The mediating role of the visceral fat area in the correlation between the serum osteocalcin levels and a prolonged QTc interval.


AIMS:Osteocalcin, a bone-derived factor, could be a feasible marker for metabolic disorders and adverse cardiovascular outcomes. This study aimed to explore the correlation between serum osteocalcin levels and correct QT interval (QTc) interval prolongation, a risk factor of cardiac morbidity and mortality. METHODS:We recruited 1210 subjects (age range: 26-80 years) in communities in Shanghai. Serum osteocalcin levels were determined using an electrochemiluminescence immunoassay. The QTc interval was measured using a 12-lead electrocardiogram and was calculated by the Bazett formula. A prolonged QTc interval was defined as QTc > 440 ms. Visceral fat area (VFA) was assessed by magnetic resonance imaging. A VFA of 80 cm2 was applied as a cut-off point for central obesity. RESULTS:Subjects with diabetes, overweight/obesity, or central obesity had significantly lower serum osteocalcin levels than those without (all P < 0.01). In subjects with a normal QTc interval, QTc interval lengthening accompanied decreasing osteocalcin levels (Pfor trend = 0.033), and the decline was more obvious in subjects with a prolonged QTc interval (Pfor trend = 0.022). Serum osteocalcin levels were correlated with the QTc interval (standardized β = -0.082, P = 0.005). Neither diabetes nor overweight/obesity was correlated with the QTc interval, whereas central obesity was positively correlated (P = 0.032). In addition, the correlation between osteocalcin levels and the QTc interval was attenuated when central obesity was included in the model simultaneously (standardized β = -0.075, P = 0.010). Mediation analysis revealed that VFA played a mediating role in the aforementioned correlation, and the estimated percentage of the total effect mediated by VFA was 20.9% (P = 0.007). CONCLUSIONS:VFA partially mediated the inverse correlation between the serum osteocalcin levels and QTc interval, suggesting that improving fat metabolism may be a mechanism by which osteocalcin protects against cardiovascular diseases.






Xu Y,Wang Y,Ma X,Xiao Y,Wang Y,Bao Y




Has Abstract


2020-12-01 00:00:00














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    abstract:BACKGROUND:Published studies on association between IL12B (G/A) rs10045431, (T/C)rs6887695 polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian population have yielded conflicting results. The aim of this study was to potentially provide more reliable conclusions by conducting a meta-analysis. METHODS:...


    pub_type: 杂志文章


    authors: Wu PB,Wu XM,Qian R,Hong C,Yitian G,Zhang G,Yu YJ

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  • Marked cell-type-specific differences in glycosylation of human interleukin-6.

    abstract::Human interleukin-6 (IL-6) secreted by cytokine- or endotoxin-induced fibroblasts, monocytes, keratinocytes, endometrial stromal cells, and endothelial cells, when analyzed under denaturing and reducing conditions, consists of a set of differentially modified phosphoglycoproteins of molecular mass in the range from 23...


    pub_type: 杂志文章


    authors: May LT,Shaw JE,Khanna AK,Zabriskie JB,Sehgal PB

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  • Modification of biological responses to interleukin-1 by agents that perturb signal transduction pathways.

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    pub_type: 杂志文章


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  • Inflammations mediators and circulating levels of matrix metalloproteinases: Biomarkers of diabetes in Tunisians metabolic syndrome patients.

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    pub_type: 杂志文章


    authors: Zayani Y,El Golli N,Zidi W,Guizani I,Boussairi S,Aloui S,Ayadi I,Ftouhi B,Feki M,Ben Romdhane N,Ben Sliman H,Allal-Elasmi M,Kaabachi N

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  • Serum factors potentiate hypoxia-induced hepatotoxicity in vitro through increasing transforming growth factor-beta1 activation and release.

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  • Pattern of cytokine expression by rat liver epithelial cells supporting long-term culture of human CD34(+)umbilical cord blood cells.

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    authors: Rialland M,Corlu A,Ilyin G,Cabillic F,Lamy I,Guguen-Guillouzo C

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  • Combination interleukin-2 and interleukin-12 induces severe gastrointestinal toxicity and epithelial cell apoptosis in mice.

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    authors: Kaufman HL,Swartout BG,Hörig H,Lubensky I

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    authors: Overbergh L,Valckx D,Waer M,Mathieu C

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    authors: Ishimoto K,Iwata T,Taniguchi H,Mizusawa N,Tanaka E,Yoshimoto K

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    pub_type: 杂志文章


    authors: Zhu J,Carver W

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  • A short course of infusion of a hydrogen sulfide-donor attenuates endotoxemia induced organ injury via stimulation of anti-inflammatory pathways, with no additional protection from prolonged infusion.

