Abstract:
:Interleukin-17A (IL-17A) contributes to the pathogenesis of arthritis. Data from experimental arthritis indicate IL-17 receptor signaling as a critical pathway in turning an acute synovitis into a chronic destructive arthritis. The identification of six IL-17 family members (IL-17A-F) may extend the role of this novel cytokine family in the pathogenesis of chronic destructive joint inflammation. Whether the successful anti-IL-17A cytokine therapy in murine arthritis can be effectively translated to human arthritis need to be tested in clinical trials in humans. Interestingly, IL-17A and IL-17F are secreted by the novel T helper subset named Th17. This novel pathogenic T cell population induces autoimmune inflammation in mice and is far more efficient at inducing Th1-mediated autoimmune inflammation in mice than classical Th1 cells (IFN-gamma). In addition to IL-17A and IL-17F, Th17 cells are characterized by expression of IL-6, TNF, GM-CSF, IL-21, IL-22 and IL-26. Th17 cells have been established as a separate lineage of T helper cells in mice distinct from conventional Th1 and Th2 cells. Whether this also applies to human Th17 and whether RA is a Th1 or a Th17 mediated disease is still not clear. This review summarizes the findings about the role of IL-17 in arthritis and discusses the impact of the discovery of the novel Th17 cells for arthritis. Further studies are needed to unravel the role of Th17 cells and the interplay of IL-17 and other Th17 cytokines in the pathogenesis of arthritis and whether regulating Th17 cell activity will have additional value compared to neutralizing IL-17A activity alone. This might help to reach the ultimate goal not only to treat RA patients but to prevent the development of this crippling disease.
journal_name
Cytokinejournal_title
Cytokineauthors
Lubberts Edoi
10.1016/j.cyto.2007.09.014subject
Has Abstractpub_date
2008-02-01 00:00:00pages
84-91issue
2eissn
1043-4666issn
1096-0023pii
S1043-4666(07)00434-6journal_volume
41pub_type
杂志文章,评审相关文献
CYTOKINE文献大全abstract::Obesity, a chronic low-grade inflammation metabolic abnormality, is related to high proinflammatory cytokines concentrations. Epstein-Barr virus-induced gene 3 (EBI3) encodes for the EBI3 beta subunit that constitutes interleukin (IL) 27 and 35. Our objective was to assess the association of three EBI3 single nucleoti...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155225
更新日期:2020-11-01 00:00:00
abstract::Since its first description in 1966, macrophage migration inhibitory factor (MIF) was found to play a critical role in inflammatory and immune responses as well as in disease pathogenesis especially in tumor pathogenesis and cancer progression. MIF is expressed in different cell types and is associated with many disea...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.06.006
更新日期:2017-09-01 00:00:00
abstract::Preeclampsia is a common disease of pregnancy characterised by maternal hypertension and proteinuria. Abnormal placentation in early pregnancy and abnormal cytokine and anti-angiogenic factor expression are thought to contribute to the clinical syndrome of endothelial dysfunction evident in the second half of gestatio...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.06.003
更新日期:2011-11-01 00:00:00
abstract::Ras expression has been suggested to be a marker for tumor aggressiveness of breast cancer. We previously showed that H-Ras, but not N-Ras, induced invasive/migratory phenotypes in MCF10A human breast epithelial cells. The present study aimed to determine the role of granulocyte colony-stimulating factor in H-Ras-indu...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.03.002
更新日期:2011-07-01 00:00:00
abstract::The aim of this study is to investigate the relationship between chemokines and the inflammation in Familial Mediterranean Fever (FMF). Forty-nine patients with FMF (41 in remission and 8 in acute attack period) and 20 healthy controls were included in the study. Serum levels of macrophage inflammatory protein-1alpha ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.12.005
更新日期:2007-01-01 00:00:00
abstract::IL-1 family members regulate innate immune responses, are produced by gestation-associated tissues, and have a role in healthy and adverse pregnancy outcomes. To better understand their role at the materno-fetal interface we used a human tissue explant model to map lipopolysaccharide (LPS)-stimulated production of IL-...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.07.005
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:HIV-1 and HIV-2 are two related viruses with distinct clinical outcomes, where HIV-1 is more pathogenic and transmissible than HIV-2. The pathogenesis of both infections is influenced by the dysregulation and deterioration of the adaptive immune system. However, their effects on the responsiveness of innate ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.03.003
