Abstract:
:Three representative cytokines interleukin (IL-8), RANTES and tumour necrosis factor alpha (TNF-alpha) have a concentration-dependent chemotactic effect on the unicellular Tetrahymena. Maximal effective concentrations of IL-8 (1 ng/ml) and RANTES (75 ng/ml) are in the same range as in mammals, which indicates an evolutionary background of physiological effects elicited. Progeny generations of cells selected for their affinity to cytokines (IL-8 and TNF-alpha) show an enhanced positive chemosensory reaction to the cytokines. The changed reaction of these cells to the chemoattraction of the culturing medium was also observed. The results call attention to the presence of cytokine-dependent processes at a low phylogenetic level.
journal_name
Cytokinejournal_title
Cytokineauthors
Köhidai L,Csaba Gdoi
10.1006/cyto.1997.0328subject
Has Abstractpub_date
1998-07-01 00:00:00pages
481-6issue
7eissn
1043-4666issn
1096-0023pii
S1043-4666(97)90328-8journal_volume
10pub_type
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