Abstract:
:Granulocyte colony-stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSCs) are more frequently used as the cellular source in allogeneic hematopoietic stem cell transplantation (HSCT) than bone marrow stem cells (BMSCs) because they promote more rapid engraftment and immune reconstitution. However, the underlying mechanism for this is not fully understood. Here, we investigated the role of Toll-like receptor 2 (TLR2) on PBSCs in promoting rapid engraftment after allogeneic HSCT. We found that PBSCs highly expressed TLR2 in comparison to BMSCs, and TLR2 was directly induced by G-CSF signaling. Treatment with the TLR2 ligand, Pam(3)CSK(4) (PAM), more efficiently induced myeloid differentiation of PBSCs than BMSCs. Similarly, endogenous TLR2 ligands from the serum of recipients of allogeneic transplantation more rapidly stimulated myeloid differentiation of PBSCs compared with BMSCs. PAM treatment of TLR2(-/-) syngeneic recipient mice transplanted with PBSCs resulted in significantly elevated numbers of PBSC-derived myeloid cells and spleen colony formation compared with controls. Our results demonstrate that TLR2 signaling in PBSCs correlates with their ability to rapidly differentiate into myeloid cells, resulting in improved engraftment. Thus, TLR2 may be a novel target for increasing the efficiency of allogeneic HSCT by overcoming engraftment failure or delayed engraftment.
journal_name
Cytokinejournal_title
Cytokineauthors
Joo YD,Lee WS,Won HJ,Lee SM,Choi JH,Lee SM,Han KH,Park SG,Choi IW,Seo SKdoi
10.1016/j.cyto.2010.12.020subject
Has Abstractpub_date
2011-04-01 00:00:00pages
36-42issue
1eissn
1043-4666issn
1096-0023pii
S1043-4666(10)00803-3journal_volume
54pub_type
杂志文章相关文献
CYTOKINE文献大全abstract:RATIONALE:Sarcoidosis is an idiopathic granulomatous disorder with heterogeneous clinical manifestations and variable prognosis. Monitoring disease activity is important to identify patients requiring treatment. Several cytokines have previously been shown to be elevated in the serum of patients with sarcoidosis and ma...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.07.010
更新日期:2013-10-01 00:00:00
abstract::The hypothalamic-pituitary-adrenal (HPA) axis is stimulated during immune and inflammatory processes. Interleukin 1beta (IL-1beta) and lipopolysaccharide (LPS) are known to be potent stimulators of this axis. During postnatal development, the rat seems to be hyporesponsive to many stimuli. The effects of repeated syst...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1999.0423
更新日期:1999-03-01 00:00:00
abstract::To clarify the biological significance of tumour necrosis factor alpha (TNF-alpha) precursor, we analysed its expression at the primed and triggered stages using human monocyte-like cell line THP-1. To prime them, THP-1 cells were treated with either recombinant human interferon gamma (rIFN-gamma) or recombinant human...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(94)90056-6
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVES:Vascular endothelial cell growth factor (VEGF) plays an important role in the biology of gynecological cancer, usually linked with aggressive tumour behaviour and a poor postoperative outcome. Yet, its role in benign breast/gynecological conditions is less clear. METHODS:Serum VEGF was analysed in a series ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.12.007
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:The initial study has reported the increased level of oncostatin M (OSM) in gingival crevicular fluid (GCF) of chronic periodontitis patients, and no study has reported its level in gingivitis patients. Therefore, the present study has been carried out to measure the level of OSM in gingival crevicular fluid ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.02.002
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Unregulated inflammatory and thrombotic responses have been proposed to be important causes of early brain injury and worse clinical outcomes after subarachnoid hemorrhage (SAH). OBJECTIVE:We hypothesize that SAH is characterized by an increased inflammatory and thrombotic state and disruption of associatio...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.09.003
更新日期:2018-11-01 00:00:00
abstract::Since liver regeneration after partial hepatectomy (PHx) is known to improve by pretreatment with recombinant human G-CSF (rhG-CSF), we investigated the mechanism by evaluating the distribution and activity of sinusoidal NK cells. F344 rats were treated with rhG-CSF (250 microg/kg/day) for 5 days before PHx. Pretreatm...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.04.001
更新日期:2006-04-01 00:00:00
abstract::Estrogens have been shown to markedly modulate the immune system. One mechanism by which estrogens could modulate the immune system is by regulating cytokines, an aspect not well-studied thus far. To address this issue, normal C57BL/6 orchiectomized mice were given estrogen and its effects on selected cytokines, inter...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2001.0876
更新日期:2001-05-21 00:00:00
