IL17 and IFNgamma production by peripheral blood mononuclear cells from clinically isolated syndrome to secondary progressive multiple sclerosis.

abstract：:Interleukin 6 (IL-6) stimulates fibrinogen (Fg) gene expression both in vivo and in vitro; while interleukin 1 (IL-1) paradoxically stimulates in vivo, yet inhibits in vitro, Fg synthesis. The naturally occurring interleukin 1 receptor antagonist (IL-1ra) and passive immunization with anti-IL-6 antiserum were used to ...

journal_title：Cytokine

authors： Rokita H,Neta R,Sipe JD

更新日期：1993-09-01 00:00:00

abstract：:Muscle wasting is a decline in skeletal muscle mass and function that is associated with aging, obesity, and a spectrum of pathologies including cancer. Cancer-associated wasting not only reduces quality of life, but also directly impacts cancer mortality, chemotherapeutic efficacy, and surgical outcomes. There is an ...

journal_title：Cytokine

authors： Hogan KA,Cho DS,Arneson PC,Samani A,Palines P,Yang Y,Doles JD

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder which presents with abdominal pain and alterations of the bowel habits. The pathophysiology of IBS is not well-recognized. Low grade inflammation has been suggested as one of the underlying mechanisms of IBS. Variations in the ci...

journal_title：Cytokine

authors： Bashashati M,Moradi M,Sarosiek I

更新日期：2017-11-01 00:00:00

abstract：:Flt3 ligand (FL) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are important growth factors for dendritic cells (DC). Substantial numbers of DC can be generated in vivo following the administration of either factor. We sought to extend our knowledge of the functional properties of these cells including...

journal_title：Cytokine

authors： Daro E,Butz E,Smith J,Teepe M,Maliszewski CR,McKenna HJ

更新日期：2002-02-07 00:00:00

abstract：:TNF-alpha, IL-1, IL-6 and TGF-beta are important macrophage-derived mediators which play the pleiotropic role in inflammatory, metabolic, hematopoietic and immunologic processes. Studies have shown that haemorrhagic shock without significant tissue trauma induces profound immunosuppression which is associated with ele...

journal_title：Cytokine

authors： Zhu XL,Zellweger R,Zhu XH,Ayala A,Chaudry IH

更新日期：1995-01-01 00:00:00

abstract：:Cytokines are key mediators of immune responses to autoantigens, tumor antigens and foreign antigens including pathogens and transplant antigens. The cytokines are produced by a variety of immune and non-immune cells and are dynamically regulated. Remarkably, during toxic and septic shock syndromes, anaphylactic shock...

journal_title：Cytokine

authors： Saha B,Silvestre R

更新日期：2020-10-27 00:00:00

abstract：:We have investigated phosphatidylinositol 3-kinase (PI3K)-dependent survival signalling pathways using several cytokines in three different hemopoietic cell lines, MC/9, FDC-P1, and TF-1. Cytokines caused PI3K- and PKB-dependent phosphorylation of FOXO3a (previously known as FKHRL1) at three distinct sites. Following ...

journal_title：Cytokine

authors： Behzad H,Jamil S,Denny TA,Duronio V

更新日期：2007-05-01 00:00:00

abstract：:To date, the biological activity of granulocyte macrophage-colony stimulating factor (GM-CSF) has been investigated by using mostly Escherichia coli- or yeast cell-derived recombinant human GM-CSF (erhGM-CSF and yrhGM-CSF, respectively). However, Chinese hamster ovary cell-derived recombinant human GM-CSF (crhGM-CSF),...

journal_title：Cytokine

authors： Hashimoto A,Tanaka T,Itoh Y,Yamagata A,Kitamura N,Tazawa R,Nakagaki K,Nakata K

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Endothelial injury is recognized to trigger organ failures during the first 48h of septic shock. We evaluate endothelial biomarkers at ICU admission in their ability to predict severity, outcome, and organ failures in septic shock patients. METHODS:This prospective observational pilot study was conducted in...

journal_title：Cytokine

authors： Palud A,Parmentier-Decrucq E,Pastre J,De Freitas Caires N,Lassalle P,Mathieu D

更新日期：2015-06-01 00:00:00

abstract：:IL-1 strikingly enhances antigen-driven responses of CD4 and CD8 T cells. It is substantially more effective than LPS and when added to a priming regime of antigen plus LPS, it strikingly enhances cell expansion. The effect is mediated by direct action on CD4 and CD8 T cells; the response occurs when OT-I or OT-II cel...

journal_title：Cytokine

authors： Ben-Sasson SZ,Caucheteux S,Crank M,Hu-Li J,Paul WE

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVES:To determine the relationship of serum resistin concentrations to biochemical determinants of bone metabolism, comorbidity and outcomes in patients with hip fracture (HF). METHODS:In 256 consecutive patients (mean age 81.9±7.8 years; 71.1% women) serum levels of resistin (determined by ELISA), biochemical p...