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    authors: Aslami H,Beurskens CJ,de Beer FM,Kuipers MT,Roelofs JJ,Hegeman MA,Van der Sluijs KF,Schultz MJ,Juffermans NP

    更新日期:2013-02-01 00:00:00

  • Tumor necrosis factor-α and interleukin-1β gene polymorphisms and risk of brain abscess in North Indian population.

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    authors: Mishra P,Prasad KN,Singh K,Bajpai A,Sahu RN,Ojha BK

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    pub_type: 杂志文章


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    authors: Melhus A,Ryan AF

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    authors: Kathamuthu GR,Moideen K,Sridhar R,Baskaran D,Babu S

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    pub_type: 杂志文章


    authors: Pusztai L,Lewis CE,McGee JO

    更新日期:1993-03-01 00:00:00

  • The IL-17 G-152A single nucleotide polymorphism is associated with pulmonary tuberculosis in northern Spain.

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    authors: Ocejo-Vinyals JG,de Mateo EP,Hoz MÁ,Arroyo JL,Agüero R,Ausín F,Fariñas MC

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  • Developmental changes in circulating IL-8/CXCL8 isoforms in neonates.

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  • Interferon alpha induces generation of semi-mature dendritic cells with high pro-inflammatory and cytotoxic potential.

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    pub_type: 杂志文章


    authors: Leplina OY,Tyrinova TV,Tikhonova MA,Ostanin AA,Chernykh ER

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  • Seasonal variation in whole blood cytokine production after LPS stimulation in normal individuals.

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    pub_type: 杂志文章


    authors: Myrianthefs P,Karatzas S,Venetsanou K,Grouzi E,Evagelopoulou P,Boutzouka E,Fildissis G,Spiliotopoulou I,Baltopoulos G

    更新日期:2003-12-21 00:00:00

  • Molecular cloning and functional characterization of Cynomolgus monkey (Macaca fascicularis) CC chemokine receptor, CCR3.

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    pub_type: 杂志文章


    authors: Iino T,Sugimoto H,Watanabe A,Encinas JA,Liu N,Floeckner J,Bacon KB

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  • Changes in immune-endocrine response after surgery.

    abstract::The authors evaluated the relationship between hormonal and cytokine responses after surgery. Patients who underwent thoracic oesophagectomy (O group; n = 7), pulmonary lobectomy (P group; n = 5), modified mastectomy (M group; n = 5) and laparoscopic cholecystectomy (LC group; n = 7), were randomly selected. Circulati...


    pub_type: 杂志文章


    authors: Yamauchi H,Kobayashi E,Yoshida T,Kiyozaki H,Hozumi Y,Kohiyama R,Suminaga Y,Sakurabayashi I,Fujimura A,Miyata M

    更新日期:1998-07-01 00:00:00

  • Supplemental vitamin D increases serum cytokines in those with initially low 25-hydroxyvitamin D: a randomized, double blind, placebo-controlled study.

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    pub_type: 杂志文章,随机对照试验


    authors: Barker T,Rogers VE,Levy M,Templeton J,Goldfine H,Schneider ED,Dixon BM,Henriksen VT,Weaver LK

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  • Proinflammatory cytokines (TNF-alpha and IL-6) in Egyptian patients with SLE: its correlation with disease activity.

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    pub_type: 杂志文章


    authors: Sabry A,Sheashaa H,El-Husseini A,Mahmoud K,Eldahshan KF,George SK,Abdel-Khalek E,El-Shafey EM,Abo-Zenah H

    更新日期:2006-08-01 00:00:00

  • Transcutaneous IL-2 uptake mediated by Transfersomes depends on concentration and fractionated application.

    abstract:INTRODUCTION:Transfersomes (TF) are new, ultradeformable carriers with characteristics that enable them to penetrate the skin spontaneously. TFs are able to transport noninvasively both low- and high-molecular-weight molecules into the body. MATERIALS AND METHODS:TFs contain phosphatidylcholine and sodium cholate. Rec...


    pub_type: 杂志文章


    authors: Hofer C,van Randenborgh H,Lehmer A,Hartung R,Breul J

    更新日期:2004-02-21 00:00:00

  • Cytokines in the immunity and immunopathogenesis in leishmaniases.

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    pub_type: 杂志文章


    authors: Saha B,Silvestre R

    更新日期:2020-10-27 00:00:00

  • Level of tear cytokines in population-level participants and correlation with clinical features.

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    pub_type: 杂志文章


    authors: Tong L,Wong TY,Cheng Y

    更新日期:2018-10-01 00:00:00

  • The effects of soy supplementation on inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials.

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    pub_type: 杂志文章


    authors: Asbaghi O,Yaghubi E,Nazarian B,Kelishadi MR,Khadem H,Moodi V,Naeini F,Ghaedi E

    更新日期:2020-12-01 00:00:00