abstract::iNKT cells, CD1d dependent natural killer T cells are a unique population of T cells. The capacity of iNKT cells to produce regulatory cytokines first provided an indication of their regulatory potential. Later on, in experimental models as well as in patients afflicted with an auto-immune disease, such as Type 1 diab...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2010.11.001
更新日期:2011-03-01 00:00:00
abstract::The chemokine eotaxin (CCL11) is a key player in the trafficking of eosinophils to normal tissues and in the tissue eosinophilia associated with human allergic disease. We have recently cloned equine eotaxin and here we report the production of rEq eotaxin, with and without a C-terminal fusion peptide, in a novel expr...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2002.1052
更新日期:2002-07-07 00:00:00
abstract::A well-known association between vitamin D(3) and infection with Mycobacterium tuberculosis has previously been reported, but little is known regarding the underlying mechanisms. We have investigated how 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] affects the proinflammatory cytokine production induced by M. tubercul...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.04.016
更新日期:2011-08-01 00:00:00
abstract::Emerging evidence indicates that chemokine receptor expression patterns are critical in determining the spectrum of action of the chemokines. We have analysed the expression patterns of 17 chemokine receptors and two orphan chemokine receptor-like genes in various freshly prepared human peripheral blood leucocyte popu...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0851
更新日期:2001-04-07 00:00:00
abstract::The objectives were to determine if blood IL-10 levels rise during the early stages of acute (wasting) pre-pubescent malnutrition in metabolically distinct murine models known to depress inflammatory immune competence and whether systemic IL-10 production is affected in these pathologies. Weanling C57BL/6J mice were a...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.05.015
更新日期:2009-08-01 00:00:00
abstract::The purpose of this study is to evaluate local levels of interleukin-1 beta (IL-1 beta), -4 (IL-4), -6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha), in a model of murine osteomyelitis due to Staphylococcus aureus. Cytokine levels in supernatants derived from bone homogenates were determined by enzyme-linked im...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2002.1039
更新日期:2002-07-21 00:00:00
abstract:BACKGROUND:HIV rapid progressors (RPs) present with a rapid decline of CD4+ T cells within a few years of infection. Determining the underlying mechanisms throughout this decline is important to identify prognostic biomarkers and intervention strategies. Determining the numbers of CD4+ and CD8+ T cells is essential for...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2019.154801
更新日期:2020-01-01 00:00:00
abstract::Interleukin (IL)-33 (or IL-1F11) was recently identified as a ligand for the orphan IL-1 receptor family member T1/ST2 (ST2). IL-33 belongs to the IL-1 cytokine family and, upon binding to ST2, induces intracellular signals similar to those utilized by IL-1. The effects of other IL-1 family cytokines are mediated by t...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.03.008
更新日期:2008-06-01 00:00:00
abstract::The aim of this study was to characterize the association between adipocyte enlargement and circulating levels of serum amyloid A (SAA). Furthermore, we wanted to search for possible associations with measures of glycemic control and levels of circulating adipokines and/or inflammatory markers in men and women with a ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.08.005
更新日期:2009-12-01 00:00:00
abstract::Dysregulation of cytokines synthesis is thought to play a role in the development of a number of age-related conditions, such as rheumatoid arthritis, osteoporosis, atherosclerosis, and others, but observational studies have led to contradictory results. We investigated potential familial influences on the plasma leve...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2002.1959
更新日期:2002-08-07 00:00:00
abstract:RATIONALE:Inflammation exacerbates a number of deleterious effects on the heart, most notable being left ventricular dysfunction (LVD). A promoter polymorphism of the NFKB1 gene (encodes p50 subunit) results in lower protein levels of NFkB p50 subunits, which in its dimmer (p50) form has anti-inflammatory effects. The ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.12.020
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by a wide variety of autoantibodies, some of which are pathogenic. In recent years it has become more evident that the polyclonal B cell activation in SLE is T-cell dependent. The stimulation of the autoantibody producing B cells is li...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.07.023
更新日期:2006-08-01 00:00:00
abstract::We investigated the effects of two low doses of interferon-alpha (IFN-alpha) on nocturnal sleep in 18 healthy men by means of polysomnographic sleep recordings. At 1900h, human recombinant IFN-alpha (1000 or 10000 U/kg body weight) or placebo was administered subcutaneously. Between 2300h and 0700h subjects were allow...