journal_title：Cytokine

authors： Fisher A,Southcott E,Li R,Srikusalanukul W,Davis M,Smith P

更新日期：2011-11-01 00:00:00

abstract：:Sickle cell anemia (SCA) is a disorder characterized by a heterogeneous clinical outcome. In the present study, we investigated the associations between Tumor Necrosis Factor-alpha (TNF-alpha) -308G>A and Interleukin 8 (IL-8) -251A>T gene polymorphisms, medical history and classical biomarkers in children with steady-...

journal_title：Cytokine

authors： Cajado C,Cerqueira BA,Couto FD,Moura-Neto JP,Vilas-Boas W,Dorea MJ,Lyra IM,Barbosa CG,Reis MG,Goncalves MS

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by a wide variety of autoantibodies, some of which are pathogenic. In recent years it has become more evident that the polyclonal B cell activation in SLE is T-cell dependent. The stimulation of the autoantibody producing B cells is li...

journal_title：Cytokine

authors： Sabry A,Sheashaa H,El-Husseini A,Mahmoud K,Eldahshan KF,George SK,Abdel-Khalek E,El-Shafey EM,Abo-Zenah H

更新日期：2006-08-01 00:00:00

abstract：:Systemic sclerosis (SSc) has the highest fatality rate among connective tissue diseases and is characterized by vascular damage, inflammation and fibrosis. Currently, no therapy has proven effective in modifying the course of SSc, a reflection of its complex pathogenesis. T cell-derived cytokines have been implicated ...

journal_title：Cytokine

authors： Fuschiotti P

更新日期：2011-12-01 00:00:00

abstract：:Cisplatin is commonly prescribed for the treatment of various solid tumors but its use is limited due to certain side effects and renal injury is a true example. Oxidative stress and inflammation may contribute to the cisplatin induced nephrotoxicity. Accordingly, we evaluated the effect of oral vanillin intake (100mg...

journal_title：Cytokine

authors： Elseweidy MM,Askar ME,Elswefy SE,Shawky M

更新日期：2017-11-01 00:00:00

abstract：:The present study was aimed at defining the activity of human and mouse monocyte chemotactic protein-1 (MCP-1) on homologous and heterologous mononuclear phagocytes. Human natural and recombinant MCP-1 and mouse natural MCP-1/JE were tested as chemoattractants on human blood monocytes and mouse peritoneal macrophages....

journal_title：Cytokine

authors： Luini W,Sozzani S,Van Damme J,Mantovani A

更新日期：1994-01-01 00:00:00

abstract：:Although numerous studies have shown that visfatin is linked to several cancers, its prognostic value is still unclear. This first comprehensive meta-analysis was performed to evaluate the prognostic effect of visfatin in cancer patients. A systematic search was conducted for relevant studies in health-related electro...

journal_title：Cytokine

authors： Mohammadi M,Moradi A,Farhadi J,Akbari A,Pourmandi S,Mehrad-Majd H

更新日期：2020-03-01 00:00:00

abstract：:Preeclampsia is a common disease of pregnancy characterised by maternal hypertension and proteinuria. Abnormal placentation in early pregnancy and abnormal cytokine and anti-angiogenic factor expression are thought to contribute to the clinical syndrome of endothelial dysfunction evident in the second half of gestatio...

journal_title：Cytokine

authors： Sunderland NS,Thomson SE,Heffernan SJ,Lim S,Thompson J,Ogle R,McKenzie P,Kirwan PJ,Makris A,Hennessy A

更新日期：2011-11-01 00:00:00

abstract：AIMS:Osteocalcin, a bone-derived factor, could be a feasible marker for metabolic disorders and adverse cardiovascular outcomes. This study aimed to explore the correlation between serum osteocalcin levels and correct QT interval (QTc) interval prolongation, a risk factor of cardiac morbidity and mortality. METHODS:We...

journal_title：Cytokine

authors： Xu Y,Wang Y,Ma X,Xiao Y,Wang Y,Bao Y

更新日期：2020-12-01 00:00:00

abstract：:Although immune responses following soft-tissue trauma-hemorrhage are markedly different in young (6-8 weeks) and aged (18-20 months) mice, it remains unknown if there are any differences in immune responses in middle-aged and young mice following bone fracture, soft-tissue trauma-hemorrhage (Fx-TH). To study this, yo...

