstract：:Interleukin-6 (IL-6) is a multifunctional cytokine having primarily anti-apoptotic and anti-inflammatory effects. Recent reports have documented that IL-6 plays a key role in liver regeneration. Intracellular deficiency of S-adenosylmethionine (SAMe) is a hallmark of toxin-induced liver injury. Although the administra...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2004.08.004

    authors： Song Z,Chen T,Deaciuc IV,Uriarte S,Hill D,Barve S,McClain CJ

    更新日期：2004-12-21 00:00:00

  • Atherogenic cytokines and chemokines in chronic hepatitis C are not associated with the presence of cardiovascular diseases.

    abstract：:There appears to be an associative link between chronic hepatitis C (CHC) and cardiovascular diseases (CVDs). However, the exact nature of the relationship between CHC and CVDs has not been elucidated. We investigated the presence of CVDs and the clinical and laboratory alterations associated with these diseases in CH...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2018.12.005

    authors： Santos TPS,Pereira MM,Schinoni MI,Sampaio GP,Aras R Jr,Atta MLS,Atta AM

    更新日期：2019-03-01 00:00:00

  • Expression of cytokines and their receptors by psoriatic fibroblasts. II. decreased TNF receptor expression.

    abstract：:Psoriatic fibroblasts produce enhanced amounts of IL-6 in vitro. This state of activation may reflect an altered expression of cytokine receptors, involved in auto/paracrine induction of IL-6. Cultures of dermal fibroblasts derived from lesional psoriatic (PP) and normal control (NN) skin were therefore analysed for t...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1996.0011

    authors： Debets R,Hegmans JP,Buurman WA,Benner R,Prens EP

    更新日期：1996-01-01 00:00:00

  • Regulation of the interleukin-1 receptor antagonist in THP-1 cells by ligands of the peroxisome proliferator-activated receptor gamma.

    abstract：:Monocytes/macrophages (Mphi) play a pivotal role in the persistence of chronic inflammation and local tissue destruction in diseases such as rheumatoid arthritis and atherosclerosis. The production by Mphi of cytokines, chemokines, metalloproteinases and their inhibitors is an essential component in this process, whic...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2002.1945

    authors： Meier CA,Chicheportiche R,Juge-Aubry CE,Dreyer MG,Dayer JM

    更新日期：2002-06-21 00:00:00

  • Regulation of the interleukin 2 receptor complex tyrosine kinase activity in vitro.

    abstract：:Interleukin 2 (IL-2) has been shown to stimulate tyrosine phosphorylation of a number of proteins requiring only the p75 beta chain of the IL-2 receptor. Unlike the receptors for epidermal growth factor, insulin, and other growth factors, the p55-alpha and p75-beta chains of the IL-2 receptor have no tyrosine protein ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(91)90047-h

    authors： Michiel DF,Garcia GG,Evans GA,Farrar WL

    更新日期：1991-09-01 00:00:00

  • Expression of tumour necrosis factor-alpha, -beta and interferon-gamma genes within human neuroglial tumour cells and brain specimens.

    abstract：:Expression of cytokine genes, TNF-alpha, TNF-beta and IFN-gamma, in human astroglial cell lines and in fresh brain specimens was studied by PCR. mRNA transcripts of TNF-alpha could be detected in three out of five astrocytomas and neuroblastoma cell lines, and after stimulation with IL-1 beta/IFN-gamma or LPS/IFN-gamm...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(94)90039-6

    authors： Nitta T,Ebato M,Sato K,Okumura K

    更新日期：1994-03-01 00:00:00

  • Modulation of the response of rheumatoid arthritis synovial fibroblasts to proinflammatory stimulants with cyclic tensile strain.

    abstract：:Although physical therapy has been shown to be an effective method for treatment of rheumatoid arthritis, a thorough investigation on the impact of mechanical signals upon the complex cytokine network associated with pathogenesis has not yet been conducted. In the current study, our research group investigated the eff...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.03.015

    authors： Bader RA,Wagoner KL

    更新日期：2010-07-01 00:00:00

  • Porcine interleukin 18: cloning, characterization of the cDNA and expression with the baculovirus system.

