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The mediating role of the visceral fat area in the correlation between the serum osteocalcin levels and a prolonged QTc interval.

Abstract：

AIMS:Osteocalcin, a bone-derived factor, could be a feasible marker for metabolic disorders and adverse cardiovascular outcomes. This study aimed to explore the correlation between serum osteocalcin levels and correct QT interval (QTc) interval prolongation, a risk factor of cardiac morbidity and mortality. METHODS:We recruited 1210 subjects (age range: 26-80 years) in communities in Shanghai. Serum osteocalcin levels were determined using an electrochemiluminescence immunoassay. The QTc interval was measured using a 12-lead electrocardiogram and was calculated by the Bazett formula. A prolonged QTc interval was defined as QTc > 440 ms. Visceral fat area (VFA) was assessed by magnetic resonance imaging. A VFA of 80 cm2 was applied as a cut-off point for central obesity. RESULTS:Subjects with diabetes, overweight/obesity, or central obesity had significantly lower serum osteocalcin levels than those without (all P < 0.01). In subjects with a normal QTc interval, QTc interval lengthening accompanied decreasing osteocalcin levels (Pfor trend = 0.033), and the decline was more obvious in subjects with a prolonged QTc interval (Pfor trend = 0.022). Serum osteocalcin levels were correlated with the QTc interval (standardized β = -0.082, P = 0.005). Neither diabetes nor overweight/obesity was correlated with the QTc interval, whereas central obesity was positively correlated (P = 0.032). In addition, the correlation between osteocalcin levels and the QTc interval was attenuated when central obesity was included in the model simultaneously (standardized β = -0.075, P = 0.010). Mediation analysis revealed that VFA played a mediating role in the aforementioned correlation, and the estimated percentage of the total effect mediated by VFA was 20.9% (P = 0.007). CONCLUSIONS:VFA partially mediated the inverse correlation between the serum osteocalcin levels and QTc interval, suggesting that improving fat metabolism may be a mechanism by which osteocalcin protects against cardiovascular diseases.

journal_name

Cytokine

journal_title

Cytokine

authors

Xu Y,Wang Y,Ma X,Xiao Y,Wang Y,Bao Y

doi

10.1016/j.cyto.2020.155261

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

155261

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(20)30277-5

journal_volume

136

pub_type

杂志文章

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The mediating role of the visceral fat area in the correlation between the serum osteocalcin levels and a prolonged QTc interval.