更新日期:2009-06-01 00:00:00
abstract::Transforming Growth Factor-beta (TGFbeta) is known to be a negative regulator of G1 cyclin/cdk activity. It is not clear whether TGFbeta has any effect on G2 checkpoint kinases. We have found that TGFbeta downregulated the expression of several G2 checkpoint kinases including cdc2, cyclin B1, and cdc25c without causin...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.03.009
更新日期:2007-02-01 00:00:00
abstract::Leishmania major, the causative agent of zoonotic cutaneous leishmaniasis shows heterogeneity and diverse clinical manifestations in different areas of infection and experimental models. Such polymorphism may cause difficulties in selection of reliable strains for development of prophylaxes. Hence, the aim of this stu...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2015.05.022
更新日期:2015-12-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a fast-growing cancer characterized by high occurrences of nodal and distant metastases and poor prognosis. It is therefore important to identify new serum biomarkers for the early diagnosis and prognostic prediction of this disease. The present study identifies biomarkers in NPC pati...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.04.031
更新日期:2019-06-01 00:00:00
abstract::Functional diversity of the memory T-cell-derived cytokine IL-17 was explored at the receptor level. IL-17 inhibited TNF-induced chemokine Rantes expression in human synovial fibroblasts and mouse lung fibroblasts. This inhibitory activity of IL-17 (IC50=0.2 ng/ml) was 6-fold more potent than its stimulatory activity ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2005.02.012
更新日期:2005-08-07 00:00:00
abstract:BACKGROUND:Obesity is associated with endothelial dysfunction and increased inflammation as well as with expansion of the capillary bed in regional adipose deposits, and a balance between these factors is involved in angiogenesis. Osteopontin (OPN) is a proinflammatory cytokine involved in regulating immune processes a...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.03.020
更新日期:2011-07-01 00:00:00
abstract::The effects of scatter factor on the cytoskeleton of MDCK and PtK2 cells are described. During the first 6 h after the addition of scatter factor, MDCK cells were found to increase their projected areas twofold, as well as the number and size of their F-actin stress fibers. In contrast PtK2 cells showed no change in t...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(91)90498-3
更新日期:1991-07-01 00:00:00
abstract::The expression of oncostatin M and leukemia inhibitory factor (LIF), JAK-STAT activators and members of the interleukin-6 family of cytokines, were examined in a series of primary ovarian carcinomas using immunohistochemistry. The malignant epithelial cells of all 29 ovarian carcinomas examined expressed oncostatin M;...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2002.1022
更新日期:2002-03-21 00:00:00
abstract::We have demonstrated that ingested murine interferon alpha (IFN-alpha) suppressed clinical relapse in chronic relapsing experimental autoimmune encephalomyelitis (CR-EAE), decreased inflammation and suppressed the adoptive transfer of EAE, and is a biological response modifier in patients with multiple sclerosis. We e...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1998.0450
更新日期:1999-07-01 00:00:00
abstract::During T-lymphocyte differentiation in the thymus, the majority of thymocytes die by apoptosis in situ. This process is characterized by internucleosomal DNA fragmentation and is induced by a number of stimuli including glucocorticoids, calcium ionophore, cAMP and 12-o-tetradecanoylphorbol 13-acetate (TPA). In this st...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(93)90066-e
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:We aimed to investigate the use of novel serum biomarkers for predicting the recurrence and survival of patients with hepatitis B virus (HBV)-related early hepatocellular carcinoma (HCC) after hepatic resection or radiofrequency ablation (RFA). METHODS:One hundred and five patients with HBV-related HCC, who...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2015.02.027
更新日期:2015-06-01 00:00:00
abstract::The purpose of this study was to clone and characterize the bovine IL-1rII. Using a human IL-1rII probe, three putative exons of the bovine IL-1rII were identified from a bovine genomic library. The full length cDNA for bovine IL-1rII was cloned from a bovine endometrial cDNA library using oligonucleotides designed fr...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0129
更新日期:1997-01-01 00:00:00
