Abstract:
OBJECTIVES:To measure the serum and synovial fluid (SF) levels of interleukin (IL)-37 in patients with rheumatoid arthritis (RA) and to investigate the effect of recombinant human (rh)IL-37 on inflammatory cytokine production (tumor necrosis factor [TNF]-α, IL-6, IL-17 and IL-10) by peripheral blood mononuclear cells (PBMCs) in RA patients. METHODS:An enzyme-linked immunosorbent assay (ELISA) was used to analyse the serum and SF IL-37 levels. RhIL-37 was used to stimulate RA patient PBMCs. The supernatant TNF-α, IL-17, IL-6 and IL-10 levels were detected with ELISAs. RESULTS:The serum IL-37 levels in RA patients were significantly increased compared with those of osteoarthritis (OA) and healthy controls (HC), and they were especially elevated in RA patients with positive rheumatoid factor (RF) and anti-citrullinated peptide antibody (CCP) levels. Furthermore, the serum IL-37 levels were positively correlated with RF values. In 20 matched RA SF and serum samples, the SF IL-37 levels were much higher than those in the serum. After anti-TNF-α therapy, the serum IL-37 levels significantly decreased. Additionally, rhIL-37 significantly down-regulated TNF-α, IL-17 and IL-6 production by RA patient PBMCs. CONCLUSIONS:IL-37 is an important anti-inflammatory cytokine in the control of RA pathogenesis by suppressing inflammatory cytokine production. Thus, IL-37 administration may be a novel therapy for RA.
journal_name
Cytokinejournal_title
Cytokineauthors
Xia L,Shen H,Lu Jdoi
10.1016/j.cyto.2015.06.005subject
Has Abstractpub_date
2015-12-01 00:00:00pages
553-557issue
2eissn
1043-4666issn
1096-0023pii
S1043-4666(15)00239-2journal_volume
76pub_type
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