Abstract:
:IFN-gamma signalling involves the Jak-STAT pathway. However, several hypothesis have been proposed where the receptor and its ligand itself took an active role within the cell. Using a quantitative immunogold approach, we found that both IFN-gamma and its receptor are rapidly internalized and translocated in the nucleus. We found that cell surface heparan sulfate, which binds IFN-gamma, delayed the nuclear accumulation of IFN-gamma suggesting that these molecules serve as storage depot around the cell for local delivery of the cytokine.
journal_name
Cytokinejournal_title
Cytokineauthors
Sadir R,Lortat-Jacob H,Morel Gdoi
10.1006/cyto.1999.0606keywords:
subject
Has Abstractpub_date
2000-06-01 00:00:00pages
711-4issue
6eissn
1043-4666issn
1096-0023pii
S1043-4666(99)90606-3journal_volume
12pub_type
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