journal_title:Cytokine
pub_type: 临床试验,杂志文章
doi:10.1006/cyto.1999.0587
更新日期:2000-05-01 00:00:00
abstract::C-reactive protein (CRP) has been demonstrated to induce blood-brain barrier disruption (BBB) involving NAD(P)H-oxidase dependent oxidative stress. It is unclear why CRP affects the BBB and not other vascular beds following stroke. Therefore we examined CRP receptor and NAD(P)H-oxidase expression levels in bovine brai...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.02.011
更新日期:2010-05-01 00:00:00
abstract::We have investigated phosphatidylinositol 3-kinase (PI3K)-dependent survival signalling pathways using several cytokines in three different hemopoietic cell lines, MC/9, FDC-P1, and TF-1. Cytokines caused PI3K- and PKB-dependent phosphorylation of FOXO3a (previously known as FKHRL1) at three distinct sites. Following ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.05.004
更新日期:2007-05-01 00:00:00
abstract::Flt3 ligand (FL) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are important growth factors for dendritic cells (DC). Substantial numbers of DC can be generated in vivo following the administration of either factor. We sought to extend our knowledge of the functional properties of these cells including...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2001.0995
更新日期:2002-02-07 00:00:00
abstract::The objective of this study was to investigate the effects of the cytokines IFN-alpha, IL-6 and IL-10 present in the serum of systemic lupus erythematosus (SLE) patients on the differentiation and maturation of DCs derived from CD34(+) hematopoietic precursor cells (HPCs). CD34(+) HPCs cultured in SLE serum containing...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.02.017
更新日期:2010-05-01 00:00:00
abstract::Increased levels of serum IgE have been described in gliadin-intolerant patients; however, biological mechanisms implicated in this immunoglobulin production remained unknown. In this study, we demonstrated that in vitro crude gliadins and gliadin lysates (Glilys) promoted the IL-4-induced IgE production by human peri...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/s1043-4666(03)00100-5
更新日期:2003-03-21 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the signaling mechanisms surrounding changes in tight junction (TJ) and the permeability of human intestinal epithelial cell induced by tumor necrosis factor-alpha (TNF-α). METHODS:To confirm that TNF-α induces epithelial barrier hyperpermeability by disrupting tight ju...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.04.008
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease mediated by an autoimmune reaction to hepatocytes, the present study aimed to assess the possible associations between interleukin-4 (IL-4) variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms and susceptibility to aut...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.01.009
更新日期:2018-10-01 00:00:00
abstract::Castration-refractory prostate cancer (CRPC) is treated with taxane-based chemotherapy, but eventually becomes drug resistant. It is thus essential to identify novel therapeutic targets for taxane resistance in CRPC patients. We investigated the role of the chemokine (C-C motif) receptor 1 (CCR1) and its ligand, chemo...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.06.313
更新日期:2013-10-01 00:00:00
abstract::Pregnancy in sickle cell disease is a problem due to the adverse outcomes related to the disease. Research into the role of chemokines in sickle cell disease is available, but studies investigating the disease in pregnancy are scarce. Our data show the chemokine profiles of pregnant women with sickle cell disease comp...
journal_title:Cytokine
pub_type: 临床试验,杂志文章
doi:10.1016/j.cyto.2018.07.002
更新日期:2019-01-01 00:00:00