    abstract：:We have isolated and sequenced a cDNA that contains the coding sequence of porcine interleukin 18 (IL-18) and the recombinant protein of porcine IL-18 was expressed using the baculovirus system. The open reading frame (ORF) of the porcine IL-18 cDNA is 579 base pairs (bp) in length and encodes 192 amino acids. The pre...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1999.0648

    authors： Muneta Y,Mori Y,Shimoji Y,Yokomizo Y

    更新日期：2000-06-01 00:00:00

  • Respiratory syncytial virus upregulates IL-33 expression in mouse model of virus-induced inflammation exacerbation in OVA-sensitized mice and in asthmatic subjects.

    abstract：BACKGROUND:Bronchial asthma (BA) is a chronic disease of the airways. The great majority of BA exacerbations are associated with respiratory viral infections. Recent findings point out a possible role of proinflammatory cytokine interleukin-33 (IL-33) in the development of atopic diseases. Although, little is known abo...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2020.155349

    authors： Nikonova A,Shilovskiy I,Galitskaya M,Sokolova A,Sundukova M,Dmitrieva-Posocco O,Mitin A,Komogorova V,Litvina M,Sharova N,Zhernov Y,Kudlay D,Dvornikov A,Kurbacheva O,Khaitov R,Khaitov M

    更新日期：2021-02-01 00:00:00

  • Effects of amoxicillin on cytokine and osteocalcin expression in bone tissue during experimental acute otitis media.

    abstract：:There are indications that bone regulatory and immune systems are closely related. Of special interest in this context is the acute otitis media (AOM), which mainly affects immunologically immature patients and, when complicated, involves bone tissue. To explore host responses in bone tissue during Haemophilus influen...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2003.11.009

    authors： Melhus A,Ryan AF

    更新日期：2004-03-21 00:00:00

  • Association between cytokine removal by polymyxin B hemoperfusion and improved pulmonary oxygenation in patients with acute exacerbation of idiopathic pulmonary fibrosis.

    abstract：:Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is characterized by severe worsening dyspnea of unknown etiology and high mortality without effective treatment. Recently, direct hemoperfusion with polymyxin B (PMX)-immobilized fiber cartridge (PMX-DHP) has been reported to improve pulmonary oxygenation an...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.08.032

    authors： Oishi K,Mimura-Kimura Y,Miyasho T,Aoe K,Ogata Y,Katayama H,Murata Y,Ueoka H,Matsumoto T,Mimura Y

    更新日期：2013-01-01 00:00:00

  • Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, AND CX3C families of chemokines.

    abstract：:Chemokines are small chemoattractant cytokines involved in normal and pathological immune processes. Although extensive nucleotide sequence data are available for human and murine chemokine cDNA sequences, very few data are currently available regarding rhesus macaque sequences. To increase our understanding of immune...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2002.0875

    authors： Basu S,Schaefer TM,Ghosh M,Fuller CL,Reinhart TA

    更新日期：2002-05-07 00:00:00

  • Polycyclic aromatic hydrocarbons induce IL-8 expression through nuclear factor kappaB activation in A549 cell line.

    abstract：:Air pollution causes increased cardiopulmonary morbidity and mortality. Airway inflammation plays a major role in the pathophysiology of many lung diseases. Proinflammatory cytokines, such as interleukin-8 (IL-8), are responsible in part for the initiation and maintenance of airway inflammation. Asbestos exposure and ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：

    authors： Pei XH,Nakanishi Y,Inoue H,Takayama K,Bai F,Hara N

    更新日期：2002-09-07 00:00:00

  • Internalization and nuclear translocation of IFN-gamma and IFN-gammaR: an ultrastructural approach.

