Abstract:
:IL-4 and IL-13 are pleiotropic Th2 cytokines produced by a wide variety of different cell types and responsible for a broad range of biology and functions. Physiologically, Th2 cytokines are known to mediate host defense against parasites but they can also trigger disease if their activities are dysregulated. In this review we discuss the rationale for targeting the IL-4/IL-13 axes in asthma, atopic dermatitis, allergic rhinitis, COPD, cancer, inflammatory bowel disease, autoimmune disease and fibrotic disease as well as evaluating the associated clinical data derived from blocking IL-4, IL-13 or IL-4 and IL-13 together.
journal_name
Cytokinejournal_title
Cytokineauthors
May RD,Fung Mdoi
10.1016/j.cyto.2015.05.018subject
Has Abstractpub_date
2015-09-01 00:00:00pages
89-116issue
1eissn
1043-4666issn
1096-0023pii
S1043-4666(15)00204-5journal_volume
75pub_type
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