Abstract:
:Pregnancy in sickle cell disease is a problem due to the adverse outcomes related to the disease. Research into the role of chemokines in sickle cell disease is available, but studies investigating the disease in pregnancy are scarce. Our data show the chemokine profiles of pregnant women with sickle cell disease compared with control groups. There were no differences in MCP-1 level among the groups, but IL-8 and MIG were likely related with disease activity. In addition, levels of IP-10 were higher in pregnant women with sickle cell disease and, interestingly, RANTES levels were higher in normal pregnancy when compared to pregnancy in sickle cell disease. More studies should be encouraged to fully elucidate chemokine activity during pregnancy in sickle cell disease.
journal_name
Cytokinejournal_title
Cytokineauthors
Hazin-Costa MF,da Silva Aráujo A,Guerra GL,da Matta MC,Torres LC,Souza AIdoi
10.1016/j.cyto.2018.07.002subject
Has Abstractpub_date
2019-01-01 00:00:00pages
195-199eissn
1043-4666issn
1096-0023pii
S1043-4666(18)30288-6journal_volume
113pub_type
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