    abstract：:IFN-gamma signalling involves the Jak-STAT pathway. However, several hypothesis have been proposed where the receptor and its ligand itself took an active role within the cell. Using a quantitative immunogold approach, we found that both IFN-gamma and its receptor are rapidly internalized and translocated in the nucle...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1999.0606

    authors： Sadir R,Lortat-Jacob H,Morel G

    更新日期：2000-06-01 00:00:00

  • Wheat gliadin promotes the interleukin-4-induced IgE production by normal human peripheral mononuclear cells through a redox-dependent mechanism.

    abstract：:Increased levels of serum IgE have been described in gliadin-intolerant patients; however, biological mechanisms implicated in this immunoglobulin production remained unknown. In this study, we demonstrated that in vitro crude gliadins and gliadin lysates (Glilys) promoted the IL-4-induced IgE production by human peri...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/s1043-4666(03)00100-5

    authors： Dugas B,Dugas N,Conti M,Calenda A,Pino P,Thomas Y,Mazier D,Vouldoukis I

    更新日期：2003-03-21 00:00:00

  • Studies on toll-like receptor stimuli responsiveness in HIV-1 and HIV-2 infections.

    abstract：BACKGROUND:HIV-1 and HIV-2 are two related viruses with distinct clinical outcomes, where HIV-1 is more pathogenic and transmissible than HIV-2. The pathogenesis of both infections is influenced by the dysregulation and deterioration of the adaptive immune system. However, their effects on the responsiveness of innate ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2009.03.003

    authors： Nowroozalizadeh S,Månsson F,da Silva Z,Repits J,Dabo B,Pereira C,Biague A,Albert J,Nielsen J,Aaby P,Fenyö EM,Norrgren H,Holmgren B,Jansson M

    更新日期：2009-06-01 00:00:00

  • Association between IL12B polymorphisms and inflammatory bowel disease in Caucasian population: A meta-analysis.

    abstract：BACKGROUND:Published studies on association between IL12B (G/A) rs10045431, (T/C)rs6887695 polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian population have yielded conflicting results. The aim of this study was to potentially provide more reliable conclusions by conducting a meta-analysis. METHODS:...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2020.155296

    authors： Wu PB,Wu XM,Qian R,Hong C,Yitian G,Zhang G,Yu YJ

    更新日期：2020-12-01 00:00:00

  • Associations of polymorphisms in interleukins with susceptibility to breast cancer: Evidence from a meta-analysis.

    abstract：BACKGROUND:Associations between polymorphisms in interleukins and breast cancer (BC) were already investigated by many studies, yet with controversial findings. The aim of this meta-analysis was to better clarify associations between polymorphisms in interleukins and BC by combing the results of all relevant articles. ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2020.154988

    authors： Xu G,Wang F

    更新日期：2020-03-09 00:00:00

  • Role of IL-13 in systemic sclerosis.

    abstract：:Systemic sclerosis (SSc) has the highest fatality rate among connective tissue diseases and is characterized by vascular damage, inflammation and fibrosis. Currently, no therapy has proven effective in modifying the course of SSc, a reflection of its complex pathogenesis. T cell-derived cytokines have been implicated ...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2011.08.030

    authors： Fuschiotti P

    更新日期：2011-12-01 00:00:00

  • Common genetic variant on BMP4 contributes to colorectal adenoma and cancer: A meta-analysis based on 15 studies.

    abstract：:Epidemiological studies indicate a genetic contribution to colorectal cancer (CRC), but specific genetic variants remain unknown. Genome-wide association studies have identified rs4444235 at BMP4 as a new colorectal cancer (CRC) and colorectal adenoma (CRA) susceptibility locus in populations of European descent. Afte...

    journal_title：Cytokine

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.cyto.2014.12.021

    authors： Zhou L,Xie J,Gu EL,Huang Y,Qu Y,Xu AP,Zhu Y,Wang H

    更新日期：2015-04-01 00:00:00

  • Differences in the inducible gene expression and protein production of IL-12p40, IL-12p70 and IL-23: involvement of p38 and JNK kinase pathways.