journal_title：Cytokine

authors： Kang SC,Matsutani T,Choudhry MA,Schwacha MG,Rue LW,Bland KI,Chaudry IH

更新日期：2004-06-07 00:00:00

abstract：:An anti-inflammatory cytokine, interleukin-10 (IL-10) exerts inhibitory effects on vascular inflammation. Chemokines promote vascular inflammation and play a pathogenic role in the development and maintenance of hypertension. However, chemokine CCL5 has down-regulatory effects on angiotensin II (Ang II)-induced hypert...

journal_title：Cytokine

authors： Kim HY,Kim HS

更新日期：2014-07-01 00:00:00

abstract：:Organ failure is associated with increased mortality and morbidity in patients with systemic inflammatory response syndrome. Previously, we showed that a short course of infusion of a hydrogen sulfide (H(2)S) donor reduced metabolism with concurrent reduction of lung injury. Here, we hypothesize that prolonged H(2)S i...

journal_title：Cytokine

authors： Aslami H,Beurskens CJ,de Beer FM,Kuipers MT,Roelofs JJ,Hegeman MA,Van der Sluijs KF,Schultz MJ,Juffermans NP

更新日期：2013-02-01 00:00:00

abstract：:The authors have shown previously that in addition to its survival effects on neurons and glia, ciliary neurotrophic factor (CNTF) induced potent cachectic effects and acute phase proteins when present in the peripheral circulation at concentrations of < or = 10 ng/ml. These effects did not depend upon the induction o...

journal_title：Cytokine

authors： Henderson JT,Mullen BJ,Roder JC

更新日期：1996-10-01 00:00:00

abstract：:In order to study structure-function relationships of the M(r) 55,000 subunit of the murine IL-2R (p55 IL-2R) by epitope mapping, we have expressed the p55 IL-2R molecule in a cell-free translation system. Under these in vitro conditions, we detected the expected p55 IL-2R polypeptide initiated at Met 1 and, in additi...

journal_title：Cytokine

authors： Lorenzo F,Jaulin C,Jankovic DL,Theze J

更新日期：1992-07-01 00:00:00

abstract：:The monocytic cell line U937 is a frequently used model in studies on the cytotoxic effect of tumour necrosis factor (TNF). Two sublines of this cell line, termed U937(G) and U937(M), revealing different patterns of response to this cytokine, have been identified. The U937(G) cells, similarly to the cells obtained fro...

journal_title：Cytokine

authors： Kaszubowska L,Engelmann H,Gotartowska M,Iliszko M,Bigda J

更新日期：2001-03-21 00:00:00

abstract：:Dendritic cell-based vaccines are considered as a new and promising immunotherapeutic approach for cancer treatment. However, the choice of optimal protocol of dendritic cell generation in vitro represents the major challenge. Here, we compared phenotype and functional characteristics of human monocyte-derived dendrit...

journal_title：Cytokine

authors： Leplina OY,Tyrinova TV,Tikhonova MA,Ostanin AA,Chernykh ER

更新日期：2015-01-01 00:00:00

abstract：:Among New Mexican Hispanic women, breast cancer is detected at a more advanced stage than compared to Non-Hispanic White women. One central factor that has been little studied is the role of critical cytokines. We genotyped incident breast cancer cases and their age-, gender- and smoking-matched controls (N=40 matched...

journal_title：Cytokine

authors： Erdei E,Kang H,Meisner A,White K,Pickett G,Baca C,Royce M,Berwick M

更新日期：2010-07-01 00:00:00

abstract：:Neuregulin-4 (Nrg4) is a novel adipokine associated with obesity, hyperglycemia, insulin resistance, dislipidemia, inflammation, and oxidative stress in mice and humans. However, no report has demonstrated the relationship of circulating Nrg4 with diabetic peripheral neuropathy (DPN). The objective of our study was to...

journal_title：Cytokine

authors： Yan P,Xu Y,Zhang Z,Gao C,Zhu J,Li H,Wan Q

更新日期：2019-01-01 00:00:00

abstract：:To verify the role of macrophage migration inhibitory factor (MIF) in tumourigenesis, we examined the effect of an anti-MIF antibody on tumour growth and angiogenesis. We inoculated murine colon adenocarcinoma cell line colon 26 cells subcutaneously into the flank in BALB/c mice. After nine days, we treated tumour-bea...

journal_title：Cytokine

authors： Ogawa H,Nishihira J,Sato Y,Kondo M,Takahashi N,Oshima T,Todo S

更新日期：2000-04-01 00:00:00

abstract：:The objectives were to determine if blood IL-10 levels rise during the early stages of acute (wasting) pre-pubescent malnutrition in metabolically distinct murine models known to depress inflammatory immune competence and whether systemic IL-10 production is affected in these pathologies. Weanling C57BL/6J mice were a...

journal_title：Cytokine

authors： Monk JM,Woodward B

更新日期：2009-08-01 00:00:00