abstract::Surgery is followed by an acute-phase response, including hypothalamo-pituitary-adrenal (HPA)-axis activation and fever. Considering its physiological properties and its behaviour in plasma after stress and surgery, the pro-inflammatory cytokine interleukin (IL)-6 is a putative candidate in eliciting these stress-rela...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/s1043-4666(03)00093-0
更新日期:2003-03-07 00:00:00
abstract::Vascular smooth muscle cells (VSMC) may be programmed by nutrient deprivation. We found that after 2 and 12 h exposure to 75% reduced amino acids, the release of basic fibroblast growth factor (bFGF) and transforming growth factor beta1 (TGF beta 1) from VSMC was significantly greater than that from cells maintained i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0710
更新日期:2000-09-01 00:00:00
abstract::The JAK-STAT3 signaling pathway is engaged by many cytokines and growth factor stimuli to control diverse biological processes including proliferation, angiogenesis, survival, immune modulation, and metabolism. For over two decades it has been accepted that STAT3-dependent biology is due to its potency as a transcript...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2016.05.019
更新日期:2016-11-01 00:00:00
abstract::We have examined basal and lipopolysaccharide (LPS)-induced release of interleukin 1 beta (IL-1 beta), interleukin 6 (IL-6), interleukin 8 (IL-8), tumour necrosis factor-alpha (TNF-alpha) and soluble CD14 (sCD14) in whole blood and peripheral blood mononuclear cells (PBMC) from 20 persons with either high (1.62-2.47 m...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(94)90080-9
更新日期:1994-09-01 00:00:00
abstract::Sickle cell anemia (SCA) is a disorder characterized by a heterogeneous clinical outcome. In the present study, we investigated the associations between Tumor Necrosis Factor-alpha (TNF-alpha) -308G>A and Interleukin 8 (IL-8) -251A>T gene polymorphisms, medical history and classical biomarkers in children with steady-...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.07.002
更新日期:2011-11-01 00:00:00
abstract::Most studies have shown that interleukin-1 (IL-1) acts as a helper or co-stimulator in T-lymphocyte activation and proliferation by mitogens or antigens. We describe here a stable subclone (D10S) of the murine D10.G4.1 helper T-cell which proliferates to subfemtomolar (attomolar) concentrations of IL-1 beta or alpha i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(89)91044-2
更新日期:1989-11-01 00:00:00
abstract::Three molecules, interleukin 1 (IL-1) receptor I (IL-1RI), IL-1 receptor II (IL-1RII or decoy) and IL-1 receptor accessory protein (IL-1R AcP or IL-1RIII), are involved in IL-1 binding and signal transduction. In addition, three homologous genes (T1/ST2, MyD88 and rsc786) have been identified. Expression of the signal...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1998.0359
更新日期:1998-10-01 00:00:00
abstract::Cisplatin is commonly prescribed for the treatment of various solid tumors but its use is limited due to certain side effects and renal injury is a true example. Oxidative stress and inflammation may contribute to the cisplatin induced nephrotoxicity. Accordingly, we evaluated the effect of oral vanillin intake (100mg...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.07.025
更新日期:2017-11-01 00:00:00
abstract::An accurate and simultaneous estimate of cellular levels of a large cytokine number is very useful to obtain information about an organ dysfunction leading to cancer because through the understanding of the evolution of cytokine patterns we can recognize and predict the disease progression. Cancer cell lines are commo...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.09.002
更新日期:2013-11-01 00:00:00
abstract::We analyzed the gut immune stimulation induced by Gram-positive bacteria: non probiotic Lactobacillus acidophilus CRL 1462 and Lactobacillus acidophilus A9; two potentially probiotic strains: L. acidophilus CRL 924 and Lactobacillusdelbrueckii subsp. bulgaricus CRL 423; comparatively with a probiotic strain: Lactobaci...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.11.014
更新日期:2008-03-01 00:00:00
abstract::Estrogens have been shown to markedly modulate the immune system. One mechanism by which estrogens could modulate the immune system is by regulating cytokines, an aspect not well-studied thus far. To address this issue, normal C57BL/6 orchiectomized mice were given estrogen and its effects on selected cytokines, inter...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2001.0876
更新日期:2001-05-21 00:00:00
abstract::A number of chemokines induce angiogenesis and endothelial cells express several chemokine receptors. To date, only a limited number of CC chemokines for CCR1 have been reported to induce angiogenic responses. We investigated the ability of CCL23 (also known as MPIF-1, MIP-3, or CKbeta8) to promote angiogenesis, which...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2005.01.018
更新日期:2005-06-07 00:00:00