    abstract：:The proper balance between IL-12p40-related cytokines controls the appearance of normal and pathological Th1 immune responses. In this study, we examined the inducible IL-12p40, IL-12p35 and IL-23p19 mRNA expression and protein production in human peripheral blood mononuclear cells (PBMC) and purified monocytes, isola...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2008.04.003

    authors： Dobreva ZG,Stanilova SA,Miteva LD

    更新日期：2008-07-01 00:00:00

  • Multiple cytokine analysis in gastroschisis: Association with adverse outcomes including fetal brain damage.

    abstract：OBJECTIVES:To investigate the distribution of multiple cytokines in gastroschisis and reveal its association with clinical outcomes, including gastrointestinal disorders and fetal brain damage caused by chronic inflammation in gastroschisis. METHODS:We obtained amniotic fluid and arterial cord blood from 10 patients w...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2020.155406

    authors： Owaki T,Imai K,Miki R,Niwa Y,Kotani T,Nakano-Kobayashi T,Ushida T,Kajiyama H

    更新日期：2021-02-01 00:00:00

  • The effect of interleukin 1 alpha on acetaminophen-induced hepatotoxicity.

    abstract：:The protective effect of interleukin 1 alpha (IL-1 alpha) in mice with acetaminophen (AAP)-induced hepatitis was investigated. IL-1 alpha had a significant protective effect if given 2 or more hours (up to 24 hours) before AAP; it significantly reduced mortality of mice and decreased serum transaminase level. The maxi...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(93)90004-o

    authors： Renić M,Culo F,Bilić A,Bukovec Z,Sabolović D,Zupanović Z

    更新日期：1993-05-01 00:00:00

  • Evaluation of the clinical diagnostic value of traditional inflammatory markers and novel biomarkers in intracellular bacterial bloodstream infections.

    abstract：OBJECTIVES:The clinical symptoms of the patients with intracellular bacterial bloodstream infections (Intra-bac BSIs) are atypical, and no early and accurate diagnostic biomarkers exist, which can easily lead to misdiagnosis, inappropriate and delayed treatment. Therefore, it is imperative to find novel biomarkers to h...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2020.155238

    authors： Lin MF,Sun B,Liu ZY,Tang P,Zhang LJ,Wang YY

    更新日期：2020-12-01 00:00:00

  • Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy.

    abstract：:Staphylococcus aureus is one of the versatile Gram positive bacteria causing a range of diseases. Upon challenge, host immune cells recognize S. aureus and mount diverse immune responses including production of pro-inflammatory cytokines such as IL-1β and TNF-α. These cytokines are important mediators of inflammation ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2016.03.007

    authors： Javed N,Xue G,Lu A,Xing Y,Iwakura Y,Xiao H,Lecoeur H,Späth GF,Meng G

    更新日期：2016-05-01 00:00:00

  • Gut immune stimulation by non pathogenic Gram(+) and Gram(-) bacteria. Comparison with a probiotic strain.

    abstract：:We analyzed the gut immune stimulation induced by Gram-positive bacteria: non probiotic Lactobacillus acidophilus CRL 1462 and Lactobacillus acidophilus A9; two potentially probiotic strains: L. acidophilus CRL 924 and Lactobacillusdelbrueckii subsp. bulgaricus CRL 423; comparatively with a probiotic strain: Lactobaci...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2007.11.014

    authors： Dogi CA,Galdeano CM,Perdigón G

    更新日期：2008-03-01 00:00:00

  • Comparison of RT-qPCR and Nanostring in the measurement of blood interferon response for the diagnosis of type I interferonopathies.

    abstract：:Type I interferonopathies are characterized by an increase of circulating type I interferon (IFN) concentration. Type I interferonopathies refer to rare Mendelian genetic disorders such as Aicardi-Goutières Syndrome (AGS) as well as more frequent and polygenic auto-immune diseases like systemic lupus erythematosus (SL...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2018.10.023

    authors： Pescarmona R,Belot A,Villard M,Besson L,Lopez J,Mosnier I,Mathieu AL,Lombard C,Garnier L,Frachette C,Walzer T,Viel S

    更新日期：2019-01-01 00:00:00