Serum VEGF levels and tissue activation of VEGFR2/KDR receptors in patients with breast and gynecologic cancer.

abstract：:Sickle cell anemia (SCA) is a disorder characterized by a heterogeneous clinical outcome. In the present study, we investigated the associations between Tumor Necrosis Factor-alpha (TNF-alpha) -308G>A and Interleukin 8 (IL-8) -251A>T gene polymorphisms, medical history and classical biomarkers in children with steady-...

journal_title：Cytokine

authors： Cajado C,Cerqueira BA,Couto FD,Moura-Neto JP,Vilas-Boas W,Dorea MJ,Lyra IM,Barbosa CG,Reis MG,Goncalves MS

更新日期：2011-11-01 00:00:00

abstract：:Chronic liver injury causes liver regeneration, resulting in fibrosis. The proinflammatory cytokine tumor necrosis factor (TNF) is involved in the pathogenesis of many acute and chronic liver diseases. TNF has pleiotropic functions, but its role in liver fibrosis has not been clarified. Chronic repeated injection of C...

journal_title：Cytokine

authors： Sudo K,Yamada Y,Moriwaki H,Saito K,Seishima M

更新日期：2005-03-07 00:00:00

abstract：BACKGROUND:Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in the MEFV gene. Mutations in exon 10 are associated with typical FMF phenotypes, and patients with exon 10 mutations have higher serum levels of interleukin (IL)-18 both during attacks and afebrile phases, compared to tho...

journal_title：Cytokine

authors： Wada T,Toma T,Miyazawa H,Koizumi E,Shirahashi T,Matsuda Y,Yachie A

更新日期：2018-04-01 00:00:00

abstract：:We recently reported an association between interleukin-6 (IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study was to investigate this association in a larger cohort of subjects, affected by either aggressive or chronic periodontitis. Five IL6 SNPs were analyzed in 765 su...

journal_title：Cytokine

authors： Nibali L,D'Aiuto F,Donos N,Griffiths GS,Parkar M,Tonetti MS,Humphries SE,Brett PM

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:The effects of LDL-apheresis (LDLa) with dextran sulphate on plasma cytokines in 6 homozygous familial hypercholesterolemic (HozFH) patients, were evaluated. METHODS:Plasma IL-1α; IL-1ra; IL-4; IL-6; IL-10; IL-12(p40); IL-12(p70); TNF-α, sTNF-R, VEGF, VEGF-R1, E-Selectin (ESEL), and P-Selectin (PSEL) concent...

journal_title：Cytokine

authors： Stefanutti C,Vivenzio A,Di Giacomo S,Ferraro PM

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:This study evaluates the potential of gingival crevicular fluid and serum cytokines as HIV stage biomarkers. METHODS:Gingival crevicular fluid (GCF) and serum samples from 78 HIV-positive adult male subjects (cases) and 39 HIV-negative male subjects (controls) from Mexico were examined for 17 cytokines using...

journal_title：Cytokine

authors： Elizondo JE,Rocha-Pizaña MD,Treviño AC,Violant D,Álvarez MM,Rivas-Estilla AM

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:Functions of the Th9 cells and its signature cytokine IL-9 in human autoimmune diseases is currently under extensive research. Here we are reporting new functions of IL-9-receptor (IL-9R); its regulatory role on (i) FLS (fibroblast like synoviocyte) biology and (ii) pannus formation in rheumatoid arthritis (R...

journal_title：Cytokine

authors： Raychaudhuri SK,Abria C,Maverakis EM,Raychaudhuri SP

更新日期：2018-11-01 00:00:00

abstract：:Neuropilin-1 (NRP-1) is a co-receptor for vascular endothelial growth factor (VEGF). During neovascularization, vascular smooth muscle cells (VSMCs) and pericytes modulate the function of endothelial cells. Factors that mediate NRP-1 in human VSMCs (hVSMCs) remain to be elucidated. We studied various angiogenic cytoki...

journal_title：Cytokine

authors： Liu W,Parikh AA,Stoeltzing O,Fan F,McCarty MF,Wey J,Hicklin DJ,Ellis LM

更新日期：2005-12-07 00:00:00

abstract：:Neutrophil microparticles (NMs) are scarce in the circulation but are highly enriched at sites of inflammation and exert profound effects on immune cells. In the present study, we addressed whether NMs modulate cytokine-producing capacity of natural killer (NK) cells. NMs inhibited the production of IFN-γ and TNF-α bu...

journal_title：Cytokine

authors： Pliyev BK,Kalintseva MV,Abdulaeva SV,Yarygin KN,Savchenko VG

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Recently, attenuation of anti-inflammatory and increase of pro-inflammatory mediators was demonstrated in individuals with Down syndrome (DS) in comparison with euploid patients during periodontal disease (PD), suggesting a shift to a more aggressive inflammation in DS. AIM:To determine the influence of DS ...

journal_title：Cytokine

authors： Tanaka MH,Giro EM,Cavalcante LB,Pires JR,Apponi LH,Valentini SR,Spolidório DM,Capela MV,Rossa C Jr,Scarel-Caminaga RM

更新日期：2012-12-01 00:00:00

abstract：:Within the human TNF promoter we have identified two sites at positions -189 and -101 that show C/EBP specific binding of nuclear proteins from cells of the human monocytic line Mono Mac 6. Supershift analysis with anti C/EBP antibodies revealed that the complexes formed consist of both C/EBP alpha and C/EBP beta. Whe...

journal_title：Cytokine

authors： Wedel A,Sulski G,Ziegler-Heitbrock HW

更新日期：1996-05-01 00:00:00

abstract：:Therapeutic plasmapheresis is a recognized medical procedure in which various techniques are used to separate and remove undesirable or excessively elevated plasma elements from blood. The main purpose of the procedure is to remove the substances responsible for the disease (autoantibodies, circulating immune complexe...

journal_title：Cytokine

authors： Zenti MG,Stefanutti C

更新日期：2011-12-01 00:00:00

abstract：:Recent studies have implicated leptin as a "stress" hormone and highlighted its association with increases in inflammatory cytokines, C-reactive protein and cortisol. In order to investigate the exact temporal leptin response to stress we undertook a detailed longitudinal study of circulating leptin concentrations dur...

journal_title：Cytokine

authors： Wallace AM,Sattar N,Mcmillan DC

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:IL-10 family cytokines are associated with the host immune response to pulmonary tuberculosis (PTB), but their association with host response in tuberculous lymphadenitis (TBL) is not known. METHODS:Hence, we examined the circulating levels of the whole panel of IL-10 family cytokines in TBL (n = 44) and co...

journal_title：Cytokine

authors： Kathamuthu GR,Kumar NP,Moideen K,Baskaran D,Hissar S,Shrinivasa BM,Sridhar R,Babu S

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:Atherosclerosis is a chronic inflammatory disease regulated by T lymphocyte subsets. Recently, CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells and Th17 cells have been described as two distinct subsets and have the opposite effects on autoimmunity. Clinical observation has revealed that the Th17/Treg imbala...

journal_title：Cytokine

authors： Xie JJ,Wang J,Tang TT,Chen J,Gao XL,Yuan J,Zhou ZH,Liao MY,Yao R,Yu X,Wang D,Cheng Y,Liao YH,Cheng X

更新日期：2010-02-01 00:00:00

abstract：:Although tumor necrosis factor (TNF) and interleukin 6 (IL 6) are purported to be important mediators of inflammatory responses following trauma, it is not known if the serum levels of these cytokines are altered by simple hemorrhage. The objective of this study therefore was to determine whether or not: 1) there is a...

journal_title：Cytokine

authors： Ayala A,Perrin MM,Meldrum DR,Ertel W,Chaudry IH

更新日期：1990-05-01 00:00:00

abstract：:The proinflammatory cytokines TNFalpha and IL-1beta are thought to play a role in the mechanism of septic vasodilatory shock. Most evidence indicate that the vascular effects these cytokines are mediated through increased expression of inducible nitric oxide synthase, whereas several animal studies report a more rapid...

journal_title：Cytokine

authors： Pickkers P,Netea MG,van der Meer JW,Smits P

更新日期：2002-12-07 00:00:00

abstract：:The hyper-inflammatory response is thought to be a major cause of acute respiratory distress syndrome (ARDS) in patients with COVID-19. Although multiple cytokines are reportedly associated with disease severity, the key mediators of SARS-CoV-2 induced cytokine storm and their predictive values have not been fully elu...

journal_title：Cytokine

authors： Liu Y,Chen D,Hou J,Li H,Cao D,Guo M,Ling Y,Gao M,Zhou Y,Wan Y,Zhu Z

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Adiponectin is an anti-atherogenic insulin-sensitizer hormone whose plasma concentration is lower in patients with metabolic syndrome (MS). Visceral adiposity, including epicardial adipose tissue (EAT), is closely related to the development of MS and coronary artery disease (CAD). We sought to study whether ...

journal_title：Cytokine

authors： Teijeira-Fernandez E,Eiras S,Shamagian LG,Somoza AS,Delgado C,Gonzalez-Juanatey JR

更新日期：2011-05-01 00:00:00

abstract：:We have cloned and performed the first functional characterization of the chemokine receptor, CCR3, of Cynomolgus monkey (Macaca fascicularis). The deduced amino acid sequence of the cloned Cynomolgus CCR3 was found to be more similar to that of a previously-reported Rhesus (Macaca mulatta) CCR3 (99.4%) than that of a...

journal_title：Cytokine

authors： Iino T,Sugimoto H,Watanabe A,Encinas JA,Liu N,Floeckner J,Bacon KB

更新日期：2002-09-21 00:00:00

abstract：:Tumour necrosis factor (TNF) is a pleiotropic cytokine which plays a central role in infection, inflammation and autoimmune diseases. Its functions are mediated through binding to high affinity cell surface receptors. An approach to modulate excessive levels of TNF-alpha in the serum is the use of soluble receptors. I...

journal_title：Cytokine

authors： Chirinos-Rojas CL,Steward MW,Partidos CD

更新日期：1997-04-01 00:00:00

abstract：:We evaluated the spontaneous IL17, IFNgamma and IL10 production by peripheral blood mononuclear cells from patients affected by clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS) both in acute phase and in remission, relapsing remitting MS (RRMS) both in relapse and in remission, not-relapsing s...

journal_title：Cytokine

authors： Frisullo G,Nociti V,Iorio R,Patanella AK,Marti A,Caggiula M,Mirabella M,Tonali PA,Batocchi AP

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVES:The clinical symptoms of the patients with intracellular bacterial bloodstream infections (Intra-bac BSIs) are atypical, and no early and accurate diagnostic biomarkers exist, which can easily lead to misdiagnosis, inappropriate and delayed treatment. Therefore, it is imperative to find novel biomarkers to h...

journal_title：Cytokine

authors： Lin MF,Sun B,Liu ZY,Tang P,Zhang LJ,Wang YY

更新日期：2020-12-01 00:00:00

abstract：:Air pollution causes increased cardiopulmonary morbidity and mortality. Airway inflammation plays a major role in the pathophysiology of many lung diseases. Proinflammatory cytokines, such as interleukin-8 (IL-8), are responsible in part for the initiation and maintenance of airway inflammation. Asbestos exposure and ...

journal_title：Cytokine

authors： Pei XH,Nakanishi Y,Inoue H,Takayama K,Bai F,Hara N

更新日期：2002-09-07 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is the key regulator of angiogenesis in the development of various cancers. Previous studies have examined the relationship between VEGF gene promoter polymorphisms such as -2578C/A and -460C/T and bladder cancer risk; however, these results are inconclusive. Therefo...

journal_title：Cytokine

authors： Chen CH,Ho CH,Kuan-Hua Huang S,Shen CH,Wu CC,Wang YH

更新日期：2020-07-01 00:00:00

abstract：:Pro-inflammatory cytokines are important mediators in tissue responses to a wide range of endogenous (e.g. autoantigens) and exogenous (e.g. infections, wounds, biomaterials) stimuli. The complex interactions taking place between different cell types in such processes are difficult to examine in vivo. Here we studied ...

journal_title：Cytokine

authors： Gretzer C,Thomsen P,Jansson S,Nilsson M

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Why severity varies in blastomycosis outbreaks remains unresolved. In experimental pulmonary blastomycosis, susceptibility varied in mouse strains. In susceptible BALB/c the response is Th-2, in immunized, resistance is associated with Th-1. Can susceptibility be redirected by IL-12? Methods, results: BALB/c...

journal_title：Cytokine

authors： Brummer E,Vinoda V,Stevens DA

更新日期：2006-09-01 00:00:00

abstract：:It is known that both interleukin-4 (IL-4) and IL-13 are produced by Th2-type cells and share similar biological functions with each other. However, recently accumulated evidences have revealed that IL-4 may be involved in the Th1-type response. Both thymus and activation-regulated chemokine (TARC/CCL17), a ligand for...

journal_title：Cytokine

authors： Kakinuma T,Nakamura K,Wakugawa M,Yano S,Saeki H,Torii H,Komine M,Asahina A,Tamaki K

更新日期：2002-10-07 00:00:00

abstract：:Published data on the association between microRNA-146a (miR-146a) G/C polymorphism and cancer susceptibility are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 23 studies including 10,585 cases and 12,183 controls were used in the meta-analysis. Overal...

journal_title：Cytokine

authors： Qiu LX,He J,Wang MY,Zhang RX,Shi TY,Zhu ML,Mao C,Sun S,Lv FF,Zheng CL,Zhu XD

更新日期：2011-12-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a notable chemokine that plays critical roles in angiogenesis and vasculogenesis. The contemporary body of literature contains a substantial amount of information regarding its chemical properties as well as its fundamental role in vascular development. Studies strongly ind...

journal_title：Cytokine

authors： Crafts TD,Jensen AR,Blocher-Smith EC,Markel TA

更新日期：2015-02-01 00:00:00